Vincenzo Di Marzo

Summary

Affiliation: Istituto di Chimica Biomolecolare
Country: Italy

Publications

  1. doi request reprint The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy
    Francesca Rossi
    Department of Pediatrics, Second University of Naples, Naples, Italy
    Bone 48:997-1007. 2011
  2. pmc Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter
    Alessia Ligresti
    Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    PLoS ONE 5:e10239. 2010
  3. ncbi request reprint Endocannabinoid pathways and their role in multiple sclerosis-related muscular dysfunction
    Vincenzo Di Marzo
    Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
    Expert Rev Neurother 11:9-14. 2011
  4. pmc Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice
    Fabiana Piscitelli
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR, Pozzuoli NA, Italy
    Nutr Metab (Lond) 8:51. 2011
  5. pmc Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects
    Sebastiano Banni
    Dipartimento Biologia Sperimentale, Universita di Cagliari, Cittadella Universitaria, 09042 Monserrato CA, Italy
    Nutr Metab (Lond) 8:7. 2011
  6. pmc Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Lipids Health Dis 9:43. 2010
  7. pmc Possible Anandamide and Palmitoylethanolamide involvement in human stroke
    Marcello Naccarato
    Department of Medical, Technological and Translational Sciences, Neurology Unit, University of Trieste, Strada di Fiume 447, 34100 Trieste TS, Italy
    Lipids Health Dis 9:47. 2010
  8. pmc Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation
    Ravi Murumalla
    GEICO, Groupe d Etude sur l Inflammation et l Obésité Chronique, Universite de la Reunion, Plateforme CYROI, 15 Avenue Rene Cassin, 97715 Saint Denis Messag Cedex, France
    J Inflamm (Lond) 8:33. 2011
  9. ncbi request reprint Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli NA, Italy
    Chem Biol 14:741-56. 2007
  10. doi request reprint The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation
    V Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli NA, Italy
    Int J Obes (Lond) 33:S18-24. 2009

Detail Information

Publications128 found, 100 shown here

  1. doi request reprint The endovanilloid/endocannabinoid system: a new potential target for osteoporosis therapy
    Francesca Rossi
    Department of Pediatrics, Second University of Naples, Naples, Italy
    Bone 48:997-1007. 2011
    ..Our data pave the way to the use of TRPV1 agonist together with CB2 agonists or CB1 antagonists in osteoporosis...
  2. pmc Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter
    Alessia Ligresti
    Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    PLoS ONE 5:e10239. 2010
    ..Furthermore, the main evidence in favor of the existence of an "anandamide transporter" relies on synthetic inhibitors of this process, the selectivity of which has been questioned...
  3. ncbi request reprint Endocannabinoid pathways and their role in multiple sclerosis-related muscular dysfunction
    Vincenzo Di Marzo
    Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
    Expert Rev Neurother 11:9-14. 2011
    ..Furthermore, research into the endocannabinoid system may offer potential in other neurodegenerative, inflammatory and pain disorders...
  4. pmc Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice
    Fabiana Piscitelli
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR, Pozzuoli NA, Italy
    Nutr Metab (Lond) 8:51. 2011
    ..abstract:..
  5. pmc Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects
    Sebastiano Banni
    Dipartimento Biologia Sperimentale, Universita di Cagliari, Cittadella Universitaria, 09042 Monserrato CA, Italy
    Nutr Metab (Lond) 8:7. 2011
    ....
  6. pmc Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients
    Giovanni Annuzzi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Lipids Health Dis 9:43. 2010
    ....
  7. pmc Possible Anandamide and Palmitoylethanolamide involvement in human stroke
    Marcello Naccarato
    Department of Medical, Technological and Translational Sciences, Neurology Unit, University of Trieste, Strada di Fiume 447, 34100 Trieste TS, Italy
    Lipids Health Dis 9:47. 2010
    ..Our aim was to determine eCB peripheral levels in acute stroke patients and evaluate their relationship with clinical disability and stroke volume...
  8. pmc Effect of the Cannabinoid Receptor-1 antagonist SR141716A on human adipocyte inflammatory profile and differentiation
    Ravi Murumalla
    GEICO, Groupe d Etude sur l Inflammation et l Obésité Chronique, Universite de la Reunion, Plateforme CYROI, 15 Avenue Rene Cassin, 97715 Saint Denis Messag Cedex, France
    J Inflamm (Lond) 8:33. 2011
    ..abstract:..
  9. ncbi request reprint Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli NA, Italy
    Chem Biol 14:741-56. 2007
    ....
  10. doi request reprint The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation
    V Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli NA, Italy
    Int J Obes (Lond) 33:S18-24. 2009
    ....
  11. pmc Endocannabinoid overactivity and intestinal inflammation
    V Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy
    Gut 55:1373-6. 2006
    ..The pathological significance of this "endocannabinoid overactivity" and its possible exploitation for therapeutic purposes are discussed here...
  12. ncbi request reprint Plant, synthetic, and endogenous cannabinoids in medicine
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institutes of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Annu Rev Med 57:553-74. 2006
    ....
  13. pmc Manipulation of the endocannabinoid system by a general anaesthetic
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbr 70, 80078 Pozzuoli, Napoli, Italy
    Br J Pharmacol 139:885-6. 2003
    ....
  14. ncbi request reprint The endocannabinoid system: its general strategy of action, tools for its pharmacological manipulation and potential therapeutic exploitation
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Pharmacol Res 60:77-84. 2009
    ..Compounds that selectively manipulate the action and levels of endocannabinoids at their targets have been and are being developed, and represent templates for potential new therapeutic drugs...
  15. ncbi request reprint Role of insulin as a negative regulator of plasma endocannabinoid levels in obese and nonobese subjects
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei, 34, Comprensorio Olivetti, 80078 Pozzuoli NA, Italy
    Eur J Endocrinol 161:715-22. 2009
    ..We investigated in two different cohorts of nonobese or obese volunteers whether oral glucose in glucose tolerance tests (OGTT) or acute insulin infusion during euglycemic hyperinsulinemic clamp affect plasma EC levels...
  16. ncbi request reprint A brief history of cannabinoid and endocannabinoid pharmacology as inspired by the work of British scientists
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbr 70, 80078 Pozzuoli NA Italy
    Trends Pharmacol Sci 27:134-40. 2006
    ..Stemming from the many innovative ideas and achievements of these researchers, I provide a personal view of where these studies have led us thus far and where they are likely to take us in the future...
  17. doi request reprint Changes in plasma endocannabinoid levels in viscerally obese men following a 1 year lifestyle modification programme and waist circumference reduction: associations with changes in metabolic risk factors
    V Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli NA, Italy
    Diabetologia 52:213-7. 2009
    ..We analysed the changes in endocannabinoid levels in a subsample from the same cohort following a 1 year lifestyle modification programme, and correlated them with changes in VAT and metabolic risk factors...
  18. doi request reprint CB(1) receptor antagonism: biological basis for metabolic effects
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Drug Discov Today 13:1026-41. 2008
    ..The biological basis for the metabolic effects of rimonabant (SR141716) appears to involve the modulation of metabolism through antagonism at a single receptor with several target organs...
  19. ncbi request reprint New Potential Therapies from Vanilloid Transient Receptor Cation (TRPV) Channels
    Vincenzo Di Marzo
    Institute of Biomolecular Chemistry, C N R, via dei Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli Naples, Italy
    Curr Pharm Des 14:1. 2008
  20. ncbi request reprint Endocannabinoid control of food intake and energy balance
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy
    Nat Neurosci 8:585-9. 2005
    ..Here we discuss the multifaceted regulation of energy homeostasis by endocannabinoids, together with its applications to the treatment of eating disorders and metabolic syndromes...
  21. doi request reprint FAAH and anandamide: is 2-AG really the odd one out?
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, Italy
    Trends Pharmacol Sci 29:229-33. 2008
    ....
  22. doi request reprint Targeting the endocannabinoid system: to enhance or reduce?
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council CNR, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy
    Nat Rev Drug Discov 7:438-55. 2008
    ..When moving to the clinic, however, the pleiotropic nature of endocannabinoid functions will require careful judgement in the choice of patients and stage of the disorder for treatment...
  23. ncbi request reprint The endocannabinoid system and its therapeutic exploitation
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Napoli, Italy
    Nat Rev Drug Discov 3:771-84. 2004
    ..We explore the conditions under which the potential of targeting the endocannabinoid system might be realized in the years to come...
  24. doi request reprint Endocannabinoids: synthesis and degradation
    V Di Marzo
    Consiglio Nazionale delle Ricerche, Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbr 70, 80078 Pozzuoli NA, Italy
    Rev Physiol Biochem Pharmacol 160:1-24. 2008
    ....
  25. ncbi request reprint Endocannabinoids and the regulation of their levels in health and disease
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Curr Opin Lipidol 18:129-40. 2007
    ..Here we review the mechanisms for the regulation of their levels under physiological and pathological conditions, and recent findings on their role in disease...
  26. ncbi request reprint CB1 antagonists for obesity--what lessons have we learned from rimonabant?
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Nat Rev Endocrinol 5:633-8. 2009
    ..Finally, we discuss how pharmacological approaches that aim to counteract overactivity of the endocannabinoid system should be revisited in the future to treat visceral (intra-abdominal) obesity and its metabolic consequences...
  27. doi request reprint The endocannabinoid system in obesity and type 2 diabetes
    V Di Marzo
    Endocannabinoid Research Group at the Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078, Pozzuoli NA, Italy
    Diabetologia 51:1356-67. 2008
    ..It also helps to explain why some of the beneficial actions of these new therapeutics appear to be partly independent from weight loss...
  28. ncbi request reprint Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
    V Di Marzo
    School of Biological Sciences, University of Manchester, United Kingdom
    FASEB J 14:1432-8. 2000
    ....
  29. ncbi request reprint Anandamide receptors
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomdecolare, 80078 Pozzuoli, Naples, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:377-91. 2002
    ....
  30. ncbi request reprint A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Pozzuoli, Napoli, Italy
    J Pharmacol Exp Ther 300:984-91. 2002
    ..04 mg/kg), did not activate VR1 or CB1 receptors. Our findings suggest that VR1 and/or as yet uncharacterized receptors produce cannabimimetic responses in mice in vivo...
  31. pmc Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Biochem J 358:249-55. 2001
    ..We suggest that long-term PEA treatment of cells may positively affect the pharmacological activity of AEA, in part by inhibiting FAAH expression...
  32. ncbi request reprint Anandamide: some like it hot
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Viale Toiano 6, Arco Felice, 80072 Napoli, Italy
    Trends Pharmacol Sci 22:346-9. 2001
    ..However, very recent reports demonstrate that activation of VR1 by anandamide can be significantly enhanced by various regulatory factors, suggesting that this compound might act as an "endovanilloid" under certain conditions...
  33. ncbi request reprint Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, C N R, Via Toiano 6, 80072, Arco Felice, Naples, Italy
    Eur J Pharmacol 420:123-31. 2001
    ....
  34. ncbi request reprint Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice Na, Italy
    Biochem Biophys Res Commun 281:444-51. 2001
    ....
  35. ncbi request reprint Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Arco Felice, Italy
    J Neurochem 75:2434-44. 2000
    ..We suggest that non-CB(1), non-CB(2) G protein-coupled receptors might mediate in mice some of the neuro-behavioral actions of AEA...
  36. ncbi request reprint Endocannabinoids: new targets for drug development
    - Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Curr Pharm Des 6:1361-80. 2000
    ..These studies are reviewed in this article with special emphasis on the chemical features that determine the interaction of endocannabinoids with the proteins mediating their activity and degradation...
  37. ncbi request reprint Cannabimimetic fatty acid derivatives in cancer and inflammation
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Prostaglandins Other Lipid Mediat 61:43-61. 2000
    ..The possibility that CFADs act as local inhibitors of the proliferation of human breast cancer is discussed here...
  38. ncbi request reprint Endovanilloid signaling in pain
    Vincenzo Di Marzo
    Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Edificio 70, 80078 Pozzuoli, Napoli, Italy
    Curr Opin Neurobiol 12:372-9. 2002
    ..Conversely, downregulation of VR1 expression and/or activity is a promising therapeutic strategy for novel analgesic drugs...
  39. doi request reprint Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, CNR, Pozzuoli, Italy
    Nat Neurosci 14:9-15. 2011
    ..However, even with these new tools, the cross-talk between anandamide and 2-arachidonoylglycerol biosynthesis makes it difficult to dissect one from the other, and data will need to be interpreted with this in mind...
  40. doi request reprint Gut feelings about the endocannabinoid system
    V Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Neurogastroenterol Motil 23:391-8. 2011
    ....
  41. doi request reprint Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-alpha ligands in Zucker rats
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Obesity (Silver Spring) 18:55-62. 2010
    ..Changes in PEA levels might be relevant to the inflammatory state of Zucker rats...
  42. doi request reprint The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats
    Vito De Novellis
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    Neuropharmacology 55:1105-13. 2008
    ..All AA-5-HT effects were antagonized by cannabinoid CB1 and TRPV1 receptor antagonists thus suggesting that co-localization of these receptors in the PAG can be an appropriate neural substrate for AA-5-HT-induced analgesia...
  43. pmc Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 166:1444-60. 2012
    ..Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Here, we investigated the effect of CBC on mouse intestinal motility in physiological and pathological states...
  44. doi request reprint Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia
    Sabatino Maione
    Endocannabinoid Research Group, Second University of Naples 80138, Dept of Experimental Medicine, Via Costantinopoli 16, Naples, Italy
    J Neurophysiol 101:2411-22. 2009
    ....
  45. pmc Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, CNR, Pozzuoli NA, Italy
    Br J Pharmacol 163:1479-94. 2011
    ..Cannabidiol (CBD) and Δ(9) -tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system...
  46. pmc TRPV1-dependent and -independent alterations in the limbic cortex of neuropathic mice: impact on glial caspases and pain perception
    Catia Giordano
    Endocannabinoid Research Group, Department of Experimental Medicine, Division of Pharmacology L Donatelli, Second University of Naples, Italy
    Cereb Cortex 22:2495-518. 2012
    ..We suggest that SNI triggers both TRPV1-dependent and independent glutamate- and caspase-mediated cross-talk among IL-PL cortex neurons and glia, which either participates or counteracts pain...
  47. doi request reprint Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo
    Tiziana Bisogno
    Institute of Biomolecular Chemistry, C N R, Pozzuoli Naples, Italy
    Biochim Biophys Acta 1791:53-60. 2009
    ..p.). OMDM69 might represent a template for the development of selective and even more potent inhibitors of 2-AG hydrolysis...
  48. doi request reprint Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet
    Katarzyna M Starowicz
    Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Obesity (Silver Spring) 16:553-65. 2008
    ..Their pancreatic and adipose tissue levels are elevated during hyperglycemia and obesity, but the mechanisms underlying these alterations are not understood...
  49. ncbi request reprint Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways
    Katarzyna Starowicz
    The Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, Naples, Italy
    J Neurosci 27:13739-49. 2007
    ..The results obtained with the TRPV1 antagonist alone suggest that this pathway is tonically activated by endovanilloids...
  50. ncbi request reprint Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Exp Cell Res 313:2993-3004. 2007
    ..These results suggest that, in RIN m5F cells, CB(1) receptors are coupled to PI-PLC-mediated mobilization of [Ca(2+)](i) and might inhibit bombesin signaling...
  51. doi request reprint Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as "dual-target" analgesics
    Sabatino Maione
    Endocannabinoid Research Group, Department of Experimental Medicine Division of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    Pharmacol Res 76:98-105. 2013
    ..These data suggest that "dual" fatty acid amide hydrolase and transient receptor potential channel modulators should be clinically evaluated as novel analgesics...
  52. ncbi request reprint Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
    Teresa Iuvone
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano, 49, 80131, Naples, Italy
    J Mol Med (Berl) 85:1379-92. 2007
    ..Our data suggest that selective activation of CB1 receptors by either exogenous or endogenous cannabinoids might afford neuroprotection in MPTP-induced neurotoxicity also by controlling S100B up-regulation in activated glial cells...
  53. pmc Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 158:451-61. 2009
    ..Here we evaluate endocannabinoid dysregulation in the small intestine of mice with diet-induced obesity (DIO) and in peripheral tissues of Zucker and lean rats following food deprivation and re-feeding...
  54. ncbi request reprint Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
    Luciano De Petrocellis
    Istituto di Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli, Napoli, Italy
    Fundam Clin Pharmacol 16:297-302. 2002
    ..These 'entourage' effects of PEA might be attributable to modulation of VR1 activity, and could underlie the enhancement by PEA, described here for the first time, of the antiproliferative effects of VR1 receptor agonists...
  55. ncbi request reprint Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry of the National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli Naples, Italy
    J Clin Endocrinol Metab 91:3171-80. 2006
    ..Cannabinoid CB(1) receptor blockade decreases weight and hyperinsulinemia in obese animals and humans in a way greatly independent from food intake...
  56. ncbi request reprint Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    Alessia Ligresti
    Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche Pozzuoli, Italy
    J Pharmacol Exp Ther 318:1375-87. 2006
    ..Our data support the further testing of cannabidiol and cannabidiol-rich extracts for the potential treatment of cancer...
  57. ncbi request reprint Development of the first potent and specific inhibitors of endocannabinoid biosynthesis
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, C N R, Via Campi Flegrei, 34 80078 Pozzuoli NA, Italy
    Biochim Biophys Acta 1761:205-12. 2006
    ..8-0.1 and 3.7-3.2 microM, respectively). Thus, we report the first potent and specific inhibitors of the biosynthesis of 2-AG that may be used as pharmacological tools to investigate the biological role of this endocannabinoid...
  58. ncbi request reprint Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation
    Giuseppe D'Argenio
    Gastroenterologia, Universita di Napoli Federico II, Naples, Italy
    FASEB J 20:568-70. 2006
    ....
  59. pmc Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
    Sabatino Maione
    Endocannabinoid Research Group, Department of Experimental Medicine Division of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    Br J Pharmacol 162:584-96. 2011
    ..Here we have tested these two cannabinoids on the activity of the descending pathway of antinociception...
  60. ncbi request reprint Fatty acid amide hydrolase controls mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 129:941-51. 2005
    ..The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo...
  61. doi request reprint Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice
    Gabriella Aviello
    Endocannabinoid Research Group, Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:413-22. 2008
    ..The inhibitory effect of OEA on gastric emptying here observed might underlie part of the anorexic effects of this compound previously reported...
  62. ncbi request reprint An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
    Gastroenterology 125:765-74. 2003
    ..In this study, we investigated the role of the endogenous cannabinoid system (i.e., the cannabinoid receptors and their endogenous ligands) in CT-induced fluid accumulation in the mouse small intestine...
  63. doi request reprint Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli NA, Italy
    Mol Cell Endocrinol 286:S66-78. 2008
    ..The potential implications of these and previous findings in the general framework of the proposed roles of the EC system in the control of metabolic, endocrine and cardiovascular and renal functions are discussed...
  64. pmc Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:89-98. 2008
    ..The protective effect appears to involve caspase-3 (but not caspase-9) activation...
  65. ncbi request reprint New metabolically stable fatty acid amide ligands of cannabinoid receptors: Synthesis and receptor affinity studies
    Paolo Urbani
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Bldg 70, 80078 Pozzuoli NA, Italy
    Bioorg Med Chem Lett 16:138-41. 2006
    ..For the first time a tertiary amide of arachidonic acid was found to possess moderate affinity (K(i)=300 nM) for cannabinoid CB(1), but not CB(2), receptors...
  66. ncbi request reprint Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception
    Ida Marabese
    Dept of Experimental Medicine, Sect of Pharmacology L Donatelli, Faculty of Medicine and Surgery, Second University of Naples, Via Constantinopoli, Naples, Italy
    J Neurophysiol 98:43-53. 2007
    ..The opposite effects on pain behavior correlate with the opposite roles played by mGluR(7) and mGluR(8) on glutamate and GABA release and the ongoing and tail flick-related activities of the RVM on and off cells...
  67. ncbi request reprint Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Exp Cell Res 313:1911-20. 2007
    ....
  68. ncbi request reprint Development of the first potential covalent inhibitors of anandamide cellular uptake
    Aniello Schiano Moriello
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli Napoli, Italy
    J Med Chem 49:2320-32. 2006
    ..None of the new compounds inhibited [(14)C]anandamide hydrolysis with IC(50) < 50 microM, except for 1b...
  69. ncbi request reprint Possible endocannabinoid control of colorectal cancer growth
    Alessia Ligresti
    Endovannabinoid Research Group, Institute of Biomolecular Chemistry, Pozzuoli, Italy
    Gastroenterology 125:677-87. 2003
    ..the effects of endocannabinoids, and of inhibitors of their inactivation, on human CRC cell proliferation...
  70. ncbi request reprint Overactivity of the intestinal endocannabinoid system in celiac disease and in methotrexate-treated rats
    Giuseppe D'Argenio
    Dipartimento di Gastroenterologia, Universita di Napoli Federico II, Naples, Italy
    J Mol Med (Berl) 85:523-30. 2007
    ..The latter might be used as a model to study the role of the endocannabinoid system in celiac disease...
  71. pmc Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, 80078 Pozzuoli, Italy
    J Cell Biol 163:463-8. 2003
    ..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders...
  72. doi request reprint Plant-derived cannabinoids modulate the activity of transient receptor potential channels of ankyrin type-1 and melastatin type-8
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti 80078, Pozzuoli NA, Italy
    J Pharmacol Exp Ther 325:1007-15. 2008
    ..Our findings suggest that phytocannabinoids and cannabis extracts exert some of their pharmacological actions also by interacting with TRPA1 and TRPM8 channels, with potential implications for the treatment of pain and cancer...
  73. ncbi request reprint Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
    Stefania Petrosino
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche C N R, via dei Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli, Naples 80078, Italy
    Neuropharmacology 52:415-22. 2007
    ..Yet to be developed substances that inhibit both endocannabinoid and PEA inactivation might be useful for the treatment of neuropathic pain...
  74. pmc Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, National Research Council, Pozzuoli, Napoli, Italy
    Br J Pharmacol 143:251-6. 2004
    ....
  75. pmc Further evidence for the existence of a specific process for the membrane transport of anandamide
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, Comprensorio Olivetti, Bldg 70, 80078 Pozzuoli NA, Italy
    Biochem J 380:265-72. 2004
    ..We suggest that at least one protein different from FAAH is required to facilitate AEA transport across the plasma membrane in a selective and bi-directional way...
  76. ncbi request reprint Presence and regulation of the endocannabinoid system in human dendritic cells
    Isabel Matias
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli Napoli, Italy
    Eur J Biochem 269:3771-8. 2002
    ..These findings demonstrate for the first time that the endogenous cannabinoid system is present in human dendritic cells and can be regulated by cell activation...
  77. ncbi request reprint Endocannabinoids as physiological regulators of colonic propulsion in mice
    Luisa Pinto
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 123:227-34. 2002
    ..In the present study, we investigated the possible involvement of endocannabinoids in regulating intestinal propulsion in the mouse colon in vivo...
  78. doi request reprint From endocannabinoid profiling to 'endocannabinoid therapeutics'
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
    Curr Opin Chem Biol 13:321-31. 2009
    ....
  79. ncbi request reprint The endocannabinoid signalling system: biochemical aspects
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078 Pozzuoli Napoli, Italy
    Pharmacol Biochem Behav 81:224-38. 2005
    ..In particular we review the mechanisms for the biosynthesis and inactivation of the endocannabinoids, as well as the various molecular targets for some of the endocannabinoids described so far...
  80. ncbi request reprint A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease
    Mario Van Der Stelt
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, NA, Italy
    FASEB J 19:1140-2. 2005
    ..These data highlight the potential roles played by endocannabinoids and CB1 in PD and LID and suggest the need for further research to pursue the multiple therapeutic opportunities for manipulating this system in movement disorders...
  81. doi request reprint Endocannabinoid chemical biology: a tool for the development of novel therapies
    Stefania Petrosino
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
    Curr Opin Chem Biol 13:309-20. 2009
    ....
  82. ncbi request reprint Cannabinoid receptors and their role in neuroprotection
    Mario Van Der Stelt
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, NA, Italy
    Neuromolecular Med 7:37-50. 2005
    ..If this neuroprotective function of cannabinoid receptor activation can be transferred to the clinic, it might represent an interesting target to develop neuroprotective agents...
  83. ncbi request reprint Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Pozzuoli, Pozzuoli NA, Italy
    Curr Pharm Des 8:533-47. 2002
    ....
  84. ncbi request reprint The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses
    Tiziana Bisogno
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli Naples, Italy
    Curr Pharm Des 14:2299-3305. 2008
    ....
  85. ncbi request reprint Cannabimimetic eicosanoids in cancer and inflammation: an update
    Dominique Melck
    Endocannabinoid Research Group, Istituto per la Chimica di Molecule di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, NA, Italy
    Adv Exp Med Biol 507:381-6. 2002
  86. doi request reprint Synthesis and pharmacological activity of a potent inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol
    Tiziana Bisogno
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli NA, Italy
    ChemMedChem 4:946-50. 2009
    ....
  87. doi request reprint An introduction to the endocannabinoid system: from the early to the latest concepts
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry and Institute of Cybernetics, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, 80078 Pozzuoli, Naples, Italy
    Best Pract Res Clin Endocrinol Metab 23:1-15. 2009
    ..The complexity of the endocannabinoid system and of its physiological and pathological function is outlined in this introductory chapter, for a better understanding of the subsequent chapters in this special issue...
  88. ncbi request reprint Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis
    Giuseppe Portella
    Endocannabinoid Research Group, Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 17:1771-3. 2003
    ..Our findings indicate that CB1 receptor agonists might be used therapeutically to retard tumor growth in vivo by inhibiting at once tumor growth, angiogenesis, and metastasis...
  89. ncbi request reprint N-Acylvanillamides: development of an expeditious synthesis and discovery of new acyl templates for powerful activation of the vanilloid receptor
    Giovanni Appendino
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, Via Campi Flegrei 34, Comprensorio A Olivetti, Building 70, 80078 Pozzuoli NA, Italy
    J Med Chem 45:3739-45. 2002
    ..Nevertheless, a series of new highly active leads was identified, validating the pharmacological potential of the unnatural combination of natural building blocks to provide new bioactive compounds...
  90. ncbi request reprint Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tick
    Filomena Fezza
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, I 80078 Pozzuoli, Napoli, Italy
    Biochim Biophys Acta 1633:61-7. 2003
    ....
  91. ncbi request reprint Anandamide as an intracellular messenger regulating ion channel activity
    Mario Van Der Stelt
    Endocannabinoid Research Group, Istituto Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Bldg 70, 80078 Pozzuoli NA, Italy
    Prostaglandins Other Lipid Mediat 77:111-22. 2005
    ..Here, we will review the evidence for this hypothesis...
  92. doi request reprint A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up
    Gilda Cobellis
    Dipartimento di Medicina Sperimentale, Seconda Universita degli Studi di Napoli, Napoli, Italy
    Biol Reprod 82:451-8. 2010
    ..This gradient-regulated mechanism may encourage further research for future therapies related to male infertility...
  93. ncbi request reprint FAAH and MAGL inhibitors: therapeutic opportunities from regulating endocannabinoid levels
    Stefania Petrosino
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy
    Curr Opin Investig Drugs 11:51-62. 2010
    ..This review describes the major biochemical properties of FAAH and MAGL, and the design and pharmacological properties of inhibitors of these enzymes...
  94. ncbi request reprint Occurrence and possible biological role of the endocannabinoid system in the sea squirt Ciona intestinalis
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli Napoli, Italy
    J Neurochem 93:1141-56. 2005
    ....
  95. ncbi request reprint A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
    Maurizio Bifulco
    Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare L Califano, Universita di Napoli Federico II, Italy
    FASEB J 18:1606-8. 2004
    ....
  96. ncbi request reprint Endocannabinoids and the control of energy balance
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli Napoli, Italy
    Trends Endocrinol Metab 18:27-37. 2007
    ..Accordingly, clinical trials have shown that CB(1) receptor antagonists are efficacious at reducing not only food intake, but also abdominal adiposity and its metabolic sequelae...
  97. ncbi request reprint Anandamide inhibits adhesion and migration of breast cancer cells
    Claudia Grimaldi
    Dipartimento di Scienze Farmaceutiche, Endocannabinoid Research Group, , Fisciano SA, Italy
    Exp Cell Res 312:363-73. 2006
    ....
  98. ncbi request reprint Endocannabinoid metabolic pathways and enzymes
    Alessia Ligresti
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbr 70, 80078 Pozzuoli NA, Italy
    Curr Drug Targets CNS Neurol Disord 4:615-23. 2005
    ....
  99. ncbi request reprint Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: insulin and melanocortins
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli NA, Italy
    Neuropharmacology 54:206-12. 2008
    ....
  100. ncbi request reprint Effect of polyunsaturated fatty acids on endocannabinoid and N-acyl-ethanolamine levels in mouse adipocytes
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, via dei Campi Flegrei 34, 80078 Pozzuoli Napoli, Italy
    Biochim Biophys Acta 1781:52-60. 2008
    ..We suggest that dietary PUFAs might modulate the levels of adipocyte phospholipids that act as endocannabinoid precursors...
  101. ncbi request reprint Neuropathic pain and the endocannabinoid system in the dorsal raphe: pharmacological treatment and interactions with the serotonergic system
    Enza Palazzo
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Faculty of Medicine and Surgery, The Second University of Naples, Via Costantinopoli 16, 80138 Naples, Italy
    Eur J Neurosci 24:2011-20. 2006
    ..However, an elevated level of endogenous anandamide in the DR does not necessarily contribute to the CB1-mediated tonic control of analgesia and serotonergic neuronal activity...