G De Gaetano

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Historical overview of the role of platelets in hemostasis and thrombosis
    G De Gaetano
    Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Haematologica 86:349-56. 2001
  2. ncbi request reprint Response of human platelets exposed to arachidonate upon stimulation with other agonists: possible role of Ca2+i movement
    Z M Chen
    Laboratory of Cardiovascular Clinical Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Biochem Biophys Res Commun 149:1193-9. 1987
  3. ncbi request reprint Antiplatelet activity of 2-(6-carboxyhexyl)-3-n-hexylcyclohexylamine (IBI P-05006), a thromboxane receptor antagonist
    S Rotondo
    Giulio Bizzozero Laboratory of Platelet and Leucocyte Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Eur J Pharmacol 232:41-5. 1993
  4. ncbi request reprint Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes
    P Piccardoni
    Istituto di Ricerche Farmacologiche, Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Thromb Haemost 76:780-5. 1996
  5. ncbi request reprint Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes: a comparison with thrombin
    M Molino
    Instituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Blood 82:2442-51. 1993
  6. ncbi request reprint Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets
    G Di Minno
    Thromb Haemost 45:103-6. 1981
  7. ncbi request reprint More on: tissue factor in neutrophils
    N Maugeri
    J Thromb Haemost 3:1114. 2005
  8. ncbi request reprint Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation
    N Maugeri
    Research Laboratories, Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    J Thromb Haemost 4:1323-30. 2006
  9. ncbi request reprint Inhibition of tissue factor expression by hydroxyurea in polymorphonuclear leukocytes from patients with myeloproliferative disorders: a new effect for an old drug?
    N Maugeri
    Laboratory of Cell Biology and Pharmacology of Thrombosis, Research Laboratories, Catholic University, Campobasso, Italy
    J Thromb Haemost 4:2593-8. 2006
  10. ncbi request reprint Platelet function, antiplatelet therapy and clinical outcomes: to test or not to test?
    G De Gaetano
    Research Laboratories, John Paul II Centre for High Technology, Research and Education in Biomedical Sciences, Catholic University, 86100, Campobasso, Italy
    J Thromb Haemost 5:1835-8. 2007

Collaborators

  • Norma Maugeri
  • C Cerletti
  • P Piccardoni
  • M Molino
  • A Walz
  • A Piccoli
  • S Rotondo
  • V Evangelista
  • M Di Lallo
  • N Martelli
  • G Di Minno
  • Z M Chen
  • V Bertele
  • M J Silver
  • L Bianchi
  • E Dejana
  • B Barbieri

Detail Information

Publications10

  1. ncbi request reprint Historical overview of the role of platelets in hemostasis and thrombosis
    G De Gaetano
    Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Haematologica 86:349-56. 2001
    ..But the taming of the shrew is far from being achieved...
  2. ncbi request reprint Response of human platelets exposed to arachidonate upon stimulation with other agonists: possible role of Ca2+i movement
    Z M Chen
    Laboratory of Cardiovascular Clinical Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Biochem Biophys Res Commun 149:1193-9. 1987
    ..These findings suggest that thrombin may employ pools of cytoplasmic ionized calcium and/or mechanisms to mobilize it different from those utilized by arachidonate and its metabolites...
  3. ncbi request reprint Antiplatelet activity of 2-(6-carboxyhexyl)-3-n-hexylcyclohexylamine (IBI P-05006), a thromboxane receptor antagonist
    S Rotondo
    Giulio Bizzozero Laboratory of Platelet and Leucocyte Pharmacology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Eur J Pharmacol 232:41-5. 1993
    ..In conclusion, IBI P-05006 inhibits in vitro human platelet aggregation through a specific mechanism of competition for the TxA2/PG-cyclic endoperoxides receptor...
  4. ncbi request reprint Thrombin-activated human platelets release two NAP-2 variants that stimulate polymorphonuclear leukocytes
    P Piccardoni
    Istituto di Ricerche Farmacologiche, Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Thromb Haemost 76:780-5. 1996
    ..This finding enhances our understanding of platelet-PMN interaction in thrombosis and inflammation...
  5. ncbi request reprint Effects of leukocyte-derived cathepsin G on platelet membrane glycoprotein Ib-IX and IIb-IIIa complexes: a comparison with thrombin
    M Molino
    Instituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy
    Blood 82:2442-51. 1993
    ..These changes, induced by a product of activated PMN, might reduce the reactivity of platelets to the subendothelium, while increasing their ability to undergo aggregation and release reaction...
  6. ncbi request reprint Effects of any epoxymethano stable analogue of prostaglandin endoperoxides (U-46619) on human platelets
    G Di Minno
    Thromb Haemost 45:103-6. 1981
    ..This compound, however, aggregated washed platelets resuspended in Ca++-free-tyrode-albumin containing fibrinogen. The mechanism by which U-46619 activates platelets differs from that of all other common aggregating agents...
  7. ncbi request reprint More on: tissue factor in neutrophils
    N Maugeri
    J Thromb Haemost 3:1114. 2005
  8. ncbi request reprint Human polymorphonuclear leukocytes produce and express functional tissue factor upon stimulation
    N Maugeri
    Research Laboratories, Center for High Technology Research and Education in Biomedical Sciences, Catholic University, Campobasso, Italy
    J Thromb Haemost 4:1323-30. 2006
    ..Blood-borne tissue factor (TF) plays a crucial role in thrombogenesis...
  9. ncbi request reprint Inhibition of tissue factor expression by hydroxyurea in polymorphonuclear leukocytes from patients with myeloproliferative disorders: a new effect for an old drug?
    N Maugeri
    Laboratory of Cell Biology and Pharmacology of Thrombosis, Research Laboratories, Catholic University, Campobasso, Italy
    J Thromb Haemost 4:2593-8. 2006
    ..Polymorphonuclear leukocytes (PMN) from healthy subjects can produce and store tissue factor (TF), which is expressed on PMN surface upon in vitro stimulation with P-selectin...
  10. ncbi request reprint Platelet function, antiplatelet therapy and clinical outcomes: to test or not to test?
    G De Gaetano
    Research Laboratories, John Paul II Centre for High Technology, Research and Education in Biomedical Sciences, Catholic University, 86100, Campobasso, Italy
    J Thromb Haemost 5:1835-8. 2007