Lidia Cova

Summary

Affiliation: Istituto Auxologico Italiano-IRCCS
Location: Milan, Italy
Publications:
1.Metalloproteinase alterations in the bone marrow of ALS patients.

Bossolasco P, Cova L, Calzarossa C, Servida F, Mencacci NE, Onida F, Polli E, Lambertenghi Deliliers G, Silani V.

J Mol Med. 2010 Jun;88(6):553-64. Epub 2010 Jan 21.

PMID: [PubMed - indexed for MEDLINE]
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2.Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinsons disease.

Cova L, Armentero MT, Zennaro E, Calzarossa C, Bossolasco P, Busca G, Lambertenghi Deliliers G, Polli E, Nappi G, Silani V, Blandini F.

Brain Res. 2010 Jan 22;1311:12-27. Epub 2009 Nov 26.

PMID: [PubMed - indexed for MEDLINE]
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3.Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential.

Montemurro T, Bossolasco P, Cova L, Zangrossi S, Calzarossa C, Buiatiotis S, Soligo D, Silani V, Lambertenghi Deliliers G, Rebulla P, Lazzari L.

Biomed Mater Eng. 2008;18(4-5):183-5. No abstract available.

PMID: [PubMed - indexed for MEDLINE]
Related citations

4.Stem cell research: State of the art.

Eridani S, Cova L.

Cytotechnology. 2003 Mar;41(2-3):53-7. No abstract available.

PMID: [PubMed - in process]
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5.Preface.

Eridani S, Cova L.

Cytotechnology. 2003 Mar;41(2-3):51-2. No abstract available.

PMID: [PubMed - in process]
Related citations

6.Stem cell transplantation in multiple sclerosis: safety and ethics.

Silani V, Cova L.

J Neurol Sci. 2008 Feb 15;265(1-2):116-21. Epub 2007 Jul 9. Review.

PMID: [PubMed - indexed for MEDLINE]
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7.Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases.

Pisati F, Bossolasco P, Meregalli M, Cova L, Belicchi M, Gavina M, Marchesi C, Calzarossa C, Soligo D, Lambertenghi-Deliliers G, Bresolin N, Silani V, Torrente Y, Polli E.

Cell Transplant. 2007;16(1):41-55.

PMID: [PubMed - indexed for MEDLINE]
Related citations

8.Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential.

Bossolasco P, Montemurro T, Cova L, Zangrossi S, Calzarossa C, Buiatiotis S, Soligo D, Bosari S, Silani V, Deliliers GL, Rebulla P, Lazzari L.

Cell Res. 2006 Apr;16(4):329-36.

PMID: [PubMed - indexed for MEDLINE] Free Article
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9.A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA.

Ratti A, Fallini C, Cova L, Fantozzi R, Calzarossa C, Zennaro E, Pascale A, Quattrone A, Silani V.

J Cell Sci. 2006 Apr 1;119(Pt 7):1442-52.

PMID: [PubMed - indexed for MEDLINE] Free Article
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10.Neuro-glial differentiation of human bone marrow stem cells in vitro.

Bossolasco P, Cova L, Calzarossa C, Rimoldi SG, Borsotti C, Deliliers GL, Silani V, Soligo D, Polli E.

Exp Neurol. 2005 Jun;193(2):312-25.

PMID: [PubMed - indexed for MEDLINE]
Related citations

11.Stem-cell therapy for amyotrophic lateral sclerosis.

Silani V, Cova L, Corbo M, Ciammola A, Polli E.

Lancet. 2004 Jul 10-16;364(9429):200-2. Review.

PMID: [PubMed - indexed for MEDLINE]
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12.Stem cell therapy for neurodegenerative diseases: the issue of transdifferentiation.

Cova L, Ratti A, Volta M, Fogh I, Cardin V, Corbo M, Silani V.

Stem Cells Dev. 2004 Feb;13(1):121-31. Review.

PMID: [PubMed - indexed for MEDLINE]
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13.Stem cells in the treatment of amyotrophic lateral sclerosis (ALS).

Silani V, Fogh I, Ratti A, Sassone J, Ciammola A, Cova L.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Dec;3(4):173-81. Review.

PMID: [PubMed - indexed for MEDLINE]
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14.Human neural stem cells express extra-neural markers.

Parati EA, Bez A, Ponti D, de Grazia U, Corsini E, Cova L, Sala S, Colombo A, Alessandri G, Pagano SF.

Brain Res. 2002 Jan 25;925(2):213-21.

PMID: [PubMed - indexed for MEDLINE]
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15.Isolation and characterization of neural stem cells from the adult human olfactory bulb.

Pagano SF, Impagnatiello F, Girelli M, Cova L, Grioni E, Onofri M, Cavallaro M, Etteri S, Vitello F, Giombini S, Solero CL, Parati EA.

Stem Cells. 2000;18(4):295-300.

PMID: [PubMed - indexed for MEDLINE] Free Article
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16.Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain.

Gritti A, Fr

Publications

  1. ncbi Isolation and characterization of neural stem cells from the adult human olfactory bulb
    S F Pagano
    Laboratory of Neuropharmacology, National Neurological Institute C Besta, Milan, Italy
    Stem Cells 18:295-300. 2000
  2. doi Metalloproteinase alterations in the bone marrow of ALS patients
    Patrizia Bossolasco
    Fondazione Matarelli, Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Universita degli Studi di Milano, Via Vanvitelli, 32 20129, Milan, Italy
    J Mol Med (Berl) 88:553-64. 2010
  3. doi Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, Centro Dino Ferrari, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy
    Brain Res 1311:12-27. 2010
  4. ncbi Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential
    Tiziana Montemurro
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Biomed Mater Eng 18:183-5. 2008
  5. pmc Stem cell research: State of the art
    Sandro Eridani
    National Research Council, ITB CNR, Milan, Italy Author for correspondence E mail
    Cytotechnology 41:53-7. 2003
  6. pmc Preface
    Sandro Eridani
    ITB CNR, Milan, Italy
    Cytotechnology 41:51-2. 2003
  7. ncbi Stem cell transplantation in multiple sclerosis: safety and ethics
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milano, Italy
    J Neurol Sci 265:116-21. 2008
  8. ncbi Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases
    Federica Pisati
    Fondazione IRCCS Ospedale Maggiore, Department of Neurological Sciences, Stem Cell Laboratory, Dino Ferrari Center, University of Milan, Milan, Italy
    Cell Transplant 16:41-55. 2007
  9. ncbi Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential
    Patrizia Bossolasco
    Fondazione Matarelli, 20121 Milan, Italy
    Cell Res 16:329-36. 2006
  10. ncbi Human neural stem cells express extra-neural markers
    Eugenio A Parati
    Laboratory of Neuropharmacology, National Neurological Institute C Besta, Via Celoria 11, Milan 20133, Italy
    Brain Res 925:213-21. 2002

Collaborators

  • Vincenzo Silani
  • Patrizia Bossolasco
  • Antonia Ratti
  • Paolo Rebulla
  • Isabella Fogh
  • Silvano Bosari
  • Nereo Bresolin
  • Marie Therese Armentero
  • Fabio Blandini
  • E A Parati
  • Yvan Torrente
  • Valentina Diana
  • Sandro Eridani
  • Davide Moscatelli
  • Paolo Bigini
  • Tiziana Montemurro
  • Cinzia Calzarossa
  • Davide Soligo
  • Federica Pisati
  • Luisa Ottobrini
  • Ilaria Vittoria Libani
  • Giovanni Lucignani
  • Alessandra Paladini
  • Gianluigi Forloni
  • Leopoldo Sitia
  • Francesca Malvestiti
  • Mario Salmona
  • Daniela Giardino
  • Pina Manca
  • Laura Colombo
  • Laura Coloca
  • Fabio Fiordaliso
  • Massimo Morbidelli
  • Elena Fumagalli
  • Laura De Grada
  • Sara Barbera
  • Cinzia Bisighini
  • Edoardo Micotti
  • Tiziana Mennini
  • S F Pagano
  • Stefano Zangrossi
  • Simona Buiatiotis
  • Lorenza Lazzari
  • Giorgio Lambertenghi Deliliers
  • Manuela Gavina
  • Mirella Meregalli
  • Elio Polli
  • Giorgio Lambertenghi-Deliliers
  • Marzia Belicchi
  • Chiara Marchesi
  • M Girelli
  • C L Solero
  • S Giombini
  • F Vitello
  • M Onofri
  • S Etteri
  • E Grioni
  • F Impagnatiello
  • M Cavallaro

Detail Information

Publications19

  1. ncbi Isolation and characterization of neural stem cells from the adult human olfactory bulb
    S F Pagano
    Laboratory of Neuropharmacology, National Neurological Institute C Besta, Milan, Italy
    Stem Cells 18:295-300. 2000
    ..Also, after exposition to leukemia inhibitory factor, we are able to improve the number of neurons, an ideal biological source for transplantation in various neurodegenerative disorders...
  2. doi Metalloproteinase alterations in the bone marrow of ALS patients
    Patrizia Bossolasco
    Fondazione Matarelli, Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica, Universita degli Studi di Milano, Via Vanvitelli, 32 20129, Milan, Italy
    J Mol Med (Berl) 88:553-64. 2010
    ..Therefore, therapeutic implantation of autologous BM derived SC in ALS patients needs to be carefully reevaluated...
  3. doi Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, Centro Dino Ferrari, Università degli Studi di Milano IRCCS Istituto Auxologico Italiano, 20149 Milan, Italy
    Brain Res 1311:12-27. 2010
    ..Altogether, our data provide remarkable cues regarding the potential of hMSCs in promoting endogenous reparative mechanisms that may prove applicable and beneficial for PD treatment...
  4. ncbi Molecular and phenotypical characterization of human amniotic fluid cells and their differentiation potential
    Tiziana Montemurro
    Cell Factory, Centro di Medicina Trasfusionale, Terapia Cellulare e Criobiologia, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    Biomed Mater Eng 18:183-5. 2008
  5. pmc Stem cell research: State of the art
    Sandro Eridani
    National Research Council, ITB CNR, Milan, Italy Author for correspondence E mail
    Cytotechnology 41:53-7. 2003
  6. pmc Preface
    Sandro Eridani
    ITB CNR, Milan, Italy
    Cytotechnology 41:51-2. 2003
  7. ncbi Stem cell transplantation in multiple sclerosis: safety and ethics
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milano, Italy
    J Neurol Sci 265:116-21. 2008
    ..In conclusion, although HCST is today an established therapeutical option for MS patients, safety and ethical issues need to be further clarified...
  8. ncbi Induction of neurotrophin expression via human adult mesenchymal stem cells: implication for cell therapy in neurodegenerative diseases
    Federica Pisati
    Fondazione IRCCS Ospedale Maggiore, Department of Neurological Sciences, Stem Cell Laboratory, Dino Ferrari Center, University of Milan, Milan, Italy
    Cell Transplant 16:41-55. 2007
    ..hMSCs are further defined in their transplantation potential for treating neurological disorders...
  9. ncbi Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential
    Patrizia Bossolasco
    Fondazione Matarelli, 20121 Milan, Italy
    Cell Res 16:329-36. 2006
    ..Our results provide evidence that human amniotic fluid contains progenitor cells with multi-lineage potential showing stem and tissue-specific gene/protein presence for several lineages...
  10. ncbi Human neural stem cells express extra-neural markers
    Eugenio A Parati
    Laboratory of Neuropharmacology, National Neurological Institute C Besta, Via Celoria 11, Milan 20133, Italy
    Brain Res 925:213-21. 2002
    ....
  11. ncbi Stem cells in the treatment of amyotrophic lateral sclerosis (ALS)
    Vincenzo Silani
    Department of Neurology, Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Via Spagnoletto 3, 1 20149 Milano, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 3:173-81. 2002
    ..Stem cell technology is at an early stage but the desperate need for a therapy in ALS patients may legitimize clinical trials in absence of conclusive scientific evidence. This paper discusses the premises for stem cell therapy in ALS...
  12. ncbi Stem cell therapy for neurodegenerative diseases: the issue of transdifferentiation
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Center, University of Milan Medical School, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Stem Cells Dev 13:121-31. 2004
    ..This review summarizes recent advances gained in stem cell research applied to neurodegenerative diseases with a special emphasis to the criticisms put forward...
  13. ncbi Stem-cell therapy for amyotrophic lateral sclerosis
    Vincenzo Silani
    Department of Neurology and Laboratory of Neuroscience, Dino Ferrari Centre, University of Milan Medical School IRCCS Istituto Auxologico Italiano, Milano, Italy
    Lancet 364:200-2. 2004
    ..Therefore, autologous or allogeneic stem cells, undifferentiated or transdifferentiated and manipulated epigenetically or genetically, could be a candidate source for local or systemic cell-therapies in ALS...
  14. ncbi Neuro-glial differentiation of human bone marrow stem cells in vitro
    P Bossolasco
    Fondazione Matarelli, Milan, Italy
    Exp Neurol 193:312-25. 2005
    ..Moreover, unidentified soluble factors provided by the conditioned media and cellular contacts in co-culture systems were effective in inducing the neuro-glial phenotype, further supporting the adult BM neural differentiative capability...
  15. ncbi A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA
    Antonia Ratti
    Department of Neuroscience, Dino Ferrari Centre, University of Milan IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Italy
    J Cell Sci 119:1442-52. 2006
    ..We propose that ELAV RNA-binding proteins exert an important post-transcriptional control on Musashi-1 expression in the transition from proliferation to neural differentiation of stem/progenitor cells...
  16. pmc Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease
    Paolo Bigini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 7:e32326. 2012
    ....
  17. pmc Dose dependent side effect of superparamagnetic iron oxide nanoparticle labeling on cell motility in two fetal stem cell populations
    Valentina Diana
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Cusano Milanino, Italy
    PLoS ONE 8:e78435. 2013
    ....
  18. ncbi A reliable indirect cell-labelling protocol for optical imaging allows ex vivo visualisation of mesenchymal stem cells after transplantation
    Valentina Diana
    Department of Neurology and Laboratory of Neuroscience IRCCS Istituto Auxologico Italiano, Via Zucchi 18, 20095 Cusano Milanino, Milan, Italy Email
    Arch Ital Biol 151:114-25. 2013
    ..mCherry labelling appears to be readily applicable in the post-transplantation tracking of stem cells and could favour the rapid development of new therapeutic targets for clinical treatments. ..
  19. doi Neuroprotective effects of human mesenchymal stem cells on neural cultures exposed to 6-hydroxydopamine: implications for reparative therapy in Parkinson's disease
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano 20149, Milan, Italy
    Apoptosis 17:289-304. 2012
    ..Our findings provide novel insights for the development of therapeutic strategies designed to counteract the neurodegenerative processes of PD...