Paola Collini

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. doi request reprint High-grade sarcomatous overgrowth in solitary fibrous tumors: a clinicopathologic study of 10 cases
    Paola Collini
    Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Am J Surg Pathol 36:1202-15. 2012
  2. ncbi request reprint Papillary carcinoma of the thyroid gland of childhood and adolescence: Morphologic subtypes, biologic behavior and prognosis: a clinicopathologic study of 42 sporadic cases treated at a single institution during a 30-year period
    Paola Collini
    Department of Anatomic Pathology, Istituto Nazionale Tumori, Milan, Italy
    Am J Surg Pathol 30:1420-6. 2006
  3. ncbi request reprint Treatment of sporadic nonmedullary thyroid carcinomas in pediatric age
    Paola Collini
    Istituto Nazionale Tumori, Anatomic Pathology C Unit, Via Venezian, 1, Milan, Italy
    Expert Rev Anticancer Ther 7:23-30. 2007
  4. ncbi request reprint Minimally invasive (encapsulated) follicular carcinoma of the thyroid gland is the low-risk counterpart of widely invasive follicular carcinoma but not of insular carcinoma
    Paola Collini
    Department of Pathology, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Virchows Arch 442:71-6. 2003
  5. ncbi request reprint Extensive vascular invasion is a marker of risk of relapse in encapsulated non-Hürthle cell follicular carcinoma of the thyroid gland: a clinicopathological study of 18 consecutive cases from a single institution with a 11-year median follow-up
    P Collini
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Histopathology 44:35-9. 2004
  6. doi request reprint No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma
    Maura Massimino
    Division of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 73:1358-63. 2009
  7. ncbi request reprint Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
    Maura Massimino
    Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:1031-7. 2006
  8. ncbi request reprint Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan
    Paola Collini
    Department of Anatomical Pathology, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:300-6. 2006
  9. ncbi request reprint Myxoid/round cell and pleomorphic liposarcomas: prognostic factors and survival in a series of patients treated at a single institution
    Marco Fiore
    Department of Surgery, National Cancer Institute, Milan, Italy
    Cancer 109:2522-31. 2007
  10. doi request reprint Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian, 1 20133, Milan, Italy
    J Neurooncol 108:163-71. 2012

Detail Information

Publications97

  1. doi request reprint High-grade sarcomatous overgrowth in solitary fibrous tumors: a clinicopathologic study of 10 cases
    Paola Collini
    Department of Diagnostic Pathology and Laboratory Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Am J Surg Pathol 36:1202-15. 2012
    ..The median time to distant metastasis was 156 months after the initial diagnosis, and median overall survival from the first signs of metastasis was 8 months...
  2. ncbi request reprint Papillary carcinoma of the thyroid gland of childhood and adolescence: Morphologic subtypes, biologic behavior and prognosis: a clinicopathologic study of 42 sporadic cases treated at a single institution during a 30-year period
    Paola Collini
    Department of Anatomic Pathology, Istituto Nazionale Tumori, Milan, Italy
    Am J Surg Pathol 30:1420-6. 2006
    ..At variance with adults, presence of the tall cell morphology did not carry a worst prognostic significance...
  3. ncbi request reprint Treatment of sporadic nonmedullary thyroid carcinomas in pediatric age
    Paola Collini
    Istituto Nazionale Tumori, Anatomic Pathology C Unit, Via Venezian, 1, Milan, Italy
    Expert Rev Anticancer Ther 7:23-30. 2007
    ....
  4. ncbi request reprint Minimally invasive (encapsulated) follicular carcinoma of the thyroid gland is the low-risk counterpart of widely invasive follicular carcinoma but not of insular carcinoma
    Paola Collini
    Department of Pathology, Istituto Nazionale Tumori, Via G Venezian 1, 20133 Milan, Italy
    Virchows Arch 442:71-6. 2003
    ..By contrast, IC confirmed to be a distinct high-risk lesion, showing both follicular and papillary-related biological behavior characteristics...
  5. ncbi request reprint Extensive vascular invasion is a marker of risk of relapse in encapsulated non-Hürthle cell follicular carcinoma of the thyroid gland: a clinicopathological study of 18 consecutive cases from a single institution with a 11-year median follow-up
    P Collini
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Histopathology 44:35-9. 2004
    ..To determine the prognostic value of certain clinicopathological features in a series of 18 consecutive cases of encapsulated follicular carcinoma (EFC) of the thyroid gland with long follow-up...
  6. doi request reprint No salvage using high-dose chemotherapy plus/minus reirradiation for relapsing previously irradiated medulloblastoma
    Maura Massimino
    Division of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 73:1358-63. 2009
    ..Myeloablative regimens were frequently used for medulloblastoma relapsing after craniospinal irradiation (CSI): in 1997-2002, we used repeated surgery, standard-dose and myeloablative chemotherapy, and reirradiation...
  7. ncbi request reprint Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy
    Maura Massimino
    Neuro Oncology Functional Unit, Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 64:1031-7. 2006
    ..Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial...
  8. ncbi request reprint Papillary thyroid carcinoma of childhood and adolescence: a 30-year experience at the Istituto Nazionale Tumori in Milan
    Paola Collini
    Department of Anatomical Pathology, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:300-6. 2006
    ..The aim of this study was to verify this assumption in a single-institution series spanning a 30-year period with a very long follow-up...
  9. ncbi request reprint Myxoid/round cell and pleomorphic liposarcomas: prognostic factors and survival in a series of patients treated at a single institution
    Marco Fiore
    Department of Surgery, National Cancer Institute, Milan, Italy
    Cancer 109:2522-31. 2007
    ..The objective of this study was to investigate prognostic factors and clinical outcome of myxoid/round cell and pleomorphic liposarcoma...
  10. doi request reprint Long-term results of combined preradiation chemotherapy and age-tailored radiotherapy doses for childhood medulloblastoma
    Maura Massimino
    Pediatric Oncology Unit, Fondazione IRCCS, Istituto Nazionale Tumori, Via Venezian, 1 20133, Milan, Italy
    J Neurooncol 108:163-71. 2012
    ....
  11. ncbi request reprint Flow cytometric phenotype of rhabdomyosarcoma bone marrow metastatic cells and its implication in differential diagnosis with neuroblastoma
    Fabio Bozzi
    Department of Anatomic Pathology, Experimental Molecular Pathology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Anticancer Res 28:1565-9. 2008
    ..Myogenin (Myf4), a specific molecular RMS marker, was also investigated in the same samples. Since neuroblastoma (NB) metastasizes to the BM, the potential application of cytometry in differential diagnosis was explored...
  12. ncbi request reprint Evolving treatment strategies for parameningeal rhabdomyosarcoma: the experience of the Istituto Nazionale Tumori of Milan
    Cristina Meazza
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano MI, Italy
    Head Neck 27:49-57. 2005
    ..Ninety pediatric patients with parameningeal rhabdomyosarcoma (PM-RMS) were treated between 1970 and 2002 at the Istituto Nazionale Tumori, Milan...
  13. ncbi request reprint Adult-type soft tissue sarcomas in pediatric-age patients: experience at the Istituto Nazionale Tumori in Milan
    Andrea Ferrari
    Pediatric Oncology Unit, Department of Pathology, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milano, Italy
    J Clin Oncol 23:4021-30. 2005
    ..We report on a large group of 182 patients younger than 18 years old treated at a single institution over a 25-year period...
  14. doi request reprint Radiation-induced thyroid changes: a retrospective and a prospective view
    Maura Massimino
    Department of Medical Oncology, Paediatrics Unit, Istituto Nazionale Tumori, Via Venezian, 1, Milan 20133, Italy
    Eur J Cancer 45:2546-51. 2009
    ..Increasing numbers of children are being cured of cancers by treatments that include radiation also involving the thyroid bed: these children warrant an early diagnosis and treatment of any radiation-related thyroid changes...
  15. ncbi request reprint Advanced extremity soft tissue sarcoma: prognostic effect of isolated limb perfusion in a series of 88 patients treated at a single institution
    Elisabetta Pennacchioli
    Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, 20133, Milan, Italy
    Ann Surg Oncol 14:553-9. 2007
    ..To explore the prognostic impact of isolated limb perfusion (ILP) in locally advanced extremity soft tissue sarcomas (ESTS)...
  16. doi request reprint Leiomyosarcoma and sarcoma with myogenic differentiation: two different entities or 2 faces of the same disease?
    Chiara Colombo
    Department of Surgery Sarcoma Service, Scientific Institutes for Recovery and Cure IRCCS Foundation, National Cancer Institute, Milan, Italy
    Cancer 118:5349-57. 2012
    ..The objective of this study was to evaluate whether the distinction between leiomyosarcomas (LMS) and sarcomas with myogenic differentiation (SMD), based on the expression of muscular markers, has any clinical implications...
  17. doi request reprint Treatment of high-risk relapsed Wilms tumor with dose-intensive chemotherapy, marrow-ablative chemotherapy, and autologous hematopoietic stem cell support: experience by the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 51:23-8. 2008
    ..We evaluated an intensified chemotherapy strategy in children with Wilms tumor who relapsed with high-risk features...
  18. doi request reprint The prognostic impact of dedifferentiation in retroperitoneal liposarcoma: a series of surgically treated patients at a single institution
    Chiara Mussi
    Department of Surgery, Foundation IRCCS for National Cancer Institute, Milan, Italy
    Cancer 113:1657-65. 2008
    ..A series of patients with well differentiated (WD)/dedifferentiated (DD) retroperitoneal liposarcoma (RLS) was studied to evaluate the prognostic value of the presence, extension, and grade of the DD component...
  19. doi request reprint Synovial sarcoma of children and adolescents: the prognostic role of axial sites
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian 1, Milan, Italy
    Eur J Cancer 44:1202-9. 2008
    ..The outcome of patients with non-extremity synovial sarcoma (SS) is generally worse than that of patients with limb tumours...
  20. doi request reprint Soft tissue sarcomas: ESMO clinical recommendations for diagnosis, treatment and follow-up
    P G Casali
    Department of Cancer Medicine, Istituto Nazionale dei Tumori, Milan, Italy
    Ann Oncol 19:ii89-93. 2008
  21. ncbi request reprint Malignant peripheral nerve sheath tumors: prognostic factors and survival in a series of patients treated at a single institution
    Matteo Anghileri
    Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 107:1065-74. 2006
    ..The authors explored the prognostic factors and clinical outcomes of patients who had malignant peripheral nerve sheath tumors (MPNST) with and without neurofibromatosis type 1 (NF-1)...
  22. doi request reprint Loss of heterozygosity analysis at different chromosome regions in Wilms tumor confirms 1p allelic loss as a marker of worse prognosis: a study from the Italian Association of Pediatric Hematology and Oncology
    Filippo Spreafico
    Pediatric Unit, Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    J Urol 189:260-6. 2013
    ..The specific aims of the AIEOP-TW-2003 protocol included prospectively investigating a possible association of tumor loss of heterozygosity with outcomes in children treated for Wilms tumor...
  23. doi request reprint Functional characterization of the MTC-associated germline RET-K666E mutation: evidence of oncogenic potential enhanced by the G691S polymorphism
    Maria Grazia Borrello
    Operative Unit Molecular Mechanisms, Department of Experimental Oncology, IRCCS Istituto Nazionale dei Tumori Foundation, Milan, Italy
    Endocr Relat Cancer 18:519-27. 2011
    ..We have demonstrated that, although RET-G691S is not oncogenic per se, it enhances the transforming activity of the RET-K666E mutant, thus suggesting a modifier role for this functional polymorphism...
  24. ncbi request reprint Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:627-34. 2004
    ..The current retrospective analysis examined a large group of patients of all ages who were treated at a single institution over a 30-year period...
  25. ncbi request reprint Wilms tumor in monozygous twins: clinical, pathological, cytogenetic and molecular case report
    Daniela Perotti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    J Pediatr Hematol Oncol 27:521-5. 2005
    ..To the authors' knowledge, this is the first report describing at both the clinical and genetic level a couple of monozygotic twins concordant for WT development...
  26. doi request reprint Cutaneous melanoma in childhood and adolescence shows frequent loss of INK4A and gain of KIT
    Maria Daniotti
    Melanoma Genetics, Department of Experimental Oncology, Immunotherapy of Human Tumors Unit, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    J Invest Dermatol 129:1759-68. 2009
    ..BRAF(V600E) mutation occurred at a similar rate (approximately 50%) in lesions from pediatric and familial patients, whereas no NRAS mutations were detected...
  27. ncbi request reprint Neuroblastoma in patients over 12 years old: a 20-year experience at the Istituto Nazionale Tumori of Milan
    Marta Giorgia Podda
    Department of Paediatric Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 96:684-9. 2010
    ..As neuroblastoma is rare in adolescents and exceedingly rare in adults, few series are reported in the literature. In the present study, we analyzed the outcomes and clinical characteristics of a mono-institutional series...
  28. doi request reprint Infant ependymoma in a 10-year AIEOP (Associazione Italiana Ematologia Oncologia Pediatrica) experience with omitted or deferred radiotherapy
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 80:807-14. 2011
    ..We treated 41 children under the age of 3 years with intracranial ependymoma between 1994 and 2003...
  29. ncbi request reprint Thyroid-stimulating hormone suppression for protection against hypothyroidism due to craniospinal irradiation for childhood medulloblastoma/primitive neuroectodermal tumor
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 69:404-10. 2007
    ..Hence, our study was launched in 1998 to evaluate the protective effect of TSH suppression during CSI for medulloblastoma/primitive neuroectodermal tumor...
  30. ncbi request reprint Detecting CD56+/NB84+/CD45- immunophenotype in the bone marrow of patients with metastatic neuroblastoma using flow cytometry
    Fabio Bozzi
    Department of Medical Oncology, Division of Pediatrics, C Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Anticancer Res 26:3281-7. 2006
    ..In order to identify neuroblastoma cells infiltrating the bone marrow, a triple-color flow-cytometric assay was developed combining CD56 and CD45 with the intracellular anti-NB84 specific antibody...
  31. ncbi request reprint The murine Pou6f2 gene is temporally and spatially regulated during kidney embryogenesis and its human homolog is overexpressed in a subset of Wilms tumors
    Francesca Di Renzo
    Department of Biology, University of Milan, Milan, Italy
    J Pediatr Hematol Oncol 28:791-7. 2006
    ....
  32. ncbi request reprint Telomere maintenance in Wilms tumors: first evidence for the presence of alternative lengthening of telomeres mechanism
    Lorenza Venturini
    Department of Experimental Oncology and Molecular Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Genes Chromosomes Cancer 50:823-9. 2011
    ..The study provides the first evidence of the presence of ALT in WT, and indicates that in a small but defined fraction of cases (about 15%) ALT is the only TMM that supports the development of WT...
  33. doi request reprint Unusual myogenic and melanocytic differentiation of soft tissue pPNETs: an immunohistochemical and molecular study of 3 cases
    Marta Barisella
    Anatomic Pathology B Unit, Department of Pathology, IRCCS Istituto Nazionale Tumori of Milan, Milan, Italy
    Am J Surg Pathol 34:1002-6. 2010
    ....
  34. ncbi request reprint Salvage treatment for childhood ependymoma after surgery only: Pitfalls of omitting "at once" adjuvant treatment
    Maura Massimino
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    Int J Radiat Oncol Biol Phys 65:1440-5. 2006
    ..To discuss the results obtained by giving adjuvant treatment for childhood ependymoma (EPD) at relapse after complete surgery only...
  35. ncbi request reprint Extremity soft tissue sarcoma: adding to the prognostic meaning of local failure
    Alessandro Gronchi
    Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, 20133, Milano, Italy
    Ann Surg Oncol 14:1583-90. 2007
    ..We explored the prognostic meaning of local relapse and surgical margins in adult soft tissue sarcoma of the extremities...
  36. ncbi request reprint Thyroid as a target of metastases: a case of metastatic seminoma in a patient who died of a second cancer
    Franco Mattavelli
    Otorhinolaryngology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 95:91-3. 2009
    ..The thyroid is a rare site of metastases from any cancer, but any patient with a previous oncologic disease should inquire about a thyroid nodule...
  37. ncbi request reprint WT1 gene analysis in sporadic early-onset and bilateral wilms tumor patients without associated abnormalities
    Daniela Perotti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, 20133 Milan, Italy
    J Pediatr Hematol Oncol 27:197-201. 2005
    ..These results suggest that early age of diagnosis and bilaterality are not by themselves efficient predictors of germline WT1 alterations in WT patients without associated abnormalities...
  38. ncbi request reprint Prognostic effect of re-excision in adult soft tissue sarcoma of the extremity
    Marco Fiore
    Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian, 1, Milan, 20133, Italy
    Ann Surg Oncol 13:110-7. 2006
    ..We explored the outcome of patients with primary adult soft tissue sarcoma (STS) of the extremities undergoing re-excision after previous unplanned surgery...
  39. doi request reprint Aggressive surgical policies in a retrospectively reviewed single-institution case series of retroperitoneal soft tissue sarcoma patients
    Alessandro Gronchi
    Department of Surgery, Biostatistics, Pathology, and Radiotherapy, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 27:24-30. 2009
    ..To explore whether the adoption of a systematic attempt to perform wider resections may lead to prognostic improvements in retroperitoneal soft tissue sarcoma (RSTS)...
  40. ncbi request reprint Epithelioid sarcoma in children and adolescents: a report from the Italian Soft Tissue Sarcoma Committee
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Cancer 106:708-17. 2006
    ..The current study concerns 30 patients age<18 years who were enrolled in the Italian Soft Tissue Sarcoma Committee protocols...
  41. ncbi request reprint Non-chromosome 11-p syndromes in Wilms tumor patients: Clinical and cytogenetic report of two Down syndrome cases and one Turner syndrome case
    Filippo Spreafico
    Unit of Pediatric Oncology, Istituto Nazionale Tumori, Milano, Italy
    Am J Med Genet A 143:85-8. 2007
  42. ncbi request reprint Thyroid as a target of metastases. A case of foregut neuroendocrine carcinoma with multiple abdominal metastases and a thyroid localization after 21 years
    Franco Mattavelli
    Otorhinolaryngology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:110-3. 2008
    ..e., a medullary thyroid carcinoma. This case report is peculiar because of the multiple sites of abdominal relapses, the long time interval between relapses (21 years), and the positive outcome after surgical treatment...
  43. doi request reprint Extremity soft tissue sarcoma in a series of patients treated at a single institution: local control directly impacts survival
    Alessandro Gronchi
    Department of Surgery, Istituto Nazionale Tumori, Milan, Italy
    Ann Surg 251:506-11. 2010
    ..To improve understanding of what is adequate in local treatment of extremity soft tissue sarcomas (ESTS), to maximize the ratio between local control, limb preservation and prognosis...
  44. pmc Sequential chemotherapy, high-dose thiotepa, circulating progenitor cell rescue, and radiotherapy for childhood high-grade glioma
    Maura Massimino
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Neuro Oncol 7:41-8. 2005
    ..Sequential and high-dose chemotherapy can be afforded in front-line therapy of childhood malignant glioma without excessive morbidity and rather encouraging results...
  45. doi request reprint A prospective protocol for nasopharyngeal carcinoma in children and adolescents: the Italian Rare Tumors in Pediatric Age (TREP) project
    Michela Casanova
    Foundation for the Research and Cure of Cancer, National Cancer Institute, Milan, Italy
    Cancer 118:2718-25. 2012
    ..The risk of long-term treatment-related toxicity also may be a more important issue in younger individuals...
  46. doi request reprint Renal cell carcinoma in children and adolescents
    Filippo Spreafico
    Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Expert Rev Anticancer Ther 10:1967-78. 2010
    ..On the other hand, the utility of targeted therapies in the adjuvant setting remains to be seen for both adults and children...
  47. doi request reprint Alveolar soft part sarcoma: clinical presentation, treatment, and outcome in a series of 33 patients at a single institution
    Elisabetta Pennacchioli
    Department of Surgery, Istituto Nazionale Tumori, Milan, Italy
    Ann Surg Oncol 17:3229-33. 2010
    ..A comprehensive retrospective review was performed of clinical presentation, treatment, outcome, and patterns of failure in a consecutive series of patients with localized or metastatic ASPS between 1975 and 2008...
  48. doi request reprint Histology-specific nomogram for primary retroperitoneal soft tissue sarcoma
    Ilaria Ardoino
    Unit of Medical Statistics, Biometry and Bioinformatics, National Cancer Institute, Milan, Italy
    Cancer 116:2429-36. 2010
    ..This study was conducted to develop a histology-specific nomogram to predict postoperative overall survival (OS) at 5 and 10 years in primary retroperitoneal soft tissue sarcoma (STS)...
  49. ncbi request reprint Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan
    Marco Guzzo
    Otorhinolaryngology Unit, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 47:806-10. 2006
    ..These results are presented in conjunction with a literature review of salivary tumors with a view to providing an up-to-date overview of the clinical course, prognosis, and treatment options for this rare tumor...
  50. ncbi request reprint Conservative surgical approach for thyroid and lymph-node involvement in papillary thyroid carcinoma of childhood and adolescence
    Maura Massimino
    Unit of Pediatrics, Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 46:307-13. 2006
    ..The aim of this study is to outline the possibility of a conservative approach (hemithyroidectomy plus selective neck dissection of clinically involved nodes, followed by TSH-suppressive therapy) in a selected group of patients...
  51. doi request reprint Localised thoracic sarcomas: outcome improvement over time at a single institution
    Leonardo Duranti
    Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, Milan, Italy
    Eur J Cancer 49:2689-97. 2013
    ..To assess changes in survival over time in patients affected by thoracic soft tissue sarcomas treated at a single institution...
  52. doi request reprint Histological variants of medulloblastoma are the most powerful clinical prognostic indicators
    Maura Massimino
    Department of Pediatrics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Pediatr Blood Cancer 60:210-6. 2013
    ..We centrally reviewed medulloblastoma cases from past 10 years reassessing their histology to ascertain its prognostic significance...
  53. doi request reprint Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse
    Daniela Perotti
    Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Genes Chromosomes Cancer 51:644-53. 2012
    ..Our study, besides confirming the role of 1q gains, identified a number of additional candidate genetic markers, warranting further molecular investigations...
  54. doi request reprint Dermatofibrosarcoma protuberans-derived fibrosarcoma: clinical history, biological profile and sensitivity to imatinib
    Silvia Stacchiotti
    Adult Sarcoma Medical Oncology Unit, Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Int J Cancer 129:1761-72. 2011
    ..In conclusion, DFSP-derived FS maintains the fusion-gene, being sensitive to imatinib. However, responses are short-lasting. Secondary resistance to imatinib is not related to PDGFRB...
  55. ncbi request reprint Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milan, Italy
    Cancer 98:571-80. 2003
    ..Published series have reported definitively worse results for adults with RMS compared with children with RMS. This finding casts doubt on whether RMS is the same disease in adults as it is in children...
  56. ncbi request reprint Adult Wilms' tumor: A monoinstitutional experience and a review of the literature
    Monica Terenziani
    Unità di Oncologia Pediatrica, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 101:289-93. 2004
    ..The authors reviewed their institutional experience regarding adult patients with Wilms' tumor (WT) to assess their clinical characteristics and compliance with respect to children's treatment guidelines...
  57. ncbi request reprint Germline mutations of the POU6F2 gene in Wilms tumors with loss of heterozygosity on chromosome 7p14
    Daniela Perotti
    Department of Experimental Oncology and Laboratories, Istituto Nazionale Tumori, Milan, Italy
    Hum Mutat 24:400-7. 2004
    ..Together with the finding of the expression of the POU6F2 mouse homolog in both fetal and adult kidney, our observations suggest that the gene is a tumor suppressor and is involved in hereditary predisposition to WT...
  58. pmc Soft-tissue sarcomas of the extremities in patients of pediatric age
    Michela Casanova
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Via G Venezian, 1, 20133, Milan MI, Italy
    J Child Orthop 1:195-203. 2007
    ..Here we report the experience of the Pediatric Oncology Unit of the Istituto Nazionale Tumori of Milan, Italy, concerning 204 patients with STS of the limbs treated between 1977 and 2006...
  59. doi request reprint High-grade soft-tissue sarcomas: tumor response assessment--pilot study to assess the correlation between radiologic and pathologic response by using RECIST and Choi criteria
    Silvia Stacchiotti
    Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Radiology 251:447-56. 2009
    ....
  60. ncbi request reprint Endodermal sinus tumor of the vagina
    Monica Terenziani
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 48:577-8. 2007
    ..Both patients remained alive and disease-free, without having had surgical procedures except for biopsies. Platinum-based chemotherapy is able to achieve complete remissions and should be considered for vaginal endodermal sinus tumors...
  61. doi request reprint Late relapse of embryonal rhabdomyosarcoma, botryoid variant, of the vagina
    Roberto Vasquez
    Department of Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 51:140-1. 2008
    ..A possible causal association with estrogen hormones is hypothesized, particularly for the second case described, in which estrogen receptors were negative in the primary tumor specimen and positive in the relapsing tumor specimen...
  62. doi request reprint Clinical and molecular description of a Wilms tumor in a patient with tuberous sclerosis complex
    Filippo Spreafico
    Pediatric Oncology Unit, Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Am J Med Genet A 155:1419-24. 2011
    ..To the best of our knowledge, this is the second report of a patient with tuberous sclerosis who developed a WT, and it represents the first case in which a detailed clinical and molecular description is provided...
  63. doi request reprint Mutation-independent anaplastic lymphoma kinase overexpression in poor prognosis neuroblastoma patients
    Lorena Passoni
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
    Cancer Res 69:7338-46. 2009
    ..Alternative mechanisms other than direct mutations and/or gene amplification regulate the ALK level of expression in NBL cells. Wild-type ALK is a potential therapeutic target for advanced/metastatic NBLs...
  64. ncbi request reprint Response to chemotherapy in a child with primary bronchopulmonary leiomyosarcoma
    Andrea Ferrari
    Pediatric Oncology Units, Istituto Nazionale Tumori, Milano, Italy
    Med Pediatr Oncol 39:55-7. 2002
  65. pmc Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
    Maria Grazia Borrello
    Departments of Experimental Oncology, Research Units 3 and 14, and Pathology, Istituto Nazionale Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 102:14825-30. 2005
    ..These results, demonstrating that the RET/PTC1 oncogene activates a proinflammatory program, provide a direct link between a transforming human oncogene, inflammation, and malignant behavior...
  66. ncbi request reprint Undifferentiated high-grade pleomorphic sarcomas in children: a clinicopathologic study of 10 cases and review of literature
    Rita Alaggio
    Department of Pathology, University of Padova, Padua, Italy
    Pediatr Dev Pathol 13:209-17. 2010
    ..In summary, UHGPS is rare in children and frequently located in the head. A more favorable outcome is associated with superficial location. Foci of epithelioid cell may portend an aggressive behavior...
  67. ncbi request reprint Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone
    Paola Collini
    Department of Pathology, Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Am J Surg Pathol 27:1161-6. 2003
    ....
  68. doi request reprint Desmoid-type fibromatosis: a front-line conservative approach to select patients for surgical treatment
    Marco Fiore
    Department of Surgery, Istituto Nazionale Tumori, Milan, Italy
    Ann Surg Oncol 16:2587-93. 2009
    ..The disease remained stable in more than half of patients. This study was designed to evaluate this approach on the natural history of the disease in a larger series of patients...
  69. ncbi request reprint Molecular detection of dopamine decarboxylase expression by means of reverse transcriptase and polymerase chain reaction in bone marrow and peripheral blood: utility as a tumor marker for neuroblastoma
    Fabio Bozzi
    Department of Medical Oncology, Division of Pediatrics, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Diagn Mol Pathol 13:135-43. 2004
    ..These results suggest that finding DDC mRNA in NB patients could be a potential marker for minimal residual disease study...
  70. doi request reprint Inflammatory myofibroblastic tumor of the conjunctiva: response to chemotherapy with low-dose methotrexate and vinorelbine
    Francesca Favini
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Pediatr Blood Cancer 54:483-5. 2010
    ..This regimen is usually well tolerated and may be considered as the treatment of choice for cases of unresectable advanced IMT...
  71. ncbi request reprint Hyperfractionated radiotherapy and chemotherapy for childhood ependymoma: final results of the first prospective AIEOP (Associazione Italiana di Ematologia-Oncologia Pediatrica) study
    Maura Massimino
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milano, Italy
    Int J Radiat Oncol Biol Phys 58:1336-45. 2004
    ..A postsurgical "stage-based" protocol for ependymoma was designed...
  72. ncbi request reprint The familial medullary thyroid carcinoma-associated RET E768D mutation in a multiple endocrine neoplasia type 2A case
    Antonella Aiello
    Department of Pathology and Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Surgery 137:574-6. 2005
  73. doi request reprint A case of congenital peripheral primitive neuroectodermal tumor presenting with multiple metastases
    Cristina Meazza
    Pathology Department, Istituto Nazionale Tumori, Milan, Italy
    J Pediatr Hematol Oncol 30:36-8. 2008
    ..Peripheral primitive neuroectodermal tumor is an exceedingly uncommon tumor in this age group and is characterized by very aggressive behavior and poor prognosis...
  74. ncbi request reprint Efficacy of trabectedin (ecteinascidin-743) in advanced pretreated myxoid liposarcomas: a retrospective study
    Federica Grosso
    Cancer Medicine Department, Adult Sarcoma Medical Treatment Unit, IRCCS Foundation National Cancer Institute, Milan, Italy
    Lancet Oncol 8:595-602. 2007
    ....
  75. ncbi request reprint Postoperative radiotherapy for synovial sarcoma of the head and neck during pregnancy: clinical and technical management and fetal dose estimates
    Ester Orlandi
    Department of Radiation Oncology I, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 93:45-52. 2007
    ....
  76. doi request reprint Sarcomas with spindle cell morphology
    Paola Collini
    Department of Anatomic Pathology, IRCCS Foundation, Istituto Nazionale Tumori, Milan, Italy
    Semin Oncol 36:324-37. 2009
    ..In this article, we describe some of the clinical and biological characteristics of this group of sarcomas...
  77. ncbi request reprint Alternative mutations of BRAF, RET and NTRK1 are associated with similar but distinct gene expression patterns in papillary thyroid cancer
    Milo Frattini
    Department of Pathology, Experimental Molecular Pathology, Istituto Nazionale Tumori, Milan, Italy
    Oncogene 23:7436-40. 2004
    ..However, a supervised analysis of the obtained data identified a subset of genes differentially expressed in tumors carrying BRAF mutation or RTK rearrangement...
  78. doi request reprint Teratoma with a malignant somatic component in pediatric patients: the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience
    Monica Terenziani
    Pediatric Oncology Unit, Fondazione IRCCS National Cancer Institute, Milano, Italy
    Pediatr Blood Cancer 54:532-7. 2010
    ..Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse...
  79. ncbi request reprint Intensive, very short-term chemotherapy for advanced Burkitt's lymphoma in children
    Filippo Spreafico
    Department of Pediatric Oncology, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 20:2783-8. 2002
    ..To improve the 63% event-free survival (EFS) achieved before 1986 in Murphy's stage III to IV Burkitt's lymphoma (BL), both chemotherapy and supportive care were intensified...
  80. ncbi request reprint Colorectal carcinoma in children and adolescents: the experience of the Istituto Nazionale Tumori of Milan, Italy
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Pediatr Blood Cancer 50:588-93. 2008
    ..This study retrospectively reports on a group of 27 patients <30 years of age, and particularly on 7 cases <18 years old, treated at the Istituto Nazionale Tumori, Milan, Italy, between 1985 and 2005...
  81. ncbi request reprint Solid-pseudopapillary tumor of the pancreas (Frantz tumor) in children
    Michela Casanova
    Pediatric Oncology Unit, Istituto Nazionale Tumori, Via G Venezian, Milano, Italy
    Med Pediatr Oncol 41:74-6. 2003
  82. doi request reprint Soft tissue sarcomas of childhood and adolescence: the prognostic role of tumor size in relation to patient body size
    Andrea Ferrari
    Pediatric Oncology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano, Italy
    J Clin Oncol 27:371-6. 2009
    ....
  83. ncbi request reprint Double, metachronous thyroid metastases of colon cancer
    Franco Mattavelli
    Otorhinolaryngology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 92:249-51. 2006
  84. ncbi request reprint Does melanoma behave differently in younger children than in adults? A retrospective study of 33 cases of childhood melanoma from a single institution
    Andrea Ferrari
    Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Pediatrics 115:649-54. 2005
    ....
  85. ncbi request reprint Antigen-specific immunity in neuroblastoma patients: antibody and T-cell recognition of NY-ESO-1 tumor antigen
    Monica Rodolfo
    Units of Melanoma Genetics, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Cancer Res 63:6948-55. 2003
    ..We conclude that NY-ESO-1 is an immunogenic antigen in neuroblastoma patients and represents a candidate target for immune-based therapy...
  86. doi request reprint Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour
    Flavia Cerrato
    Dipartimento di Scienze Ambientali, Seconda Universita di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Hum Mol Genet 17:1427-35. 2008
    ..Distinguishing between these two groups of cases is important for genetic counselling...
  87. ncbi request reprint Local lymph node involvement in pediatric renal cell carcinoma: a report from the Italian TREP project
    Paolo Indolfi
    Pediatric Oncology Service, Pediatric Department, Second University of Napoli, Napoli, Italy
    Pediatr Blood Cancer 51:475-8. 2008
    ..The aim of this article is to study the prognostic significance of local lymph node involvement in pediatric RCC and the role of retroperitoneal lymph node dissection (RLND) at diagnosis...
  88. ncbi request reprint Papilliferous keratoameloblastoma of mandible: a papillary ameloblastic carcinoma: report of a case with a 6-year follow-up and review of the literature
    Paola Collini
    Instituto Nazionale Tumori, Department of Pathology, Milan, Italy
    Int J Surg Pathol 10:149-55. 2002
    ..It was instead unreactive for Alcian blue, actin, maspin, and GFAP. We suggest that papilliferous keratoameloblastoma be renamed "papillary ameloblastic carcinoma."..
  89. ncbi request reprint Dermatofibrosarcoma protuberans treated at a single institution: a surgical disease with a high cure rate
    Marco Fiore
    Department of Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milano, Italy
    J Clin Oncol 23:7669-75. 2005
    ..The aim of this retrospective analysis was to explore the outcome of patients with primary or recurrent DFSP...
  90. ncbi request reprint Effectiveness of chemotherapy in non-rhabdomyosarcoma soft tissue sarcomas
    Andrea Ferrari
    Pediatr Blood Cancer 45:226-7; author reply 228. 2005
  91. ncbi request reprint Revised SIOP working classification of renal tumors of childhood
    Filippo Spreafico
    Med Pediatr Oncol 41:102. 2003
  92. ncbi request reprint Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach
    Marco Volante
    Department of Clinical and Biological Sciences at San Luigi Hospital, University of Turin, Turin, Italy
    Am J Surg Pathol 31:1256-64. 2007
    ..An algorithmic approach was devised for practical use in the diagnosis of this tumor...
  93. doi request reprint Molecular evidence of the independent origin of multiple Wilms tumors in a case of WAGR syndrome
    Stefania Uccini
    Department of Experimental Medicine and Pathology, La Sapienza University, Rome, Italy
    Pediatr Blood Cancer 51:344-8. 2008
    ..This study investigated the genetic events leading to tumorigenesis in a patient affected with WAGR syndrome who developed multiple distinct Wilms tumors (WTs)...
  94. ncbi request reprint RET mutation profile and variable clinical manifestations in a family with multiple endocrine neoplasia type 2A and Hirschsprung's disease
    Barbara Pasini
    Department of Biomedical Sciences and Advanced Therapies, Section of Endocrinology, University of Ferrara, Via Savonarola 9, I 44100 Ferrara, Italy
    Surgery 131:373-81. 2002
    ..Furthermore, we have investigated polymorphic sequence variants of the RET proto-oncogene...
  95. ncbi request reprint Differential expression of telomerase activity in neuroendocrine lung tumours: correlation with gene product immunophenotyping
    Nadia Zaffaroni
    Department of Experimental Oncology, Istituto Nazionale per la Studio e la Cura dei Tumori, Milan, Italy
    J Pathol 201:127-33. 2003
    ..These telomerase data support the previously reported evidence for two genetically unrelated groups of NE lung tumours (SCLC, and to some extent LCNEC, versus carcinoid tumours) that have distinct phenotypic profiles...
  96. ncbi request reprint Prophylactic thyroidectomy in MEN 2A syndrome
    Franco Mattavelli
    Department of Head and Neck Surgery, National Cancer Institute, Milan, Italy
    Tumori 89:553-5. 2003
    ..Our experience has confirmed the presence of CCH and medullary thyroid carcinoma even in clinically negative patients, in agreement with reports in the literature...
  97. ncbi request reprint Epithelioid sarcoma: prognostic factors and survival in a series of patients treated at a single institution
    Dario Baratti
    Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Ann Surg Oncol 14:3542-51. 2007
    ..Typically, it occurs superficially as single/multiple nodules (nodular ES), or in deeper tissues as a mass. The correlation between initial presentation and clinical outcome was investigated...