- Ciusani E, Croci D, Gelati M, Calatozzolo C, Sciacca F, Fumagalli L, et al. In vitro effects of topotecan and ionizing radiation on TRAIL/Apo2L-mediated apoptosis in malignant glioma. J Neurooncol. 2005;71:19-25 pubmed..In our experimental conditions, irradiation with 2 Gy had a modest additive effect on TRAIL-dependent apoptosis and was not able to modulate TRAIL receptor expression. ..