Francesca Cirulli

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. pmc A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 36:372-9. 2011
  2. ncbi request reprint Animal-assisted interventions as innovative tools for mental health
    Francesca Cirulli
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 47:341-8. 2011
  3. pmc Quality and timing of stressors differentially impact on brain plasticity and neuroendocrine-immune function in mice
    Sara Capoccia
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Neural Plast 2013:971817. 2013
  4. pmc Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 34:172-80. 2009
  5. doi request reprint The NGF saga: from animal models of psychosocial stress to stress-related psychopathology
    Francesca Cirulli
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità Rome, Viale Regina Elena 299, I 00161 Roma, Italy
    Front Neuroendocrinol 30:379-95. 2009
  6. doi request reprint Early life influences on emotional reactivity: evidence that social enrichment has greater effects than handling on anxiety-like behaviors, neuroendocrine responses to stress and central BDNF levels
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Neurosci Biobehav Rev 34:808-20. 2010
  7. pmc Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Neurosci Biobehav Rev 33:573-85. 2009
  8. doi request reprint Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice
    Alessandra Berry
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 37:762-72. 2012
  9. doi request reprint Conjunctivally administered NGF antibody reduces pain sensitivity and anxiety-like behavioral responses in aged female mice
    Alessandra Berry
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Res 210:284-7. 2010
  10. ncbi request reprint Early behavioural enrichment in the form of handling renders mouse pups unresponsive to anxiolytic drugs and increases NGF levels in the hippocampus
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 178:208-15. 2007

Detail Information

Publications31

  1. pmc A novel BDNF polymorphism affects plasma protein levels in interaction with early adversity in rhesus macaques
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 36:372-9. 2011
    ....
  2. ncbi request reprint Animal-assisted interventions as innovative tools for mental health
    Francesca Cirulli
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 47:341-8. 2011
    ..Overall an ever increasing research effort is needed to search for the mechanism that lie behind the human-animal bond as well as to provide standardized methodologies for a cautious and effective use of animal-assisted interventions...
  3. pmc Quality and timing of stressors differentially impact on brain plasticity and neuroendocrine-immune function in mice
    Sara Capoccia
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, Italy
    Neural Plast 2013:971817. 2013
    ..These data show a fine modulation of the crosstalk between central and peripheral pathways of adaptation and plasticity and suggest that the length of stress exposure is crucial to determine its final outcome on health or disease...
  4. pmc Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 34:172-80. 2009
    ..The selective changes in BDNF levels in females could help explain the greater vulnerability to mood disorders of this gender reported in humans...
  5. doi request reprint The NGF saga: from animal models of psychosocial stress to stress-related psychopathology
    Francesca Cirulli
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità Rome, Viale Regina Elena 299, I 00161 Roma, Italy
    Front Neuroendocrinol 30:379-95. 2009
    ....
  6. doi request reprint Early life influences on emotional reactivity: evidence that social enrichment has greater effects than handling on anxiety-like behaviors, neuroendocrine responses to stress and central BDNF levels
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Neurosci Biobehav Rev 34:808-20. 2010
    ..Overall, the availability of ever more sophisticated animal models represents a fundamental tool to translate basic research data into appropriate interventions for humans raised under traumatic or impoverished situations...
  7. pmc Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Neurosci Biobehav Rev 33:573-85. 2009
    ..Maladaptive or repeated activation of NGF and BDNF, early during postnatal life, may influence stress sensitivity at adulthood and increase vulnerability for stress-related psychopathology...
  8. doi request reprint Social deprivation stress is a triggering factor for the emergence of anxiety- and depression-like behaviours and leads to reduced brain BDNF levels in C57BL/6J mice
    Alessandra Berry
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 37:762-72. 2012
    ....
  9. doi request reprint Conjunctivally administered NGF antibody reduces pain sensitivity and anxiety-like behavioral responses in aged female mice
    Alessandra Berry
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Res 210:284-7. 2010
    ..These findings support the hypothesis that topical eye application can represent an alternative route for delivering biologically active compounds into the brain allowing studying the role of NGF on brain cell function...
  10. ncbi request reprint Early behavioural enrichment in the form of handling renders mouse pups unresponsive to anxiolytic drugs and increases NGF levels in the hippocampus
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 178:208-15. 2007
    ..Changes in hippocampal levels of NGF might be involved in the appraisal of subtle changes in the early social environment...
  11. doi request reprint Sustained hippocampal neurogenesis in females is amplified in P66(Shc-/-) mice: An animal model of healthy aging
    Alessandra Berry
    Section of Behavioral Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Hippocampus 22:2249-59. 2012
    ..Overall, our data suggest that hippocampal function is protected in the female gender at older age, an effect amplified by reduced OS in the p66(Shc-/-) mutant...
  12. doi request reprint Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice
    Alessandra Berry
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Exp Gerontol 45:343-50. 2010
    ..Overall, the greater resilience to inflammation-induced changes in the p66(Shc-/-) mutants might underlie the better health status and the longevity characterizing these mice...
  13. doi request reprint Anti-ATP synthase autoantibodies induce neuronal death by apoptosis and impair cognitive performance in C57BL/6J mice
    Alessandra Berry
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Alzheimers Dis 33:317-21. 2013
    ..Our results are suggestive of a role of anti-ATPs-Abs in the onset and progression of AD and also provide a fruitful model for the study of memory disturbances in neurodegenerative diseases...
  14. doi request reprint Developing effective animal-assisted intervention programs involving visiting dogs for institutionalized geriatric patients: a pilot study
    Alessandra Berry
    Behavioural Neuroscience Unit Neurotoxicology and Neuroendocrinology Unit, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Psychogeriatrics 12:143-50. 2012
    ..The purpose of this study was to test the value of dog-assisted interventions as an innovative tool to increase quality of life in the geriatric population...
  15. ncbi request reprint Long-term effects of the periadolescent environment on exploratory activity and aggressive behaviour in mice: social versus physical enrichment
    Susanna Pietropaolo
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Physiol Behav 81:443-53. 2004
    ....
  16. ncbi request reprint Intrahippocampal administration of BDNF in adult rats affects short-term behavioral plasticity in the Morris water maze and performance in the elevated plus-maze
    Francesca Cirulli
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Hippocampus 14:802-7. 2004
    ..Overall, these results indicate that administration of BDNF improves performance in a spatial memory task and has enduring effects on emotional behavior...
  17. ncbi request reprint Acute global anoxia during C-section birth affects dopamine-mediated behavioural responses and reactivity to stress
    Aldina Venerosi
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma I 00161, Italy
    Behav Brain Res 154:155-64. 2004
    ..Altogether, the present findings suggest that the present 20 min perinatal asphyxia model might serve for the study of neurodevelopmental disorders associated with perinatal insults...
  18. doi request reprint Assessing the interplay between fear and learning in mice exposed to a live rat in a spatial memory task (MWM)
    Luca T Bonsignore
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Anim Cogn 11:557-62. 2008
    ..Overall, this procedure represents a novel and easy test to assess the effects of stressful stimuli, contextually to spatial learning and memory performance, in mice...
  19. pmc Early interactions with mother and peers independently build adult social skills and shape BDNF and oxytocin receptor brain levels
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Psychoneuroendocrinology 38:522-32. 2013
    ..Overall these findings indicate that early interactions with mother and peers independently shape specific facets of adult social behavior and neural systems involved in social interaction...
  20. pmc Antidepressant treatment outcome depends on the quality of the living environment: a pre-clinical investigation in mice
    Igor Branchi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 8:e62226. 2013
    ..These findings may be helpful to explain variable effects of SSRI found in clinical practice and to device strategies aimed at enhancing their efficacy by means of controlling environmental conditions...
  21. doi request reprint Daily serum and salivary BDNF levels correlate with morning-evening personality type in women and are affected by light therapy
    Paola Tirassa
    Institute of Neurobiology and Molecualr Medicine CNR, Rome, Italy
    Riv Psichiatr 47:527-34. 2012
    ..The aim of the present study was to test ultradian fluctuations in serum and salivary BDNF levels and their interaction with light therapy in a sample of healthy women...
  22. doi request reprint Shaping brain development: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Psychoneuroendocrinology 35:743-51. 2010
    ..The present findings suggest that early experiences represent one of those factors to be taken into account to identify the appropriate individual pharmacological strategy to treat depression in patients...
  23. ncbi request reprint Acute perinatal asphyxia at birth has long-term effects on behavioural arousal and maternal behaviour in lactating rats
    Luca T Bonsignore
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 172:54-62. 2006
    ....
  24. doi request reprint Use of assistance and therapy dogs for children with autism spectrum disorders: a critical review of the current evidence
    Alessandra Berry
    Section of Behavioral Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Altern Complement Med 19:73-80. 2013
    ....
  25. ncbi request reprint Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice
    Alessandra Berry
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, I 00161 Rome, Italy
    Exp Gerontol 42:37-45. 2007
    ..These data are discussed in relation to recent views, indicating new and complex interactions between oxidative stress and emotional stress...
  26. pmc Moderate neonatal stress decreases within-group variation in behavioral, immune and HPA responses in adult mice
    Simone Macri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    PLoS ONE 2:e1015. 2007
    ....
  27. ncbi request reprint Prolonged perinatal AZT administration and early maternal separation: effects on social and emotional behaviour of periadolescent mice
    Aldina Venerosi
    Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Pharmacol Biochem Behav 74:671-81. 2003
    ..Overall results from this study indicate that both AZT exposure and maternal deprivation induced gender-dependent changes in social and emotional behaviour both during adolescence and at adulthood...
  28. doi request reprint The p66(Shc) gene paves the way for healthspan: evolutionary and mechanistic perspectives
    Alessandra Berry
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Neurosci Biobehav Rev 37:790-802. 2013
    ....
  29. ncbi request reprint Behavioral responses of 129/Sv, C57BL/6J and DBA/2J mice to a non-predator aversive olfactory stimulus
    Francesca Capone
    Section of Behavioral Neuroscience, Dept of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma, Italy
    Acta Neurobiol Exp (Wars) 65:29-38. 2005
    ..These features make this task as a good complement to any exploration-anxiety test battery...
  30. doi request reprint Early handling increases susceptibility to experimental autoimmune encephalomyelitis (EAE) in C57BL/6 male mice
    Sandra Columba-Cabezas
    Section of Inflammatory and Demyelinating Diseases of the Nervous System, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    J Neuroimmunol 212:10-6. 2009
    ..These effects were associated with changes in the testosterone profile of male subjects. Changes in leptin levels during the preclinical stage of EAE may predict a more severe disease course...
  31. ncbi request reprint Non conventional psychiatric rehabilitation in schizophrenia using therapeutic riding: the FISE multicentre Pindar project
    Stefania Cerino
    Dipartimento Riabilitazione Equestre, Federazione Italiana Sport Equestri, Viale Tiziano 74, Rome, Italy
    Ann Ist Super Sanita 47:409-14. 2011
    ..The results discussed in this paper point out an improvement in negative symptoms, a constant disease remission in both early onset and chronic disease subjects, as well as a reduced rate of hospitalization...