Antonio Cassone

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. pmc Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence
    Antonella Torosantucci
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 4:e5392. 2009
  2. doi request reprint Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders
    Antonio Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Catholic University of Rome, Rome, Italy
    AIDS 26:1457-72. 2012
  3. doi request reprint High rate of Quantiferon positive and tuberculin negative tests in infants born at a large Italian university hospital in 2011: a cautionary hypothesis
    Antonio Cassone
    Molecular Parasitology Course, Imperial College, London, UK
    Pathog Glob Health 106:8-11. 2012
  4. ncbi request reprint The Ag85B protein of Mycobacterium tuberculosis may turn a protective immune response induced by Ag85B-DNA vaccine into a potent but non-protective Th1 immune response in mice
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Cell Microbiol 9:1455-65. 2007
  5. ncbi request reprint Protection against rat vaginal candidiasis by adoptive transfer of vaginal B lymphocytes
    Flavia De Bernardis
    Department of Infectious Parasitic and Immune mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    FEMS Yeast Res 10:432-40. 2010
  6. doi request reprint The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Vaccine 26:4237-43. 2008
  7. ncbi request reprint Anti-retroviral therapy with protease inhibitors decreases virulence enzyme expression in vivo by Candida albicans without selection of avirulent fungus strains or decreasing their anti-mycotic susceptibility
    Flavia De Bernardis
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    FEMS Immunol Med Microbiol 41:27-34. 2004
  8. ncbi request reprint beta-Glucan of Candida albicans cell wall causes the subversion of human monocyte differentiation into dendritic cells
    Roberto Nisini
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    J Leukoc Biol 82:1136-42. 2007
  9. pmc In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species
    Francesca Mondello
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    BMC Infect Dis 6:158. 2006
  10. ncbi request reprint The 65 kDa mannoprotein gene of Candida albicans encodes a putative beta-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity
    Silvia Sandini
    Department of Infectious, Parasitic and Immuno Mediated Diseases, Instituto Superiore di Sanita, Rome, Italy
    Cell Microbiol 9:1223-38. 2007

Detail Information

Publications55

  1. pmc Protection by anti-beta-glucan antibodies is associated with restricted beta-1,3 glucan binding specificity and inhibition of fungal growth and adherence
    Antonella Torosantucci
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 4:e5392. 2009
    ....
  2. doi request reprint Candida and candidiasis in HIV-infected patients: where commensalism, opportunistic behavior and frank pathogenicity lose their borders
    Antonio Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Catholic University of Rome, Rome, Italy
    AIDS 26:1457-72. 2012
    ....
  3. doi request reprint High rate of Quantiferon positive and tuberculin negative tests in infants born at a large Italian university hospital in 2011: a cautionary hypothesis
    Antonio Cassone
    Molecular Parasitology Course, Imperial College, London, UK
    Pathog Glob Health 106:8-11. 2012
    ..We present here several theoretical arguments and literature data suggesting caution in interpreting the interferon-gamma released assays positivity alone as indication of latent TB infection in newborns...
  4. ncbi request reprint The Ag85B protein of Mycobacterium tuberculosis may turn a protective immune response induced by Ag85B-DNA vaccine into a potent but non-protective Th1 immune response in mice
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Cell Microbiol 9:1455-65. 2007
    ..They also suggest that Ag85B protein secreted during MTB infection could be involved in the instability of protective anti-tuberculosis immune response, and actually concur to disease progression...
  5. ncbi request reprint Protection against rat vaginal candidiasis by adoptive transfer of vaginal B lymphocytes
    Flavia De Bernardis
    Department of Infectious Parasitic and Immune mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    FEMS Yeast Res 10:432-40. 2010
    ..These data are evidence of a partial anti-Candida protective role of CD3(-) CD5(+) IgM(+) vaginal B lymphocytes in our experimental model...
  6. doi request reprint The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Vaccine 26:4237-43. 2008
    ..The recovery of protection through a down-modulation of antigen-specific IFN-gamma response by an adjuvant is a novel finding which could be of relevance in tuberculosis vaccination...
  7. ncbi request reprint Anti-retroviral therapy with protease inhibitors decreases virulence enzyme expression in vivo by Candida albicans without selection of avirulent fungus strains or decreasing their anti-mycotic susceptibility
    Flavia De Bernardis
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    FEMS Immunol Med Microbiol 41:27-34. 2004
    ..While further demonstrating that HIV-PI inhibit Sap expressions, our results do not support the view that the mentioned inhibition could eliminate Candida or its selection of the oral cavity...
  8. ncbi request reprint beta-Glucan of Candida albicans cell wall causes the subversion of human monocyte differentiation into dendritic cells
    Roberto Nisini
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    J Leukoc Biol 82:1136-42. 2007
    ..In particular, our data suggest that beta-glucan could bias noninfected, bystander monocytes, thus aggravating the general immunodeficiency, predisposing to systemic fungal infection...
  9. pmc In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species
    Francesca Mondello
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    BMC Infect Dis 6:158. 2006
    ..Thus, the aim of our study was to investigate the in vitro and the in vivo anti-Candida activity of two critical bioactive constituents of TTO, terpinen-4-ol and 1,8-cineole...
  10. ncbi request reprint The 65 kDa mannoprotein gene of Candida albicans encodes a putative beta-glucanase adhesin required for hyphal morphogenesis and experimental pathogenicity
    Silvia Sandini
    Department of Infectious, Parasitic and Immuno Mediated Diseases, Instituto Superiore di Sanita, Rome, Italy
    Cell Microbiol 9:1223-38. 2007
    ..albicans encodes a putative beta-glucanase, mannoprotein adhesin, which has a dual role (hyphal cell wall construction and virulence), accounting for the particular relevance of host immune response against this mannoprotein...
  11. doi request reprint Beta-glucan-CRM197 conjugates as candidates antifungal vaccines
    Carla Bromuro
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, 00161 Rome, Italy
    Vaccine 28:2615-23. 2010
    ..These data provide some insights on beta-glucan epitope(s) mediating antifungal protection and open the way to develop a synthetic oligosaccharide vaccine against fungal diseases...
  12. ncbi request reprint Plant production of anti-β-glucan antibodies for immunotherapy of fungal infections in humans
    Cristina Capodicasa
    ENEA, UT BIORAD, Laboratory of Biotechnology, Research Center Casaccia, Rome, Italy
    Plant Biotechnol J 9:776-87. 2011
    ..albicans infection. These recombinant Abs represent valuable molecules for developing novel, plant-derived immunotherapeutics against candidiasis and, possibly, other fungal diseases...
  13. pmc A novel glyco-conjugate vaccine against fungal pathogens
    Antonella Torosantucci
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Exp Med 202:597-606. 2005
    ..fumigatus hyphae. Thus, this novel conjugate vaccine can efficiently immunize and protect against two major fungal pathogens by mechanisms that may include direct antifungal properties of anti-beta-glucan antibodies...
  14. doi request reprint Characterization of the serological response to phospholipase D protein of Chlamydophila pneumoniae in patients with acute coronary syndromes
    Fabiola Mancini
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Microbes Infect 11:367-73. 2009
    ..pneumoniae infection. The CpPLD protein and its P5 peptide could be plausible antigens for the diagnosis of C. pneumoniae chronic infections in ACS patients...
  15. ncbi request reprint In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts
    Francesca Mondello
    Laboratory of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, Italy
    J Antimicrob Chemother 51:1223-9. 2003
    ..Overall, the use of a reliable animal model of infection has confirmed and extended our data on the therapeutic effectiveness of TTO against fungi, in particular against C. albicans...
  16. doi request reprint A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine
    Silvia Sandini
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    FEMS Immunol Med Microbiol 62:215-24. 2011
    ....
  17. pmc The M. tuberculosis phosphate-binding lipoproteins PstS1 and PstS3 induce Th1 and Th17 responses that are not associated with protection against M. tuberculosis infection
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Clin Dev Immunol 2011:690328. 2011
    ..tuberculosis infection which is of interest in the study of anti-M. tuberculosis immunity and as potential immunomodulator in combined vaccines...
  18. pmc Interplay between protective and inhibitory antibodies dictates the outcome of experimentally disseminated Candidiasis in recipients of a Candida albicans vaccine
    Carla Bromuro
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, USA
    Infect Immun 70:5462-70. 2002
    ..Our observations may also help explain why subjects with elevated anti-Candida antibody titers, inclusive of anti-MP and anti-GG antibodies, remain nonetheless susceptible to invasive candidiasis...
  19. ncbi request reprint Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis
    Flavia De Bernardis
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 00161 Rome, Italy
    J Infect Dis 195:149-57. 2007
    ..albicans. This is the first demonstration that human DAbs lacking the Fc constituent can efficiently control an infection and can act largely by inhibiting adherence...
  20. doi request reprint Localisation of Bgl2p upon antifungal drug treatment in Candida albicans
    Letizia Angiolella
    Department of Public Health Sciences G Sanarelli, University of Rome La Sapienza, Rome, Italy
    Int J Antimicrob Agents 33:143-8. 2009
    ..albicans and thus could be considered the molecular basis of antifungal resistance and also as a potential valuable candidate for future vaccine development...
  21. ncbi request reprint Transcription, expression, localization and immunoreactivity of Chlamydophila pneumoniae Phospholipase D protein
    Alessandra Ciervo
    Department of Infectious, Parasitic and Immuno Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Microb Pathog 43:96-105. 2007
    ..rCpPLD may be a useful tool for future studies concerning the role that this enzyme plays in the pathology of, and immune response to, C. pneumoniae...
  22. doi request reprint Fungal vaccines: real progress from real challenges
    Antonio Cassone
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Lancet Infect Dis 8:114-24. 2008
    ..Together with the demonstrated efficacy of various antibodies in passive vaccination approaches, there is growing confidence in the future availability of safe and efficacious immunological tools to combat deadly microbes in a weak host...
  23. pmc Generation of human antibody fragments recognizing distinct epitopes of the nucleocapsid (N) SARS-CoV protein using a phage display approach
    Michela Flego
    Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Rome, Italy
    BMC Infect Dis 5:73. 2005
    ....
  24. pmc Candida albicans yeast and germ tube forms interfere differently with human monocyte differentiation into dendritic cells: a novel dimorphism-dependent mechanism to escape the host's immune response
    Antonella Torosantucci
    Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, 00161 Rome, Italy
    Infect Immun 72:833-43. 2004
    ..Thus, the differentiation of human monocytes into DCs appears to be tunable and exploitable by C. albicans to elude immune surveillance...
  25. doi request reprint Candida albicans cell wall comprises a branched beta-D-(1-->6)-glucan with beta-D-(1-->3)-side chains
    Egidio Iorio
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena, 299, Roma 00161, Italy
    Carbohydr Res 343:1050-61. 2008
    ..This finding may provide the grounds for further elucidation of the cell wall structure and a better understanding of the biological properties of C. albicans beta-glucans...
  26. ncbi request reprint Detection of human P-glycoprotein-like molecule in azole-resistant Candida albicans from HIV+ patients
    Annarita Stringaro
    Laboratorio di Ultrastrutture, Istituto Superiore di Sanita, Rome, Italy
    Microb Drug Resist 8:235-44. 2002
    ..albicans or the ATCC 6458 strain of C. krusei. Overall, our data suggest the existence of a P-gp-like drug efflux pump in C. albicans that may participate in the mechanisms of azole-resistance of this fungus...
  27. ncbi request reprint 60-kDa heat shock protein of Chlamydia pneumoniae promotes a T helper type 1 immune response through IL-12/IL-23 production in monocyte-derived dendritic cells
    Clara Maria Ausiello
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Microbes Infect 8:714-20. 2006
    ..Our data suggest that Cp-HSP60-matured DC may contribute to T-cell mediated immunopathology of atherosclerosis via a chronic stimulation of Th1 immune responses...
  28. ncbi request reprint Use of 65 kDa mannoprotein gene primers in Real Time PCR identification of Candida albicans in biological samples
    Silvia Arancia
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Mol Cell Probes 20:263-8. 2006
    ..Finally, the real-time PCR was employed in order to detect and quantify C. albicans in the sera from patients with invasive candidiasis...
  29. pmc Role of 4-1BB receptor in the control played by CD8(+) T cells on IFN-gamma production by Mycobacterium tuberculosis antigen-specific CD4(+) T Cells
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e11019. 2010
    ..Discovering new tools to control nonprotective antigen-specific IFN-gamma production without affecting protective IFN-gamma is a challenge in tuberculosis research...
  30. pmc Persistent Chlamydia pneumoniae infection of cardiomyocytes is correlated with fatal myocardial infarction
    Luigi Giusto Spagnoli
    Cattedra di Anatomia ed Istologia Patologica, Dipartimento di Biopatologia e Diagnostica per Immagini, Universita di Roma Tor Vergata, Via Montpellier 1, Rome, Italy
    Am J Pathol 170:33-42. 2007
    ..Our results suggest that CP may underlie both coronary and myocardial vulnerabilities in patients who died of AMI and corroborate the notion that CP may act by reducing cardiac reserves, thus worsening the ischemic burden of myocardium...
  31. ncbi request reprint Low prevalence of antibodies against heat shock protein 10 of Chlamydophila pneumoniae in patients with coronary heart disease
    Alessandra Ciervo
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Microbiol Methods 63:248-53. 2005
    ..2/60=3.3%). Overall, our data indicate that CP-HSP10, at variance with CP-HSP60, to which it is genetically and physiologically linked, should not be regarded as a major expressed immunogen or a marker of infection by CP in CHD patients...
  32. pmc Anticandidal immunity and vaginitis: novel opportunities for immune intervention
    Antonio Cassone
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    Infect Immun 75:4675-86. 2007
  33. doi request reprint A virosomal vaccine against candidal vaginitis: immunogenicity, efficacy and safety profile in animal models
    Flavia De Bernardis
    Department of Infectious, Parasitic and Immunomediated Diseases, ISS, Rome, Italy
    Vaccine 30:4490-8. 2012
    ..PEV7 was also found to be safe in a repeated-dose toxicological study in rats. Overall, these data provide a sound basis to envisage the clinical development of this new candidate vaccine against candidal vaginitis...
  34. ncbi request reprint Antiretroviral therapy with protease inhibitors has an early, immune reconstitution-independent beneficial effect on Candida virulence and oral candidiasis in human immunodeficiency virus-infected subjects
    Antonio Cassone
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161 Rome, Italy
    J Infect Dis 185:188-95. 2002
    ..Thus, PIs exert an early, immune reconstitution-independent effect on Candida virulence in the oral cavities of HIV-positive subjects...
  35. pmc Fourteen years of severe arthralgia in a man without gastrointestinal symptoms: atypical Whipple's disease
    Fabiola Mancini
    Department of Infectious, Istituto Superiore di Sanita, Rome, Italy
    J Clin Microbiol 47:492-5. 2009
    ..We identified Tropheryma whipplei by real-time PCR. Molecular typing was also performed by sequencing the 16S-23S rRNA intergenic spacer region and domain III of the 23S rRNA gene...
  36. pmc Identification of major glucan-associated cell wall proteins of Candida albicans and their role in fluconazole resistance
    Letizia Angiolella
    Institute of Microbiology, Faculty of Pharmacy, Rome, Italy
    Antimicrob Agents Chemother 46:1688-94. 2002
    ....
  37. pmc Recent progress in vaccines against fungal diseases
    Antonio Cassone
    Department of Infectious Diseases, Istituto Superiore di Sanita, Rome, Italy
    Curr Opin Microbiol 15:427-33. 2012
    ..A number of highly immunogenic and protective vaccine formulations in preclinical setting have been developed, and at least two have undergone Phase 1 clinical trials as preventive and/or therapeutic tools against candidiasis...
  38. pmc Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus
    Simona Puzelli
    National Institute of Health, Rome, Italy
    Emerg Infect Dis 16:863-5. 2010
    ..Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain...
  39. ncbi request reprint Opportunistic fungi and fungal infections: the challenge of a single, general antifungal vaccine
    Antonio Cassone
    Istituto Superiore di Sanita, Department of Infectious, Parasitic and Immuno Mediated Diseases, Viale Regina Elena, Rome, Italy
    Expert Rev Vaccines 5:859-67. 2006
    ..The generation of antibodies with the potential to directly inhibit the growth of, or kill the fungal cells also opens an exciting perspective for both active and passive vaccination in immunocompromised subjects...
  40. pmc Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus
    Simona Puzelli
    Istituto Superiore di Sanità ISS, National Institute of Health, Rome, Italy
    J Clin Microbiol 48:2298-300. 2010
    ..Pandemic H1N1 2009 influenza A virus sequences were identified in throat and myocardial tissues and pericardial fluid, suggesting damage of myocardial cells directly caused by the virus...
  41. ncbi request reprint HIV proteinase inhibitors: do they really work against Candida in a clinical setting?
    Antonio Cassone
    Dept of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome, Italy
    Trends Microbiol 10:177-8. 2002
  42. pmc Intravaginal and intranasal immunizations are equally effective in inducing vaginal antibodies and conferring protection against vaginal candidiasis
    Flavia De Bernardis
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, 00161 Rome, Italy
    Infect Immun 70:2725-9. 2002
    ..These data suggest that appropriate fungal antigens and adjuvant can be used to protect against candidal vaginitis, by either route...
  43. pmc Deletion of the two-component histidine kinase gene (CHK1) of Candida albicans contributes to enhanced growth inhibition and killing by human neutrophils in vitro
    Antonella Torosantucci
    Istituto Superiore di Sanita, Laboratory of Bacteriology and Mycology, Viale Regina Elena 299, Rome 00196, Italy
    Infect Immun 70:985-7. 2002
    ..The PMN effect was not due to increased phagocytosis of the null strain. This observation may partially explain the reduced virulence in a hematogenously disseminated murine model of candidiasis...
  44. ncbi request reprint Immune response and protection by DNA vaccines expressing antigen 85B of Mycobacterium tuberculosis
    Manuela Pardini
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    FEMS Microbiol Lett 262:210-5. 2006
    ..97 log10 CFU decrease). Multipromoter plasmids, which permit the reduction of the total amount of DNA injected, can be useful for DNA vaccination against tuberculosis...
  45. ncbi request reprint Recombinant protein-based ELISA and immuno-cytochemical assay for the diagnosis of SARS
    Alessandra Carattoli
    Department of Infectious, Parasitic and Immuno Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Med Virol 76:137-42. 2005
    ..The specificity of these sera was confirmed by an immunocytochemical assay on biochips of SARS-CoV infected and uninfected cells...
  46. ncbi request reprint Extensively drug-resistant (XDR) tuberculosis: an old and new threat
    Lanfranco Fattorini
    Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 43:317-9. 2007
    ..e., the multidrug-resistant TB, which in its extreme and highly lethal form is called XDR TB (extensively drug-resistant TB). How to fight XDR TB is a high research and public health priority...
  47. pmc Different pH requirements are associated with divergent inhibitory effects of chloroquine on human and avian influenza A viruses
    Livia Di Trani
    Dept of Food and Animal Health, Istituto Superiore di Sanita, Rome, Italy
    Virol J 4:39. 2007
    ..Overall, the present study highlights the critical importance of a host cell factor such as intravesicular pH in determining the anti-influenza activity of chloroquine and other lysosomotropic agents...
  48. ncbi request reprint Evaluation and optimization of ELISA for detection of anti-Chlamydophila pneumoniae IgG and IgA in patients with coronary heart diseases
    Alessandra Ciervo
    Department of Infectious, Parasitic and Immune Mediated Diseases, Unit of Respiratory and Systemic Bacterial Diseases, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    J Microbiol Methods 59:135-40. 2004
    ..These ELISA tests proved to be a useful semiquantitative method for seroprevalence studies in CHD patients, with remarkable advantages over MIF test in terms of objective measurement, thus reproducibility, performance and interpretation...
  49. doi request reprint Caprine herpesvirus-1-specific IgG subclasses in naturally and experimentally infected goats
    Mariarosaria Marinaro
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Vet Microbiol 138:266-72. 2009
    ..The results are discussed from the standpoint that the profile of the IgG subclasses is instrumental to study immune responses to CpHV-1 and that vaccination strategies may benefit from this information...
  50. ncbi request reprint Mitochondrial membrane hyperpolarization hijacks activated T lymphocytes toward the apoptotic-prone phenotype: homeostatic mechanisms of HIV protease inhibitors
    Paola Matarrese
    Department of Ultrastructures, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 170:6006-15. 2003
    ..They also suggest that HIV protease inhibitors, by interfering with induction of the mitochondrial hyperpolarization state, can result in cell survival even independent of any viral infection...
  51. ncbi request reprint Optimization of high-resolution melting analysis for low-cost and rapid screening of allelic variants of Bacillus anthracis by multiple-locus variable-number tandem repeat analysis
    Daniela Fortini
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Clin Chem 53:1377-80. 2007
    ..Although the method has great differentiating power and reproducibility, faster genotyping at low cost may be requested to accurately identify B. anthracis strains in the field...
  52. pmc The toll-like receptor 2/6 ligand MALP-2 reduces the viability of Mycobacterium tuberculosis in murine macrophages
    Carla Palma
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Open Microbiol J 3:47-52. 2009
    ..These results suggest that the activation of microbicidal defense via TLR ligands is an appealing target for the establishment on immune intervention against tuberculosis...
  53. ncbi request reprint Native and genetically inactivated pertussis toxins induce human dendritic cell maturation and synergize with lipopolysaccharide in promoting T helper type 1 responses
    Clara M Ausiello
    Department of Bacteriology and Medical Mycology, Istituto Superiore di Sanita, Rome 00161, Italy
    J Infect Dis 186:351-60. 2002
    ..The synergic interaction between PT and LPS in IL-12 production might be relevant for the mechanisms of vaccine-induced protection...
  54. doi request reprint A preliminary assessment of the occupational risk of acquiring Legionnaires' disease for people working in telephone manholes, a new workplace environment for Legionella growth
    Maria Luisa Ricci
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Am J Infect Control 38:540-5. 2010
    ..Following a fatal case of Legionnaires' disease (LD), acquired during working activity in a TM, we investigated whether Legionella was present in TMs and could be a risk for manhole workers (MWs)...
  55. ncbi request reprint Effects of chloroquine on viral infections: an old drug against today's diseases?
    Andrea Savarino
    Department of Infectious Diseases, Universita Cattolica del Sacro Cuore, Rome, Italy
    Lancet Infect Dis 3:722-7. 2003
    ....