Antonino Carbone

Summary

Affiliation: Istituto Nazionale Tumori
Country: Italy

Publications

  1. doi request reprint Radical dissection after positive groin sentinel biopsy in melanoma patients: rate of further positive nodes
    Mario Santinami
    Fondazione Istituto Tumori, Milan, Italy
    Melanoma Res 19:112-8. 2009
  2. doi request reprint PEL and HHV8-unrelated effusion lymphomas: classification and diagnosis
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Cancer 114:225-7. 2008
  3. doi request reprint HIV-associated Hodgkin lymphoma
    Antonino Carbone
    Department of Pathology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Curr Opin HIV AIDS 4:3-10. 2009
  4. pmc KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype
    A Carbone
    Department of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Venezian 1, Milano I 20133, Italy
    J Clin Pathol 58:1039-45. 2005
  5. ncbi request reprint AIDS-related lymphomas: from pathogenesis to pathology
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 130:662-70. 2005
  6. doi request reprint The Germinal centre-derived lymphomas seen through their cellular microenvironment
    Antonino Carbone
    Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 145:468-80. 2009
  7. ncbi request reprint Differentiating germinal center-derived lymphomas through their cellular microenvironment
    Antonino Carbone
    Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy
    Am J Hematol 84:435-8. 2009
  8. doi request reprint B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology
    Antonino Carbone
    Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori, 20133 Milano, Italy
    Hum Pathol 41:621-31. 2010
  9. ncbi request reprint EBV-associated lymphoproliferative disorders: classification and treatment
    Antonino Carbone
    Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, Milano I 20133, Italy
    Oncologist 13:577-85. 2008
  10. pmc Understanding pathogenetic aspects and clinical presentation of primary effusion lymphoma through its derived cell lines
    Antonino Carbone
    Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori Milano, Milan, Italy
    AIDS 24:479-90. 2010

Detail Information

Publications113 found, 100 shown here

  1. doi request reprint Radical dissection after positive groin sentinel biopsy in melanoma patients: rate of further positive nodes
    Mario Santinami
    Fondazione Istituto Tumori, Milan, Italy
    Melanoma Res 19:112-8. 2009
    ..This could be considered a standard treatment until new data, provided by ongoing studies, indicate new parameters for selecting patients for completion lymph node dissection...
  2. doi request reprint PEL and HHV8-unrelated effusion lymphomas: classification and diagnosis
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Cancer 114:225-7. 2008
  3. doi request reprint HIV-associated Hodgkin lymphoma
    Antonino Carbone
    Department of Pathology, Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Curr Opin HIV AIDS 4:3-10. 2009
    ..The focus of this review is on the current knowledge on epidemiology, pathology and treatment of HIV-associated Hodgkin lymphoma (HIV-HL)...
  4. pmc KSHV/HHV-8 associated lymph node based lymphomas in HIV seronegative subjects. Report of two cases with anaplastic large cell morphology and plasmablastic immunophenotype
    A Carbone
    Department of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Venezian 1, Milano I 20133, Italy
    J Clin Pathol 58:1039-45. 2005
    ..Interestingly, KSHV/HHV-8 associated lymphomas that present as solid or extracavitary based lesions in HIV seropositive patients without serous effusions have been reported recently...
  5. ncbi request reprint AIDS-related lymphomas: from pathogenesis to pathology
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 130:662-70. 2005
    ....
  6. doi request reprint The Germinal centre-derived lymphomas seen through their cellular microenvironment
    Antonino Carbone
    Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy
    Br J Haematol 145:468-80. 2009
    ....
  7. ncbi request reprint Differentiating germinal center-derived lymphomas through their cellular microenvironment
    Antonino Carbone
    Department of Pathology and Laboratory and Transfusion Medicine, Istituto Nazionale Tumori, Milano, Italy
    Am J Hematol 84:435-8. 2009
    ..Am. J. Hematol., 2009. (c) 2009 Wiley-Liss, Inc...
  8. doi request reprint B-cell lymphomas with features intermediate between distinct pathologic entities. From pathogenesis to pathology
    Antonino Carbone
    Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori, 20133 Milano, Italy
    Hum Pathol 41:621-31. 2010
    ..For the provisional borderline categories, unresolved issues include understanding molecular pathogenesis and defining an effective treatment...
  9. ncbi request reprint EBV-associated lymphoproliferative disorders: classification and treatment
    Antonino Carbone
    Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Via Venezian 1, Milano I 20133, Italy
    Oncologist 13:577-85. 2008
    ..Recent advances in EBV cell-based immunotherapy, which is beginning to show promise in the treatment of EBV-related disorders, are discussed...
  10. pmc Understanding pathogenetic aspects and clinical presentation of primary effusion lymphoma through its derived cell lines
    Antonino Carbone
    Department of Pathology and Laboratory Medicine, Istituto Nazionale Tumori Milano, Milan, Italy
    AIDS 24:479-90. 2010
    ..Also, PEL cell lines are important model systems for the study of the disorder of PEL including the lack of invasive or destructive growth patterns and the peculiar propensity of PEL to involve body cavity surfaces...
  11. doi request reprint HIV-associated lymphomas and gamma-herpesviruses
    Antonino Carbone
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy
    Blood 113:1213-24. 2009
    ....
  12. pmc Delineation of HER2 gene status in breast carcinoma by silver in situ hybridization is reproducible among laboratories and pathologists
    Antonino Carbone
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy
    J Mol Diagn 10:527-36. 2008
    ..6% (86/89), respectively. Overall concordance between positive and negative SISH and fluorescence ISH results, as well as between individual and consensus positive and negative SISH results, was excellent (P < 0.001)...
  13. ncbi request reprint KSHV/HHV8-associated lymphomas
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Br J Haematol 140:13-24. 2008
    ..These include the addition of antiviral therapy as well as inhibition of specific cellular targets...
  14. ncbi request reprint Plasmablastic lymphoma: one or more entities?
    Antonino Carbone
    Department of Pathology, National Cancer Institute of Milan, Milan, Italy
    Am J Hematol 83:763-4. 2008
  15. ncbi request reprint HHV-8-associated lymphoma: state-of-the-art review
    Antonino Carbone
    Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Acta Haematol 117:129-31. 2007
    ..Despite the diversification in the clinical presentation of KSHV/HHV-8-associated lymphomas, most cases demonstrated a similar morphology, immunophenotype and KSHV/HHV-8 viral status...
  16. doi request reprint Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma
    Lara Cattaruzza
    Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Int J Cancer 125:1092-101. 2009
    ....
  17. ncbi request reprint A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milano, Italy
    Mod Pathol 19:299-306. 2006
    ..The germinal center phenotype, with restricted expression of BCL-6, was associated with the presence of a primary extranodal origin, normal lactate dehydrogenase levels, and good response to treatment...
  18. ncbi request reprint Heterogeneous phenotype of human melanoma cells with in vitro and in vivo features of tumor-initiating cells
    Michela Perego
    Department of Experimental Oncology, Fondazione IRCSS, Istituto Nazionale dei Tumori, Milan, Italy
    J Invest Dermatol 130:1877-86. 2010
    ....
  19. ncbi request reprint Aggressive forms of non-Hodgkin's lymphoma in two patients bearing coinfection of Epstein-Barr and hepatitis C viruses
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Via Pedemontana Occidentale 12, I 33081 Aviano, PN, Italy
    Int J Oncol 26:945-50. 2005
    ..Together, these data suggest that EBV infection may cooperate with HCV infection during progression of B-cell NHL in immunocompetent individuals. Such an interaction may accelerate the course of disease in B-cell NHL patients...
  20. ncbi request reprint IRF4 is modulated by CD40L and by apoptotic and anti-proliferative signals in Hodgkin lymphoma
    Donatella Aldinucci
    Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano PN, Italy
    Br J Haematol 148:115-8. 2010
    ..These results demonstrated, for the first time, that IRF4 was up-modulated by CD40 engagement, and down-modulated by apoptotic and anti-proliferative signals, suggesting an involvement of IRF4 also in HL pathobiology...
  21. ncbi request reprint Expression of CCR5 receptors on Reed-Sternberg cells and Hodgkin lymphoma cell lines: involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactions
    Donatella Aldinucci
    Experimental Oncology 2, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
    Int J Cancer 122:769-76. 2008
    ..Taken together, our results indicate a possible involvement of the CCR5/CCR5-ligands signaling in the regulation of H-RS cells growth and in the formation/maintenance of the typical tissue microenvironment of HL...
  22. ncbi request reprint Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts
    Marta Celegato
    Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Leuk Lymphoma 55:149-59. 2014
    ..However, inclusion of bortezomib in the cHL drug regimen, by reducing IRF4 expression and interactions with the microenvironment, could increase the efficacy of current chemotherapeutic treatment of relapsed/refractory cHL...
  23. ncbi request reprint c-Kit/PDGFRA gene status alterations possibly related to primary imatinib resistance in gastrointestinal stromal tumors
    Francesca C Miselli
    Experimental Molecular Pathology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 13:2369-77. 2007
    ..To correlate morphologic changes with molecular, biochemical, and cytogenetic profiles in gastrointestinal stromal tumor (GIST) patients before and after imatinib treatment...
  24. ncbi request reprint Analysis of aberrant somatic hypermutation (SHM) in non-Hodgkin's lymphomas of patients with chronic HCV infection
    Massimo Libra
    Experimental Oncology 1, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    J Pathol 206:87-91. 2005
    ..This indicates that, unlike B-cell lymphomas from HCV-negative patients, aberrant SHM may not contribute significantly to malignant transformation in HCV-associated B-cell lymphomas...
  25. ncbi request reprint Hodgkin and Reed-Sternberg cells express functional c-kit receptors and interact with primary fibroblasts from Hodgkin's disease-involved lymph nodes through soluble and membrane-bound stem cell factor
    Donatella Aldinucci
    Clinical and Experimental Haematology Research Unit, Centro di Riferimento Oncologico, I R C C S, Istituto Nazionale Tumori, Aviano, Italy
    Br J Haematol 118:1055-64. 2002
    ..Taken together, our data indicated the expression of functional c-kit receptor by H-RS cells and suggests a role of SCF in the pathobiology of cHD...
  26. doi request reprint Pure desmoplastic melanoma: a melanoma with distinctive clinical behavior
    Andrea Maurichi
    Departments of Surgery and Biometry, Fonda zione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Ann Surg 252:1052-7. 2010
    ..The purpose of the study was to evaluate the excision margin necessary for desmoplastic melanoma (DM)...
  27. doi request reprint Human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand target both tumor cells and tumor vasculature
    Cristiana Lavazza
    Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy
    Blood 115:2231-40. 2010
    ..These results demonstrate that tumor homing of CD34-TRAIL+ cells induces early vascular disruption, resulting in hemorrhagic necrosis and tumor destruction...
  28. ncbi request reprint p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx
    Federica Perrone
    Unit of Experimental Molecular Pathology, Fondazione IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer 109:2461-5. 2007
    ..The TP53 polymorphism, in which an arginine (R) is changed to proline (P) at codon 72, is functionally significant and could therefore be a predisposing genetic defect...
  29. ncbi request reprint IFN-gamma enhances the antimyeloma activity of the fully human anti-human leukocyte antigen-DR monoclonal antibody 1D09C3
    Carmelo Carlo-Stella
    Cristina Gandini Medical Oncology Unit, Medical Oncology, University of Milano, Milan, Italy
    Cancer Res 67:3269-75. 2007
    ..Our data show that (a) one fourth of MM patients express HLA-DR on CD138(+) cells and (b) IFN-gamma-induced up-regulation of HLA-DR results in a potent enhancement of the in vivo antimyeloma activity of 1D09C3...
  30. pmc Kaposi's sarcoma-associated herpesvirus/human herpesvirus type 8-positive solid lymphomas: a tissue-based variant of primary effusion lymphoma
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Via Pedemontana Occidentale, Aviano I 33081, Italy
    J Mol Diagn 7:17-27. 2005
    ....
  31. ncbi request reprint The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape
    Donatella Aldinucci
    Department of Experimental Oncology 2, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    J Pathol 221:248-63. 2010
    ....
  32. pmc Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1
    Annunziata Gloghini
    Division of Pathology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Am J Pathol 161:163-71. 2002
    ....
  33. doi request reprint Anticancer cell therapy with TRAIL-armed CD34+ progenitor cells
    Carmelo Carlo-Stella
    University of Milano, Istituto Nazionale Tumori, Department of Medical Oncology, Milano, Italy
    Adv Exp Med Biol 610:100-11. 2008
  34. pmc Latent membrane protein 1 deletion mutants accumulate in reed-sternberg cells of human immunodeficiency virus-related Hodgkin's lymphoma
    Massimo Guidoboni
    Immunovirology and Biotherapy Unit, Department of Pre Clinical and Epidemiological Research, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Via Pedemontana Occidentale 12, 33081 Aviano PN Italy
    J Virol 79:2643-9. 2005
    ....
  35. ncbi request reprint Non-Hodgkin's lymphoma and hepatitis C virus: a case-control study from northern and southern Italy
    Renato Talamini
    Servizio di Epidemiologia e Biostatistica, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Int J Cancer 110:380-5. 2004
    ..In conclusion, HCV infection was associated with an increase in NHL risk, and the fraction of NHL cases attributable to HCV was 12.4% (range 6.3-18.5%)...
  36. ncbi request reprint The role of interleukin-3 in classical Hodgkin's disease
    Donatella Aldinucci
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, IRCCS, Aviano PN, Italy
    Leuk Lymphoma 46:303-11. 2005
    ..This review will outline the biological activity of IL-3 and summarize the evidence indicating IL-3 as a growth and anti-apoptotic factor for H-RS cells in classical HD...
  37. pmc Expression of histone deacetylases in lymphoma: implication for the development of selective inhibitors
    Annunziata Gloghini
    Department of Pathology, National Cancer Institute, Milan, Italy
    Br J Haematol 147:515-25. 2009
    ..Collectively, our data demonstrate that HDAC6 is rarely expressed in primary lymphoma cases, suggesting that it may not be an important therapeutic target in these lymphoid malignancies...
  38. ncbi request reprint Multiple gene expression analyses in human lymphoid tissues by taqman low-density array using amplified rna isolated from paraffin-embedded samples
    Annunziata Gloghini
    Department of Pathology, Fondazione IRCCS, Istituto Nazionale Tumori, Milano, Italy
    Diagn Mol Pathol 18:156-64. 2009
    ..Consequently, TaqMan low-density array technology could be used successfully for the analysis of archival fixed and paraffin-embedded lymphoid tissue...
  39. pmc RT-PCR analysis of RNA extracted from Bouin-fixed and paraffin-embedded lymphoid tissues
    Annunziata Gloghini
    Division of Pathology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico National Cancer Institute, Via Pedemontana Occidentale, Aviano I 33081, Italy
    J Mol Diagn 6:290-6. 2004
    ..90) for all of the tested genes. These results show that the method of RNA extraction we propose is suitable for giving accurate real time quantitative RT-PCR results...
  40. ncbi request reprint Small nodular melanoma: the beginning of a life-threatening lesion. A clinical study on 11 cases
    Aldo Bono
    Day Surgery Unit, Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy
    Tumori 97:35-8. 2011
    ..The principal aim of the present study was to better define the initial clinical features of nodular melanoma to allow an early diagnosis. A secondary aim was to establish the prognosis of this type of lesion...
  41. ncbi request reprint Second primary lymphoma or recurrence: a dilemma solved by VDJ rearrangement analysis
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, Aviano, Pordenone, Italy
    Leuk Lymphoma 45:1539-43. 2004
    ..Furthermore, this technique has the potential to improve treatment of lymphoma patients because management of recurrent lymphomas differs from that of new lymphomas...
  42. ncbi request reprint Carcinogenic viruses and solid cancers without sufficient evidence of causal association
    Paolo De Paoli
    Scientific Directorate, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Via Franco Gallini 2, Aviano, Italy
    Int J Cancer 133:1517-29. 2013
    ....
  43. pmc A different immunologic profile characterizes patients with HER-2-overexpressing and HER-2-negative locally advanced breast cancer: implications for immune-based therapies
    Elena Muraro
    Cancer Bio Immunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Via Franco Gallini 2, Aviano PN, 33081, Italy
    Breast Cancer Res 13:R117. 2011
    ..On these grounds, a careful analysis of basal immune profile may be capital to dissect the heterogeneity of clinical responses to these drugs in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy...
  44. ncbi request reprint The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment
    Donatella Aldinucci
    Experimental Oncology, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Leuk Lymphoma 53:195-201. 2012
    ....
  45. pmc TRK-A, HER-2/neu, and KIT Expression/Activation Profiles in Salivary Gland Carcinoma
    Tiziana Negri
    Experimental Molecular Pathology Unit, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Transl Oncol 1:121-8. 2008
    ..In conclusion, SDCs and ACCs, although sharing TRK-A autocrine loop activation, have different pathologically activated RTK-deregulated profiles that may be potential targets for pharmacological RTK inhibitors...
  46. ncbi request reprint A novel bcl-1/JH breakpoint from a patient affected by mantle cell lymphoma extends the major translocation cluster
    Massimo Degan
    Clinical and Experimental Hematology Research Unit, Division of Experimental Oncology 2, Centro di Riferimento Oncologico, I R C C S, Aviano I 33981, Italy
    J Pathol 197:256-63. 2002
    ..The recognition of this novel breakpoint may have important implications for the diagnosis and detection of minimal residual disease in t(11;14)-positive lymphomas...
  47. ncbi request reprint Expression pattern of MUM1/IRF4 in the spectrum of pathology of Hodgkin's disease
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, via Pedemontali Occidentale, Aviano I 33081, Italy
    Br J Haematol 117:366-72. 2002
    ....
  48. doi request reprint Classical Hodgkin's lymphoma arising in different host's conditions: pathobiology parameters, therapeutic options, and outcome
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Aviano, Italy
    Am J Hematol 86:170-9. 2011
    ..Refractory CHL, a clinical condition that may occur throughout the entire spectrum of CHL, is discussed separately...
  49. doi request reprint IRF4 silencing inhibits Hodgkin lymphoma cell proliferation, survival and CCL5 secretion
    Donatella Aldinucci
    Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, Italy
    Br J Haematol 152:182-90. 2011
    ....
  50. ncbi request reprint Transcriptional profiling of melanoma sentinel nodes identify patients with poor outcome and reveal an association of CD30(+) T lymphocytes with progression
    Viviana Vallacchi
    Authors Affiliations Immunotherapy Unit Department of Pathology Functional Genomics Unit Immunobiology of Human Tumors Unit Department of Medical Statistics and University of Milan, Medical Statistics Biometry and Bioinformatics Unit Department of Surgery, Melanoma and Sarcoma Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan Microscopy and Image Analysis, University of Milan Bicocca, Milan Department of Immunohematology and Transfusion Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Cancer Res 74:130-40. 2014
    ..Our findings reinforce the concept that sentinel nodes act as pivotal sites for determining progression patterns, revealing that the presence of CD30(+) lymphocytes at those sites associate positively with melanoma progression...
  51. doi request reprint Cancers related to viral agents that have a direct role in carcinogenesis: pathological and diagnostic techniques
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico, IRCCS, National Cancer Institute, Aviano, Italy
    J Clin Pathol 65:680-6. 2012
    ..This review also focuses on the new oncological scenario ahead, once strategies against carcinogenic infectious agents are found to be effective...
  52. doi request reprint IGKV3 proteins as candidate "off-the-shelf" vaccines for kappa-light chain-restricted B-cell non-Hodgkin lymphomas
    Debora Martorelli
    Cancer Bio Immunotherapy Unit, IRCCS National Cancer Institute, Aviano, Italy
    Clin Cancer Res 18:4080-91. 2012
    ..An increasing set of B-cell non-Hodgkin lymphomas (B-NHL) show a biased usage of IGKV3-20 and IGKV3-15 immunoglobulin genes, a feature that could be exploited for the development of ready-to-use, broadly applicable cancer vaccines...
  53. ncbi request reprint "Intrafollicular neoplasia" of nodular lymphocyte predominant Hodgkin lymphoma: description of a hypothetic early step of the disease
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, 33081 Aviano, Italy
    Hum Pathol 43:619-28. 2012
    ..An appropriate immunohistochemical characterization for diagnosis should include lymphocyte predominant (BCL6 and CD20) and microenvironmental (CD23, immunoglobulin D, and PD1) cell markers...
  54. doi request reprint CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma
    Viviana Vallacchi
    Unit of Immunotherapy of Human Tumors, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
    Cancer Res 68:715-23. 2008
    ..Together, these data indicate a role for CCN3 in melanoma cell interaction with the ECM by regulating integrin expression, resulting in altered cell adhesion and leading melanoma progression to aggressive disease...
  55. ncbi request reprint Transcription deregulation at the 15q25 locus in association with lung adenocarcinoma risk
    Felicia S Falvella
    Fondazione IRCCS, Istituto Nazionale Tumori, Milan, Italy
    Clin Cancer Res 15:1837-42. 2009
    ....
  56. pmc Relationships between lymphomas linked to hepatitis C virus infection and their microenvironment
    Antonino Carbone
    Antonino Carbone, Department of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano and Pordenone Hospital, 33081 Aviano, Italy
    World J Gastroenterol 19:7874-9. 2013
    ..Importantly, clinically responses were linked to the eradication of the HCV-RNA, providing a strong argument in favor of a causative link between HCV and lymphoproliferation. ..
  57. ncbi request reprint Diagnosis and management of lymphomas and other cancers in HIV-infected patients
    Antonino Carbone
    Department of Pathology, Centro di Riferimento Oncologico Aviano CRO, Istituto Nazionale Tumori, Italy
    Nat Rev Clin Oncol 11:223-38. 2014
    ..We also provide an update of epidemiological data, diagnostic issues, and strategies regarding the most-appropriate management of patients with both HIV and lymphomas. ..
  58. ncbi request reprint Molecular and biochemical analyses of platelet-derived growth factor receptor (PDGFR) B, PDGFRA, and KIT receptors in chordomas
    Elena Tamborini
    Experimental Molecular Pathology, Department of Pathology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy
    Clin Cancer Res 12:6920-8. 2006
    ..This article describes the results of comprehensive molecular/biochemical analyses of the three receptors targeted by the drug (PDGFRB, PDGFRA, and KIT) in a series of 31 chordoma patients...
  59. ncbi request reprint Exocrine and endocrine modulation in common gastric carcinoma
    Vincenzo Canzonieri
    Division of Pathology, CRO National Cancer Institute, IRCCS, Aviano, Italy
    Am J Clin Pathol 137:712-21. 2012
    ..Endocrine differentiation and maturely exocrine/endocrine gastric phenotypes are associated with an unfavorable prognosis and may identify subsets of patients for tailored therapy...
  60. doi request reprint Therapeutic options for HIV-associated lymphomas
    Michele Spina
    Department of Medical Oncology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Italy
    Expert Opin Pharmacother 11:2471-81. 2010
    ..The failure to improve outcomes with treatment intensification indicates the need for the introduction of new therapeutic options...
  61. doi request reprint How I treat: diagnosing and managing "in situ" lymphoma
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Italy
    Blood 117:3954-60. 2011
    ..For patients with concomitant overt lymphoma, staging and treatment procedures must be done according to malignant counterpart...
  62. doi request reprint Spontaneous T cell responses to Epstein-Barr virus-encoded BARF1 protein and derived peptides in patients with nasopharyngeal carcinoma: bases for improved immunotherapy
    Debora Martorelli
    Cancer Bioimmunotherapy Unit, Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Aviano, PN, Italy
    Int J Cancer 123:1100-7. 2008
    ....
  63. pmc Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: case report with molecular analysis
    Marta Barisella
    Anathomic Pathology, Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G Venezian 1, Milano 20133, Italy
    World J Gastroenterol 14:6575-7. 2008
    ..The immunohistochemical and molecular analyses showed that the different morphology of CCA does not reflect a distinct biological entity but only an unusual morphological variant of intestinal carcinoma...
  64. ncbi request reprint Sentinel and nonsentinel node status in stage IB and II melanoma patients: two-step prognostic indicators of survival
    Natale Cascinelli
    Nuclear Medicine Unit, Istituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 24:4464-71. 2006
    ..To evaluate the prognostic significance of sentinel node biopsy in the management of stage IB and II melanoma patients, and to evaluate the status of nonsentinel nodes as a "second step key factor" to assess the prognosis of these patients...
  65. ncbi request reprint Metamorphosis of melanoma. Trends in size and thickness of cutaneous melanoma over one decade at the Istituto Nazionale Tumori, Milan
    Aldo Bono
    Day Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Tumori 94:11-3. 2008
    ..The aim of this study was to examine trends in the presentation of CM over the last decade at our Institution, focusing on two characteristics of the disease: size and thickness...
  66. doi request reprint In situ follicular lymphoma associated with nonlymphoid malignancies
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Leuk Lymphoma 53:603-8. 2012
    ..include: (1) how to approach these patients who have a risk of progression to overt lymphoma; (2) is the association of in situ FL with concurrent nonlymphoid neoplasia incidental, related to immunosuppression or to previous treatment?..
  67. doi request reprint In situ follicular lymphoma: pathologic characteristics and diagnostic features
    Antonino Carbone
    Division of Pathology, Centro di Riferimento Oncologico Aviano, Istituto Nazionale Tumori, IRCCS, Aviano, Italy
    Hematol Oncol 30:1-7. 2012
    ..Other open questions remain on the frequency with which in situ FLs occur and the frequency of concomitant systemic disease...
  68. ncbi request reprint True identity by immunohistochemistry and molecular morphology of undifferentiated malignancies of the head and neck
    Antonino Carbone
    Department of Pathology, Fondazione IRCCS Istituto Nazionale Tumori, Milano, Italy
    Head Neck 31:949-61. 2009
    ....
  69. ncbi request reprint Is diversified clinical presentation of Kaposi sarcoma-associated herpesvirus/human herpesvirus-8-associated lymphoma related to the host's changed conditions?
    Antonino Carbone
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Clin Lymphoma Myeloma 6:153-5. 2005
  70. pmc Simian virus 40 sequences in human lymphoblastoid B-cell lines
    Riccardo Dolcetti
    Divisions of Experimental Oncology, Centro di Riferimento Oncologico, IRCCS, 33081 Aviano Pordenone, Italy
    J Virol 77:1595-7. 2003
    ..These results suggest that SV40 may play a role in the early phases of human lymphomagenesis...
  71. ncbi request reprint Comparison of ultrasonography, hysteroscopy, and biopsy in the diagnosis of endometrial lesions in postmenopausal tamoxifen-treated patients
    Giorgio Giorda
    Division of Gynecologic Oncology, Centro di Riferimento Oncologico, Istituto Nazionale Tumori, Aviano, Italy
    Acta Obstet Gynecol Scand 81:975-80. 2002
    ..At present, no proven recommendations can be made for the surveillance of tamoxifen-treated women. The aim of the present study was to evaluate ultrasonography and hysteroscopy in this setting...
  72. ncbi request reprint Molecular and cytogenetic subgroups of oropharyngeal squamous cell carcinoma
    Federica Perrone
    Unit of Experimental Molecular Pathology, Department of Pathology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Italy
    Clin Cancer Res 12:6643-51. 2006
    ....
  73. ncbi request reprint Salivary gland B cell lymphoproliferative disorders in Sjögren's syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non-Hodgkins's lymphomas
    Valli De Re
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCS, Aviano, Italy
    Eur J Immunol 32:903-10. 2002
    ....
  74. ncbi request reprint CXCL12, CXCR4 and CXCR7 expression in brain metastases
    Andrea Salmaggi
    Department of Neurology, Fondazione IRCCS Istituto Neurologico C Besta, Via Celoria 11, Milan, Italy
    Cancer Biol Ther 8:1608-14. 2009
    ..04 log-rank), perhaps identifying more aggressive tumors. Thus, this is the first study evaluating at the same time the expression of CXCL12 and its two receptors in a cohort of brain metastases...
  75. ncbi request reprint Antitumor activity of human CD34+ cells expressing membrane-bound tumor necrosis factor-related apoptosis-inducing ligand
    Carmelo Carlo-Stella
    Cristina Gandini Medical Oncology Unit, Istituto Nazionale Tumori, 20133 Milan, Italy
    Hum Gene Ther 17:1225-40. 2006
    ....
  76. pmc Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells
    Donatella Aldinucci
    Clinical and Experimental Hematology Research Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale 12, Aviano I 33081, Italy
    Am J Pathol 160:585-96. 2002
    ..This data suggests an involvement of IL-3/IL-3R interactions in the cellular growth of HD through paracrine mechanisms...
  77. ncbi request reprint Nutrient intake and ovarian cancer: an Italian case-control study
    Ettore Bidoli
    Epidemiology Unit, Centro di Riferimento Oncologico, Aviano, Italy
    Cancer Causes Control 13:255-61. 2002
    ..The role of selected macronutrients, cholesterol, and fatty acids in the etiology of epithelial ovarian cancer was analyzed using data from a case-control study carried out in five Italian areas between January 1992 and December 1999...
  78. ncbi request reprint Interobserver agreement of the dermoscopic diagnosis of 129 small melanocytic skin lesions
    Maria Antonietta Pizzichetta
    Division of Medical Oncology C and Oncology Prevention, Centro di Riferimento Oncologico, Via Pedemontana Occidentale 12, 33081 Aviano, PN, Italy
    Tumori 88:234-8. 2002
    ..The aim of the study was to investigate the interobserver agreement of standard dermoscopic criteria between two observers and the diagnostic validity of dermoscopic diagnosis by pattern analysis and by the ABCD rule...
  79. doi request reprint Influence of morphology on survival for non-Hodgkin lymphoma in Europe and the United States
    Milena Sant
    Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, I 20133, Milan, Italy
    Eur J Cancer 44:579-87. 2008
    ..Interpretation of marked variation in survival with morphology is complicated by classification inconsistencies. The completeness and standardisation of cancer registry morphology data needs to be improved...
  80. ncbi request reprint Infection of HHV-8+ primary effusion lymphoma cells with a recombinant Epstein-Barr virus leads to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression
    Pankaj Trivedi
    Department of Experimental Medicine and Pathology, University of Rome, La Sapienza, Rome, Italy
    Blood 103:313-6. 2004
    ..The data suggest an important role of EBV in the pathogenesis of PEL...
  81. ncbi request reprint Molecular histogenesis of posttransplantation lymphoproliferative disorders
    Daniela Capello
    Hematology Unit, Department of Medical Sciences and Interdisciplinary Research Center on Autoimmune Diseases, Amedeo Avogadro University of Eastern Piedmont, Via Solaroli 17, 28100 Novara, Italy
    Blood 102:3775-85. 2003
    ..Overall, the histogenetic diversity of monoclonal B-cell PTLDs may help define biologically homogeneous categories of the disease...
  82. ncbi request reprint Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts
    Ulf Klein
    Institute for Cancer Genetics, Columbia University, New York, NY, USA
    Blood 101:4115-21. 2003
    ..Finally, our results identify a set of genes specifically expressed in PEL tumor cells. Their expression was validated at the protein level, suggesting their potential pathogenetic and clinical significance...
  83. ncbi request reprint Emerging pathways in the development of AIDS-related lymphomas
    Antonino Carbone
    Centro di Riferimento Oncologico IRCCS, Aviano, Italy
    Lancet Oncol 4:22-9. 2003
    ..New molecular and virological evidence of such pathways and a greater knowledge of other biological features of AIDS-related NHLs may lead to new targets for pathogenetically and biologically oriented therapies...
  84. ncbi request reprint Characterization of Epstein-Barr virus genotype in AIDS-related non-Hodgkin's lymphoma
    Lucia Fassone
    Division of Internal Medicine, Department of Medical Sciences, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    AIDS Res Hum Retroviruses 18:19-26. 2002
    ..In conclusion, we found that the distribution of the EBV genotype in all of the AIDS-NHL samples analyzed is similar to the viral representation found in control individuals of both immunocompetent and immunocompromised populations...
  85. ncbi request reprint Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma
    Manel Esteller
    Division of Cancer Biology, The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA
    J Natl Cancer Inst 94:26-32. 2002
    ..MGMT promoter hypermethylation is a favorable prognostic marker in patients with brain tumors treated with alkylating agents...
  86. ncbi request reprint Molecular histogenesis of plasmablastic lymphoma of the oral cavity
    Gianluca Gaidano
    Hematology Unit, Division of Internal Medicine, Department of Medical Sciences, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 119:622-8. 2002
    ..Conversely, another fraction of these lymphomas were devoid of somatic IgVH mutations and appeared to originate from naive B cells that have undergone preterminal differentiation independent of GC transit...
  87. ncbi request reprint Lack of HCV infection in malignant cells refutes the hypothesis of a direct transforming action of the virus in the pathogenesis of HCV-associated B-cell NHLs
    Salvatore De Vita
    Division of Rheumatology, DPMSC, University of Udine, Italy
    Tumori 88:400-6. 2002
    ..A direct oncogenetic role of HCV by direct cell infection and deregulation has only been hypothesized on the basis of the lymphotropism of the virus...
  88. ncbi request reprint Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis
    Stefano Lazzi
    Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
    Hum Pathol 33:723-31. 2002
    ..In conclusion, our results seem to suggest that pRb2/p130 oncosuppressor protein may be a target in the interaction between the HIV-1 gene products and host proteins...
  89. ncbi request reprint p16INK4a loss and sensitivity in KSHV associated primary effusion lymphoma
    Georgina Platt
    Centre for Molecular and Cell Biology, The Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, UK
    Oncogene 21:1823-31. 2002
    ..They furthermore argue that despite the presence of KSHV DNA and expression of a latent gene program Rb function is intact in PEL...
  90. ncbi request reprint Differentiation between non-Hodgkin's lymphoma recurrence and second primary lymphoma by VDJ rearrangement analysis
    Massimo Libra
    Division of Experimental Oncology 1, Centro di Riferimento Oncologico Aviano, Italy
    Br J Haematol 118:809-12. 2002
    ..In contrast, primary and secondary tumours in two patients were of different clonal origin. Our data indicate that VDJ analysis is a fundamental tool for identification of relapses in NHL...
  91. ncbi request reprint Frequent aberrant promoter hypermethylation of O6-methylguanine-DNA methyltransferase and death-associated protein kinase genes in immunodeficiency-related lymphomas
    Davide Rossi
    Department of Medical Sciences and IRCAD, Haematology Unit, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Br J Haematol 123:475-8. 2003
    ..In particular, promoter hypermethylation of DAP-K represents the most frequent molecular alteration yet identified in immunodeficiency-related lymphomas...
  92. ncbi request reprint Aberrant somatic hypermutation in multiple subtypes of AIDS-associated non-Hodgkin lymphoma
    Gianluca Gaidano
    Institute for Cancer Genetics, Columbia University, Russ Berrie Science Pavilion, 1150 St Nicholas Ave, Rm 303B, New York, NY 10032, USA
    Blood 102:1833-41. 2003
    ..These data indicate that aberrant hypermutation is associated with various subtypes of AIDS-NHL and may represent a major contributor to their pathogenesis...
  93. ncbi request reprint Prognostic factors in human herpesvirus 8-related lymphoproliferative disorders associated with HIV infection
    Cecilia Simonelli
    J Clin Oncol 24:209; author reply 209-10. 2006
  94. ncbi request reprint AIDS-related non-Hodgkin lymphoma: final analysis of 485 patients treated with risk-adapted intensive chemotherapy
    Nicolas Mounier
    Institut Universitaire d Hématologie GELA, INSERM U728 Hôpital Saint Louis AP HP 1, avenue Claude Vellefaux, 75010 Paris, France
    Blood 107:3832-40. 2006
    ..5, P < .001) but not chemotherapy regimen. Our findings indicate that in ARL patients, HIV score, IPI score, and HAART affect survival but not the intensity of the CHOP-based chemotherapy...
  95. ncbi request reprint Aberrant somatic hypermutation in tumor cells of nodular-lymphocyte-predominant and classic Hodgkin lymphoma
    Arcangelo Liso
    Institute of Hematology, University of Perugia, Policlinico, Monteluce, 06122 Perugia, Italy
    Blood 108:1013-20. 2006
    ..Our finding that NLPHL and cHL are targeted by aberrant SHM, as is DLBCL, suggests that these lymphomas may share common molecular pathogenetic events...
  96. ncbi request reprint Is plasmablastic lymphoma of the oral cavity an HHV-8-associated disease?
    Antonino Carbone
    Am J Surg Pathol 28:1538-40; author reply 1540. 2004
  97. ncbi request reprint Is plasmablastic lymphoma of the oral cavity an HHV-8-associated disease?
    Antonino Carbone
    Am J Surg Pathol 28:1251-2. 2004
  98. ncbi request reprint Distinct cellular origins of primary effusion lymphoma with and without EBV infection
    Rifat Hamoudi
    Department of Histopathology, Royal Free and University College Medical School, University College London, Rockefeller Building, University Street, London WC1E 6JJ, UK
    Leuk Res 28:333-8. 2004
    ..Our results indicate that EBV positive PELs are derived from germinal centre or post-germinal centre B-cells, whereas EBV negative PELs may originate from either germinal/post-germinal centre or naïve B-cells...
  99. ncbi request reprint CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
    Semra Aydin
    Department of Genetics, Biology, and Biochemistry, University of Torino Medical School, Turin, Italy
    Blood 111:5646-53. 2008
    ..Multivariate analysis on a total of 30 RS patients confirmed that the probability of transformation is strongly associated with G allele, likely representing an independent risk factor for RS development...
  100. ncbi request reprint Prognostic value of extracapsular tumor spread for locoregional control in premenopausal patients with node-positive breast cancer treated with classical cyclophosphamide, methotrexate, and fluorouracil: long-term observations from International Breast Ca
    Günther Gruber
    Department of Radiation Oncology, and the Institute of Medical Oncology, Inselspital, Switzerland
    J Clin Oncol 23:7089-97. 2005
    ..We sought to determine retrospectively whether extracapsular spread (ECS) might identify a subgroup that could benefit from radiotherapy after mastectomy, especially patients with 1 to 3 positive lymph nodes (LN1-3+)...
  101. ncbi request reprint Analysis of immunoglobulin heavy and light chain variable genes in post-transplant lymphoproliferative disorders
    Daniela Capello
    Department of Clinical and Experimental Medicine and IRCAD, Division of Hematology, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Hematol Oncol 24:212-9. 2006
    ..The high frequency of IGV loci inactivation appears to be a peculiar feature of PTLD among immunodeficiency-associated lymphoproliferations...