Gemma Calamandrei

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. ncbi request reprint Effects of prenatal AZT on mouse neurobehavioral development and passive avoidance learning
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicol Teratol 21:29-40. 1999
  2. ncbi request reprint Effects of prenatal zidovudine treatment on learning and memory capacities of preweanling and young adult mice
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Roma, Italy
    Neurotoxicology 20:17-25. 1999
  3. ncbi request reprint Neurobehavioral effects of prenatal lamivudine (3TC) exposure in preweaning mice
    G Calamandrei
    Comparative Psychology Section, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicol Teratol 21:365-73. 1999
  4. ncbi request reprint Prenatal exposure to anti-HIV drugs. long-term neurobehavioral effects of lamivudine (3TC) in CD-1 mice
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Neurotoxicol Teratol 22:369-79. 2000
  5. ncbi request reprint Effects of prenatal AZT+3TC treatment on open field behavior and responsiveness to scopolamine in adult mice
    G Calamandrei
    Section of Comparative Psychology, Laboratory of Pathophysiology O S, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Pharmacol Biochem Behav 67:511-7. 2000
  6. ncbi request reprint Ethological and methodological considerations in the use of newborn rodents in biomedical research
    Gemma Calamandrei
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 40:195-200. 2004
  7. ncbi request reprint Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats
    Laura Ricceri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Res 183:111-7. 2007
  8. doi request reprint Does age matter? Behavioral and neuro-anatomical effects of neonatal and adult basal forebrain cholinergic lesions
    Paola De Bartolo
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 20:207-27. 2010
  9. ncbi request reprint Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats
    Maria L Scattoni
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Pharmacol 17:517-24. 2006
  10. ncbi request reprint Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease
    Maria Luisa Scattoni
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 176:216-21. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Effects of prenatal AZT on mouse neurobehavioral development and passive avoidance learning
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicol Teratol 21:29-40. 1999
    ..Moreover, sexual differences in some items of the social behavior repertoire appeared to be affected by AZT treatment...
  2. ncbi request reprint Effects of prenatal zidovudine treatment on learning and memory capacities of preweanling and young adult mice
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Roma, Italy
    Neurotoxicology 20:17-25. 1999
    ..Retention of the passive avoidance response was mildly impaired in the offspring exposed to the 0.8 mg/ml AZT solution, whereas spatial learning on PND 45 was unaffected...
  3. ncbi request reprint Neurobehavioral effects of prenatal lamivudine (3TC) exposure in preweaning mice
    G Calamandrei
    Comparative Psychology Section, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicol Teratol 21:365-73. 1999
    ....
  4. ncbi request reprint Prenatal exposure to anti-HIV drugs. long-term neurobehavioral effects of lamivudine (3TC) in CD-1 mice
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Neurotoxicol Teratol 22:369-79. 2000
    ..No significant changes in either pain sensitivity, social/affiliative, or maternal behavior were found, although a higher occurrence of aggressive behavior toward foster pups was noted in both 125- and 500-mg/kg 3TC females...
  5. ncbi request reprint Effects of prenatal AZT+3TC treatment on open field behavior and responsiveness to scopolamine in adult mice
    G Calamandrei
    Section of Comparative Psychology, Laboratory of Pathophysiology O S, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Pharmacol Biochem Behav 67:511-7. 2000
    ..However, this would need confirmatory experiments...
  6. ncbi request reprint Ethological and methodological considerations in the use of newborn rodents in biomedical research
    Gemma Calamandrei
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 40:195-200. 2004
    ..To this end, the present work provides some ethological and methodological considerations in the maintenance, handling, and testing of newborn rats and mice in biomedical research...
  7. ncbi request reprint Neonatal basal forebrain cholinergic hypofunction affects ultrasonic vocalizations and fear conditioning responses in preweaning rats
    Laura Ricceri
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Res 183:111-7. 2007
    ..These results suggest that early selective removal of the cholinergic basal forebrain paradoxically enhances hippocampally dependent fear-conditioned responses on pnd 19...
  8. doi request reprint Does age matter? Behavioral and neuro-anatomical effects of neonatal and adult basal forebrain cholinergic lesions
    Paola De Bartolo
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 20:207-27. 2010
    ....
  9. ncbi request reprint Long-term effects of neonatal basal forebrain cholinergic lesions on radial maze learning and impulsivity in rats
    Maria L Scattoni
    Section of Behavioural Neuroscience, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Pharmacol 17:517-24. 2006
    ..This animal model may thus be useful to investigate some cognitive deficits and other secondary symptoms seen in Alzheimer's disease...
  10. ncbi request reprint Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease
    Maria Luisa Scattoni
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 176:216-21. 2007
    ..These findings extend to the behavioural parameters the protective effects of SCH 58261 in the QA model of Huntington's disease...
  11. doi request reprint Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthood
    Aldina Venerosi
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
    Neurotoxicol Teratol 30:468-74. 2008
    ....
  12. ncbi request reprint Acute global anoxia during C-section birth affects dopamine-mediated behavioural responses and reactivity to stress
    Aldina Venerosi
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, Roma I 00161, Italy
    Behav Brain Res 154:155-64. 2004
    ..Altogether, the present findings suggest that the present 20 min perinatal asphyxia model might serve for the study of neurodevelopmental disorders associated with perinatal insults...
  13. doi request reprint Early behavioural markers of disease in P301S tau transgenic mice
    Maria Luisa Scattoni
    Neurotoxicology and Neuroendocrinology Section, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Res 208:250-7. 2010
    ..Behavioural abnormalities can be detected well before occurrence of neurodegeneration in this transgenic strain, thus representing precocious markers of pathology...
  14. ncbi request reprint Basal forebrain cholinergic lesions in 7-day-old rats alter ultrasound vocalisations and homing behaviour
    Maria Luisa Scattoni
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 161:169-72. 2005
    ..These data suggest that early damage to the basal forebrain cholinergic nuclei induces significant changes in the rat behavioural repertoire as early as the second-postnatal week...
  15. doi request reprint Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice
    Aldina Venerosi
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, V le Regina Elena 299, Rome, Italy
    Psychopharmacology (Berl) 208:99-107. 2010
    ..Studies from animal models indicate that CPF exposure during development at low doses can target different neurotransmitter systems in the absence of overt cholinergic effects...
  16. ncbi request reprint Cognitive and neurological deficits induced by early and prolonged basal forebrain cholinergic hypofunction in rats
    Laura Ricceri
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Exp Neurol 189:162-72. 2004
    ....
  17. ncbi request reprint Altered expression of cyclooxygenase-2, presenilins and oxygen radical scavenging enzymes in a rat model of global perinatal asphyxia
    Paola Piscopo
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Roma, Italy
    Exp Neurol 209:192-8. 2008
    ....
  18. ncbi request reprint A social recognition test for female mice reveals behavioral effects of developmental chlorpyrifos exposure
    Aldina Venerosi
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, V le Regina Elena 299 I 00161 Rome, Italy
    Neurotoxicol Teratol 28:466-71. 2006
    ....
  19. ncbi request reprint Neurobehavioral effects of prenatal exposure to AZT: a preliminary investigation with the D1 receptor agonist SKF 38393 in mice
    Aldina Venerosi
    Section of Behavioral Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Neurotoxicol Teratol 27:169-73. 2005
    ..These data suggest that the D1 receptorial dopaminergic subsystem might be hyporesponsive in mice prenatally exposed to AZT...
  20. ncbi request reprint Developmental exposure to chlorpyrifos alters reactivity to environmental and social cues in adolescent mice
    Laura Ricceri
    Laboratorio di Fisiopatologia, Istituto Superiore di Sanita, Rome, Italy
    Toxicol Appl Pharmacol 191:189-201. 2003
    ....
  21. ncbi request reprint C-section birth per se or followed by acute global asphyxia altered emotional behaviour in neonate and adult rats
    Aldina Venerosi
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 168:56-63. 2006
    ..In conclusion, differential effects appear to be brought about by c-section and by hypoxia mainly related to emotional/anxious responses...
  22. pmc Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups
    Aldina Venerosi
    Section of Neurotoxicology and Neuroendocrinology Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Roma, Italy
    Environ Health 8:12. 2009
    ..So far, few data are available on the potential short- and long-term adverse effects in children deriving from low-level exposures during prenatal life and infancy...
  23. ncbi request reprint Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice
    Laura Ricceri
    Section of Behavioral Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Toxicol Sci 93:105-13. 2006
    ..These findings support the hypothesis that developmental CPF may represent a risk factor for increased vulnerability to neurodevelopmental disorders in humans...
  24. doi request reprint Early social enrichment affects responsiveness to different social cues in female mice
    Giulia Gracceva
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Behav Brain Res 196:304-9. 2009
    ..As a whole these data suggest that CN rearing render female mice less reactive to social novelty...
  25. pmc Transplacental exposure to AZT induces adverse neurochemical and behavioral effects in a mouse model: protection by L-acetylcarnitine
    Anna Rita Zuena
    Department of Physiology and Pharmacology Vittorio Erspamer, I Faculty of Medicine, Sapienza University of Rome, Rome, Italy
    PLoS ONE 8:e55753. 2013
    ....
  26. ncbi request reprint Developmental exposure to the antiretroviral drug zidovudine increases brain levels of brain-derived neurotrophic factor in mice
    Gemma Calamandrei
    Section of Comparative Psychology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Roma, Italy
    Neurosci Lett 333:111-4. 2002
    ..These findings support the hypothesis that developmental AZT exposure interferes with CNS development...
  27. ncbi request reprint Opposite effects of the A2A receptor agonist CGS21680 in the striatum of Huntington's disease versus wild-type mice
    Alberto Martire
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Neurosci Lett 417:78-83. 2007
    ..At the same age, the behavioural effects elicited by CGS21680 were qualitatively identical in WT and HD mice. These findings may have very important implications for the neuroprotective potential of A(2A)R ligands in HD...
  28. pmc Long-term effects on hypothalamic neuropeptides after developmental exposure to chlorpyrifos in mice
    Sabrina Tait
    Section of Food and Veterinary Toxicology, Department of Food Safety and Veterinary Public Health, Rome, Italy
    Environ Health Perspect 117:112-6. 2009
    ..Developmental exposure to CPF in rodents induces sex-dimorphic behavioral changes at adulthood, including social and agonistic responses, which suggests that CPF may interfere with maturation of neuroendocrine mechanisms...
  29. pmc Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study
    Aldina Venerosi
    Department Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Environ Health 14:32. 2015
    ..Our aim was to determine if developmental exposure to CPF affects social responsiveness and associated molecular neuroendocrine markers at adulthood...
  30. doi request reprint Complex behavioral and synaptic effects of dietary branched chain amino acids in a mouse model of amyotrophic lateral sclerosis
    Aldina Venerosi
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    Mol Nutr Food Res 55:541-52. 2011
    ..We hypothesized that chronic supplementation with branched chain amino acids (BCAAs) affects neurobehavioral development in vulnerable gene backgrounds...
  31. doi request reprint Developmental exposure to chlorpyrifos induces alterations in thyroid and thyroid hormone levels without other toxicity signs in CD-1 mice
    Simona De Angelis
    Department of Cellular Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    Toxicol Sci 108:311-9. 2009
    ..Thyroid may be a sensitive target to CPF developmental exposure possibly leading to long-term effects on thyroid function. Because thyroid plays a pivotal role in mammalian development, these findings can be relevant to humans...
  32. ncbi request reprint Increased brain levels of F2-isoprostane are an early marker of behavioral sequels in a rat model of global perinatal asphyxia
    Gemma Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Pediatr Res 55:85-92. 2004
    ..The present 20-min asphyxia model might serve for the assessment of preventive and curative strategies to treat neurologic/behavioral disturbances associated with perinatal asphyxia...
  33. doi request reprint Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1
    Gabriele De Luca
    Department of Environment and Primary Prevention, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Aging Cell 12:695-705. 2013
    ..Longevity conferred by overexpression of a single nucleotide hydrolase in hMTH1-Tg animals is an example of lifespan extension associated with healthy aging. It provides a link between aging and oxidative damage to nucleic acids. ..
  34. doi request reprint The application of Russell and Burch 3R principle in rodent models of neurodegenerative disease: the case of Parkinson's disease
    Arianna Manciocco
    Section of Behavioral Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome I 00161, Italy
    Neurosci Biobehav Rev 33:18-32. 2009
    ..The formal inclusion in scientific papers of a section devoted to 3Rs may increase knowledge and eventually adherence to this principle by scientists...
  35. ncbi request reprint Progressive behavioural changes in the spatial open-field in the quinolinic acid rat model of Huntington's disease
    Maria Luisa Scattoni
    Comparative Psychology Section, Laboratory of Pathophysiology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 152:375-83. 2004
    ..The main implication of these findings is that, besides genetic mice models of HD, QA-lesioned rats may represent a suitable mean to test the ability of new drugs to slow down disease progression...
  36. doi request reprint Foetal and neonatal exposure to chlorpyrifos: biochemical and metabolic alterations in the mouse liver at different developmental stages
    Franca Maria Buratti
    Environment and Primary Prevention Department, Mechanisms of Toxicity Unit, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Toxicology 280:98-108. 2011
    ..The hypothesis that observed effects on aromatase and sex-specific Cyp activity may be associated with a possible interference with the long-term alterations in sex-specific behavioural pattern deserves further investigation...
  37. doi request reprint Sex-dimorphic effects of gestational exposure to the organophosphate insecticide chlorpyrifos on social investigation in mice
    Alessia De Felice
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Piazzale Aldo Moro 5, I 00161 Rome, Italy Electronic address
    Neurotoxicol Teratol 46:32-9. 2014
    ..These findings are discussed within the framework of recent data pointing to the limbic/hypothalamic circuitry and steroid hormonal regulations as possible targets for CPF neurotoxicity...
  38. ncbi request reprint NGF induces appearance of adult-like response to spatial novelty in 18-day male mice
    Gemma Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Behav Brain Res 136:289-98. 2002
    ..The behavioral and neurochemical effects disappeared by pnd 28. NGF triggers adult-like responding to spatial novelty in developing mice and such effect is gender-specific...
  39. ncbi request reprint Long-term effects of developmental exposure to zidovudine on exploratory behavior and novelty discrimination in CD-1 mice
    Gemma Calamandrei
    Laboratory of Pathophysiology, Section of Comparative Psychology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Neurotoxicol Teratol 24:529-40. 2002
    ..Both AZT and control mice failed to respond to object rearrangement at adulthood, a discrepancy from previous data, which is discussed in relation to perinatal stress effects...
  40. pmc Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism
    Alessia De Felice
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    J Neuroinflammation 13:149. 2016
    ..In the present study, we aimed at investigating whether the behavioral effects of gestational CPF administration are associated with brain increased oxidative stress and altered lipid mediator profile...
  41. pmc Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism
    Alessia De Felice
    Section of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, Rome, Italy
    PLoS ONE 10:e0121663. 2015
    ..These findings strengthen the need of future studies to evaluate the role of environmental chemicals in the etiology of neurodevelopment disorders...
  42. ncbi request reprint Efficient testing strategies for evaluation of xenobiotics with neuroendocrine activity
    Gemma Calamandrei
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 0016 Roma, Italy
    Reprod Toxicol 22:164-74. 2006
    ....
  43. ncbi request reprint Animal models of anti-HIV drugs exposure during pregnancy: effects on neurobehavioral development
    Aldina Venerosi
    Section of Behavioral Pathophysiology, Laboratorio di Fisiopatologia O S, Istituto Superiore di Sanita, Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 26:747-61. 2002
    ....
  44. doi request reprint Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases-an Overview of Experimental Studies
    Anna Maria Tartaglione
    Unit of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Curr Top Behav Neurosci 29:231-64. 2016
    ....
  45. doi request reprint Aberrant self-grooming as early marker of motor dysfunction in a rat model of Huntington's disease
    Anna Maria Tartaglione
    Unit of Neurotoxicology and Neuroendocrinology, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
    Behav Brain Res 313:53-7. 2016
    ....
  46. pmc Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies
    Sandra Coecke
    ECVAM European Centre for the Validation of Alternative Methods, Institute for Health and Consumer Protection, European Commission, Joint Research Center, Ispra, Italy
    Environ Health Perspect 115:924-31. 2007
    ..This report summarizes these discussions and details the recommendations and priorities for future work...
  47. doi request reprint B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    Andrea Fuso
    Department of Surgery P Valdoni, Sapienza University of Rome, Italy
    Mol Cell Neurosci 37:731-46. 2008
    ..Collectively, these findings are consistent with the hypothesis that abnormal methylation in association with hyperhomocysteinemia may contribute to Alzheimer's disease...