Silvio Caccia

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. doi Pharmacokinetics and metabolism update for some recent antipsychotics
    Silvio Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan 20156, Italy
    Expert Opin Drug Metab Toxicol 7:829-46. 2011
  2. doi Safety and pharmacokinetics of atypical antipsychotics in children and adolescents
    Silvio Caccia
    Istituto di Ricerche Farmacologiche IRCCS Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Paediatr Drugs 15:217-33. 2013
  3. doi Antipsychotic drug toxicology in children
    Silvio Caccia
    Mario Negri Institute for Pharmacological Research, Department of Molecular Biochemistry and Pharmacology, Milan, Italy
    Expert Opin Drug Metab Toxicol 7:591-608. 2011
  4. pmc New atypical antipsychotics for schizophrenia: iloperidone
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, 20156, Milan, Italy
    Drug Des Devel Ther 4:33-48. 2010
  5. ncbi St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects
    Silvio Caccia
    Laboratory of Drug Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Curr Drug Metab 10:1055-65. 2009
  6. doi Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin
    Sara Guzzetti
    Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, Laboratory of Experimental Psychopharmacology, Via La Masa 19, 20156 Milan, Italy
    Eur J Pharmacol 594:117-24. 2008
  7. doi Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice
    Eleonora Calcagno
    Laboratory of Neurochemistry and Behaviour, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    Int J Neuropsychopharmacol 12:793-803. 2009
  8. ncbi Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin
    Luigi Cervo
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Eur Neuropsychopharmacol 15:211-8. 2005
  9. ncbi Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse
    Milena Colovic
    Department of Neuroscience, Drug Metabolism Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Drug Metab Lett 2:90-4. 2008
  10. ncbi Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
    Luigi Cervo
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Neurosci 25:8165-72. 2005

Collaborators

Detail Information

Publications26

  1. doi Pharmacokinetics and metabolism update for some recent antipsychotics
    Silvio Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan 20156, Italy
    Expert Opin Drug Metab Toxicol 7:829-46. 2011
    ..These agents, which include aripiprazole, lurasidone and perospirone, act by targeting both Dâ‚‚ and 5-HT(1A) receptors, in addition to other characteristic receptors...
  2. doi Safety and pharmacokinetics of atypical antipsychotics in children and adolescents
    Silvio Caccia
    Istituto di Ricerche Farmacologiche IRCCS Mario Negri, Via Giuseppe La Masa 19, 20156 Milan, Italy
    Paediatr Drugs 15:217-33. 2013
    ....
  3. doi Antipsychotic drug toxicology in children
    Silvio Caccia
    Mario Negri Institute for Pharmacological Research, Department of Molecular Biochemistry and Pharmacology, Milan, Italy
    Expert Opin Drug Metab Toxicol 7:591-608. 2011
    ....
  4. pmc New atypical antipsychotics for schizophrenia: iloperidone
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, 20156, Milan, Italy
    Drug Des Devel Ther 4:33-48. 2010
    ..Further comparative studies are needed to clarify the benefit/risk profile of iloperidone and its role in the treatment of schizophrenia...
  5. ncbi St. John's wort components and the brain: uptake, concentrations reached and the mechanisms underlying pharmacological effects
    Silvio Caccia
    Laboratory of Drug Metabolism, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Curr Drug Metab 10:1055-65. 2009
    ..Additional pharmacokinetic data on the brain concentrations of these and other constituents and their metabolites are therefore required for a more meaningful interpretation of the central effects of St. John's Wort extracts...
  6. doi Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: role of serotonin
    Sara Guzzetti
    Istituto di Ricerche Farmacologiche Mario Negri, Department of Neuroscience, Laboratory of Experimental Psychopharmacology, Via La Masa 19, 20156 Milan, Italy
    Eur J Pharmacol 594:117-24. 2008
    ..These results support the importance of 5-HT synthesis in the response to SSRIs and suggest that melatonin does not contribute to the ability of tryptophan to rescue the antidepressant-like effect of paroxetine...
  7. doi Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice
    Eleonora Calcagno
    Laboratory of Neurochemistry and Behaviour, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    Int J Neuropsychopharmacol 12:793-803. 2009
    ....
  8. ncbi Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin
    Luigi Cervo
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Eur Neuropsychopharmacol 15:211-8. 2005
    ..Ex-vivo binding studies showed that brain sigma1 receptors are occupied after in vivo treatment with IDN 5491, possibly by an unknown metabolite or by endogenous ligand induced by hyperforin...
  9. ncbi Brain-to-plasma distribution ratio of the biflavone amentoflavone in the mouse
    Milena Colovic
    Department of Neuroscience, Drug Metabolism Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, Milan, Italy
    Drug Metab Lett 2:90-4. 2008
    ..02. These concentrations were possibly related to the compound's contribution from residual blood, but in any case are too low to support any interaction with central mechanisms so far tested...
  10. ncbi Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
    Luigi Cervo
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Neurosci 25:8165-72. 2005
    ..Interstrain comparisons could probably be a useful strategy for understanding the mechanisms underlying the response to selective serotonin reuptake inhibitors...
  11. ncbi Role of hyperforin in the antidepressant-like activity of Hypericum perforatum extracts
    Luigi Cervo
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Psychopharmacology (Berl) 164:423-8. 2002
    ..Hyperforin has been identified as an active constituent of Hypericum perforatum but its importance in the antidepressant effect of this plant's extracts is not really known...
  12. ncbi Hyperforin contributes to the hepatic CYP3A-inducing effect of Hypericum perforatum extract in the mouse
    Lavinia Cantoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Toxicol Sci 75:25-30. 2003
    ..Standardization of the extracts based on the hyperforin content can be proposed for further evaluation of their potential action on first-pass metabolism and clearance of coadministered CYP3A substrates...
  13. ncbi Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease
    Massimo Tortarolo
    Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Neurosci Res 83:134-46. 2006
    ..In support of this, we showed that treatment with a new noncompetitive AMPA antagonist, ZK 187638, partially protected motor neurons, improved motor function, and prolonged the survival of SOD1(G93A) mice...
  14. doi Liquid chromatography-tandem mass spectrometry of I3,II8-biapigenin, the major biflavone in Hypericum perforatum extracts
    Milena Colovic
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 863:74-9. 2008
    ..Biapigenin concentrations were measurable in mice after intraperitoneal biapigenin (10mgkg(-1)) but these amounted to about 2% of the equivalent systemic exposure, after correction for the contribution from residual blood...
  15. ncbi Selective antagonist at D3 receptors, but not non-selective partial agonists, influences the expression of cocaine-induced conditioned place preference in free-feeding rats
    Luigi Cervo
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharmacol Biochem Behav 82:727-34. 2005
    ..p.) antagonized the expression of cocaine-induced CPP, supporting the suggestion that "full" antagonist activity at D(3) receptors is necessary to prevent 10 mg/kg cocaine-induced place conditioning in free-feeding rats...
  16. doi How pre-marketing data can be used for predicting the weight of drug interactions in clinical practice
    Silvio Caccia
    Laboratory for Quality Assessment of Geriatric Therapies Services, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Eur J Intern Med 24:217-21. 2013
    ....
  17. ncbi Predicting the clinical relevance of drug interactions from pre-approval studies
    Silvio Caccia
    Laboratory of Drug Metabolism, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Drug Saf 32:1017-39. 2009
    ....
  18. ncbi Liquid chromatographic assay for riluzole in mouse plasma and central nervous system tissues
    Milena Colovic
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 803:305-9. 2004
    ....
  19. pmc Critical appraisal of lurasidone in the management of schizophrenia
    Silvio Caccia
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Neuropsychiatr Dis Treat 8:155-68. 2012
    ..Ongoing trials in patients with bipolar disorder are being completed but, again, efficacy and safety have been investigated only in a few short-term clinical trials...
  20. doi The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan 20156, Italy
    J Neurochem 110:1445-56. 2009
    ....
  21. ncbi A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine
    Nicola Marchi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsia 46:1613-9. 2005
    ....
  22. ncbi Metabolism of the newest antidepressants: comparisons with related predecessors
    Silvio Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    IDrugs 7:143-50. 2004
    ..Duloxetine is metabolized by CYP2D6 and CYP1A2, with moderate potential for interactions at CYP2D6. The metabolism of gepirone involves CYP3A4 and to a lesser extent CYP2D6...
  23. ncbi Liquid chromatographic determination of minocycline in brain-to-plasma distribution studies in the rat
    Milena Colovic
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 791:337-43. 2003
    ..In the rat minocycline crossed the blood-brain barrier slowly, achieving mean brain concentrations between 30 and 40% of the equivalent systemic exposure, regardless of the dose and route of administration...
  24. ncbi N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines formed
    Silvio Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan, Italy caccia marionegri it
    Curr Drug Metab 8:612-22. 2007
    ....
  25. ncbi New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update
    Silvio Caccia
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Curr Opin Investig Drugs 3:1073-80. 2002
    ..The main metabolites of risperidone, zotepine and possibly perospirone and ziprasidone contribute to the parent drug's effect. Information is limited, however, on some promising antipsychotics in the pipeline...