I Branchi

Summary

Affiliation: Istituto Superiore di Sanit
Country: Italy

Publications

  1. pmc Antidepressant treatment outcome depends on the quality of the living environment: a pre-clinical investigation in mice
    Igor Branchi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 8:e62226. 2013
  2. doi Not all stressors are equal: early social enrichment favors resilience to social but not physical stress in male mice
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Horm Behav 63:503-9. 2013
  3. ncbi Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Neurosci Res 83:965-73. 2006
  4. ncbi Scopolamine effects on ultrasonic vocalization emission and behavior in the neonatal mouse
    Igor Branchi
    Section of Behavioral Pathophysiology, Laboratorio Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
    Behav Brain Res 151:9-16. 2004
  5. ncbi Animal models of mental retardation: from gene to cognitive function
    Igor Branchi
    Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Neurosci Biobehav Rev 27:141-53. 2003
  6. doi Shaping brain development: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Psychoneuroendocrinology 35:743-51. 2010
  7. doi The richness of social stimuli shapes developmental trajectories: Are laboratory mouse pups impoverished?
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 35:1452-60. 2011
  8. doi The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Psychoneuroendocrinology 36:339-51. 2011
  9. doi Birth spacing in the mouse communal nest shapes adult emotional and social behavior
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Physiol Behav 96:532-9. 2009
  10. ncbi Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route
    Igor Branchi
    Istituto Superiore di Sanita, Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Viale Regina Elena 299, 00161 Rome, Italy
    Neurotoxicology 26:183-92. 2005

Collaborators

Detail Information

Publications36

  1. pmc Antidepressant treatment outcome depends on the quality of the living environment: a pre-clinical investigation in mice
    Igor Branchi
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 8:e62226. 2013
    ..These findings may be helpful to explain variable effects of SSRI found in clinical practice and to device strategies aimed at enhancing their efficacy by means of controlling environmental conditions...
  2. doi Not all stressors are equal: early social enrichment favors resilience to social but not physical stress in male mice
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Horm Behav 63:503-9. 2013
    ..In addition, the stressor to which CN mice are resilient is qualitatively similar to the stimuli they have experienced early on, both concerning the social domain...
  3. ncbi Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Neurosci Res 83:965-73. 2006
    ..These findings are discussed in the framework of the neurotrophin hypothesis of depression...
  4. ncbi Scopolamine effects on ultrasonic vocalization emission and behavior in the neonatal mouse
    Igor Branchi
    Section of Behavioral Pathophysiology, Laboratorio Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
    Behav Brain Res 151:9-16. 2004
    ....
  5. ncbi Animal models of mental retardation: from gene to cognitive function
    Igor Branchi
    Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Neurosci Biobehav Rev 27:141-53. 2003
    ..Identifying the role of specific genes in neuropathologies provides a framework in which to understand key stages of human brain development, and provides a target for potential therapeutic intervention...
  6. doi Shaping brain development: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Psychoneuroendocrinology 35:743-51. 2010
    ..The present findings suggest that early experiences represent one of those factors to be taken into account to identify the appropriate individual pharmacological strategy to treat depression in patients...
  7. doi The richness of social stimuli shapes developmental trajectories: Are laboratory mouse pups impoverished?
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 35:1452-60. 2011
    ..Indeed, the more elaborate social competences shown by these mice at adulthood may allow to better characterize deficits in the social domain induced by genetic and/or environmental manipulations...
  8. doi The double edged sword of neural plasticity: increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Psychoneuroendocrinology 36:339-51. 2011
    ....
  9. doi Birth spacing in the mouse communal nest shapes adult emotional and social behavior
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Physiol Behav 96:532-9. 2009
    ..Overall, these findings show that birth spacing shapes the early mouse social environment and, in turn, affects the development of social skills and emotional responses...
  10. ncbi Early developmental exposure to BDE 99 or Aroclor 1254 affects neurobehavioural profile: interference from the administration route
    Igor Branchi
    Istituto Superiore di Sanita, Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Viale Regina Elena 299, 00161 Rome, Italy
    Neurotoxicology 26:183-92. 2005
    ....
  11. ncbi Early social enrichment shapes social behavior and nerve growth factor and brain-derived neurotrophic factor levels in the adult mouse brain
    Igor Branchi
    Department of Cell Biology and Neuroscience, Section of Behavioural Neurosciences, Istituto Superiore di Sanita, Viale Regian Elena 299, I 00161 Roma, Rome, Italy
    Biol Psychiatry 60:690-6. 2006
    ....
  12. ncbi Communal nesting, an early social enrichment, increases the adult anxiety-like response and shapes the role of social context in modulating the emotional behavior
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 172:299-306. 2006
    ....
  13. doi Nonmotor symptoms in Parkinson's disease: investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Neurosci Res 86:2050-61. 2008
    ..Overall, the PD rat model used here displays behavioral alterations having face validity with psychiatric symptoms of the pathology and thus appears to be a valuable tool for investigating the neural bases of the early phases of PD...
  14. doi The mouse communal nest: investigating the epigenetic influences of the early social environment on brain and behavior development
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Roma, Italy
    Neurosci Biobehav Rev 33:551-9. 2009
    ..Overall, CN appears as an experimental strategy different and complementary to the ones currently used for studying how the early environment determines developmental trajectories...
  15. ncbi Refining learning and memory assessment in laboratory rodents. An ethological perspective
    Igor Branchi
    Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Rome, Italy
    Ann Ist Super Sanita 40:231-6. 2004
    ....
  16. ncbi Epigenetic control of neurobehavioural plasticity: the role of neurotrophins
    I Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, 00161 Rome, Italy
    Behav Pharmacol 15:353-62. 2004
    ..Overall, these findings suggest a role of neurotrophins as factors mediating both short- and long-term effects of experience on brain structure and function...
  17. ncbi Ultrasonic vocalisation emitted by infant rodents: a tool for assessment of neurobehavioural development
    I Branchi
    UPR 9074 CNRS, Génétique Neurogénétique Comportement, 3B rue de la Ferollerie, 45071 Orleans, France
    Behav Brain Res 125:49-56. 2001
    ....
  18. ncbi Effects of perinatal exposure to a polybrominated diphenyl ether (PBDE 99) on mouse neurobehavioural development
    Igor Branchi
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Italy
    Neurotoxicology 23:375-84. 2002
    ..The possibility of exposure of neonates to PBDEs warrants further studies to characterise their developmental neurotoxicity...
  19. ncbi Transgenic mouse in vivo library of human Down syndrome critical region 1: association between DYRK1A overexpression, brain development abnormalities, and cell cycle protein alteration
    Igor Branchi
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
    J Neuropathol Exp Neurol 63:429-40. 2004
    ..Our findings support a role of DYRK1A overexpression in the neuronal abnormalities seen in Down syndrome and suggest that this pathology is linked to altered levels of proteins involved in the regulation of cell cycle...
  20. ncbi Polybrominated diphenyl ethers: neurobehavioral effects following developmental exposure
    Igor Branchi
    Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicology 24:449-62. 2003
    ....
  21. ncbi Neonatal behaviors associated with ultrasonic vocalizations in mice (mus musculus): A slow-motion analysis
    Igor Branchi
    Section of Behavioral Pathophysiology, Laboratorio di Fisiopatologia di, Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Roma, Italy
    Dev Psychobiol 44:37-44. 2004
    ..A significant increase of head rising behavior immediately prior to the USV and a behavioral activation displayed by pups in conjunction with it suggest that pups behave in a way that may favor interaction with their mothers...
  22. ncbi Prenatal exposure to anti-HIV drugs. long-term neurobehavioral effects of lamivudine (3TC) in CD-1 mice
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Neurotoxicol Teratol 22:369-79. 2000
    ..No significant changes in either pain sensitivity, social/affiliative, or maternal behavior were found, although a higher occurrence of aggressive behavior toward foster pups was noted in both 125- and 500-mg/kg 3TC females...
  23. ncbi Effects of prenatal AZT on mouse neurobehavioral development and passive avoidance learning
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicol Teratol 21:29-40. 1999
    ..Moreover, sexual differences in some items of the social behavior repertoire appeared to be affected by AZT treatment...
  24. ncbi Communal nesting, an early social enrichment, affects social competences but not learning and memory abilities at adulthood
    Enrico Alleva
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 183:60-6. 2007
    ..Furthermore, present data suggest that the early social enrichment specifically affect adult social behavior but not learning and memory abilities...
  25. doi Early social enrichment provided by communal nest increases resilience to depression-like behavior more in female than in male mice
    Ivana D'Andrea
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Behav Brain Res 215:71-6. 2010
    ..In particular, we show that early experiences modified developmental trajectories shaping adult endophenotypes of depression more markedly in females than in males...
  26. ncbi Effects of prenatal zidovudine treatment on learning and memory capacities of preweanling and young adult mice
    G Calamandrei
    Section of Comparative Psychology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Roma, Italy
    Neurotoxicology 20:17-25. 1999
    ..Retention of the passive avoidance response was mildly impaired in the offspring exposed to the 0.8 mg/ml AZT solution, whereas spatial learning on PND 45 was unaffected...
  27. ncbi Neurobehavioral effects of prenatal lamivudine (3TC) exposure in preweaning mice
    G Calamandrei
    Comparative Psychology Section, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Neurotoxicol Teratol 21:365-73. 1999
    ....
  28. ncbi Long-term effects of the periadolescent environment on exploratory activity and aggressive behaviour in mice: social versus physical enrichment
    Susanna Pietropaolo
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Physiol Behav 81:443-53. 2004
    ....
  29. doi Early life influences on emotional reactivity: evidence that social enrichment has greater effects than handling on anxiety-like behaviors, neuroendocrine responses to stress and central BDNF levels
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161, Rome, Italy
    Neurosci Biobehav Rev 34:808-20. 2010
    ..Overall, the availability of ever more sophisticated animal models represents a fundamental tool to translate basic research data into appropriate interventions for humans raised under traumatic or impoverished situations...
  30. doi Striatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease
    Igor Branchi
    Section of Behavioural Neurosciences, Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, 00161 Rome, Italy
    Behav Brain Res 208:137-43. 2010
    ..Overall, the present findings suggest that a change of 5-HT metabolism and a modification of oxidative stress levels may play a role in the early PD degeneration phases...
  31. ncbi A new easy accessible and low-cost method for screening olfactory sensitivity in mice: behavioural and nociceptive response in male and female CD-1 mice upon exposure to millipede aversive odour
    Francesca Capone
    Section of Behavioural Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Viale Regina Elena, Roma, Italy
    Brain Res Bull 58:193-202. 2002
    ..TQ exposure assay is a new, easily testable, and low-cost method for measuring rodents olfactory sensitivity relevant for the analysis of the pharmacological agents, lesions and transgenesis...
  32. pmc Changes in plasma levels of BDNF and NGF reveal a gender-selective vulnerability to early adversity in rhesus macaques
    Francesca Cirulli
    Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 34:172-80. 2009
    ..The selective changes in BDNF levels in females could help explain the greater vulnerability to mood disorders of this gender reported in humans...
  33. ncbi NGF: a social molecule
    Enrico Alleva
    Section of Behavioural Neurosciences, Dipartimento di Biologia Cellulare e Neuroscienze, Istituto Superiore di Sanita, Viale Regina Elena, 299, I 00161 Rome, Italy
    Psychoneuroendocrinology 31:295-6; author reply 297-8. 2006
  34. ncbi Transgenic and knock-out mouse pups: the growing need for behavioral analysis
    I Branchi
    Section of Behavioral Pathophysiology, Laboratorio di Fisiopatologia di Organo e di Sistema, Istituto Superiore di Sanita, Rome, Italy
    Genes Brain Behav 1:135-41. 2002
    ..While this knowledge should be applied to the field of transgenic and knock-out mice in general, it should be recommended, in particular, for the study of mouse models of neurodevelopmental disorders...
  35. ncbi Differential in vitro neurotoxicity of the flame retardant PBDE-99 and of the PCB Aroclor 1254 in human astrocytoma cells
    Federica Madia
    Department of Pharmacology of Natural Substances and General Physiology, University of Rome La Sapienza, Italy
    Toxicol Lett 154:11-21. 2004
    ..These results suggest that PBDE-99 and Aroclor 1254 exert differential cytotoxic effects on human astroglial cells...
  36. pmc Rhes is involved in striatal function
    Daniela Spano
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy
    Mol Cell Biol 24:5788-96. 2004
    ..These results suggest that Rhes disruption affects selected behavioral competencies...