Research Topics
| T BisognoSummaryAffiliation: Istituto di Chimica Biomolecolare Country: Italy Publications
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Publications
The role of the endocannabinoid system in Alzheimer's disease: facts and hypothesesTiziana Bisogno
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli Naples, Italy
Curr Pharm Des 14:2299-3305. 2008....
Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed miceFabiana Piscitelli
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR, Pozzuoli NA, Italy
Nutr Metab (Lond) 8:51. 2011..abstract:..
Endogenous cannabinoids: structure and metabolismT Bisogno
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
J Neuroendocrinol 20:1-9. 2008..An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation...- The endocannabinoid signalling system: biochemical aspectsTiziana Bisogno
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078 Pozzuoli Napoli, Italy
Pharmacol Biochem Behav 81:224-38. 2005..In particular we review the mechanisms for the biosynthesis and inactivation of the endocannabinoids, as well as the various molecular targets for some of the endocannabinoids described so far... - Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligandsV Di Marzo
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice Na, Italy
Biochem Biophys Res Commun 281:444-51. 2001.... - The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferationL De Petrocellis
Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, Naples, Italy
Proc Natl Acad Sci U S A 95:8375-80. 1998..These data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous prolactin action at the level of prolactin receptor... - The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolismL De Petrocellis
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and the Istituto di Cibernetica, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
J Biol Chem 276:12856-63. 2001..By contrast, the CB(1) receptor antagonist SR141716A inhibited also the VR1-mediated effect of anandamide and capsaicin on cytosolic Ca(2+) concentration, although at concentrations higher than those required for CB(1) antagonism... - The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptorsT Bisogno
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico (VDM, TB, Arco Felice, Napoli, Italy
Eur J Biochem 268:1982-9. 2001.... - Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologuesV Di Marzo
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, C N R, Via Toiano 6, 80072, Arco Felice, Naples, Italy
Eur J Pharmacol 420:123-31. 2001.... - Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferationD Melck
Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Arco Felice Na, Italy
Endocrinology 141:118-26. 2000..These findings suggest that endogenous cannabinoids and CB1 receptor agonists are potential negative effectors of PRL- and NGF-induced biological responses, at least in some cancer cells... - The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinaseL De Petrocellis
Endocannabinoid Research Group, Istituto di Cibernetica (LDP, Consiglio Nazionale delle Ricerche, Arco Felice, Italy
J Neurochem 77:1660-3. 2001..This observation supports the hypothesis that endogenous AEA might stimulate VR1 under certain pathophysiological conditions... - Anandamide: some like it hotV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Viale Toiano 6, Arco Felice, 80072 Napoli, Italy
Trends Pharmacol Sci 22:346-9. 2001..However, very recent reports demonstrate that activation of VR1 by anandamide can be significantly enhanced by various regulatory factors, suggesting that this compound might act as an "endovanilloid" under certain conditions... - Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamideT Bisogno
Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078 Pozzuoli Napoli, Italy
Br J Pharmacol 134:845-52. 2001..In view of the facile high yield synthesis, and the weak affinity for CB(1) and CB(2) receptors, (-)-5'-DMH-CBD represents a valuable candidate for further investigation as inhibitor of AEA uptake and a possible new therapeutic agent... - Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intakeI Matias
Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli (NA, Italy
Int J Obes (Lond) 30:S7-S12. 2006.... - Endocannabinoids: new targets for drug development- Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
Curr Pharm Des 6:1361-80. 2000..These studies are reviewed in this article with special emphasis on the chemical features that determine the interaction of endocannabinoids with the proteins mediating their activity and degradation... - Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamideL De Petrocellis
Endocannabinoid Research Group, Institutes of Cybernetics Consiglio Nazionale delle Ricerche, Pozzuoli Napoli, Italy
J Lipid Res 50:658-66. 2009..Thus, 3R-HETE-producing yeasts might convert anandamide released by host cells at the site of infection into 3R-HAEA, and this event might contribute to the inflammatory and algogenous responses associated to fungal diseases... - Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolismI Matias
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Napoli, Italy
J Pharmacol Exp Ther 309:745-57. 2004.... - Interactions between synthetic vanilloids and the endogenous cannabinoid systemV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, CNR, Napoli, Italy
FEBS Lett 436:449-54. 1998.... - Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developmentsV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, Napoli, Italy
Lipids 34:S319-25. 1999..Here we briefly review the state of the art, and present new data from our laboratory, on these four largely unexplored aspects of endocannabinoid metabolism... - Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoidsV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072 Arco Felice, Napoli, Italy
Curr Med Chem 6:721-44. 1999.... - Cannabimimetic fatty acid derivatives in cancer and inflammationV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
Prostaglandins Other Lipid Mediat 61:43-61. 2000..The possibility that CFADs act as local inhibitors of the proliferation of human breast cancer is discussed here... - Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cellsV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
Biochem J 358:249-55. 2001..We suggest that long-term PEA treatment of cells may positively affect the pharmacological activity of AEA, in part by inhibiting FAAH expression... - Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's diseaseV Di Marzo
School of Biological Sciences, University of Manchester, United Kingdom
FASEB J 14:1432-8. 2000.... - The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamideV Di Marzo
Istituto per la Chimica di Molecole di Interesse Biologico2, Via Toiano 6, Arco Felice, Napoli, Italy
Biochem J 331:15-9. 1998..These data suggest that FAAH may be one of the enzymes deputed to the physiological inactivation of 2-AG, and create intriguing possibilities for the cross-regulation of 2-AG and AEA levels... - Anandamide receptorsVincenzo Di Marzo
Endocannabinoid Research Group, Istituto di Chimica Biomdecolare, 80078 Pozzuoli, Naples, Italy
Prostaglandins Leukot Essent Fatty Acids 66:377-91. 2002.... - In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligandsM G Cascio
Endocannabinoid Research Group, Institute of Biomolecular Chemistry CNR, Pozzuoli (Naples, Italy
Br J Pharmacol 149:431-40. 2006..CONCLUSIONS AND IMPLICATIONS: CB-25 and CB-52 behave in vitro mostly as CB1 partial agonists and CB2 neutral antagonists, whereas their activity in vivo might depend on the tonic activity of cannabinoid receptors... - Protective role of palmitoylethanolamide in contact allergic dermatitisS Petrosino
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli Naples, Italy
Allergy 65:698-711. 2010..No datum is available on PEA regulation and role in CAD... - Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implicationsEleni T Tzavara
INSERM U-513, Neurobiology and Psychiatry, , , France
Biol Psychiatry 59:508-15. 2006..In this process, TRPV1 receptors seem to play a key role and represent a novel promising pharmacological target... - Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitisAnna Maria Malfitano
Dipartimento di Scienze Farmaceutiche, Universita' di Salerno, Via Ponte don Melillo 84084 Fisciano (Salerno, Italy
J Neuroimmunol 171:110-9. 2006..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis... - Design, synthesis, and binding studies of new potent ligands of cannabinoid receptorsAntonella Brizzi
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
J Med Chem 48:7343-50. 2005..Compound 25 behaved as a inverse agonist at CB1 receptors as assessed in the cyclic AMP functional assay... - Changes in spinal and supraspinal endocannabinoid levels in neuropathic ratsStefania Petrosino
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche C N R, via dei Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli, Naples 80078, Italy
Neuropharmacology 52:415-22. 2007..Yet to be developed substances that inhibit both endocannabinoid and PEA inactivation might be useful for the treatment of neuropathic pain... - Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiologyVincenzo Di Marzo
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli NA, Italy
Chem Biol 14:741-56. 2007.... - Protective activation of the endocannabinoid system during ischemia in dopamine neuronsMiriam Melis
Centre of Excellence Neurobiology of Addiction, University of Cagliari, Italy
Neurobiol Dis 24:15-27. 2006..Lastly, they point to CB1 receptors as valuable targets in protection of DA neurons against ischemic injury and emphasize the need for a better understanding of endocannabinoid actions in the fine control of DA transmission... - Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainTiziana Bisogno
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, 80078 Pozzuoli, Italy
J Cell Biol 163:463-8. 2003..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders... - An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in miceAngelo A Izzo
Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
Gastroenterology 125:765-74. 2003..In this study, we investigated the role of the endogenous cannabinoid system (i.e., the cannabinoid receptors and their endogenous ligands) in CT-induced fluid accumulation in the mouse small intestine... - Possible endocannabinoid control of colorectal cancer growthAlessia Ligresti
Endovannabinoid Research Group, Institute of Biomolecular Chemistry, Pozzuoli, Italy
Gastroenterology 125:677-87. 2003..CONCLUSIONS: Endocannabinoid levels are enhanced in transformed colon mucosa cells possibly to counteract proliferation via CBRs. Inhibitors of endocannabinoid inactivation may prove useful anticancer agents... - A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybridVincenzo Di Marzo
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Pozzuoli, Napoli, Italy
J Pharmacol Exp Ther 300:984-91. 2002..04 mg/kg), did not activate VR1 or CB1 receptors. Our findings suggest that VR1 and/or as yet uncharacterized receptors produce cannabimimetic responses in mice in vivo... - The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female ratsTibor Wenger
Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary
Life Sci 70:1407-14. 2002.... - Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissuesFilomena Fezza
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078, Pozzuoli, Naples, Italy
FEBS Lett 513:294-8. 2002..Further data suggested that 2-AGE is taken up by cells via the anandamide/2-arachidonoyl glycerol (2-AG) membrane transporter(s), and biosynthesized in a different way as compared to 2-AG... - Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptorsJason W Brooks
Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
Eur J Pharmacol 439:83-92. 2002..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically... - Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implicationsTiziana Bisogno
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Pozzuoli, Pozzuoli (NA, Italy
Curr Pharm Des 8:533-47. 2002.... - Endocannabinoids as physiological regulators of colonic propulsion in miceLuisa Pinto
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
Gastroenterology 123:227-34. 2002..CONCLUSIONS: We conclude that endocannabinoids acting on myenteric CB1 receptors tonically inhibit colonic propulsion in mice... - The endogenous cannabinoid system controls extinction of aversive memoriesGiovanni Marsicano
Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Nature 418:530-4. 2002..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala... - The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulationGiuseppe Esposito
Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
J Biol Chem 277:50348-54. 2002..These findings show that the endocannabinoid system, through the modulation of the l-arginine/NO pathway, reduces HIV-1 Tat-induced cytotoxicity, and is itself regulated by HIV-1 Tat... - Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transferMauro Maccarrone
Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, I 00133 Rome, Italy
Mol Hum Reprod 8:188-95. 2002.... - Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tickFilomena Fezza
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche-Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, I-80078 Pozzuoli, Napoli, Italy
Biochim Biophys Acta 1633:61-7. 2003.... - Cannabimimetic eicosanoids in cancer and inflammation: an updateDominique Melck
Endocannabinoid Research Group, Istituto per la Chimica di Molecule di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, NA, Italy
Adv Exp Med Biol 507:381-6. 2002 - Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systemsLuciano De Petrocellis
Istituto di Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli, Napoli, Italy
Fundam Clin Pharmacol 16:297-302. 2002..These 'entourage' effects of PEA might be attributable to modulation of VR1 activity, and could underlie the enhancement by PEA, described here for the first time, of the antiproliferative effects of VR1 receptor agonists... - N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesiaConstance J Chu
Department of Psychology, Brown University, Providence, Rhode Island 02912, USA
J Biol Chem 278:13633-9. 2003..Analysis of the activity of six additional synthetic and potentially endogenous N-acyldopamine indicated the requirement of a long unsaturated fatty acid chain for an optimal functional interaction with VR1 receptors... - Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptorsGiovanni Appendino
DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy
Bioorg Med Chem Lett 13:43-6. 2003..The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors... - An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptorsSusan M Huang
Departments of Psychology and Neuroscience, Brown University, Providence, RI 02912, USA
Proc Natl Acad Sci U S A 99:8400-5. 2002..5 +/- 0.3 microg). Our data demonstrate the existence of a brain substance similar to capsaicin not only with respect to its chemical structure but also to its potency at VR1 receptors... - Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 reSabatino Maione
Department of Experimental Medicine, Section of Pharmacology L. Donatelli, Second University of Naples, Naples, Italy
J Pharmacol Exp Ther 316:969-82. 2006..Thus, endocannabinoids affect the descending pathways of pain control by acting at either CB1 or TRPV1 receptors in healthy rats... - Neuromodulatory actions neuromodulatory actions of endocannabinoids in pain and sedationLuciano De Petrocellis
Endocannabinoid Research Group, Institutes di Biomolecular Chemistry and Cybernetics, Consiglio Nazionale delle Ricerche - Via Campi Flegrei 34, Comprensorio Olivetti, Fabbr. 70, 80078 Pozzuoli (Napoli, Italy
Adv Exp Med Biol 523:215-25. 2003 - Cannabinoid CB1 receptor mediates fear extinction via habituation-like processesKornelia Kamprath
Neuronal Plasticity Mouse Behavior Group, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
J Neurosci 26:6677-86. 2006..Our findings underscore the importance of habituation as a determinant of fear extinction in mice and characterize the cannabinoid CB1 receptor as an essential molecular correlate of this process... - Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disordersTiziana Bisogno
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, Naples, Italy
Pharmacol Res 56:428-42. 2007..The possibility of obtaining therapeutic advantage from endocannabinoid plasticity in neuropsychiatric and neurological disorders is discussed in this review article... - Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's diseaseTiziana Bisogno
Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
Neurochem Int 52:307-13. 2008.... - Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerolBela Szabo
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universität Albertstrasse 25, D 79104 Freiburg im Breisgau, Germany
J Physiol 577:263-80. 2006.... - Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitroTeresa Iuvone
Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano, 49, 80131, Naples, Italy
J Mol Med (Berl) 85:1379-92. 2007..Our data suggest that selective activation of CB1 receptors by either exogenous or endogenous cannabinoids might afford neuroprotection in MPTP-induced neurotoxicity also by controlling S100B up-regulation in activated glial cells... - Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptorsAntonella Brizzi
Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
Bioorg Med Chem 15:5406-16. 2007.... - Development of the first potent and specific inhibitors of endocannabinoid biosynthesisTiziana Bisogno
Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, C.N.R, Via Campi Flegrei, 34-80078-Pozzuoli (NA, Italy
Biochim Biophys Acta 1761:205-12. 2006..8-0.1 and 3.7-3.2 microM, respectively). Thus, we report the first potent and specific inhibitors of the biosynthesis of 2-AG that may be used as pharmacological tools to investigate the biological role of this endocannabinoid...