T Bisogno

Summary

Affiliation: Istituto di Chimica Biomolecolare
Country: Italy

Publications

  1. ncbi request reprint The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses
    Tiziana Bisogno
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli Naples, Italy
    Curr Pharm Des 14:2299-3305. 2008
  2. pmc Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice
    Fabiana Piscitelli
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR, Pozzuoli NA, Italy
    Nutr Metab (Lond) 8:51. 2011
  3. doi request reprint Endogenous cannabinoids: structure and metabolism
    T Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
    J Neuroendocrinol 20:1-9. 2008
  4. ncbi request reprint The endocannabinoid signalling system: biochemical aspects
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078 Pozzuoli Napoli, Italy
    Pharmacol Biochem Behav 81:224-38. 2005
  5. ncbi request reprint Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice Na, Italy
    Biochem Biophys Res Commun 281:444-51. 2001
  6. pmc The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
    L De Petrocellis
    Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, Naples, Italy
    Proc Natl Acad Sci U S A 95:8375-80. 1998
  7. ncbi request reprint The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
    L De Petrocellis
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and the Istituto di Cibernetica, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    J Biol Chem 276:12856-63. 2001
  8. ncbi request reprint The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
    T Bisogno
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico (VDM, TB, Arco Felice, Napoli, Italy
    Eur J Biochem 268:1982-9. 2001
  9. ncbi request reprint Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, C N R, Via Toiano 6, 80072, Arco Felice, Naples, Italy
    Eur J Pharmacol 420:123-31. 2001
  10. ncbi request reprint Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
    D Melck
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Arco Felice Na, Italy
    Endocrinology 141:118-26. 2000

Collaborators

Detail Information

Publications60

  1. ncbi request reprint The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses
    Tiziana Bisogno
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli Naples, Italy
    Curr Pharm Des 14:2299-3305. 2008
    ....
  2. pmc Effect of dietary krill oil supplementation on the endocannabinoidome of metabolically relevant tissues from high-fat-fed mice
    Fabiana Piscitelli
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, CNR, Pozzuoli NA, Italy
    Nutr Metab (Lond) 8:51. 2011
    ..abstract:..
  3. doi request reprint Endogenous cannabinoids: structure and metabolism
    T Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy
    J Neuroendocrinol 20:1-9. 2008
    ..An overview of the current understanding of structure and metabolism of the best studied endocannabinoids is provided, with a focus on the mechanisms responsible for their biosynthesis and inactivation...
  4. ncbi request reprint The endocannabinoid signalling system: biochemical aspects
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078 Pozzuoli Napoli, Italy
    Pharmacol Biochem Behav 81:224-38. 2005
    ..In particular we review the mechanisms for the biosynthesis and inactivation of the endocannabinoids, as well as the various molecular targets for some of the endocannabinoids described so far...
  5. ncbi request reprint Highly selective CB(1) cannabinoid receptor ligands and novel CB(1)/VR(1) vanilloid receptor "hybrid" ligands
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice Na, Italy
    Biochem Biophys Res Commun 281:444-51. 2001
    ....
  6. pmc The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
    L De Petrocellis
    Istituto di Cibernetica, Consiglio Nazionale delle Ricerche, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, Naples, Italy
    Proc Natl Acad Sci U S A 95:8375-80. 1998
    ..These data suggest that anandamide blocks human breast cancer cell proliferation through CB1-like receptor-mediated inhibition of endogenous prolactin action at the level of prolactin receptor...
  7. ncbi request reprint The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism
    L De Petrocellis
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico and the Istituto di Cibernetica, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    J Biol Chem 276:12856-63. 2001
    ..By contrast, the CB(1) receptor antagonist SR141716A inhibited also the VR1-mediated effect of anandamide and capsaicin on cytosolic Ca(2+) concentration, although at concentrations higher than those required for CB(1) antagonism...
  8. ncbi request reprint The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors
    T Bisogno
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico (VDM, TB, Arco Felice, Napoli, Italy
    Eur J Biochem 268:1982-9. 2001
    ....
  9. ncbi request reprint Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, C N R, Via Toiano 6, 80072, Arco Felice, Naples, Italy
    Eur J Pharmacol 420:123-31. 2001
    ....
  10. ncbi request reprint Suppression of nerve growth factor Trk receptors and prolactin receptors by endocannabinoids leads to inhibition of human breast and prostate cancer cell proliferation
    D Melck
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Arco Felice Na, Italy
    Endocrinology 141:118-26. 2000
    ..These findings suggest that endogenous cannabinoids and CB1 receptor agonists are potential negative effectors of PRL- and NGF-induced biological responses, at least in some cancer cells...
  11. ncbi request reprint The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase
    L De Petrocellis
    Endocannabinoid Research Group, Istituto di Cibernetica (LDP, Consiglio Nazionale delle Ricerche, Arco Felice, Italy
    J Neurochem 77:1660-3. 2001
    ..This observation supports the hypothesis that endogenous AEA might stimulate VR1 under certain pathophysiological conditions...
  12. ncbi request reprint Anandamide: some like it hot
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Viale Toiano 6, Arco Felice, 80072 Napoli, Italy
    Trends Pharmacol Sci 22:346-9. 2001
    ..However, very recent reports demonstrate that activation of VR1 by anandamide can be significantly enhanced by various regulatory factors, suggesting that this compound might act as an "endovanilloid" under certain conditions...
  13. pmc Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    T Bisogno
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078 Pozzuoli Napoli, Italy
    Br J Pharmacol 134:845-52. 2001
    ..In view of the facile high yield synthesis, and the weak affinity for CB(1) and CB(2) receptors, (-)-5'-DMH-CBD represents a valuable candidate for further investigation as inhibitor of AEA uptake and a possible new therapeutic agent...
  14. ncbi request reprint Endogenous cannabinoids in the brain and peripheral tissues: regulation of their levels and control of food intake
    I Matias
    Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli NA, Italy
    Int J Obes (Lond) 30:S7-S12. 2006
    ....
  15. ncbi request reprint Endocannabinoids: new targets for drug development
    - Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Curr Pharm Des 6:1361-80. 2000
    ..These studies are reviewed in this article with special emphasis on the chemical features that determine the interaction of endocannabinoids with the proteins mediating their activity and degradation...
  16. pmc Chemical synthesis, pharmacological characterization, and possible formation in unicellular fungi of 3-hydroxy-anandamide
    L De Petrocellis
    Endocannabinoid Research Group, Institutes of Cybernetics Consiglio Nazionale delle Ricerche, Pozzuoli Napoli, Italy
    J Lipid Res 50:658-66. 2009
    ..Thus, 3R-HETE-producing yeasts might convert anandamide released by host cells at the site of infection into 3R-HAEA, and this event might contribute to the inflammatory and algogenous responses associated to fungal diseases...
  17. ncbi request reprint Prostaglandin ethanolamides (prostamides): in vitro pharmacology and metabolism
    I Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Napoli, Italy
    J Pharmacol Exp Ther 309:745-57. 2004
    ....
  18. ncbi request reprint Interactions between synthetic vanilloids and the endogenous cannabinoid system
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, CNR, Napoli, Italy
    FEBS Lett 436:449-54. 1998
    ....
  19. ncbi request reprint Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Napoli, Italy
    Lipids 34:S319-25. 1999
    ..Here we briefly review the state of the art, and present new data from our laboratory, on these four largely unexplored aspects of endocannabinoid metabolism...
  20. ncbi request reprint Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072 Arco Felice, Napoli, Italy
    Curr Med Chem 6:721-44. 1999
    ....
  21. ncbi request reprint Cannabimimetic fatty acid derivatives in cancer and inflammation
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Prostaglandins Other Lipid Mediat 61:43-61. 2000
    ..The possibility that CFADs act as local inhibitors of the proliferation of human breast cancer is discussed here...
  22. pmc Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico, Via Toiano 6, 80072, Arco Felice, Napoli, Italy
    Biochem J 358:249-55. 2001
    ..We suggest that long-term PEA treatment of cells may positively affect the pharmacological activity of AEA, in part by inhibiting FAAH expression...
  23. ncbi request reprint Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
    V Di Marzo
    School of Biological Sciences, University of Manchester, United Kingdom
    FASEB J 14:1432-8. 2000
    ....
  24. pmc The novel endogenous cannabinoid 2-arachidonoylglycerol is inactivated by neuronal- and basophil-like cells: connections with anandamide
    V Di Marzo
    Istituto per la Chimica di Molecole di Interesse Biologico2, Via Toiano 6, Arco Felice, Napoli, Italy
    Biochem J 331:15-9. 1998
    ..These data suggest that FAAH may be one of the enzymes deputed to the physiological inactivation of 2-AG, and create intriguing possibilities for the cross-regulation of 2-AG and AEA levels...
  25. ncbi request reprint Anandamide receptors
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomdecolare, 80078 Pozzuoli, Naples, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:377-91. 2002
    ....
  26. pmc In vitro and in vivo pharmacology of synthetic olivetol- or resorcinol-derived cannabinoid receptor ligands
    M G Cascio
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry CNR, Pozzuoli Naples, Italy
    Br J Pharmacol 149:431-40. 2006
    ..We have previously reported the development of CB-25 and CB-52, two ligands of CB1 and CB2 cannabinoid receptors. We assessed here their functional activity...
  27. doi request reprint Protective role of palmitoylethanolamide in contact allergic dermatitis
    S Petrosino
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli Naples, Italy
    Allergy 65:698-711. 2010
    ..No datum is available on PEA regulation and role in CAD...
  28. ncbi request reprint Endocannabinoids activate transient receptor potential vanilloid 1 receptors to reduce hyperdopaminergia-related hyperactivity: therapeutic implications
    Eleni T Tzavara
    INSERM U 513, Neurobiology and Psychiatry, Universite de Medecine, Creteil, France
    Biol Psychiatry 59:508-15. 2006
    ....
  29. ncbi request reprint Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis
    Anna Maria Malfitano
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, via Ponte Don Melillo 84084 Fisciano Salerno, Italy
    J Neuroimmunol 171:110-9. 2006
    ..Our findings have relevance for the use of arvanil and related compounds as a novel immunotherapeutic approach in the treatment of multiple sclerosis...
  30. ncbi request reprint Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors
    Antonella Brizzi
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    J Med Chem 48:7343-50. 2005
    ..Compound 25 behaved as a inverse agonist at CB1 receptors as assessed in the cyclic AMP functional assay...
  31. ncbi request reprint Changes in spinal and supraspinal endocannabinoid levels in neuropathic rats
    Stefania Petrosino
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche C N R, via dei Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli, Naples 80078, Italy
    Neuropharmacology 52:415-22. 2007
    ..Yet to be developed substances that inhibit both endocannabinoid and PEA inactivation might be useful for the treatment of neuropathic pain...
  32. ncbi request reprint Endocannabinoids and related compounds: walking back and forth between plant natural products and animal physiology
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli NA, Italy
    Chem Biol 14:741-56. 2007
    ....
  33. ncbi request reprint Protective activation of the endocannabinoid system during ischemia in dopamine neurons
    Miriam Melis
    Centre of Excellence Neurobiology of Addiction, University of Cagliari, Italy
    Neurobiol Dis 24:15-27. 2006
    ..Lastly, they point to CB1 receptors as valuable targets in protection of DA neurons against ischemic injury and emphasize the need for a better understanding of endocannabinoid actions in the fine control of DA transmission...
  34. pmc Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, 80078 Pozzuoli, Italy
    J Cell Biol 163:463-8. 2003
    ..This switch provides a possible explanation for a fundamental change in endocannabinoid function during brain development. Identification of these enzymes may offer new therapeutic opportunities for a wide range of disorders...
  35. ncbi request reprint An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
    Gastroenterology 125:765-74. 2003
    ..In this study, we investigated the role of the endogenous cannabinoid system (i.e., the cannabinoid receptors and their endogenous ligands) in CT-induced fluid accumulation in the mouse small intestine...
  36. ncbi request reprint Possible endocannabinoid control of colorectal cancer growth
    Alessia Ligresti
    Endovannabinoid Research Group, Institute of Biomolecular Chemistry, Pozzuoli, Italy
    Gastroenterology 125:677-87. 2003
    ..the effects of endocannabinoids, and of inhibitors of their inactivation, on human CRC cell proliferation...
  37. ncbi request reprint A structure/activity relationship study on arvanil, an endocannabinoid and vanilloid hybrid
    Vincenzo Di Marzo
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Pozzuoli, Napoli, Italy
    J Pharmacol Exp Ther 300:984-91. 2002
    ..04 mg/kg), did not activate VR1 or CB1 receptors. Our findings suggest that VR1 and/or as yet uncharacterized receptors produce cannabimimetic responses in mice in vivo...
  38. ncbi request reprint The hypothalamic levels of the endocannabinoid, anandamide, peak immediately before the onset of puberty in female rats
    Tibor Wenger
    Department of Human Morphology and Developmental Biology, Semmelweis University, Budapest, Hungary
    Life Sci 70:1407-14. 2002
    ....
  39. ncbi request reprint Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues
    Filomena Fezza
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, 80078, Pozzuoli, Naples, Italy
    FEBS Lett 513:294-8. 2002
    ..Further data suggested that 2-AGE is taken up by cells via the anandamide/2-arachidonoyl glycerol (2-AG) membrane transporter(s), and biosynthesized in a different way as compared to 2-AG...
  40. ncbi request reprint Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB(1)/CB(2) receptors
    Jason W Brooks
    Pain Research Group, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pharmacol 439:83-92. 2002
    ..These findings suggest that activation by arvanil of sites of action different from cannabinoid CB(1)/CB(2) receptors and vanilloid VR1 receptors leads to anti-spastic/analgesic effects that might be exploited therapeutically...
  41. ncbi request reprint Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Pozzuoli, Pozzuoli NA, Italy
    Curr Pharm Des 8:533-47. 2002
    ....
  42. ncbi request reprint Endocannabinoids as physiological regulators of colonic propulsion in mice
    Luisa Pinto
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 123:227-34. 2002
    ..In the present study, we investigated the possible involvement of endocannabinoids in regulating intestinal propulsion in the mouse colon in vivo...
  43. ncbi request reprint The endogenous cannabinoid system controls extinction of aversive memories
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Nature 418:530-4. 2002
    ..We propose that endocannabinoids facilitate extinction of aversive memories through their selective inhibitory effects on local inhibitory networks in the amygdala...
  44. ncbi request reprint The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation
    Giuseppe Esposito
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Biol Chem 277:50348-54. 2002
    ..These findings show that the endocannabinoid system, through the modulation of the l-arginine/NO pathway, reduces HIV-1 Tat-induced cytotoxicity, and is itself regulated by HIV-1 Tat...
  45. ncbi request reprint Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, I 00133 Rome, Italy
    Mol Hum Reprod 8:188-95. 2002
    ....
  46. ncbi request reprint Endocannabinoids and related fatty acid amides, and their regulation, in the salivary glands of the lone star tick
    Filomena Fezza
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche Via Campi Flegrei 34, Comprensorio Olivetti, Fabbricato 70, I 80078 Pozzuoli, Napoli, Italy
    Biochim Biophys Acta 1633:61-7. 2003
    ....
  47. ncbi request reprint Cannabimimetic eicosanoids in cancer and inflammation: an update
    Dominique Melck
    Endocannabinoid Research Group, Istituto per la Chimica di Molecule di Interesse Biologico, Consiglio Nazionale delle Ricerche, Via Toiano 6, 80072 Arco Felice, NA, Italy
    Adv Exp Med Biol 507:381-6. 2002
  48. ncbi request reprint Effect on cancer cell proliferation of palmitoylethanolamide, a fatty acid amide interacting with both the cannabinoid and vanilloid signalling systems
    Luciano De Petrocellis
    Istituto di Cibernetica Eduardo Caianiello, Consiglio Nazionale delle Ricerche, Comprensorio Olivetti, Pozzuoli, Napoli, Italy
    Fundam Clin Pharmacol 16:297-302. 2002
    ..These 'entourage' effects of PEA might be attributable to modulation of VR1 activity, and could underlie the enhancement by PEA, described here for the first time, of the antiproliferative effects of VR1 receptor agonists...
  49. ncbi request reprint N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia
    Constance J Chu
    Department of Psychology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 278:13633-9. 2003
    ..Analysis of the activity of six additional synthetic and potentially endogenous N-acyldopamine indicated the requirement of a long unsaturated fatty acid chain for an optimal functional interaction with VR1 receptors...
  50. ncbi request reprint Homologues and isomers of noladin ether, a putative novel endocannabinoid: interaction with rat cannabinoid CB(1) receptors
    Giovanni Appendino
    DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy
    Bioorg Med Chem Lett 13:43-6. 2003
    ..The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors...
  51. pmc An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
    Susan M Huang
    Departments of Psychology and Neuroscience, Brown University, Providence, RI 02912, USA
    Proc Natl Acad Sci U S A 99:8400-5. 2002
    ..5 +/- 0.3 microg). Our data demonstrate the existence of a brain substance similar to capsaicin not only with respect to its chemical structure but also to its potency at VR1 receptors...
  52. ncbi request reprint Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways via both cannabinoid receptor type 1 and transient receptor potential vanilloid type-1 re
    Sabatino Maione
    Department of Experimental Medicine, Section of Pharmacology L Donatelli, Second University of Naples, Naples, Italy
    J Pharmacol Exp Ther 316:969-82. 2006
    ..Thus, endocannabinoids affect the descending pathways of pain control by acting at either CB1 or TRPV1 receptors in healthy rats...
  53. ncbi request reprint Neuromodulatory actions neuromodulatory actions of endocannabinoids in pain and sedation
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institutes di Biomolecular Chemistry and Cybernetics, Consiglio Nazionale delle Ricerche Via Campi Flegrei 34, Comprensorio Olivetti, Fabbr 70, 80078 Pozzuoli Napoli, Italy
    Adv Exp Med Biol 523:215-25. 2003
  54. ncbi request reprint Cannabinoid CB1 receptor mediates fear extinction via habituation-like processes
    Kornelia Kamprath
    Neuronal Plasticity Mouse Behavior Group, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    J Neurosci 26:6677-86. 2006
    ..Our findings underscore the importance of habituation as a determinant of fear extinction in mice and characterize the cannabinoid CB1 receptor as an essential molecular correlate of this process...
  55. ncbi request reprint Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders
    Tiziana Bisogno
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, Pozzuoli, Naples, Italy
    Pharmacol Res 56:428-42. 2007
    ..The possibility of obtaining therapeutic advantage from endocannabinoid plasticity in neuropsychiatric and neurological disorders is discussed in this review article...
  56. ncbi request reprint Symptom-related changes of endocannabinoid and palmitoylethanolamide levels in brain areas of R6/2 mice, a transgenic model of Huntington's disease
    Tiziana Bisogno
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy
    Neurochem Int 52:307-13. 2008
    ....
  57. pmc Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol
    Bela Szabo
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universit├Ąt Albertstrasse 25, D 79104 Freiburg im Breisgau, Germany
    J Physiol 577:263-80. 2006
    ....
  58. ncbi request reprint Cannabinoid CB1 receptor stimulation affords neuroprotection in MPTP-induced neurotoxicity by attenuating S100B up-regulation in vitro
    Teresa Iuvone
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano, 49, 80131, Naples, Italy
    J Mol Med (Berl) 85:1379-92. 2007
    ..Our data suggest that selective activation of CB1 receptors by either exogenous or endogenous cannabinoids might afford neuroprotection in MPTP-induced neurotoxicity also by controlling S100B up-regulation in activated glial cells...
  59. ncbi request reprint Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors
    Antonella Brizzi
    Dipartimento Farmaco Chimico Tecnologico, Universita degli Studi di Siena, Via A Moro 2, 53100 Siena, Italy
    Bioorg Med Chem 15:5406-16. 2007
    ....
  60. ncbi request reprint Development of the first potent and specific inhibitors of endocannabinoid biosynthesis
    Tiziana Bisogno
    Endocannabinoid Research Group, Istituto di Chimica Biomolecolare, C N R, Via Campi Flegrei, 34 80078 Pozzuoli NA, Italy
    Biochim Biophys Acta 1761:205-12. 2006
    ..8-0.1 and 3.7-3.2 microM, respectively). Thus, we report the first potent and specific inhibitors of the biosynthesis of 2-AG that may be used as pharmacological tools to investigate the biological role of this endocannabinoid...