Paolo Bigini

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuropathol Exp Neurol 69:593-605. 2010
  2. ncbi request reprint Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis
    Costanza Savino
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Neuroimmunol 172:27-37. 2006
  3. ncbi request reprint Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milano, Italy
    Neurosci Lett 426:106-10. 2007
  4. pmc Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo
    Tiziana Mennini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 12:153-60. 2006
  5. pmc Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis
    Manuela Mengozzi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 14:682-8. 2008
  6. doi request reprint Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse
    Paolo Bigini
    Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Neurosci Res 90:1148-58. 2012
  7. pmc Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration
    Massimiliano De Paola
    Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 18:971-81. 2012
  8. doi request reprint Morphological features and responses to AMPA receptor-mediated excitotoxicity of mouse motor neurons: comparison in purified, mixed anterior horn or motor neuron/glia cocultures
    Massimiliano De Paola
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan, Italy
    J Neurosci Methods 170:85-95. 2008
  9. ncbi request reprint Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease
    Elena Fumagalli
    Laboratory of Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Exp Neurol 198:114-28. 2006
  10. doi request reprint Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156 Milano, Italy
    Neurobiol Dis 29:465-76. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Neuropathologic and biochemical changes during disease progression in liver X receptor beta-/- mice, a model of adult neuron disease
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Neuropathol Exp Neurol 69:593-605. 2010
    ....
  2. ncbi request reprint Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis
    Costanza Savino
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Neuroimmunol 172:27-37. 2006
    ..The possibility to dissociate the anti-neuroinflammatory action of EPO from its hematopoietic action, which may cause undesired side effects in non-anemic patients, present new avenues to the therapy of multiple sclerosis...
  3. ncbi request reprint Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milano, Italy
    Neurosci Lett 426:106-10. 2007
    ..These results strongly suggest that motor neuron death occurring in the wobbler mouse is not related to a caspase-dependent apoptotic mechanism...
  4. pmc Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo
    Tiziana Mennini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 12:153-60. 2006
    ..Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration...
  5. pmc Endogenous erythropoietin as part of the cytokine network in the pathogenesis of experimental autoimmune encephalomyelitis
    Manuela Mengozzi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 14:682-8. 2008
    ..Given the known inhibitory effect of EPO on neuroinflammation, our study indicates that EPO should be viewed as part of the inflammatory/anti-inflammatory network in MS...
  6. doi request reprint Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse
    Paolo Bigini
    Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Neurosci Res 90:1148-58. 2012
    ..Levels of glutamate 1-3 AMPA receptor subunits were increased, and levels of the NR2A NMDA receptor subunit were decreased in the hippocampus of mnd mice, suggesting an adaptive response to glutamate overstimulation...
  7. pmc Neuroprotective effects of toll-like receptor 4 antagonism in spinal cord cultures and in a mouse model of motor neuron degeneration
    Massimiliano De Paola
    Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 18:971-81. 2012
    ....
  8. doi request reprint Morphological features and responses to AMPA receptor-mediated excitotoxicity of mouse motor neurons: comparison in purified, mixed anterior horn or motor neuron/glia cocultures
    Massimiliano De Paola
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan, Italy
    J Neurosci Methods 170:85-95. 2008
    ....
  9. ncbi request reprint Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease
    Elena Fumagalli
    Laboratory of Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Exp Neurol 198:114-28. 2006
    ..Our data confirm that riluzole has beneficial effects in wobbler mice, and suggest that these effects could be associated to the increased levels of the neurotrophic and neuroprotective factor BDNF...
  10. doi request reprint Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156 Milano, Italy
    Neurobiol Dis 29:465-76. 2008
    ..rhTBP-1 might possibly bind TNF-alpha and reduce the downstream phosphorylation of two main effectors of the neuroinflammatory response, p38MAPK and JNK...
  11. doi request reprint Proteomic profiling of cervical and lumbar spinal cord reveals potential protective mechanisms in the wobbler mouse, a model of motor neuron degeneration
    Antonio Bastone
    Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Proteome Res 8:5229-40. 2009
    ..We suggest that overexpression of proteins involved in vesicle trafficking, together with proteins counteracting mitochondrial dysfunction can have neuroprotective effects, preserving lumbar spinal cord motor neurons in wobbler mice...
  12. doi request reprint Biocompatible fluorescent nanoparticles for in vivo stem cell tracking
    Lidia Cova
    Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy
    Nanotechnology 24:245603. 2013
    ..Our data suggest that these finely tunable and biocompatible fluoNPs can be exploited for the longitudinal tracking of stem cells...
  13. ncbi request reprint Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice
    Tiziana Mennini
    Department Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157, Milan, Italy
    Cytokine 25:127-35. 2004
    ..The role of TNF and TNFR-I on motor neurons is still to be demonstrated...
  14. pmc Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    BMC Neurosci 7:71. 2006
    ..Cervical regions from early or late symptomatic wobbler mice (4 or 12 weeks of age) were compared to lumbar tracts (unaffected) and to those of healthy mice...
  15. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
    ..These findings suggest that rhEPO attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-R-expressing inflammatory cells...
  16. ncbi request reprint Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia
    Angela Garau
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Cytokine 30:125-31. 2005
    ....
  17. pmc Human skeletal muscle stem cell antiinflammatory activity ameliorates clinical outcome in amyotrophic lateral sclerosis models
    Laura Canzi
    Department of Cerebrovascular Disease, IRCCS Foundation, Neurological Institute C Besta, Milan, Italy
    Mol Med 18:401-11. 2012
    ....
  18. pmc Longitudinal tracking of human fetal cells labeled with super paramagnetic iron oxide nanoparticles in the brain of mice with motor neuron disease
    Paolo Bigini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 7:e32326. 2012
    ....
  19. ncbi request reprint Immunohistochemical localization of TNFalpha and its receptors in the rodent central nervous system
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacolgical Research, Milan, Italy
    Methods Mol Med 98:73-80. 2004
    ..The technique is not quantitative, but allows qualitative comparison between samples with light-microscopic cellular resolution...
  20. pmc The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins
    Claudia Manzoni
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 6:e24909. 2011
    ..Based on these data we suggest that numerous proteins act as Aβ receptors in N2a cells, triggering a multi factorial toxicity...
  21. ncbi request reprint The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Curr Med Chem 14:3185-200. 2007
    ....
  22. ncbi request reprint Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder
    Tiziana Mennini
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Neurosci Res 70:553-60. 2002
    ..These changes in ionotropic glutamate receptors may alter glutamatergic neurotransmission and play some role in the pathology of mnd mice...
  23. doi request reprint Mesenchymal stem cell therapy promotes renal repair by limiting glomerular podocyte and progenitor cell dysfunction in adriamycin-induced nephropathy
    Carla Zoja
    Mario Negri Institute for Pharmacological Research, Centro Anna Maria Astori, Science and Technology Park Km Rosso, Via Stezzano, 87 24126 Bergamo, Italy
    Am J Physiol Renal Physiol 303:F1370-81. 2012
    ....
  24. pmc Applications of surface plasmon resonance (SPR) for the characterization of nanoparticles developed for biomedical purposes
    Mara Canovi
    Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano 20156, Italy
    Sensors (Basel) 12:16420-32. 2012
    ..e., the protein layer which coats NPs once they come into contact with biological fluids. These novel applications of SPR sensors may be very useful to characterize, screen and develop nanodevices for biomedical purposes...
  25. ncbi request reprint Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis
    Davide Agnello
    Department of Biochemistry, Mario Negri Institute of Pharmacological Research, 20157, Milan, Italy
    Brain Res 952:128-34. 2002
    ..These data suggest that EPO might act as a protective cytokine in inflammatory pathologies of the CNS...