P Bigini

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Curr Med Chem 14:3185-200. 2007
  2. doi request reprint Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse
    Paolo Bigini
    Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Neurosci Res 90:1148-58. 2012
  3. ncbi request reprint Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons
    P Bigini
    Laboratory for Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157 Milan, Italy
    Neurosci Lett 329:334-8. 2002
  4. ncbi request reprint Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milano, Italy
    Neurosci Lett 426:106-10. 2007
  5. pmc Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    BMC Neurosci 7:71. 2006
  6. ncbi request reprint Glutamate transporters in the spinal cord of the wobbler mouse
    P Bigini
    Laboratory of Receptor Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Neuroreport 12:1815-20. 2001
  7. doi request reprint Intracerebroventricular administration of human umbilical cord blood cells delays disease progression in two murine models of motor neuron degeneration
    P Bigini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Rejuvenation Res 14:623-39. 2011
  8. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
  9. doi request reprint Morphological features and responses to AMPA receptor-mediated excitotoxicity of mouse motor neurons: comparison in purified, mixed anterior horn or motor neuron/glia cocultures
    Massimiliano De Paola
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan, Italy
    J Neurosci Methods 170:85-95. 2008
  10. doi request reprint Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156 Milano, Italy
    Neurobiol Dis 29:465-76. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Curr Med Chem 14:3185-200. 2007
    ....
  2. doi request reprint Increased [³H]D-aspartate release and changes in glutamate receptor expression in the hippocampus of the mnd mouse
    Paolo Bigini
    Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    J Neurosci Res 90:1148-58. 2012
    ..Levels of glutamate 1-3 AMPA receptor subunits were increased, and levels of the NR2A NMDA receptor subunit were decreased in the hippocampus of mnd mice, suggesting an adaptive response to glutamate overstimulation...
  3. ncbi request reprint Acetyl-L-carnitine shows neuroprotective and neurotrophic activity in primary culture of rat embryo motoneurons
    P Bigini
    Laboratory for Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157 Milan, Italy
    Neurosci Lett 329:334-8. 2002
    ..These results suggest that ALCAR treatment improves the motoneurons activity, acting as a neurotrophic factor...
  4. ncbi request reprint Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milano, Italy
    Neurosci Lett 426:106-10. 2007
    ..These results strongly suggest that motor neuron death occurring in the wobbler mouse is not related to a caspase-dependent apoptotic mechanism...
  5. pmc Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice
    Paolo Bigini
    Laboratory of Receptor Pharmacology, Department of Biochemistry and Molecular Pharmacology, Mario Negri Institute for Pharmacological Research, Milano, Italy
    BMC Neurosci 7:71. 2006
    ..Cervical regions from early or late symptomatic wobbler mice (4 or 12 weeks of age) were compared to lumbar tracts (unaffected) and to those of healthy mice...
  6. ncbi request reprint Glutamate transporters in the spinal cord of the wobbler mouse
    P Bigini
    Laboratory of Receptor Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Neuroreport 12:1815-20. 2001
    ..Plasma concentrations of excitatory amino acids were no different at any time examined. Our results exclude the involvement of decrease in glutamate GLT 1 transporter in the motor neuron degeneration in wobbler mice...
  7. doi request reprint Intracerebroventricular administration of human umbilical cord blood cells delays disease progression in two murine models of motor neuron degeneration
    P Bigini
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Rejuvenation Res 14:623-39. 2011
    ..In particular, we show that HuCB-MNCs release a series of cytokines and chemokines with antiinflammatory properties that could be responsible of the functional improvement of mouse models of motor neuron degenerative disorders...
  8. pmc Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis
    Pia Villa
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Exp Med 198:971-5. 2003
    ..These findings suggest that rhEPO attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-R-expressing inflammatory cells...
  9. doi request reprint Morphological features and responses to AMPA receptor-mediated excitotoxicity of mouse motor neurons: comparison in purified, mixed anterior horn or motor neuron/glia cocultures
    Massimiliano De Paola
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan, Italy
    J Neurosci Methods 170:85-95. 2008
    ....
  10. doi request reprint Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19, 20156 Milano, Italy
    Neurobiol Dis 29:465-76. 2008
    ..rhTBP-1 might possibly bind TNF-alpha and reduce the downstream phosphorylation of two main effectors of the neuroinflammatory response, p38MAPK and JNK...
  11. pmc Nonhematopoietic erythropoietin derivatives prevent motoneuron degeneration in vitro and in vivo
    Tiziana Mennini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Mol Med 12:153-60. 2006
    ..Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration...
  12. ncbi request reprint Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder
    Tiziana Mennini
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Neurosci Res 70:553-60. 2002
    ..These changes in ionotropic glutamate receptors may alter glutamatergic neurotransmission and play some role in the pathology of mnd mice...
  13. ncbi request reprint Riluzole, unlike the AMPA antagonist RPR119990, reduces motor impairment and partially prevents motoneuron death in the wobbler mouse, a model of neurodegenerative disease
    Elena Fumagalli
    Laboratory of Receptor Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Exp Neurol 198:114-28. 2006
    ..Our data confirm that riluzole has beneficial effects in wobbler mice, and suggest that these effects could be associated to the increased levels of the neurotrophic and neuroprotective factor BDNF...
  14. ncbi request reprint Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis
    Costanza Savino
    Mario Negri Institute for Pharmacological Research, 20157, Milan, Italy
    J Neuroimmunol 172:27-37. 2006
    ..The possibility to dissociate the anti-neuroinflammatory action of EPO from its hematopoietic action, which may cause undesired side effects in non-anemic patients, present new avenues to the therapy of multiple sclerosis...
  15. ncbi request reprint Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice
    Tiziana Mennini
    Department Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacological Research, Via Eritrea, 62, 20157, Milan, Italy
    Cytokine 25:127-35. 2004
    ..The role of TNF and TNFR-I on motor neurons is still to be demonstrated...
  16. ncbi request reprint Immunohistochemical localization of TNFalpha and its receptors in the rodent central nervous system
    Paolo Bigini
    Department of Molecular Biochemistry and Pharmacology, Mario Negri Institute for Pharmacolgical Research, Milan, Italy
    Methods Mol Med 98:73-80. 2004
    ..The technique is not quantitative, but allows qualitative comparison between samples with light-microscopic cellular resolution...
  17. ncbi request reprint Retinal oxidation, apoptosis and age- and sex-differences in the mnd mutant mouse, a model of neuronal ceroid lipofuscinosis
    Rosetta Guarneri
    Istituto di Biomedicina e Immunologia Molecolare, I B I M C N R, Via Ugo La Malfa 153, Palermo 90146, Italy
    Brain Res 1014:209-20. 2004
    ..These results demonstrate the involvement of oxidation and apoptotic processes in mnd mouse retinopathy and highlight sex-related differences in retinal vulnerability to oxidative stress and damage...
  18. ncbi request reprint Evidence for chronic mitochondrial impairment in the cervical spinal cord of a murine model of motor neuron disease
    Barbara Santoro
    Department of Cellular and Molecular Physiological and Pharmacological Sciences, University of Pavia, PV, Italy
    Neurobiol Dis 17:349-57. 2004
    ..Thus, chronic mitochondrial dysfunction has a contributory role in motor neuron degeneration in the wobbler disease...
  19. ncbi request reprint Tumor necrosis factor-alpha receptor 1 (p55) knockout only transiently decreases the activation of c-Jun and does not affect the survival of axotomized dopaminergic nigral neurons
    Jan Wessig
    Institute of Pharmacology, Universitaetsklinikum Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    Eur J Neurosci 22:267-72. 2005
    ....
  20. ncbi request reprint Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis
    Davide Agnello
    Department of Biochemistry, Mario Negri Institute of Pharmacological Research, 20157, Milan, Italy
    Brain Res 952:128-34. 2002
    ..These data suggest that EPO might act as a protective cytokine in inflammatory pathologies of the CNS...
  21. pmc The interleukin-8 (IL-8/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats
    Pia Villa
    Mario Negri Institute, 20157 Milan, Italy
    Mol Med 13:125-33. 2007
    ..MRI analysis identified a decrease in the progression of infarct size by reparixin that was more evident at 48 h in permanent MCAO, and was associated with a significantly improved recovery from long-term neurological deficits...
  22. ncbi request reprint Neuroprotection with the CXCL8 inhibitor repertaxin in transient brain ischemia
    Angela Garau
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Cytokine 30:125-31. 2005
    ....
  23. ncbi request reprint S100B protein and 4-hydroxynonenal in the spinal cord of wobbler mice
    Valentina Corvino
    Institute of Anatomy, Catholic University, Rome, Italy
    Neurochem Res 28:341-5. 2003
    ..In the same spinal cord regions, scattered neurons appeared to be immunostained for 4-hydroxynonenal-modified proteins, an indicator of lipid peroxidation. This finding constitutes a sign of oxidative stress-induced neurodegeneration...