Pia Bernasconi

Summary

Affiliation: Istituto Nazionale Neurologico Carlo Besta
Country: Italy

Publications

  1. pmc Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution
    Pia Bernasconi
    Department of Neurology IV, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Am J Pathol 167:129-39. 2005
  2. pmc The empowerment of translational research: lessons from laminopathies
    Sara Benedetti
    National Research Council of Italy, Institute of Molecular Genetics, IGM CNR, Unit of Bologna, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Orphanet J Rare Dis 7:37. 2012
  3. ncbi request reprint Expression of transforming growth factor-beta1 in thymus of myasthenia gravis patients: correlation with pathological abnormalities
    Pia Bernasconi
    Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, 20133 Milan, Italy
    Ann N Y Acad Sci 998:278-83. 2003
  4. ncbi request reprint Myasthenia gravis (MG): epidemiological data and prognostic factors
    Renato Mantegazza
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, 20133 Milan, Italy
    Ann N Y Acad Sci 998:413-23. 2003
  5. ncbi request reprint Video-assisted thoracoscopic extended thymectomy and extended transsternal thymectomy (T-3b) in non-thymomatous myasthenia gravis patients: remission after 6 years of follow-up
    Renato Mantegazza
    Immunology and Muscular Pathology Unit, Department of Neuromuscular Diseases, Istituto Nazionale Neurologico Carlo Besta Via Celoria 11, 20133 Milan, Italy
    J Neurol Sci 212:31-6. 2003
  6. ncbi request reprint Analysis of SjTREC levels in thymus from MG patients and normal children
    Laura Passerini
    Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, 20133 Milan, Italy
    Ann N Y Acad Sci 998:270-4. 2003
  7. ncbi request reprint Immunomodulation of TGF-beta 1 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy
    Francesca Andreetta
    Department of Neuroimmunology and Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Neuroimmunol 175:77-86. 2006
  8. ncbi request reprint Anti-MOG autoantibodies in Italian multiple sclerosis patients: specificity, sensitivity and clinical association
    Renato Mantegazza
    Immunology and Muscular Pathology Neurology IV, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Int Immunol 16:559-65. 2004
  9. doi request reprint Etiology of myasthenia gravis: innate immunity signature in pathological thymus
    Paola Cavalcante
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Autoimmun Rev 12:863-74. 2013
  10. doi request reprint Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus
    Paola Cavalcante
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Ann Neurol 67:726-38. 2010

Collaborators

Detail Information

Publications21

  1. pmc Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution
    Pia Bernasconi
    Department of Neurology IV, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Am J Pathol 167:129-39. 2005
    ..We speculate that in a subgroup of MG patients, an exogenous or endogenous danger signal may activate the innate immune system and give rise to TLR4-mediated mechanisms contributing to autoimmunity...
  2. pmc The empowerment of translational research: lessons from laminopathies
    Sara Benedetti
    National Research Council of Italy, Institute of Molecular Genetics, IGM CNR, Unit of Bologna, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Orphanet J Rare Dis 7:37. 2012
    ....
  3. ncbi request reprint Expression of transforming growth factor-beta1 in thymus of myasthenia gravis patients: correlation with pathological abnormalities
    Pia Bernasconi
    Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, 20133 Milan, Italy
    Ann N Y Acad Sci 998:278-83. 2003
  4. ncbi request reprint Myasthenia gravis (MG): epidemiological data and prognostic factors
    Renato Mantegazza
    Immunology and Muscular Pathology Unit, National Neurological Institute Carlo Besta, 20133 Milan, Italy
    Ann N Y Acad Sci 998:413-23. 2003
    ....
  5. ncbi request reprint Video-assisted thoracoscopic extended thymectomy and extended transsternal thymectomy (T-3b) in non-thymomatous myasthenia gravis patients: remission after 6 years of follow-up
    Renato Mantegazza
    Immunology and Muscular Pathology Unit, Department of Neuromuscular Diseases, Istituto Nazionale Neurologico Carlo Besta Via Celoria 11, 20133 Milan, Italy
    J Neurol Sci 212:31-6. 2003
    ....
  6. ncbi request reprint Analysis of SjTREC levels in thymus from MG patients and normal children
    Laura Passerini
    Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, 20133 Milan, Italy
    Ann N Y Acad Sci 998:270-4. 2003
  7. ncbi request reprint Immunomodulation of TGF-beta 1 in mdx mouse inhibits connective tissue proliferation in diaphragm but increases inflammatory response: implications for antifibrotic therapy
    Francesca Andreetta
    Department of Neuroimmunology and Neuromuscular Diseases, National Neurological Institute Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    J Neuroimmunol 175:77-86. 2006
    ..Reduction of TGF-beta1 appears promising as a therapeutic approach to muscle fibrosis, but further studies are required to evaluate long term effects of TGF-beta1 immunomodulation on the immune system...
  8. ncbi request reprint Anti-MOG autoantibodies in Italian multiple sclerosis patients: specificity, sensitivity and clinical association
    Renato Mantegazza
    Immunology and Muscular Pathology Neurology IV, Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    Int Immunol 16:559-65. 2004
    ..5%) of MS patients and no OND patients. Anti-MOG antibodies are not specific for MS; however, they may characterize a subset of MS patients and this may be revealed by serial assays in relation to changing disease phase...
  9. doi request reprint Etiology of myasthenia gravis: innate immunity signature in pathological thymus
    Paola Cavalcante
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Autoimmun Rev 12:863-74. 2013
    ....
  10. doi request reprint Epstein-Barr virus persistence and reactivation in myasthenia gravis thymus
    Paola Cavalcante
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Ann Neurol 67:726-38. 2010
    ..We sought evidence of EBV infection in thymuses from patients with myasthenia gravis (MG), an autoimmune disease characterized by intrathymic B-cell activation...
  11. pmc Inflammation and epstein-barr virus infection are common features of myasthenia gravis thymus: possible roles in pathogenesis
    Paola Cavalcante
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Neurological Institute C Besta Foundation, 20133 Milan, Italy
    Autoimmune Dis 2011:213092. 2011
    ..Altogether, our results support a role of inflammation and EBV infection as pathogenic features of MG thymus...
  12. ncbi request reprint Fibrogenic cytokines and extent of fibrosis in muscle of dogs with X-linked golden retriever muscular dystrophy
    Laura Passerini
    Myopathology and Immunology Unit, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, 20133, Milan, Italy
    Neuromuscul Disord 12:828-35. 2002
    ....
  13. ncbi request reprint Human adult skeletal muscle stem cells differentiate into cardiomyocyte phenotype in vitro
    Gloria Invernici
    Neurobiology and Neuroregenerative Therapies Unit, Fondazione IRCCS Neurological Institute C Besta, Milan 20133, Italy
    Exp Cell Res 314:366-76. 2008
    ....
  14. doi request reprint Autoimmune mechanisms in myasthenia gravis
    Paola Cavalcante
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico Carlo Besta, Milan, Italy
    Curr Opin Neurol 25:621-9. 2012
    ..This article reviews recent findings on factors and mechanisms implicated in the pathogenesis of myasthenia gravis and briefly summarizes data on therapies acting at various stages of the autoimmune process...
  15. ncbi request reprint Antibodies against GluR3 peptides are not specific for Rasmussen's encephalitis but are also present in epilepsy patients with severe, early onset disease and intractable seizures
    Renato Mantegazza
    Immunology and Muscular Pathology Unit, Istituto Nazionale Neurologico Carlo Besta, Via Celoria 11, Milan, Italy
    J Neuroimmunol 131:179-85. 2002
    ..Antibodies against GluR3B peptide were significantly associated with frequent seizures compared to occasional or drug-controlled seizures...
  16. doi request reprint Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: a longitudinal MRI study
    Stefania Marcuzzo
    Department of Neurology IV, Neuromuscular Diseases and Neuroimmunology, Fondazione Istituto Neurologico Carlo Besta, Milan, 20133, Italy
    Exp Neurol 231:30-7. 2011
    ....
  17. ncbi request reprint Allorecognition of human neural stem cells by peripheral blood lymphocytes despite low expression of MHC molecules: role of TGF-beta in modulating proliferation
    Federica Ubiali
    Neurology IV, Neurological Institute Foundation Carlo Besta, Milan, Italy
    Int Immunol 19:1063-74. 2007
    ..Nevertheless, the possibility that allo-NSCs grafting might induce in the long term an immune activation, thus vanishing their therapeutical effect, should not be overlooked and deserves further investigation...
  18. doi request reprint Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies
    C Cappelletti
    Department of Neurology IV, Neurological Institute Foundation Carlo Besta, Via Celoria 11, 20133 Milan, Italy
    Neurology 76:2079-88. 2011
    ..Recent evidence suggests a key role for type I interferon (IFN)-mediated innate immunity in dermatomyositis, which we explored in JDM, dermatomyositis, and PM by gene expression profiling, and other methods...
  19. doi request reprint BDNF and its receptors in human myasthenic thymus: implications for cell fate in thymic pathology
    Angela Berzi
    Foundation IRCCS Neurological Institute Carlo Besta, Milan, Italy
    J Neuroimmunol 197:128-39. 2008
    ..In thymomas both BDNF production and receptor expression in TEC were strongly hindered. This may represent an attempt of tumour escape from cell death...
  20. doi request reprint The kinesin superfamily motor protein KIF4 is associated with immune cell activation in idiopathic inflammatory myopathies
    Pia Bernasconi
    Neurology IV, Foundation Neurological Institute Carlo Besta, Department of Medical Pharmacology, Milan, Italy
    J Neuropathol Exp Neurol 67:624-32. 2008
    ..These results imply that KIF4 is associated with activated T cells, irrespective of their functional phenotype, and that it is likely involved in cytoskeletal modifications associated with in situ T-cell activation in IIM...
  21. ncbi request reprint Decorin and biglycan expression is differentially altered in several muscular dystrophies
    Simona Zanotti
    Division of Neuromuscular Diseases and Neuroimmunology, Istituto Nazionale Neurologico C Besta, Milano, Italy
    Brain 128:2546-55. 2005
    ..The significantly lowered decorin levels in DMD and MDC1A may be related to the increased TGF-beta1 levels, suggesting a therapeutic role of decorin in these severe dystrophies...