Ettore Beghi

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi request reprint Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: facts and uncertainties underlying the causal link between animal and human diseases
    E Beghi
    Mario Negri Institute of Pharmacological Research, Via Eritrea 62, I 20157 Milan, Italy
    Neurol Sci 25:122-9. 2004
  2. ncbi request reprint Incidence of ALS in Lombardy, Italy
    E Beghi
    Clinica Neurologica, Monza, Italy
    Neurology 68:141-5. 2007
  3. ncbi request reprint Learning disorders in epilepsy
    Massimiliano Beghi
    Department of Clinical Psychiatry, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Epilepsia 47:14-8. 2006
  4. ncbi request reprint Direct cost of medical management of epilepsy among adults in Italy: a prospective cost-of-illness study (EPICOS)
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 45:171-8. 2004
  5. ncbi request reprint The epidemiology of ALS and the role of population-based registries
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Biochim Biophys Acta 1762:1150-7. 2006
  6. ncbi request reprint Surgery for epilepsy: assessing evidence from observational studies
    Ettore Beghi
    Laboratorio di Malattie Neurologiche, Istituto Mario Negri, Milano, Italy
    Epilepsy Res 70:97-102. 2006
  7. ncbi request reprint Mortality in patients with a first unprovoked seizure
    Ettore Beghi
    Centro per l Epilessia, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Epilepsia 46:40-2. 2005
  8. ncbi request reprint Basic and clinical research on amyotrophic lateral sclerosis and other motor neuron disorders in Italy: recent findings and achievements from a network of laboratories
    E Beghi
    Neurological Disorders Laboratory, Neuroscience Department, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurol Sci 25:S41-60. 2004
  9. ncbi request reprint 127th ENMC International Workshop: implementation of a European registry of ALS. Naarden, The Netherlands, 8-10 October 2004
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Neuromuscul Disord 16:46-53. 2006
  10. doi request reprint Management of a first seizure. General conclusions and recommendations
    Ettore Beghi
    Laboratory of Neurological Disorders, Institute for Pharmacological Research Mario Negri, Milano, Italy
    Epilepsia 49:58-61. 2008

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease: facts and uncertainties underlying the causal link between animal and human diseases
    E Beghi
    Mario Negri Institute of Pharmacological Research, Via Eritrea 62, I 20157 Milan, Italy
    Neurol Sci 25:122-9. 2004
    ....
  2. ncbi request reprint Incidence of ALS in Lombardy, Italy
    E Beghi
    Clinica Neurologica, Monza, Italy
    Neurology 68:141-5. 2007
    ..To assess the incidence and trends of ALS in a large population at risk...
  3. ncbi request reprint Learning disorders in epilepsy
    Massimiliano Beghi
    Department of Clinical Psychiatry, University of Milano Bicocca, San Gerardo Hospital, Monza, Italy
    Epilepsia 47:14-8. 2006
    ..In contrast, state-dependent LD are potentially reversible and treatable; they are caused by epilepsy-related factors. If allowed to persist for a long period, a state-dependent LD may become permanent...
  4. ncbi request reprint Direct cost of medical management of epilepsy among adults in Italy: a prospective cost-of-illness study (EPICOS)
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Epilepsia 45:171-8. 2004
    ..To investigate the costs of epilepsy from a nationwide survey comparing adult patients included in different prognostic categories...
  5. ncbi request reprint The epidemiology of ALS and the role of population-based registries
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy
    Biochim Biophys Acta 1762:1150-7. 2006
  6. ncbi request reprint Surgery for epilepsy: assessing evidence from observational studies
    Ettore Beghi
    Laboratorio di Malattie Neurologiche, Istituto Mario Negri, Milano, Italy
    Epilepsy Res 70:97-102. 2006
    ....
  7. ncbi request reprint Mortality in patients with a first unprovoked seizure
    Ettore Beghi
    Centro per l Epilessia, Universita di Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Epilepsia 46:40-2. 2005
    ..prospective). We review the four studies of this topic...
  8. ncbi request reprint Basic and clinical research on amyotrophic lateral sclerosis and other motor neuron disorders in Italy: recent findings and achievements from a network of laboratories
    E Beghi
    Neurological Disorders Laboratory, Neuroscience Department, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Neurol Sci 25:S41-60. 2004
    ..Information is now available on non-pharmacological treatments and palliative care, and the economic aspects and quality of life of ALS patients are being investigated...
  9. ncbi request reprint 127th ENMC International Workshop: implementation of a European registry of ALS. Naarden, The Netherlands, 8-10 October 2004
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Neuromuscul Disord 16:46-53. 2006
  10. doi request reprint Management of a first seizure. General conclusions and recommendations
    Ettore Beghi
    Laboratory of Neurological Disorders, Institute for Pharmacological Research Mario Negri, Milano, Italy
    Epilepsia 49:58-61. 2008
  11. ncbi request reprint Validity and reliability of the Italian version of the Quality-of-Life in Epilepsy Inventory (QOLIE-31)
    Ettore Beghi
    Clinica Neurologica, Universita Milano Bicocca, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Seizure 14:452-8. 2005
    ..To develop an Italian adaptation of the shortened version of the Quality-of-Life in Epilepsy Inventory (QOLIE-31)...
  12. ncbi request reprint Efficacy and tolerability of the new antiepileptic drugs: comparison of two recent guidelines
    Ettore Beghi
    Epilepsy Center, University of Milano Bicocca, Ospedale San Gerardo, Monza, Italy
    Lancet Neurol 3:618-21. 2004
    ..In addition, 20-30% of patients are refractory to these drugs...
  13. ncbi request reprint Primary prevention of epilepsy in patients with different epileptogenic conditions
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Expert Rev Neurother 4:945-52. 2004
    ..Suggestions for future research are also made as concluding remarks, by indicating the areas of investigation and the design of future studies...
  14. ncbi request reprint A review of the costs of managing childhood epilepsy
    Ettore Beghi
    Epilepsy Center, University of Milano Bicocca, Monza, Italy
    Pharmacoeconomics 23:27-45. 2005
    ..Seizure control by drugs, ketogenic diet or surgery is associated with a significant reduction in the costs of epilepsy...
  15. ncbi request reprint Methodology of studies on the epidemiology of headache
    E Beghi
    Clinica Neurologica, Ospedale San Gerardo, Monza Laboratorio di Malattie Neurologiche, Istituto Mario Negri, Milan, Italy
    Neurol Sci 25:S70-3. 2004
    ..A proper knowledge of the problems in the conduction and interpretation of the epidemiological studies helps the investigators to optimise the study protocols and the practicing physicians to critically view the published results...
  16. ncbi request reprint Diagnosis and treatment of the first epileptic seizure: guidelines of the Italian League against Epilepsy
    Ettore Beghi
    Department of Clinical Neurology, University of Milano Bicocca, Monza, and Institute, Mario Negri, Milan, Italy
    Epilepsia 47:2-8. 2006
    ..Long-term treatment may be considered in patients with abnormal EEG and imaging data and after consideration of the social, emotional, and personal implications of seizure relapse...
  17. ncbi request reprint Epilepsy
    Ettore Beghi
    Epilepsy Center, Ospedale San Gerardo, Monza, Italy
    Curr Opin Neurol 20:169-74. 2007
    ..To provide a critical review of studies published between December 2005 and November 2006, and detect the advances of basic and clinical research in epilepsy...
  18. ncbi request reprint Overview of studies to prevent posttraumatic epilepsy
    Ettore Beghi
    Epilepsy Center, University of Milano Bicocca, Monza, and Istituto Mario Negri, Milano, Italy
    Epilepsia 44:21-6. 2003
    ....
  19. doi request reprint Antiepileptic drugs and the immune system
    Ettore Beghi
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Epilepsia 52:40-4. 2011
    ..Phenytoin, carbamazepine, phenobarbital, lamotrigine, oxcarbazepine, felbamate, and zonisamide have been implicated. The pathogenic mechanisms of AHS are incompletely understood...
  20. pmc Amyotrophic lateral sclerosis, physical exercise, trauma and sports: results of a population-based pilot case-control study
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Amyotroph Lateral Scler 11:289-92. 2010
    ..68-10.88) and duration of sport-related physical exercise (OR 1.03; 95% CI 1.00-1.05) were independent variables in multivariate analysis. We concluded that ALS is associated with physical exercise but not with traumatic events...
  21. ncbi request reprint Pregnancy registries in epilepsy
    E Beghi
    Centro per l Epilessia, Ospedale San Gerardo, Monza, and Istituto Mario Negri, Milano, Italy
    Epilepsia 42:1422-5. 2001
    ....
  22. doi request reprint The concept of the epilepsy syndrome: how useful is it in clinical practice?
    Ettore Beghi
    Laboratorio di Malattie Neurologiche, Istituto Mario Negri, Milano, Italy
    Epilepsia 50:4-10. 2009
    ....
  23. doi request reprint Utilization and costs of antiepileptic drugs in the elderly: still an unsolved issue
    Massimiliano Beghi
    Department of Clinical Psychiatry, University of Milano Bicocca, Milan, Italy
    Drugs Aging 26:157-68. 2009
    ..However, there are no cost-effectiveness studies in the elderly and further evidence is needed to confirm these assumptions...
  24. doi request reprint Accidents and injuries in patients with epilepsy
    Ettore Beghi
    Dipartimento di Neuroscienze, Istituto Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Expert Rev Neurother 9:291-8. 2009
    ..When epileptogenic conditions and seizure-related events are excluded, patients with epilepsy are only at a slightly greater risk of accidents and injuries than the general population...
  25. ncbi request reprint Morbidity and accidents in patients with epilepsy: results of a European cohort study
    Ettore Beghi
    Centro Regionale per l Epilessia e Clinica Neurologica, Universita di Milano Bicocca, Monza, Italy
    Epilepsia 43:1076-83. 2002
    ..To assess the risk of illnesses and accidents in patients with epilepsy and to evaluate the proportion of those risks attributable to epilepsy...
  26. ncbi request reprint Economic analysis of newer antiepileptic drugs
    Ettore Beghi
    Laboratorio di Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    CNS Drugs 22:861-75. 2008
    ..Future studies should be implemented using a standardized approach to define the costs and outcomes of representative cohorts of patients with newly diagnosed epilepsy recruited from different countries and followed prospectively...
  27. ncbi request reprint Reliability of the El Escorial diagnostic criteria for amyotrophic lateral sclerosis
    Ettore Beghi
    Clinica Neurologica, Ospedale San Gerardo, Monza, Italia
    Neuroepidemiology 21:265-70. 2002
    ..The accuracy of the El Escorial criteria was tested in clinical practice, but the reliability is unknown when the diagnosis of ALS must be assessed on the basis of medical records...
  28. ncbi request reprint The heterogeneity of amyotrophic lateral sclerosis: a possible explanation of treatment failure
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    Curr Med Chem 14:3185-200. 2007
    ....
  29. ncbi request reprint Headache and anxiety-depressive disorder comorbidity: the HADAS study
    E Beghi
    Istituto Laboratorio di Malattie Neurologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Neurol Sci 28:S217-9. 2007
    ..3, 1.1 and 9.4% (p=0.009). Based on these results, psychopathology of primary headache can be a reflection of the burden of the disease rather than a hallmark of a specific headache category...
  30. ncbi request reprint Idiopathic generalized epilepsies of adolescence
    Massimiliano Beghi
    Clinical Psychiatry, University of Milano Bicocca, Milan, Italy
    Epilepsia 47:107-10. 2006
    ..Some patients become obstinate and are impressionable. The cognitive and behavioral aspects of these patients suggest an involvement of frontal lobes...
  31. ncbi request reprint Injuries in patients with epilepsy
    Ettore Beghi
    Epilepsy Center, University of Milano Bicocca, Monza, Italy
    Lancet Neurol 4:71-2. 2005
  32. pmc Headache, anxiety and depressive disorders: the HADAS study
    Ettore Beghi
    Dipartimento di Neuroscienze, Istituto Mario Negri, Milan, Italy
    J Headache Pain 11:141-50. 2010
    ..This also applied to obsessive-compulsive disorder (OR 4.8; 95% CI 1.1-20.9) in migraine plus tension-type headache. Psychopathology of primary headache can reflect shared risk factors, pathophysiologic mechanisms, and disease burden...
  33. doi request reprint Early versus late remission in a cohort of patients with newly diagnosed epilepsy
    Alessandra Del Felice
    Clinica Neurologica, Dipartimento di Neurologia e Scienze della Visione, Universita degli Studi di Verona, Italy
    Epilepsia 51:37-42. 2010
    ..To count patients with newly diagnosed epilepsy entering early and late remission and to identify prognostic predictors of late remission...
  34. ncbi request reprint Physical activity and amyotrophic lateral sclerosis: a European population-based case-control study
    Elisabetta Pupillo
    Neurological Diseases Laboratory, Institute of Hospitalization and Scientific Care Mario Negri Institute, Milan, Italy
    Ann Neurol 75:708-16. 2014
    ..To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS)...
  35. ncbi request reprint Long-term survival in amyotrophic lateral sclerosis: a population-based study
    Elisabetta Pupillo
    Department of Neurosciences, IRCSS, Mario Negri Institute of Pharmacological Research, Milan
    Ann Neurol 75:287-97. 2014
    ..To determine the long-term survival in amyotrophic lateral sclerosis (ALS) and identify predictors of prolonged survival in a population-based cohort of newly diagnosed patients...
  36. doi request reprint Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for ALS
    Ettore Beghi
    Dipartimento di Neuroscienze, Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milan, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 14:397-405. 2013
    ..Median survival was 45 months (ALC) and 22 months (placebo) (p = 0.0176). MRC, QoL and adverse events were similar. In conclusion, ALC may be effective, well-tolerated and safe in ALS. A pivotal phase III trial is needed...
  37. pmc The epidemiology and treatment of ALS: focus on the heterogeneity of the disease and critical appraisal of therapeutic trials
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, 20156 Milano, Italy
    Amyotroph Lateral Scler 12:1-10. 2011
    ..Further understanding of these factors will lead to improvements in patient stratification, and in the design of future clinical trials...
  38. pmc Prognostic factors in ALS: A critical review
    Adriano Chio
    Department of Neuroscience, University of Torino and San Giovanni Battista Hospital, Turin, Italy
    Amyotroph Lateral Scler 10:310-23. 2009
    ..Alternative trial designs can include the use of natural history controls, the so-called minimization method for treatment allocation, and the futility approach...
  39. ncbi request reprint Psychiatric events in epilepsy
    Cesare Maria Cornaggia
    Clinical Psychiatry, University of Milano Bicocca, V Cadore 48, 20052 Monza, Milan, Italy
    Seizure 16:586-92. 2007
    ..No correlation was found between psychiatric events, demographic and disease characteristics. Our results suggest that people with epilepsy if unselected are not at higher risk for psychiatric disorders than the general population...
  40. ncbi request reprint Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005
    R Savica
    Department of Neuroscience, Psychiatry and Anesthesiology, University of Messina, Italy
    Eur J Neurol 14:1317-21. 2007
    ..An increasing use of AEDs has been recently observed over a 6-year period in Italian general practice, mostly explained by newer compounds used for conditions other than epilepsy...
  41. doi request reprint Specific language disorders and season of birth: underlying environmental factors or chance findings?
    Alessandro Ghezzo
    Fondazione Don Carlo Gnocchi, Milan, Italy
    J Clin Exp Neuropsychol 34:836-40. 2012
    ..67 (95% CI [1.35-2.07]) chance of birth in October-December. Independent predictors were younger age at inclusion and being firstborn. Different neurobiological hypotheses can be drawn to explain these findings...
  42. doi request reprint Risk factors for a first epileptic seizure after stroke: a case control study
    Maurizio A Leone
    Clinica Neurologica, Ospedale Maggiore della Carita, Novara, Italy
    J Neurol Sci 277:138-42. 2009
    ..The risk of seizures increases after stroke, but not all risk factors are known. We aimed to identify factors that increase the risk of a first seizure after a stroke...
  43. doi request reprint Risk factors for a first epileptic seizure symptomatic of brain tumour or brain vascular malformation. A case control study
    Maurizio A Leone
    Clinica Neurologica, Ospedale Maggiore della Carita, C Mazzini 18, 28100 Novara, Italy
    Swiss Med Wkly 141:w13155. 2011
    ..We aimed to identify factors that increase the risk of a first seizure in patients with BT or BVM...
  44. ncbi request reprint Correlation between cognition and behavior in epilepsy
    Cesare Maria Cornaggia
    Clinical Psychiatry, University of Milano Bicocca, Milan, Italy
    Epilepsia 47:34-9. 2006
    ..More specifically, conditions in which behavioral disorders may be associated with epilepsy include depression, psychosis, particular personality traits, aggression, anxiety, and attention deficit and hyperactivity disorder...
  45. ncbi request reprint The costs of epilepsy in Italy: a prospective cost-of-illness study in referral patients with disease of different severity
    A Tetto
    Centro per l Epilessia e Clinica Neurologica, Ospedale San Gerardo, Monza, Italy
    Epilepsy Res 48:207-16. 2002
    ..However, information is insufficient on the comparative costs of different disease varieties. The purpose of this study was to compare the direct costs of epilepsy in referral patients with disease of different severity and duration...
  46. ncbi request reprint Treatment of the first tonic-clonic seizure does not affect long-term remission of epilepsy
    Maurizio A Leone
    Clinica Neurologica, Ospedale Maggiore della Carita, C so Mazzini, 18 28100 Novara, Italy
    Neurology 67:2227-9. 2006
    ..The probability of entering 5-year remission was 47 to 40, 58 to 58, and 64 to 64% (p = NS). Early treatment does not affect the long-term prognosis of epilepsy...
  47. ncbi request reprint Depression and altered quality of life in women with epilepsy of childbearing age
    Ettore Beghi
    Clinica Neurologica, Universita Milano Bicocca, Monza Istituto Mario Negri, Milan, Italy
    Epilepsia 45:64-70. 2004
    ..To calculate the prevalence of depression in a referral population of women of childbearing age, to define the factors associated with depression, and to assess health-related quality of life (HRQOL) in the same population...
  48. doi request reprint Withdrawal of antiepileptic drugs: guidelines of the Italian League Against Epilepsy
    Ettore Beghi
    Department of Neuroscience, IRCCS Institute of Pharmacological Research Mario Negri, Milan, Italy
    Epilepsia 54:2-12. 2013
    ..As a general habit, the decision to stop treatment should be discussed and shared with each patient, taking into account social and personal complications of a seizure relapse and the medical complications of chronic AED treatment...
  49. doi request reprint Satisfaction with antiepileptic drugs in children and adolescents with newly diagnosed and chronic epilepsy
    Ettore Beghi
    Laboratory of Neurological Disorders, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Epilepsy Res 100:142-51. 2012
    ..To assess incidence, indicators and outcome of satisfaction with antiepileptic drugs in children...
  50. ncbi request reprint Morbidity in patients with epilepsy: type and complications: a European cohort study
    Mariska van den Broek
    Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milano, Italy
    Epilepsia 45:71-6. 2004
    ..To investigate the risk of illnesses in a cohort of patients with epilepsy and in matched nonepilepsy controls, by type and complications...
  51. ncbi request reprint Outcome measures and prognostic indicators in patients with amyotrophic lateral sclerosis
    Ettore Beghi
    Clinica Neurologica, Universita di Milano Bicocca, Monza
    Amyotroph Lateral Scler 9:163-7. 2008
    ..In conclusion, patients with ALS differ in terms of measures and predictors of disability. These factors are sources of bias and confounding in randomized clinical trials...
  52. ncbi request reprint Health-related quality of life in epilepsy: findings obtained with a new Italian instrument
    Ada Piazzini
    Epilepsy Center, St Paolo Hospital, Milan, Italy
    Epilepsy Behav 13:119-26. 2008
    ..We believe that a new specific questionnaire for the evaluation of HRQOL in Italy can contribute much to the understanding of the influence of epilepsy on patients' lives...
  53. pmc Health-related quality of life in adults with epilepsy: the effect of age, age at onset and duration of epilepsy in a multicentre Italian study
    Valeria Edefonti
    Sezione di Statistica Medica e Biometria Giulio A Maccacaro, Dipartimento di Medicina del Lavoro Clinica del Lavoro L Devoto, Universita degli Studi di Milano, Milan, Italy
    BMC Neurol 11:33. 2011
    ..The potential effect of age-related factors on health-related quality of life (HRQOL) of patients with epilepsy has rarely been analyzed in the literature...
  54. doi request reprint Alternative monotherapy or add-on therapy in patients with epilepsy whose seizures do not respond to the first monotherapy: an Italian multicenter prospective observational study
    Andrea Millul
    Laboratorio di Malattie Neurologiche, IRCCS, Istituto Mario Negri di Milano, Italy
    Epilepsy Behav 28:494-500. 2013
    ..Patients were followed for 365.3person-years. Three hundred eighty-three incident AEs were reported by 46.4% of patients in monotherapy and 40.2% in polytherapy (serious AEs: 9.6% vs. 8.7%, mostly nondrug-related). ..
  55. pmc A mouse model of familial ALS has increased CNS levels of endogenous ubiquinol9/10 and does not benefit from exogenous administration of ubiquinol10
    Jacopo Lucchetti
    Department of Biochemistry and Molecular Pharmacology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    PLoS ONE 8:e69540. 2013
    ..Therefore, the very low increases of CoQ10 induced by oral treatments in CNS might be not sufficient to provide significant neuroprotection in SOD1(G93A) mice. ..
  56. ncbi request reprint Accidents at work among people with epilepsy. Results of a European prospective cohort study
    Cesare Maria Cornaggia
    Clinica Psichiatrica, Universita di Milano Bicocca, Via Cadore 48, 20052 Monza Milano, Italy
    Seizure 15:313-9. 2006
    ..This study confirms that patients with epilepsy are at higher risk of accidents compared to the general population. However, injuries provoked by work accidents are generally mild and unrelated to seizures...
  57. doi request reprint The use of recently approved antiepileptic drugs: use with caution, use in refractory patients or use as first-line indications?
    Ettore Beghi
    Laboratory of Neurological Disorders, Istituto Mario Negri, Via La Masa 19, 20156, Milano, Italy
    Expert Rev Neurother 11:1759-67. 2011
    ....
  58. ncbi request reprint Adjunctive therapy versus alternative monotherapy in patients with partial epilepsy failing on a single drug: a multicentre, randomised, pragmatic controlled trial
    Ettore Beghi
    Mario Negri Institute for Pharmacological Research, Milan, Italy
    Epilepsy Res 57:1-13. 2003
    ..To evaluate the value of alternative monotherapy versus adjunctive therapy in partial epilepsy refractory to single antiepileptic drug (AED) therapy...
  59. ncbi request reprint Does mechanism of drug action matter to inform rational polytherapy in epilepsy?
    Giorgia Giussani
    Istituto di Ricerche Farmacologiche Mario Negri, Via G La Masa 19, Milan, Italy
    CNS Neurol Disord Drug Targets 12:426-35. 2013
    ..Future studies are necessary to better define rational combinations and complementary mechanisms of action, considering also pharmacokinetic interactions and measures of toxicity and not only drug efficacy...
  60. ncbi request reprint Comprehensive educational plan for patients with epilepsy and comorbidity (EDU-COM): a pragmatic randomised trial
    Simone Beretta
    Department of Neurology, San Gerardo Hospital, University of Milano Bicocca, Monza, Italy
    J Neurol Neurosurg Psychiatry 85:889-94. 2014
    ..The impact of educational strategies in the management of adverse treatment effects and drug interactions in adult patients with epilepsy with comorbidities remains undetermined...
  61. ncbi request reprint Are professional soccer players at higher risk for ALS?
    Ettore Beghi
    IRCCS Institute of Pharmacological Research Mario Negri, Milan, Italy
    Amyotroph Lateral Scler Frontotemporal Degener 14:501-6. 2013
    ..Only cohort and case-control studies carried out with the same design in different European countries can provide a definite answer to this suspected but still unconfirmed association...
  62. ncbi request reprint Description and validation of an Italian ICHD-II-based questionnaire for use in epidemiological research
    Giorgia Abrignani
    Headache Centre, Department of Neuroscience, University of Parma, Parma, Italy
    Headache 52:1262-82. 2012
    ..In the absence of biological markers, the diagnosis of primary headache in epidemiological studies rests on clinical findings, as reported through ad-hoc interviews...
  63. ncbi request reprint Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial
    Eduardo Nobile-Orazio
    Department of Translational Medicine, Milan University, 2nd Neurology, IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy
    Lancet Neurol 11:493-502. 2012
    ..We compared the efficacy and tolerability of 6-month therapy with IVIg versus that with intravenous methylprednisolone...
  64. ncbi request reprint Incidence and clinical features of acute inflammatory polyradiculoneuropathy in Lombardy, Italy, 1996
    Graziella Bogliun
    Dipartimento di Scienze Neurologiche, Università Bicocca, Monza, Italy
    Acta Neurol Scand 110:100-6. 2004
    ..To assess the annual incidence of typical Guillain-Barré syndrome (GBS) and its main variants (atypical GBS) in a well-defined population from a large area...
  65. doi request reprint Coffee and amyotrophic lateral sclerosis: a possible preventive role
    Ettore Beghi
    Laboratory of Neurological Disorders, Mario Negri Institute, Via G La Masa 19, 20156 Milano, Italy
    Am J Epidemiol 174:1002-8. 2011
    ..7 (95% CI: 0.5, 1.0), 0.5 (95% CI: 0.3, 0.7), and 0.4 (95% CI: 0.2, 0.8), respectively. These findings provide epidemiologic evidence of an inverse correlation between coffee intake and ALS risk...
  66. doi request reprint Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy
    Giuseppe Capovilla
    Child Neuropsychiatry Department, Epilepsy Center, C Poma Hospital, Mantua, Italy
    Epilepsia 54:23-34. 2013
    ..These drugs need to be administered in intensive care units to ensure the monitoring and support of vital signs and brain electrical activity...
  67. doi request reprint Inter-rater agreement in the assessment of response to motor and cognitive rehabilitation of children and adolescents with epilepsy
    Ettore Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Paediatr Neurol 15:254-9. 2011
    ..To assess inter-rater agreement among child neurologists and psychiatrists on evaluation of response to physical and cognitive rehabilitation of children and adolescents with epilepsy...
  68. doi request reprint Recommendation for a definition of acute symptomatic seizure
    Ettore Beghi
    Mario Negri Institute, Milan, Italy
    Epilepsia 51:671-5. 2010
    ..To consider the definition of acute symptomatic seizures for epidemiological studies, and to refine the criteria used to distinguish these seizures from unprovoked seizures for specific etiologies...
  69. ncbi request reprint Cluster headache prevalence in the Italian general population
    Paola Torelli
    Headache Center, Section of Neurology, Department of Neuroscience, University of Parma, Italy
    Neurology 64:469-74. 2005
    ..Prevalence of cluster headache (CH) is estimated at 56 to 69 per 100,000...
  70. doi request reprint The management of a first seizure--still a major debate
    Ettore Beghi
    Laboratory of Neurological Disorders, Institute for Pharmacological Research Mario Negri, Milan, Italy
    Epilepsia 49:1. 2008
  71. doi request reprint AED discontinuation may not be dangerous in seizure-free patients
    Ettore Beghi
    Laboratory of Neurological Disorders, Istituto di Ricerche Famacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy
    J Neural Transm 118:187-91. 2011
    ..Patients will ultimately have to decide themselves whether they wish to discontinue drug treatment...
  72. ncbi request reprint The sinister side of Italian soccer
    Simone Beretta
    Department of Neuroscience, University of Milano Bicocca, Milan, Italy
    Lancet Neurol 2:656-7. 2003
  73. ncbi request reprint Epilepsy and quality of life in adults: a review of instruments
    Maurizio A Leone
    Clinica Neurologica, Ospedale Maggiore della Carita, Novara, Italy
    Epilepsy Res 66:23-44. 2005
    ..All the other instruments should at present be considered only for second choice...
  74. ncbi request reprint Prevalence, characteristics, and patterns of health care use for chronic headache in two areas of Italy. Results of a questionnaire interview in general practice
    E Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Cephalalgia 23:175-82. 2003
    ..Chronic headache is common among individuals seen in general practice. The patterns of health care use tend to be correlated to its severity. A better knowledge of the IHS criteria may be directly related to lower management costs...
  75. doi request reprint Modeling drop-outs in amyotrophic lateral sclerosis
    Paolo Messina
    Laboratory of Neurological Disorders, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy
    Contemp Clin Trials 33:218-22. 2012
    ..006 and p=0.0002). Pattern mixture model thus seem superior and we recommend its use to obtain more accurate estimates even when the information is missing...
  76. ncbi request reprint Epileptogenic drugs: a systematic review
    Claudio Ruffmann
    Centro per l Epilessia e Clinica Neurologica, Università Bicocca, Monza, Milan, Italy
    Expert Rev Neurother 6:575-89. 2006
    ..Drugs with low epileptogenic potential include fluorquinolones, carbapenems, bupropion and iodinated contrast media. Drugs with minimal or inconclusive epileptogenic potential include interferon alpha...
  77. doi request reprint Barriers toward epilepsy surgery. A survey among practicing neurologists
    Giuseppe Erba
    Strong Epilepsy Center, Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Epilepsia 53:35-43. 2012
    ..The aim of this study was to assess knowledge and attitudes toward epilepsy surgery among practicing neurologists and identify the barriers that delay the treatment...
  78. ncbi request reprint Validity of hospital discharge diagnoses for the assessment of the prevalence and incidence of amyotrophic lateral sclerosis
    E Beghi
    Laboratorio Malattie Neurologiche, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Amyotroph Lateral Scler Other Motor Neuron Disord 2:99-104. 2001
    ..The accuracy of HDDs was tested, to assess whether they could be used to trace patients with amyotrophic lateral sclerosis (ALS)...
  79. doi request reprint Distinct cytokine patterns associated with different forms of chronic dysimmune neuropathy
    Maira Gironi
    Department of Neurology, Don C Gnocchi Foundation IRCCS, Milan, Italy
    Muscle Nerve 42:864-70. 2010
    ..These distinctive immune alterations may represent a biological tool in differential diagnosis and future therapeutic approaches...
  80. doi request reprint Acute medical complications in patients admitted to a stroke unit and safe transfer to rehabilitation
    Donatella Bonaiuti
    Physical Medicine and Rehabilitation Department, S Gerardo Hospital, Monza, Italy
    Neurol Sci 32:619-23. 2011
    ..4%), fever (6.7%) and pulmonary disease (5.2%). Heart disease was the earliest and shortest complication. Most complications occurred during the first week. Except for hypertension, all complications resolved within 2 weeks...
  81. ncbi request reprint A post-marketing study on immunomodulating treatments for relapsing-remitting multiple sclerosis in Lombardia: preliminary results
    C Milanese
    Multiple Sclerosis Center, National Neurological Institute C Besta, Via Celoria 11, I 20133, Milan, Italy
    Neurol Sci 26:S171-3. 2005
    ..Forty-eight of them shifted to a second therapeutic agent. A different trend, to lower or higher doses of interferon or immunosuppression, according to reasons of discontinuation, was observed...
  82. ncbi request reprint Validity of hospital discharge diagnoses for public health surveillance of the Guillain-Barrè syndrome
    G Bogliun
    Department of Neurological Sciences, Bicocca University, Monza, Italy
    Neurol Sci 23:113-7. 2002
    ..0 (95% CI, 1.1-3.2) when the analysis was limited to the primary diagnostic level. HDDs from neurology departments are a fairly valid surrogate of GBS incidence in Lombardy, Italy...
  83. ncbi request reprint Epilepsy and everyday life risks. A case-referent study: rationale, study design, and preliminary results. Risk in Epilepsy Study Group
    E Beghi
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Neuroepidemiology 16:207-16. 1997
    ..Accidents and related events occurred in similar proportions in the 2 groups. Based on the results of the pilot study, idiopathic, cryptogenic and remote symptomatic epilepsy may be compatible with an at least fairly normal social life...
  84. pmc Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy
    L M Specchio
    Centro per l Epilessia, Clinica Neurologica I, Universita di Bari, Dipartimento di Scienze Neurologiche e Psichiatriche, Ospedale Policlinico, Piazza G Cesare, 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 72:22-5. 2002
    ..To assess the recurrence rate of epilepsy attributable to discontinuation of treatment in seizure free patients and to identify the risk factors for recurrence...
  85. ncbi request reprint BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson's disease
    F R Guerini
    Laboratory of Molecular Medicine and Biotechnology, Don C Gnocchi Foundation IRCCS, Milan, Italy
    Eur J Neurol 16:1240-5. 2009
    ..The purpose of this study was to analyze such possible association in a cohort of Italian PD patients...
  86. ncbi request reprint The Cochrane collaboration in neurology: acquisitions, research, and new initiatives
    C Tonini
    Clinica Neurologica, Ospedale 'San Gerardo, Monza, Italy
    Neuroepidemiology 20:153-9. 2001
    ....
  87. ncbi request reprint Decreased platelet glutamate uptake in patients with amyotrophic lateral sclerosis
    C Ferrarese
    Department of Neurosciences and Biomedical Technologies, University of Milano-Bicocca, Ospedale San Gerardo, Monza, Italy
    Neurology 56:270-2. 2001
    ..A 43% reduction of high-affinity glutamate uptake rate (p < 0.0001) was observed in patients with ALS compared with normal controls and chronic neurologic disorder patients, suggesting a systemic impairment of glutamate uptake in ALS...
  88. ncbi request reprint Hemodynamic instability after extracranial carotid stenting
    G Pappadà
    Department of Neurosurgery, University of Milano Bicocca, Ospedale San Gerardo, Monza Milan, Italy
    Acta Neurochir (Wien) 148:639-45. 2006
    ..CAS implies instrumentation of the carotid bulb, so baroceptor dysfunction may provoke hemodynamic instability. The aim of this work was to calculate the incidence of this complication and to detect factors to predict it...
  89. ncbi request reprint Management of headache in emergency room
    E Agostoni
    Stroke Unit, Centro Cefalee, Clinica Neurologica, Universita degli Studi Milano Bicocca, Ospedale San Gerardo, Via Donizetti 106, I 20052 Monza MI, Italy
    Neurol Sci 25:S187-9. 2004
    ..Based on our results, patients seen at the ER for a headache episode can be fairly successfully managed by the ER physician, except those who present a first attack, for whom neurological consultation is needed...
  90. ncbi request reprint Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial
    A Chio
    Department of Neuroscience, Via Cherasco 15, 10126 Torino, Italy
    Neurology 75:619-25. 2010
    ..4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG])...
  91. ncbi request reprint Validation of a questionnaire for the detection of cluster headache
    P Torelli
    Department of Neuroscience, Headache Center, Section of Neurology, University of Parma, c o Ospedale Maggiore, Via Gramsci 14, 43100 Parma, Italy
    Headache 45:644-52. 2005
    ..In the absence of biological markers, the diagnosis of cluster headache (CH) rests on clinical evidence as reported through ad-hoc interviews...
  92. ncbi request reprint Predictors of epilepsy surgery outcome: a meta-analysis
    C Tonini
    Laboratory of Neurological Disorders, Institute for Pharmacological Research Mario Negri, Via Eritrea, 62, 20157 Milan, Italy
    Epilepsy Res 62:75-87. 2004
    ....
  93. pmc The first seizure and its management in adults and children
    Bernd Pohlmann-Eden
    Bethel Epilepsy Centre, Bethel, Germany
    BMJ 332:339-42. 2006
  94. ncbi request reprint Accidents in patients with epilepsy: types, circumstances, and complications: a European cohort study
    Mariska van den Broek
    Epilepsia 45:667-72. 2004
    ..To investigate the risk of accidents in a cohort of patients with epilepsy and in matched nonepilepsy controls, by type, circumstances, and complications...
  95. ncbi request reprint Medical risks in epilepsy: a review with focus on physical injuries, mortality, traffic accidents and their prevention
    Torbjorn Tomson
    Department of Clinical Neuroscience, Karolinska Institute, SE 171 76 Stockholm, Sweden
    Epilepsy Res 60:1-16. 2004
    ..Moreover, the preventive measures in legislation may be ignored by many people with epilepsy...
  96. ncbi request reprint Should antiepileptic drugs be withdrawn in seizure-free patients?
    Luigi M Specchio
    Clinic of Neurology, University of Foggia, Ospedali Riuniti, Foggia, Italy
    CNS Drugs 18:201-12. 2004
    ..The decision plan should also take into account social factors (driving license, job and leisure activities) as well as emotional and personal factors, and must be tailored to and discussed with the individual patient and his/her family...
  97. ncbi request reprint ILAE Commission on the Burden of Epilepsy, Subcommission on the Economic Burden of Epilepsy: Final report 1998-2001
    Charles E Begley
    School of Public Health, University of Texas Houston, Houston, USA
    Epilepsia 43:668-73. 2002
  98. ncbi request reprint Should anti-epileptic drugs be used for preventing seizures after acute traumatic brain injury?
    Alfonso Iudice
    Neuroepidemiology 22:100. 2003
  99. doi request reprint Cost of disorders of the brain in Italy
    Maura Pugliatti
    Dipartimento di Neuroscienze e Scienze Materno Infantili, Universita di Sassari, Viale San Pietro 10, 07100, Sassari, Italy
    Neurol Sci 29:99-107. 2008
    ..This figure is however likely to be underestimated as it is based on retrospective methodology and samples of brain disorders, and does not include intangible costs...
  100. ncbi request reprint Prevalence and characteristics of epilepsy in the Aeolian islands
    Guiseppe Gallitto
    Neurology Unit, University Hospital, Messina, Italy
    Epilepsia 46:1828-35. 2005
    ..To estimate the prevalence and define the clinical characteristics of epileptic disorders in the 13,431 residents of the Sicilian Aeolian archipelago, on June 1, 1999...