Gianfranco Bazzoni

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi Glial cells drive preconditioning-induced blood-brain barrier protection
    Raffaella Gesuete
    Laboratory of Inflammation and Nervous System Diseases, Mario Negri Institute, Via G La Masa 19, 20156 Milan, Italy
    Stroke 42:1445-53. 2011
  2. ncbi The JAM family of junctional adhesion molecules
    Gianfranco Bazzoni
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157, Milano, Italy
    Curr Opin Cell Biol 15:525-30. 2003
  3. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
  4. ncbi Signalling pathways and adhesion molecules as targets for antiangiogenesis therapy in tumors
    Gianfranco Bazzoni
    Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Adv Exp Med Biol 610:74-87. 2008
  5. ncbi Expression of junctional adhesion molecule-A prevents spontaneous and random motility
    Gianfranco Bazzoni
    Laboratory of Systems Biology, Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Cell Sci 118:623-32. 2005
  6. ncbi Endothelial tight junctions: permeable barriers of the vessel wall
    Gianfranco Bazzoni
    Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milano, Italy
    Thromb Haemost 95:36-42. 2006
  7. ncbi Effect of microtubule-targeting drugs on cell-cell and cell-matrix junctions in tumor epithelial cells
    Laura Tonutti
    Mario Negri Institute of Pharmacological Research, Milano, Italy
    Anticancer Drugs 22:234-44. 2011
  8. ncbi Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells
    Ofelia M Martinez-Estrada
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157 Milan, Italy
    Am J Physiol Lung Cell Mol Physiol 288:L1081-8. 2005
  9. ncbi The protein interaction network of the epithelial junctional complex: a system-level analysis
    Luca Paris
    Istituto di Ricerche Farmacologiche Mario Negri, I 20156 Milan, Italy
    Mol Biol Cell 19:5409-21. 2008
  10. ncbi Pathobiology of junctional adhesion molecules
    Gianfranco Bazzoni
    Department of Biochemistry and Molecular Pharmacology Mario Negri Institute of Pharmacological Research, Milano, Italy
    Antioxid Redox Signal 15:1221-34. 2011

Collaborators

Detail Information

Publications16

  1. ncbi Glial cells drive preconditioning-induced blood-brain barrier protection
    Raffaella Gesuete
    Laboratory of Inflammation and Nervous System Diseases, Mario Negri Institute, Via G La Masa 19, 20156 Milan, Italy
    Stroke 42:1445-53. 2011
    ..The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components...
  2. ncbi The JAM family of junctional adhesion molecules
    Gianfranco Bazzoni
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157, Milano, Italy
    Curr Opin Cell Biol 15:525-30. 2003
    ..All these features represent the likely determinants for the role of junctional adhesion molecule proteins in processes as diverse as junction assembly, leukocyte transmigration and platelet activation...
  3. ncbi Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
    ..Finally, we analyze in vivo studies and highlight information that specifically relates to the role of junctions in vascular endothelial cells...
  4. ncbi Signalling pathways and adhesion molecules as targets for antiangiogenesis therapy in tumors
    Gianfranco Bazzoni
    Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Adv Exp Med Biol 610:74-87. 2008
  5. ncbi Expression of junctional adhesion molecule-A prevents spontaneous and random motility
    Gianfranco Bazzoni
    Laboratory of Systems Biology, Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Cell Sci 118:623-32. 2005
    ..Thus, by regulating cytoskeletal and adhesive structures, JAM-A expression prevents cell motility, probably in a PSD95-Dlg-ZO1-dependent manner...
  6. ncbi Endothelial tight junctions: permeable barriers of the vessel wall
    Gianfranco Bazzoni
    Department of Biochemistry and Molecular Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milano, Italy
    Thromb Haemost 95:36-42. 2006
    ..Finally, the signaling events that regulate paracellular permeability are discussed...
  7. ncbi Effect of microtubule-targeting drugs on cell-cell and cell-matrix junctions in tumor epithelial cells
    Laura Tonutti
    Mario Negri Institute of Pharmacological Research, Milano, Italy
    Anticancer Drugs 22:234-44. 2011
    ..g. cell confluence and junction opening, respectively), when determining the final effects of microtubule manipulation on cell adhesiveness...
  8. ncbi Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells
    Ofelia M Martinez-Estrada
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157 Milan, Italy
    Am J Physiol Lung Cell Mol Physiol 288:L1081-8. 2005
    ..We found that fibronectin reduces the effect of TNF on the disassembly of JAM-A, but not on its dispersal, thus further stressing that disassembly and dispersal can be functionally dissociated...
  9. ncbi The protein interaction network of the epithelial junctional complex: a system-level analysis
    Luca Paris
    Istituto di Ricerche Farmacologiche Mario Negri, I 20156 Milan, Italy
    Mol Biol Cell 19:5409-21. 2008
    ..In particular, two major modules (corresponding to the tight junctions and to the adherens junctions/desmosomes) were linked preferentially to two other modules that acted as structural and signaling platforms...
  10. ncbi Pathobiology of junctional adhesion molecules
    Gianfranco Bazzoni
    Department of Biochemistry and Molecular Pharmacology Mario Negri Institute of Pharmacological Research, Milano, Italy
    Antioxid Redox Signal 15:1221-34. 2011
    ..This review focuses on the different roles of junctional adhesion molecules in normal and pathologic conditions, with emphasis on inflammatory reactions and vascular responses to injury...
  11. ncbi Structural organization of the tight junctions
    Luca Paris
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Biochim Biophys Acta 1778:646-59. 2008
    ....
  12. ncbi Eicosapentaenoic acid inhibits endothelial cell migration in vitro
    Laura Tonutti
    Mario Negri Institute of Pharmacological Research, Via La Masa 19, Milano, Italy
    J Angiogenes Res 2:12. 2010
    ..As n-3 Polyunsaturated Fatty Acids exert a beneficial action on the cardiovascular system, it is important to investigate their effects on endothelial cell responses that (like migration) contribute to repairing vascular lesions...
  13. ncbi Keratinocyte junctions and the epidermal barrier: how to make a skin-tight dress
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Cell Biol 156:947-9. 2002
    ..Furuse et al. (2002)(this issue) demonstrate that functional tight junctions may indeed be a necessary part of the permeability barrier of the skin...
  14. ncbi Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo
    Fay C Thomas
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    J Cell Sci 117:5599-608. 2004
    ....
  15. ncbi Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice
    Maria Rosaria Cera
    Department of Vascular Biology, Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
    J Clin Invest 114:729-38. 2004
    ..Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity...
  16. ncbi Junctional adhesion molecule-A regulates cell migration and resistance to shear stress
    Hayden Huang
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Cell Physiol 209:122-30. 2006
    ..Taken together, these data indicate that JAM-A regulates cell motility by cooperating with microtubule-stabilizing pathways...