Research Topics
| F AloisiSummaryAffiliation: Istituto Superiore di Sanit Country: Italy Publications
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Detail Information
Publications
Intracerebral regulation of immune responsesF Aloisi
Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Rome, Italy
Ann Med 33:510-5. 2001..In this article we shall briefly review current knowledge of how the immune response is regulated locally in the CNS and which cell types and molecular mechanisms are involved in shaping intracerebral immune responses...- Lymphoid neogenesis in chronic inflammatory diseasesFrancesca Aloisi
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Rome, Italy
Nat Rev Immunol 6:205-17. 2006..As more information on these issues becomes available, a better understanding of the role of lymphoid neogenesis in promoting chronic inflammation might eventually lead to new strategies to target immunopathological processes... - Immune function of microgliaF Aloisi
Neurophysiology Unit, Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Roma, Italy
Glia 36:165-79. 2001..This article focuses on the signals regulating microglia innate immune functions, the role of microglia in antigen presentation, and their possible involvement in the development of CNS immunopathology... - Glia-T cell dialogueF Aloisi
Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Roma, Italy
J Neuroimmunol 107:111-7. 2000.... - Relative efficiency of microglia, astrocytes, dendritic cells and B cells in naive CD4+ T cell priming and Th1/Th2 cell restimulationF Aloisi
Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Roma, Italy
Eur J Immunol 29:2705-14. 1999..These potentially pathogenic responses could be counteracted by the high efficiency of astrocytes as well as microglia in restimulating Th2 cells... 
Lymphoid chemokines in chronic neuroinflammationFrancesca Aloisi
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, 00161 Rome, Italy
J Neuroimmunol 198:106-12. 2008....- Opposite effects of interferon-gamma and prostaglandin E2 on tumor necrosis factor and interleukin-10 production in microglia: a regulatory loop controlling microglia pro- and anti-inflammatory activitiesF Aloisi
Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Roma, Italy
J Neurosci Res 56:571-80. 1999..We suggest that the activity and role of microglia in the damaged CNS could be finely tuned by the local concentration ratio of these mediators... - ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation: involvement of metabotropic P2 receptorsC Agresti
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Roma, Italy
Brain Res Brain Res Rev 48:157-65. 2005..These findings suggest that ATP, which is released in high amounts under inflammatory conditions and following cell death, might regulate remyelination processes in inflammatory demyelinating diseases of the CNS, like multiple sclerosis... - Synergistic stimulation of MHC class I and IRF-1 gene expression by IFN-gamma and TNF-alpha in oligodendrocytesC Agresti
Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Rome, Italy
Eur J Neurosci 10:2975-83. 1998..The synergism demonstrated in the present study highlights the importance of cytokine interactions in magnifying their biological effects during brain injury and inflammation... - Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and developmentC Agresti
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
Glia 50:132-44. 2005..These data indicate that ATP and ADP may regulate oligodendrocyte progenitor functions by a mechanism that involves mainly activation of P2Y(1) receptors... - Astrocyte cultures from human embryonic brain: characterization and modulation of surface molecules by inflammatory cytokinesF Aloisi
Neurobiology Section, , Rome, Italy
J Neurosci Res 32:494-506. 1992..The human astrocyte cultures developed here represent a useful in vitro model to further investigate mechanisms involved in bidirectional communication between central glia and cells of the immune system... - Epstein-Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twinsR Mechelli
S Andrea Hospital Site, Sapienza University, Rome, Italy
Mult Scler 17:1290-4. 2011..Compared with quantitative observations, the search for qualitative changes that may characterize the immune response to Epstein-Barr virus (EBV) in multiple sclerosis (MS) has been less intense... - Growth factorsF Aloisi
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanit, Viale Regina Elena 299, I-00161, Rome, Italy
Neurol Sci 24:S291-4. 2003..A future challenge is to use this knowledge to boost remyelination and ameliorate clinical symptoms in patients with demyelinating diseases, like multiple sclerosis... - HIV-1 Nef alters the expression of betaII and epsilon isoforms of protein kinase C and the activation of the long terminal repeat promoter in human astrocytoma cellsE Ambrosini
Istituto Superiore di Sanita, Rome, Italy
Glia 27:143-51. 1999..These results suggest that Nef may alter astrocytic functions by interfering with PKC expression and activation and contribute to the restriction of HIV-1 replication in astrocytes... - Peripheral tissue release of interleukin-6 in patients with chronic kidney diseases: effects of end-stage renal disease and microinflammatory stateG Garibotto
Department of Internal Medicine, Nephrology Division, Genoa University, Genoa, Italy
Kidney Int 70:384-90. 2006..The release of IL-6 from peripheral tissues may act as a signal for the inflammatory response and contribute to functional dysregulation in uremia...