Paola Allavena

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. ncbi Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production
    Paola Allavena
    Department of Immunology, Mario Negri Institute, Milan, Italy
    Cancer Res 65:2964-71. 2005
  2. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
  3. ncbi Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
    Monica Rimoldi
    Department of Experimental Oncology, European Institute of Oncology, I 20141 Milan, Italy
    Nat Immunol 6:507-14. 2005
  4. ncbi Linking inflammation reactions to cancer: novel targets for therapeutic strategies
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
    Adv Exp Med Biol 610:112-27. 2008
  5. doi The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
  6. ncbi From pattern recognition receptor to regulator of homeostasis: the double-faced macrophage mannose receptor
    Paola Allavena
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea, 62, 20157 Milan, Italy
    Crit Rev Immunol 24:179-92. 2004
  7. ncbi Monocytes from Wiskott-Aldrich patients differentiate in functional mature dendritic cells with a defect in CD83 expression
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:3413-21. 2001
  8. doi Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
  9. ncbi Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin
    Valeria Sordi
    Immunology of Diabetes Unit, San Raffaele Scientific Institute, Milan, Italy
    Transplantation 82:826-34. 2006
  10. doi The chemokine system in cancer biology and therapy
    Alberto Mantovani
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Cytokine Growth Factor Rev 21:27-39. 2010

Detail Information

Publications92

  1. ncbi Anti-inflammatory properties of the novel antitumor agent yondelis (trabectedin): inhibition of macrophage differentiation and cytokine production
    Paola Allavena
    Department of Immunology, Mario Negri Institute, Milan, Italy
    Cancer Res 65:2964-71. 2005
    ....
  2. ncbi Cross-linking of the mannose receptor on monocyte-derived dendritic cells activates an anti-inflammatory immunosuppressive program
    Marcello Chieppa
    Department of Immunology, Istituto Mario Negri, Milan, Italy
    J Immunol 171:4552-60. 2003
    ....
  3. ncbi Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
    Monica Rimoldi
    Department of Experimental Oncology, European Institute of Oncology, I 20141 Milan, Italy
    Nat Immunol 6:507-14. 2005
    ..This control of immune responses seemed to be lost in patients with Crohn disease. Thus, the intimate interplay between intestinal epithelial cells and dendritic cells may help to maintain gut immune homeostasis...
  4. ncbi Linking inflammation reactions to cancer: novel targets for therapeutic strategies
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
    Adv Exp Med Biol 610:112-27. 2008
  5. doi The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Immunol Rev 222:155-61. 2008
    ..Herein, the 'macrophage balance' is discussed in the context of the apparent paradox of tumor promotion by innate immunity-driven inflammation and the seemingly opposed tumor surveillance by adaptive immune responses...
  6. ncbi From pattern recognition receptor to regulator of homeostasis: the double-faced macrophage mannose receptor
    Paola Allavena
    Department of Immunology and Cell Biology, Mario Negri Institute, Via Eritrea, 62, 20157 Milan, Italy
    Crit Rev Immunol 24:179-92. 2004
    ....
  7. ncbi Monocytes from Wiskott-Aldrich patients differentiate in functional mature dendritic cells with a defect in CD83 expression
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:3413-21. 2001
    ....
  8. doi Macrophage polarization in tumour progression
    Antonio Sica
    Department of Inflammation and Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Semin Cancer Biol 18:349-55. 2008
    ..Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer...
  9. ncbi Differential effects of immunosuppressive drugs on chemokine receptor CCR7 in human monocyte-derived dendritic cells: selective upregulation by rapamycin
    Valeria Sordi
    Immunology of Diabetes Unit, San Raffaele Scientific Institute, Milan, Italy
    Transplantation 82:826-34. 2006
    ..The proper localization of DC in selected tissues is guided primarily by the coordinated expression of chemokine receptors (CKR). Here we show that immunosuppressive drugs have divergent effects on the modulation of CKR in maturing DC...
  10. doi The chemokine system in cancer biology and therapy
    Alberto Mantovani
    Department of Translational Medicine, University of Milan, I 20089 Rozzano, Milan, Italy
    Cytokine Growth Factor Rev 21:27-39. 2010
    ..Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies...
  11. ncbi Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Tumori 89:459-68. 2003
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumor growth and progression...
  12. ncbi Infiltration of tumours by macrophages and dendritic cells: tumour-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 256:137-45; discussion 146-8, 259-69. 2004
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumours, play a key role in subversion of adaptive immunity and in inflammatory circuits which promote tumour growth and progression...
  13. ncbi Role of macrophage targeting in the antitumor activity of trabectedin
    Giovanni Germano
    Department Immunology and Inflammation, IRCCS Clinical and Research Institute Humanitas, 20089 Rozzano, Milan, Italy
    Cancer Cell 23:249-62. 2013
    ..This unexpected property may be exploited in different therapeutic strategies...
  14. ncbi The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages
    Paola Allavena
    IRCCS Istituto Clinico Humanitas, Via Manzoni 56, Rozzano 20089, Milan, Italy
    Crit Rev Oncol Hematol 66:1-9. 2008
    ..In this review we will discuss the role of TAM in the inflammatory micro-environment of solid tumors and will try to identify potential target for future therapeutic approaches...
  15. doi Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Hum Immunol 70:325-30. 2009
    ..As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer...
  16. ncbi Targeting tumour-associated macrophages
    Antonio Sica
    Department of Immunology, Fondazione Humanitas per la Ricerca, 20089 Rozzano, Milan, Italy
    Expert Opin Ther Targets 11:1219-29. 2007
    ..This evidence strongly supports the idea that TAM are central orchestrators of the inflammatory networks expressed in the tumour microenvironment, and suggest these cells as possible targets of anticancer therapies...
  17. ncbi Role of CX3CR1/CX3CL1 axis in primary and secondary involvement of the nervous system by cancer
    Federica Marchesi
    Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    J Neuroimmunol 224:39-44. 2010
    ..This peculiar route of tumor spread is used also by other carcinomas (e.g. prostate, head and neck) and may represent a target for therapeutic intervention...
  18. doi Targeting of the innate immunity/inflammation as complementary anti-tumor therapies
    Giovanni Germano
    Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Rozzano, Milan, Italy
    Ann Med 43:581-93. 2011
    ..For these reasons new molecules with anti-tumor and anti-inflammatory features (e.g. trabectedin) are looked at with new eyes in the light of the crucial link between inflammation and cancer...
  19. doi Cancer related inflammation: the macrophage connection
    Antonio Sica
    Fondazione Humanitas per Ricerca, 20089 Rozzano, Milan, Italy
    Cancer Lett 267:204-15. 2008
    ..This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches...
  20. ncbi Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4
    Federica Marchesi
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    Cancer Res 64:8420-7. 2004
    ..CXCR4 not only stimulates cell motility and invasion but also promotes survival and proliferation. Strategies to target CXCR4 expressed on tumor cells may be of benefit in patients with pancreatic cancer...
  21. ncbi Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
    Francesco Colotta
    Nerviano Medical Sciences, Nerviano, Milan, Italy
    Carcinogenesis 30:1073-81. 2009
    ..In a seminal contribution, Hanahan and Weinberg [(2000) Cell, 100, 57-70] identified the six hallmarks of cancer. We surmise that CRI represents the seventh hallmark...
  22. ncbi Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13
    Patrick Perrier
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 172:7031-42. 2004
    ..This novel finding reveals that IL-10 sustains humoral immunity by inducing the production in APCs of the chemokine, CXCL13, which amplifies B cell recruitment and promotes lymphoid tissue neogenesis...
  23. ncbi Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy
    Antonio Sica
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Eur J Cancer 42:717-27. 2006
    ..Evidence is presented here supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and are a potential target for anti-cancer therapy...
  24. doi The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma
    Federica Marchesi
    Department of Immunology and Inflammation, IRCCS Clinical Institute Humanitas, Rozzano, Milano, Italy
    Cancer Res 68:9060-9. 2008
    ..Thus, the CX3CR1-CX3CL1 axis could represent a valuable therapeutic target to prevent tumor perineural dissemination in pancreatic cancer...
  25. ncbi Chemokines in the recruitment and shaping of the leukocyte infiltrate of tumors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, Milan 20157, Italy
    Semin Cancer Biol 14:155-60. 2004
    ..Chemokine-recruited and positioned tumor infiltrating leukocytes are a key component of inflammatory circuits which promote tumor progression...
  26. ncbi Rapamycin impairs antigen uptake of human dendritic cells
    Paolo Monti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Milan, Italy
    Transplantation 75:137-45. 2003
    ..Rapamycin is a recently introduced immunosuppressive agent. Its effect on lymphocytes has been extensively studied. Whether it can also modulate dendritic cell (DC) function is unknown...
  27. ncbi Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells
    Andrea Doni
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur J Immunol 33:2886-93. 2003
    ..These results suggest that DC of myelomonocytic origin are a major source of PTX3, a molecule which facilitates pathogen recognition and subsequent activation of innate and adaptive immunity...
  28. doi Inflammation-mediated promotion of invasion and metastasis
    Graziella Solinas
    Laboratory for Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Cancer Metastasis Rev 29:243-8. 2010
    ..These results provide impetus for efforts aimed at translating cancer-related inflammation into diagnostic-prognostic markers and innovative therapeutic strategies...
  29. ncbi Role of tumor-associated macrophages in tumor progression and invasion
    Alberto Mantovani
    Istituto Clinico Humanitas, 20089 Rozzano, Milan, Italy
    Cancer Metastasis Rev 25:315-22. 2006
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  30. doi Cytokines as a key component of cancer-related inflammation
    Giovanni Germano
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Cytokine 43:374-9. 2008
    ..Cytokines involved in cancer-related inflammation represent a target for innovative diagnostic and therapeutic strategies, and a future challenge for scientists and clinicians...
  31. ncbi Inflammation and cancer: breast cancer as a prototype
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Breast 16:S27-33. 2007
    ..Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy...
  32. doi Comparison of in vitro and in vivo biological effects of trabectedin, lurbinectedin (PM01183) and Zalypsis® (PM00104)
    Michela Romano
    Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, Milan, Italy
    Int J Cancer 133:2024-33. 2013
    ....
  33. doi Pathways connecting inflammation and cancer
    Paola Allavena
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Curr Opin Genet Dev 18:3-10. 2008
    ..Thus, an intrinsic pathway of inflammation (driven in tumor cells), as well as an extrinsic pathway (in tumor-infiltrating leukocytes) have been described and both contribute to tumor progression...
  34. doi Molecular pathways and targets in cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, Milan, Italy
    Ann Med 42:161-70. 2010
    ..Emerging evidence also suggests that cancer-related inflammation promotes genetic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  35. ncbi Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression
    Alberto Mantovani
    Instituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Eur J Cancer 40:1660-7. 2004
    ..As polarised type II macrophages, TAM are a key component of the inflammatory circuits that promote tumour progression...
  36. ncbi Monocyte-derived dendritic cells activated by bacteria or by bacteria-stimulated epithelial cells are functionally different
    Monica Rimoldi
    Department of Experimental Oncology, European Institute of Oncology, Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Blood 106:2818-26. 2005
    ..These results suggest that ECs are not simply a barrier to bacteria entering via the oral route, but they actively influence the activating properties of DCs...
  37. ncbi Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers
    Giuseppe Di Caro
    Authors Affiliations Departments of Immunology and Inflammation and Gastroenterology Laboratory of Molecular Gastroenterology, Humanitas Clinical and Research Center, Rozzano and Department of Biotechnologies and Translational Medicine, University of Milan, Milan, Italy
    Clin Cancer Res 20:2147-58. 2014
    ..Its occurrence in cancer is sporadically documented and its role and clinical relevance is largely unknown...
  38. doi Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis
    Federica Marchesi
    Dpt Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    Cytokine Growth Factor Rev 21:77-82. 2010
    ..Better understanding of the neurotropism of malignant cells and of the clinical significance of PNI would help the design of innovative strategies for the control of tumor dissemination and pain in cancer patients...
  39. doi Chemokines in cancer related inflammation
    Paola Allavena
    Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089, Rozzano, Milan, Italy
    Exp Cell Res 317:664-73. 2011
    ..Evidence in pre-clinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies...
  40. ncbi Molecular pathways in cancer-related inflammation
    Annalisa Del Prete
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Biochem Med (Zagreb) 21:264-75. 2011
    ..Emerging evidence also suggests that persistent inflammation promotes genetic instability. Thus, cancer-related inflammation represents a target for innovative diagnostic and therapeutic strategies...
  41. ncbi Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    Alberto Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Trends Immunol 23:549-55. 2002
    ..These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression...
  42. ncbi Chemotaxis and interaction with vascular or lymphatic endothelium
    Silvano Sozzani
    The Mario Negri Institute of Pharmacological Research, Milan, Italy
    Methods Mol Biol 239:1-16. 2004
  43. ncbi Generation and functional characterisation of dendritic cells from patients with pancreatic carcinoma with special regard to clinical applicability
    L Piemonti
    Surgical Department, S Raffaele Scientific Institute, Milan, Italy
    Cancer Immunol Immunother 49:544-50. 2000
    ..We studied dendritic cell (DC) function in patients affected by pancreatic carcinoma, and the possibility of obtaining DC adequate for immunological treatment modalities...
  44. ncbi Differential responsiveness to constitutive vs. inducible chemokines of immature and mature mouse dendritic cells
    A Vecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:489-94. 1999
    ..This study shows that selective responsiveness of mature and immature DC to inducible vs. constitutively produced chemokines can contribute to the regulated trafficking of DC...
  45. doi Human glioblastoma tumours and neural cancer stem cells express the chemokine CX3CL1 and its receptor CX3CR1
    Marco Erreni
    Dept Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Eur J Cancer 46:3383-92. 2010
    ..The high expression of CXC3L1 in the most severe forms of gliomas suggests the involvement of this chemokine and its receptor in the malignant behaviour of these tumours...
  46. ncbi Tuning of innate immunity and polarized responses by decoy receptors
    Alberto Mantovani
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Faculty of Medicine, University of Milan, Milan, Italy
    Int Arch Allergy Immunol 132:109-15. 2003
    ..Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses...
  47. ncbi Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation
    Lorenzo Piemonti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Via Olgettina, Milan, Italy University of Milano Bicocca, Milan, Italy
    Diabetes 51:55-65. 2002
    ....
  48. ncbi Differential regulation of chemokine receptors during dendritic cell maturation: a model for their trafficking properties
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 161:1083-6. 1998
    ..Conversely, the slower acquisition of responsiveness to ELC/MIP-3beta may guide subsequent localization of DC in lymphoid organs...
  49. ncbi Decoy receptors: a strategy to regulate inflammatory cytokines and chemokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milan, Italy
    Trends Immunol 22:328-36. 2001
    ..Moreover, silent nonsignaling receptors could act as decoys for chemokines. Therefore, the use of decoy receptors is a general strategy to regulate the action of primary pro-inflammatory cytokines and chemokines...
  50. ncbi Glucocorticoids affect human dendritic cell differentiation and maturation
    L Piemonti
    Laboratory of Experimental Surgery, Surgical Department, S Raffaele Scientific Institute, Milan, Italy
    J Immunol 162:6473-81. 1999
    ..In conclusion, our data suggest that glucocorticoids may act at the very first step of the immune response by modulating DC differentiation, maturation, and function...
  51. ncbi Receptor expression and responsiveness of human dendritic cells to a defined set of CC and CXC chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 159:1993-2000. 1997
    ..Chemokines may play a role in the trafficking of DC under resting or stimulated conditions. Chemokine receptors expressed in DC are likely to underlie HIV infection of this cell type...
  52. doi Secretome analysis of multiple pancreatic cancer cell lines reveals perturbations of key functional networks
    Silvia Schiarea
    Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy
    J Proteome Res 9:4376-92. 2010
    ..g., CD9 and Vimentin), while others (PLOD3, SH3L3, PCBP1, and SFRS1) represent novel PDAC-secreted proteins that may be worth investigating...
  53. ncbi Defective expression of the monocyte chemotactic protein-1 receptor CCR2 in macrophages associated with human ovarian carcinoma
    A Sica
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:733-8. 2000
    ....
  54. ncbi The role of chemokines in the regulation of dendritic cell trafficking
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Leukoc Biol 66:1-9. 1999
    ..A better understanding of the molecular basis of DC trafficking may provide molecular and conceptual tools to direct and modulate DC traffic as a strategy to up-regulate and orient specific immunity...
  55. doi Human glioma tumors express high levels of the chemokine receptor CX3CR1
    Marco Locatelli
    Neurosurgery, Fondazione IRCCS, Ca Granda Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
    Eur Cytokine Netw 21:27-33. 2010
    ..Thus, CX3CR1 expression is a frequent event in gliomas, irrespective of tumor classification and clinical severity. The molecular basis underlying CX3CR1 up-regulation and its functional biological significance remain to be determined...
  56. doi CD3+ cells at the invasive margin of deeply invading (pT3-T4) colorectal cancer and risk of post-surgical metastasis: a longitudinal study
    Luigi Laghi
    Laboratories of Molecular Gastroenterology, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Lancet Oncol 10:877-84. 2009
    ..The aim of this study was to assess the relationship between the density of CD3+ TIL and the postsurgical occurrence of distant-organ metastases in a large series of patients with deeply invading and MSI-typed colorectal cancer...
  57. pmc Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
    Marco Erreni
    Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Via Manzoni, 56, Rozzano, Milan, Italy
    Cancer Microenviron 4:141-54. 2011
    ..The characterization of the most relevant inflammatory pathways in CRC is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment...
  58. ncbi Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells
    L Piemonti
    Laboratory of Experimental Surgery, Surgical Department, San Raffaele Scientific Institute, Milan, Italy
    J Immunol 164:4443-51. 2000
    ..In conclusion, our data suggest that 1alpha,25-(OH)2D3 may modulate the immune system, acting at the very first step of the immune response through the inhibition of DC differentiation and maturation into potent APC...
  59. ncbi Induction of functional IL-8 receptors by IL-4 and IL-13 in human monocytes
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Immunol 164:3862-9. 2000
    ..Therefore, IL-8 and related chemokines may contribute to the accumulation and positioning of mononuclear phagocytes in Th2-dominated responses...
  60. ncbi Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells
    M Muzio
    Department of Immunology and Cell Biology, Mario Negri Institute, Milan, Italy
    J Immunol 164:5998-6004. 2000
    ..These data suggest that TLR can be classified based on expression pattern as ubiquitous (TLR1), restricted (TLR2, TLR4, and TLR5 in myelomonocytic cells), and specific (TLR3 in DC) molecules...
  61. ncbi Macrophage control of inflammation: negative pathways of regulation of inflammatory cytokines
    A Mantovani
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milan, Italy
    Novartis Found Symp 234:120-31; discussion 131-5. 2001
    ..These mediators offer new paradigms to understand diverse pathologies, and provide tools and targets for the development of novel therapeutic strategies...
  62. ncbi Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo
    M Vulcano
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Eur J Immunol 31:812-22. 2001
    ..Processing of MDC to MDC(3-69) and shorter forms which do not recognize CCR4 is likely to represent a feedback mechanism of negative regulation...
  63. ncbi IL-10 prevents the differentiation of monocytes to dendritic cells but promotes their maturation to macrophages
    P Allavena
    Department of Immunology and Cell Biology Mario Negri Institute, Milano, Italy
    Eur J Immunol 28:359-69. 1998
    ..Intriguingly, IL-10 inhibits antigen presentation while it stimulates endocytic activity...
  64. pmc Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
    R Bonecchi
    Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    J Exp Med 187:129-34. 1998
    ..It may also determine different susceptibility of Th1s and Th2s to human immunodeficiency virus strains using different fusion coreceptors...
  65. ncbi Human monocyte-derived and CD34+ cell-derived dendritic cells express functional receptors for platelet activating factor
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    FEBS Lett 418:98-100. 1997
    ..Since DC are highly motile cells, protein chemoattractants as well as bioactive phospholipids are likely to contribute to tissue localization of DC, in vivo...
  66. ncbi IL-2-regulated expression of the monocyte chemotactic protein-1 receptor (CCR2) in human NK cells: characterization of a predominant 3.4-kilobase transcript containing CCR2B and CCR2A sequences
    N Polentarutti
    Institute of Pharmacologic Research, Mario Negri, Milano, Italy
    J Immunol 158:2689-94. 1997
    ..The predominant long transcript is polyadenylated and present in the cytoplasm. The augmented migratory capacity of IL-2 activated vs resting NK cells was associated with increased CCR2 transcript levels...
  67. doi Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    G Solinas
    Department of Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano, Milan, Italy
    J Leukoc Biol 86:1065-73. 2009
    ..Thus, together with other myeloid-related cells present at the tumor site (Tie2 macrophages and MDSCs), TAM represent an attractive target of novel biological therapies of tumors...
  68. ncbi Chemokine receptors: interaction with HIV-1 and viral-encoded chemokines
    S Sozzani
    Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Pharm Acta Helv 74:305-12. 2000
    ..This biological activity could represent a strategy developed by the virus to subvert immunity impairing the generation of an effective anti-viral immune response...
  69. ncbi Regulation of the chemokine system at the level of chemokine receptor expression and signaling activity
    M Locati
    Istituto di Patologia Generale, University of Milan, Milano, Italy
    Immunobiology 204:536-42. 2001
    ..Receptor signaling activity represents a further potential level of regulation of the system. Finally, chemokines can also influence the microenvironment by modulating gene expression in target cells...
  70. ncbi Migration of natural killer cells across endothelial cell monolayers
    G Bianchi
    Istituto di Ricerche Farmacologiche Mario Negri Via Eritrea, Milano, Italy
    J Immunol 151:5135-44. 1993
    ..The capacity to bind and migrate across endothelial monolayers underlies the recruitment of NK cells in tissues under certain physiologic and pathologic conditions...
  71. pmc Fractalkine (CX3CL1) as an amplification circuit of polarized Th1 responses
    P Fraticelli
    Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche Mario Negri, Milan, Italy
    J Clin Invest 107:1173-81. 2001
    ..These results indicate that regulated expression of FKN in ECs participates in an amplification circuit of polarized type I responses...
  72. ncbi Migratory response of human natural killer cells to lymphotactin
    B Giancarlo
    Department of Immunology and Cell Biology, Mario Negri Institute, Milano, Italy
    Eur J Immunol 26:3238-41. 1996
    ..Finally, in contrast to other cytokines (IL-2 and IL-12) which in addition to chemotaxis augment NK cell adhesion to endothelial cells in vitro, Lptn did not affect the adhesiveness of NK cells to vascular endothelium...
  73. ncbi Killing of tumor cells with pleiotropic drug resistance by OK432-activated effector cells
    P Allavena
    Laboratory of Immunology, Istituto di Richerche Farmacologiche Mario Negri, Milan, Italy
    Immunopharmacol Immunotoxicol 11:257-68. 1989
    ..Activation of effector cells has the potential to complement conventional cytoreductive therapy by eliminating residual-tumor cells surviving and resistant to chemotherapy...
  74. ncbi IL-4 inhibits binding and cytotoxicity of NK cells to vascular endothelium
    C Paganin
    Department of Immunology, Mario Negri Institute, Milano, Italy
    Cytokine 6:135-40. 1994
    ..The inhibition by IL-4 of NK cell binding to EC and subsequent recruitment and activation may thus contribute to development of TH2 responses...
  75. pmc Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium
    P Allavena
    Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    J Exp Med 173:439-48. 1991
    ....
  76. ncbi Role of leukocyte function-associated antigen-1 and very late antigen-4 in the adhesion and transmigration of c-myc-transfected B-lymphoblastoid cell lines across vascular endothelium
    C Paganin
    Immunology Laboratory, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Int J Clin Lab Res 24:29-32. 1994
    ..This may be relevant in the localization and malignant behavior of B-cell lymphomas carrying an activated c-myc oncogene...
  77. ncbi Identification and genomic organization of a gene coding for a new member of the cell adhesion molecule family mapping to Xq25
    A Frattini
    Department of Human Genome and Multifactorial Disease Research, Istituto di Techologie Biomediche Avanzate, Milan, Italy
    Gene 214:1-6. 1998
    ..Elucidation of the IGDC1 genomic structure will allow the investigation of the basis of its alternative transcription and of its possible involvement in diseases mapped to the Xq25 interval...
  78. ncbi Tumor-derived MUC1 mucins interact with differentiating monocytes and induce IL-10highIL-12low regulatory dendritic cell
    Paolo Monti
    Laboratory of Experimental Surgery, Surgical Department, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    J Immunol 172:7341-9. 2004
    ..These findings identify mucin secretion as a novel mechanism of tumor escape from immune surveillance and provide the basis for the generation of potentially tolerogenic DC...
  79. ncbi Intestinal epithelial cells control dendritic cell function
    Monica Rimoldi
    European Institute of Oncology, Department of Experimental Oncology, Via Ripamonti 435, 20141 Milano, Italy
    Ann N Y Acad Sci 1029:66-74. 2004
    ..In conclusion, epithelial cells are not simply a barrier to bacteria entering via the oral route, but actively influence the activating properties of bystander DC...
  80. ncbi Commitment of juvenile myelo-monocytic (JMML) leukemic cells to spontaneously differentiate into dendritic cells
    Daniela Longoni
    Clinica Pediatrica Università degli Studi di Milano Bicocca, Osp San Gerardo Monza, Italy
    Hematol J 3:302-10. 2002
    ..The cytokine profile produced by these APC is likely to suppress and not to elicit a protective immune response...
  81. ncbi Chemokine expression is associated with the accumulation of tumour associated macrophages (TAMs) and progression in human colorectal cancer
    Charles Bailey
    Department of Surgical Oncology and Technology, St Mary s Hospital, Imperial College of Science, Technology, and Medicine, London, UK
    Clin Exp Metastasis 24:121-30. 2007
    ..It is concluded that CCL2 induces the accumulation of tumour promoting TAMs in human colorectal cancer and represents a therapeutic target to modify the macrophage response and direct immune mediated therapy...
  82. ncbi The chemokine system in diverse forms of macrophage activation and polarization
    Alberto Mantovani
    Centro di Eccellenza per l Innovazione Diagnostica e Terapeutica IDET, Institute of General Pathology, University of Milan, I 20133 Milan, Italy Istituto di Ricerche Farmacologiche Mario Negri, I 20157 Milan, Italy
    Trends Immunol 25:677-86. 2004
    ....
  83. ncbi The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans
    Luigina Romani
    Department of Experimental Medicine and Biochemical Science, University of Perugia, 06122 Perugia, Italy
    Int Immunol 16:149-61. 2004
    ..albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development...
  84. ncbi CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy
    Giovanna D'Amico
    Centro Ricerca M Tettamanti, Clinica Pediatrica Università Milano Bicocca, Ospedale San Gerardo, Monza MI, Italy
    Blood 104:744-51. 2004
    ..These results suggest caution against the potential use of CD40L-activated BCP-ALL cells as agents for immunotherapy unless additional stimuli, such as IL-12, are provided...
  85. ncbi Identification of biologically active chemokine isoforms from ascitic fluid and elevated levels of CCL18/pulmonary and activation-regulated chemokine in ovarian carcinoma
    Evemie Schutyser
    Laboratory of Molecular Immunology, Rega Institute for Medical Research, K U Leuven, Minderbroedersstraat 10, B 3000 Leuven, Belgium
    J Biol Chem 277:24584-93. 2002
    ..This points to a delicate balance of chemokines in epithelial ovarian cancer and to a potentially major role for CXCL8 and CCL18 in this tumor...
  86. doi Cancer-related inflammation
    Alberto Mantovani
    Istituto Clinico Humanitas IRCCS, Via Manzoni 56, Rozzano, 20089 Milan, Italy
    Nature 454:436-44. 2008
    ..The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment...
  87. ncbi A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile
    Paolo Monti
    Laboratory of Experimental Surgery, Department of Diabetes and Transplant Immunology, S Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    Virchows Arch 445:236-47. 2004
    ..In conclusion, a clear correlation between structural/genetic features and function could not be detected, suggesting the weakness of a "morphological" classification for the in vitro studies of pancreatic cancer...
  88. pmc Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
    Maria Grazia Borrello
    Departments of Experimental Oncology, Research Units 3 and 14, and Pathology, Istituto Nazionale Tumori, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 102:14825-30. 2005
    ..These results, demonstrating that the RET/PTC1 oncogene activates a proinflammatory program, provide a direct link between a transforming human oncogene, inflammation, and malignant behavior...
  89. ncbi Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells
    Paolo Monti
    Laboratory of Experimental Surgery, Surgical Department, Istituto Scientifico San Raffaele, Chirurgia II, Via Olgettina 60, 20132 Milan, Italy
    Int Immunopharmacol 3:189-96. 2003
    ....
  90. ncbi Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets
    Valeria Sordi
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, H S Raffaele Telethon Institute for Gene Therapy, and Renal Pathophysiology Laboratory, Division of Medicine, Via Olgettina 60, 20132 Milan, Italy
    Blood 106:419-27. 2005
    ..This study defines the chemokine receptor repertoire of human BM-MSCs that determines their migratory activity. Modulation of homing capacity may be instrumental for harnessing the therapeutic potential of BM-MSCs...
  91. doi Decidual natural killer cell tuning by autologous dendritic cells
    Gordana Laskarin
    Department of Physiology and Immunology, Medical Faculty, University of Rijeka, Rijeka, Croatia
    Am J Reprod Immunol 59:433-45. 2008
    ..Dendritic cells (DC)/natural killer (NK) cells interactions in the deciduas of early human pregnancies were analyzed in vitro...
  92. ncbi The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity
    Paolo Monti
    Laboratory of Experimental Surgery, Department of Surgery II, Fondazione Centro S Raffaele del Monte Tabor, Via Olgettina 60, 20132 Milan, Italy
    Cancer Res 63:7451-61. 2003
    ..On the whole, the results presented in our investigation suggest that CCL2 could be a relevant negative regulator of pancreatic cancer progression...