Diego Albani

Summary

Affiliation: Istituto di Ricerche Farmacologiche Mario Negri
Country: Italy

Publications

  1. pmc DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70
    Sara Batelli
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 3:e1884. 2008
  2. doi request reprint The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 18:125-30. 2009
  3. doi request reprint Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence
    Diego Albani
    Laboratory of Biology of Neurodegenerative Disorders, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 19:11-26. 2010
  4. doi request reprint The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan 20156, Italy
    J Neurochem 110:1445-56. 2009
  5. doi request reprint Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur Neurol 62:120-3. 2009
  6. pmc A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    BMC Geriatr 9:19. 2009
  7. pmc Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy
    Age (Dordr) 31:155-62. 2009
  8. doi request reprint Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    J Hum Genet 53:1029-33. 2008
  9. ncbi request reprint Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Aging 28:1682-8. 2007
  10. ncbi request reprint The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level
    Marzia Pesaresi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Dis 25:609-13. 2007

Collaborators

Detail Information

Publications26

  1. pmc DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70
    Sara Batelli
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    PLoS ONE 3:e1884. 2008
    ..DJ-1 (PARK7), another family-PD-linked gene causing an autosomal recessive form of the pathology, shows antioxidant and chaperone-like activities too...
  2. doi request reprint The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 18:125-30. 2009
    ..We conclude that 5-HTTLPR and rs25531 are not major genetic modulators of BPSD development in AD...
  3. doi request reprint Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence
    Diego Albani
    Laboratory of Biology of Neurodegenerative Disorders, Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 19:11-26. 2010
    ....
  4. doi request reprint The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, Milan 20156, Italy
    J Neurochem 110:1445-56. 2009
    ....
  5. doi request reprint Serotonin transporter gene polymorphic element 5-HTTLPR increases the risk of sporadic Parkinson's disease in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Eur Neurol 62:120-3. 2009
    ..5], p = 0.002) was found. The rs25531 and the haplotype 5-HTTLPR/rs25531 did not associate with risk of PD. Our data indicate that the 5-HTTLPR polymorphic element within the SLC6A4 promoter may govern the genetic risk of PD in Italians...
  6. pmc A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    BMC Geriatr 9:19. 2009
    ..In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R)...
  7. pmc Interleukin-6 plasma level increases with age in an Italian elderly population ("The Treviso Longeva"-Trelong-study) with a sex-specific contribution of rs1800795 polymorphism
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156, Milan, Italy
    Age (Dordr) 31:155-62. 2009
    ..05, Tukey's test) was also noticed. We suggest a sex-specific pattern for genetic variability linked to inflammatory response and longevity, consistent with the age-related increase in IL-6...
  8. doi request reprint Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    J Hum Genet 53:1029-33. 2008
    ..A significant correlation [P = 0.018, OR (95% CI): 2.1 (1.1-3.9)] between rs4795541 S-allele presence and FTLD susceptibility was found. In summary, the rs4795541 might be important for FTLD susceptibility in the Italian population...
  9. ncbi request reprint Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Aging 28:1682-8. 2007
    ..05, Mann-Whitney test) in the Abeta(1-42)/Abeta(1-40) ratio in PSEN-1 [E318G] carriers, suggesting a peculiar biochemical effect of this mutation...
  10. ncbi request reprint The urokinase-type plasminogen activator polymorphism PLAU_1 is a risk factor for APOE-epsilon4 non-carriers in the Italian Alzheimer's disease population and does not affect the plasma Abeta(1-42) level
    Marzia Pesaresi
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, 20157 Milan, Italy
    Neurobiol Dis 25:609-13. 2007
    ..Our data support a role for PLAU_1 as an independent genetic risk factor for AD in the Italian population for those subjects who do not have the APOE-epsilon4 allele...
  11. doi request reprint The SIRT2 polymorphism rs10410544 and risk of Alzheimer's disease in two Caucasian case-control cohorts
    Letizia Polito
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy Golgi Cenci Foundation, Abbiategrasso, Italy
    Alzheimers Dement 9:392-9. 2013
    ..This study investigated whether genetic variants in two members of the sirtuin family, SIRT2 and SIRT3, affected AD susceptibility...
  12. pmc Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study
    Diego Albani
    Laboratory of Biology of Neurodegenerative Disorders, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Age (Dordr) 34:519-26. 2012
    ..26), which was an independent predictor of dementia onset (p = 0.0002). In short, in this Italian population of oldest olds, dementia was associated to the APOE-ε4 allele only...
  13. doi request reprint Early-onset Alzheimer disease in an Italian family with presenilin-1 double mutation E318G and G394V
    Sara Batelli
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via Eritrea 62, Milan, Italy
    Alzheimer Dis Assoc Disord 22:184-7. 2008
    ..We did not find any modification of the A beta(1-42)/A beta(1-40) ratio, suggesting that this double mutation might be involved in early-onset AD etiopathogenesis by affecting a PSEN-1 function other than gamma-secretase activity...
  14. pmc Modulation of human longevity by SIRT3 single nucleotide polymorphisms in the prospective study "Treviso Longeva (TRELONG)"
    Diego Albani
    Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milan, Italy
    Age (Dordr) 36:469-78. 2014
    ..We found an increased level of SIRT3 in subjects homozygous for the (T) allele. We suggest that SIRT3 genetic variability might be relevant for the modulation of human longevity in the Italian population. ..
  15. doi request reprint Insulin-like growth factor 1 receptor polymorphism rs2229765 and circulating interleukin-6 level affect male longevity in a population-based prospective study (Treviso Longeva--TRELONG)
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Via La Masa, Milan, Italy
    Aging Male 14:257-64. 2011
    ..These findings sustain the hypothesis that sex-specific longevity relies on detectable differences in genetic and biochemical parameters between males and females...
  16. pmc A novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the italian population do not support a large effect on Alzheimer's disease risk
    Letizia Polito
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy
    Int J Alzheimers Dis 2011:312341. 2011
    ..85 (associated P value = .08). Overall, our findings are not supportive of a large genetic effect of the explored polymorphisms on AD risk...
  17. doi request reprint Neuroprotective properties of resveratrol in different neurodegenerative disorders
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Biofactors 36:370-6. 2010
    ..Here, we summarize the in vitro and in vivo experimental results highlighting the possible role of resveratrol as neuroprotective biofactor with a particular focus on AD...
  18. ncbi request reprint Protective effect of TAT-delivered alpha-synuclein: relevance of the C-terminal domain and involvement of HSP70
    Diego Albani
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    FASEB J 18:1713-5. 2004
    ..The implications for alpha-syn-mediated neurotoxicity and for PD pathogenesis and progression are discussed...
  19. doi request reprint Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors
    Filippo Martinelli-Boneschi
    San Raffaele Scientific Institute, Division of Neuroscience, Laboratory of Genetics of Complex Neurological Disorders, Institute of Experimental Neurology INSPE, Milan, Italy
    Neurobiol Aging 34:1711.e7-13. 2013
    ..Despite its limitations, this project paves the way for the application of personalized medicine in AD patients and for collaborative efforts in this field...
  20. pmc Multiplex assessment of a panel of 16 serum molecules for the differential diagnosis of Alzheimer's disease
    Gloria Biella
    Department of Neuroscience, Istituto di Ricerche Famacologiche Mario Negri IRCCS Milan, Italy
    Am J Neurodegener Dis 2:40-5. 2013
    ..63 and 0.66 for EGF and TRAIL-R4, respectively). Finally, we tried to find a diagnostic classifier by a multivariate algorithm. We found indication of diagnostic evidence for AD only, while NAD samples did not show a diagnostic pattern...
  21. ncbi request reprint A novel PSENEN mutation in a patient with complaints of memory loss and a family history of dementia
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Alzheimers Dement 3:235-8. 2007
    ..Although our data do not definitively support a pathogenetic role for this mutation, it does not appear to be a common polymorphism. Further follow-up is warranted in this family...
  22. ncbi request reprint Genotype-dependent activity of tryptophan hydroxylase-2 determines the response to citalopram in a mouse model of depression
    Luigi Cervo
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    J Neurosci 25:8165-72. 2005
    ..Interstrain comparisons could probably be a useful strategy for understanding the mechanisms underlying the response to selective serotonin reuptake inhibitors...
  23. doi request reprint Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients
    Diego Albani
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Alzheimers Dis 30:745-9. 2012
    ..74 [1.01-3.00], p = 0.04). Rs1080985 might be useful as predictor of poor response to short-term donepezil treatment...
  24. pmc Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease
    Chiara Fenoglio
    Department of Neurological Sciences, Dino Ferrari Center, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico, Milan, Italy
    J Alzheimers Dis 18:603-12. 2009
    ..14, CC = 1.22 +/- 0.23; P = 0.013). These data argue against a direct role of GRN as a susceptibility factor for sporadic AD but support a role of GRN as a disease-modifying gene, possibly contributing to the failure of neuronal survival...
  25. doi request reprint Hydrogel-based nanocomposites and mesenchymal stem cells: a promising synergistic strategy for neurodegenerative disorders therapy
    Diego Albani
    IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy
    ScientificWorldJournal 2013:270260. 2013
    ..The use of hydrogel-based nanocomposites and mesenchymal stem cells as a synergistic strategy for nervous tissue applications will be then discussed. ..
  26. doi request reprint Glial cells drive preconditioning-induced blood-brain barrier protection
    Raffaella Gesuete
    Laboratory of Inflammation and Nervous System Diseases, Mario Negri Institute, Via G La Masa 19, 20156 Milan, Italy
    Stroke 42:1445-53. 2011
    ..The cerebrovascular contribution to ischemic preconditioning (IPC) has been scarcely explored. Using in vivo and in vitro approaches, we investigated the involvement of the blood-brain barrier and the role of its cellular components...