Cristina Albanesi

Summary

Affiliation: Istituto Dermopatico dell'Immacolata
Country: Italy

Publications

  1. ncbi Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 115:81-7. 2000
  2. ncbi Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes
    Cristina Albanesi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Clin Dermatol 25:581-8. 2007
  3. ncbi Suppressor of cytokine signaling-1 inhibits interferon-gamma-induced activation of human keratinocytes
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, 00167 Rome, Italy
    Ann N Y Acad Sci 973:79-82. 2002
  4. ncbi Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Autoimmunity 43:215-9. 2010
  5. ncbi A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Leukoc Biol 70:617-23. 2001
  6. ncbi Keratinocytes in inflammatory skin diseases
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    Curr Drug Targets Inflamm Allergy 4:329-34. 2005
  7. ncbi Keratinocytes in allergic skin diseases
    Cristina Albanesi
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Curr Opin Allergy Clin Immunol 10:452-6. 2010
  8. ncbi Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment
    Cristina Albanesi
    Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 00167 Rome, Italy
    J Exp Med 206:249-58. 2009
  9. ncbi IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes
    Davide Pennino
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti di Creta 104, 00167 Rome, Italy
    J Immunol 184:4880-8. 2010
  10. ncbi Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1
    Monica Federici
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 169:434-42. 2002

Collaborators

Detail Information

Publications32

  1. ncbi Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 115:81-7. 2000
    ..As a whole, the results indicate that interleukin-17 can participate relevantly in T-cell-mediated skin immune responses by amplifying both interferon-gamma- and interleukin-4-induced activation of keratinocytes...
  2. ncbi Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes
    Cristina Albanesi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Clin Dermatol 25:581-8. 2007
    ..Other skin resident cells such as fibroblasts, mast cells, and endothelial cells also contribute to psoriasis pathogenesis by expressing molecules involved in T-cell recruitment and activation...
  3. ncbi Suppressor of cytokine signaling-1 inhibits interferon-gamma-induced activation of human keratinocytes
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, 00167 Rome, Italy
    Ann N Y Acad Sci 973:79-82. 2002
  4. ncbi Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Autoimmunity 43:215-9. 2010
    ..Once secreted, it can be activated by enzymes produced by neutrophils and mast cells, which infiltrate early psoriasis lesions. These findings propose the chemerin/ChemR23 axis as a potential novel therapeutic target in psoriasis...
  5. ncbi A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Leukoc Biol 70:617-23. 2001
    ..Thus, keratinocytes appear considerably more sensitive to Th1- than to Th2-derived lymphokines in terms of chemokine release and can support the preferential accumulation of Th1 lymphocytes in the skin...
  6. ncbi Keratinocytes in inflammatory skin diseases
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    Curr Drug Targets Inflamm Allergy 4:329-34. 2005
    ....
  7. ncbi Keratinocytes in allergic skin diseases
    Cristina Albanesi
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Curr Opin Allergy Clin Immunol 10:452-6. 2010
    ..The aim of the review is to provide up-to-date information on the multiple roles of epidermal keratinocytes in the immune reactions associated with allergic contact dermatitis and atopic dermatitis skin diseases...
  8. ncbi Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment
    Cristina Albanesi
    Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 00167 Rome, Italy
    J Exp Med 206:249-58. 2009
    ..These results support a role for the chemerin/ChemR23 axis in the early phases of psoriasis development...
  9. ncbi IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes
    Davide Pennino
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti di Creta 104, 00167 Rome, Italy
    J Immunol 184:4880-8. 2010
    ..Thus, IL-17 efficiently amplifies the allergic reaction by rendering virtually all of the T lymphocytes recruited at the site of skin inflammation capable to directly contribute to tissue damage...
  10. ncbi Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1
    Monica Federici
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 169:434-42. 2002
    ..Targeting keratinocyte SOCS1 may represent a novel therapeutic approach to IFN-gamma-dependent skin diseases...
  11. ncbi The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinoc
    Stefania Madonna
    Laboratorio di Immunologia Sperimentale, Istituto Dermopatico dell Immacolata, Rome, Italy
    J Immunol 185:2467-81. 2010
    ..However, the SOCS1 increased levels in psoriatic keratinocytes are not sufficient to completely inhibit the expression of proinflammatory genes...
  12. ncbi Low-frequency low-intensity ultrasounds do not influence the survival and immune functions of cultured keratinocytes and dendritic cells
    Claudia Scarponi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Via Monti di Creta 104, 00167 Rome, Italy
    J Biomed Biotechnol 2009:193260. 2009
    ..Our study sustains the employment of low-frequency and low-intensity US for treatment of those immune skin disorders, where keratinocytes and DC have a pathogenetic role...
  13. ncbi IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines
    C Albanesi
    Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Immunol 165:1395-402. 2000
    ....
  14. ncbi Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo
    Maria Laura Giustizieri
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura e Carattere Scientifico, Rome, Italy
    Am J Pathol 161:1409-18. 2002
    ..Finally, NO donors inhibited nuclear factor-kappa B and STAT-1, but not AP-1 activities in transiently transfected keratinocytes. These results define NO donors as negative regulators of chemokine production by keratinocytes...
  15. ncbi STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
    Rosanna Sestito
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 25:916-27. 2011
    ..In skin affected by psoriasis, SIRT1 is down-regulated by IFN-γ, which thus renders psoriatic keratinocytes more prone to respond to IL-22...
  16. ncbi IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response
    Kilian Eyerich
    Laboratory of Immunology, IDI IRCCS, Rome, Italy
    J Allergy Clin Immunol 123:59-66.e4. 2009
    ..Recent studies show that an impaired IL-17 immune response results in diseases associated with chronic skin infections...
  17. ncbi Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis
    Claudia Scarponi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, Rome, Italy
    J Interferon Cytokine Res 26:133-40. 2006
    ..Given the difference in IFN-kappa expression levels in the skin disorders examined, IFN-kappa presence or deficiency might have different pathogenetic consequences depending also on other disease-specific intrinsic alterations...
  18. ncbi Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity
    S Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy
    J Immunol 166:996-1002. 2001
    ....
  19. ncbi Nickel-specific CD4(+) and CD8(+) T cells display distinct migratory responses to chemokines produced during allergic contact dermatitis
    Silvia Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 118:1052-8. 2002
    ..Our data indicate that distinct chemokines and cell types control the accumulation of CD8(+) and CD4(+) T cells within inflamed skin...
  20. ncbi H1 histamine receptor mediates inflammatory responses in human keratinocytes
    Maria Laura Giustizieri
    Istituto Dermopatica dell'Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti de Creta 104, 00167 Rome, Italy
    J Allergy Clin Immunol 114:1176-82. 2004
    ..CONCLUSION: Histamine exerts proinflammatory effects on keratinocytes via the H1 receptor, and these effects are efficiently inhibited by levocetirizine...
  21. ncbi Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells
    Angela Orecchia
    Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    PLoS ONE 6:e24307. 2011
    ..Altogether, these findings indicated that sirtuins may represent a promising therapeutic target for the treatment of inflammatory skin diseases characterized by a prominent microvessel involvement...
  22. ncbi Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation
    Stefania Madonna
    Laboratory of Immunology, IDI IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 22:3287-97. 2008
    ..We hypothesize that SOCS1 functions as suppressor of IFN-gamma signaling, not only by inhibiting STAT1 activation but also by sustaining ERK1/2-dependent antiinflammatory pathways...
  23. ncbi Targeting tumor necrosis factor-alpha as a potential therapy in inflammatory skin diseases
    Giampiero Girolomoni
    Second Division of Dermatology and Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Via dei Monti di Creta 104, 001 67 Rome, Italy
    Curr Opin Investig Drugs 3:1590-5. 2002
    ....
  24. ncbi The role of chemokines in allergic contact dermatitis
    Silvia Sebastiani
    Istituto Dermopatico dell'Immacolata, IRCCS, Roma, Italy
    Arch Dermatol Res 293:552-9. 2002
    ..Targeting chemokines and chemokine receptors may offer new opportunities for therapeutic interventions in ACD and other chronic inflammatory skin diseases...
  25. ncbi T-cell subpopulations in the development of atopic and contact allergy
    G Girolomoni
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Via Monti di Creta 104, 00167, Roma, Italy
    Curr Opin Immunol 13:733-7. 2001
    ..In addition, studies are beginning to reveal the important contribution of skin resident cells to atopic dermatitis and the underlying molecular mechanisms...
  26. ncbi Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin
    S Pastore
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, 00167 Rome, Italy
    J Clin Invest 99:3009-17. 1997
    ....
  27. ncbi Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses
    A Cavani
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 114:295-302. 2000
    ..These inhibitory effects were completely prevented by IL-10, but not IL-5, neutralization. In aggregate, the results indicate that Tr1 cells can potently regulate the expression of Th1-mediated allergic diseases via release of IL-10...
  28. ncbi Regulatory activity of autocrine IL-10 on dendritic cell functions
    S Corinti
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 166:4312-8. 2001
    ..Moreover, IL-10R expression appears to be regulated by both transcriptional and posttranscriptional mechanisms. Endogenous IL-10 and IL-10R can be relevant targets for the manipulation of DC functions...
  29. ncbi Pathobiology of chronic inflammatory skin diseases: interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs
    C Albanesi
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Roma, Italy
    Curr Drug Metab 11:210-27. 2010
    ....
  30. ncbi A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation
    C Albanesi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma Tor Vergata, Rome, Italy
    Development 122:1291-302. 1996
    ..An immunoreactive protein of the same size can be produced in both eukaryotic and prokaryotic artificial expression systems...
  31. ncbi Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system
    Bernardetta Nardelli
    Human Genome Sciences, Rockville, MD 20850, USA
    J Immunol 169:4822-30. 2002
    ..The pattern of cytokines induced by IFN-kappa in monocytes, coupled with the unique induction of IFN-kappa mRNA by IFN-gamma, indicates a potential role for IFN-kappa in the regulation of immune cell functions...
  32. ncbi IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3
    Cristina Albanesi
    Laboratory of Immunologia and Allergology, Istituto Dermopatico dell Immacolata Instituti di Recovero e Cura a Carattere Scientifico, Roma, Italy
    J Immunol 179:984-92. 2007
    ....