Cristina Albanesi

Summary

Affiliation: Istituto Dermopatico dell'Immacolata
Country: Italy

Publications

  1. ncbi request reprint Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 115:81-7. 2000
  2. pmc Low-frequency low-intensity ultrasounds do not influence the survival and immune functions of cultured keratinocytes and dendritic cells
    Claudia Scarponi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Via Monti di Creta 104, 00167 Rome, Italy
    J Biomed Biotechnol 2009:193260. 2009
  3. ncbi request reprint Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes
    Cristina Albanesi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Clin Dermatol 25:581-8. 2007
  4. ncbi request reprint Keratinocytes in inflammatory skin diseases
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    Curr Drug Targets Inflamm Allergy 4:329-34. 2005
  5. doi request reprint Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Autoimmunity 43:215-9. 2010
  6. ncbi request reprint Suppressor of cytokine signaling-1 inhibits interferon-gamma-induced activation of human keratinocytes
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, 00167 Rome, Italy
    Ann N Y Acad Sci 973:79-82. 2002
  7. ncbi request reprint A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Leukoc Biol 70:617-23. 2001
  8. doi request reprint Keratinocytes in allergic skin diseases
    Cristina Albanesi
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Curr Opin Allergy Clin Immunol 10:452-6. 2010
  9. doi request reprint IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes
    Davide Pennino
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti di Creta 104, 00167 Rome, Italy
    J Immunol 184:4880-8. 2010
  10. pmc Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment
    Cristina Albanesi
    Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 00167 Rome, Italy
    J Exp Med 206:249-58. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 115:81-7. 2000
    ..As a whole, the results indicate that interleukin-17 can participate relevantly in T-cell-mediated skin immune responses by amplifying both interferon-gamma- and interleukin-4-induced activation of keratinocytes...
  2. pmc Low-frequency low-intensity ultrasounds do not influence the survival and immune functions of cultured keratinocytes and dendritic cells
    Claudia Scarponi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Via Monti di Creta 104, 00167 Rome, Italy
    J Biomed Biotechnol 2009:193260. 2009
    ..Our study sustains the employment of low-frequency and low-intensity US for treatment of those immune skin disorders, where keratinocytes and DC have a pathogenetic role...
  3. ncbi request reprint Resident skin cells in psoriasis: a special look at the pathogenetic functions of keratinocytes
    Cristina Albanesi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Clin Dermatol 25:581-8. 2007
    ..Other skin resident cells such as fibroblasts, mast cells, and endothelial cells also contribute to psoriasis pathogenesis by expressing molecules involved in T-cell recruitment and activation...
  4. ncbi request reprint Keratinocytes in inflammatory skin diseases
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    Curr Drug Targets Inflamm Allergy 4:329-34. 2005
    ....
  5. doi request reprint Immune functions and recruitment of plasmacytoid dendritic cells in psoriasis
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Autoimmunity 43:215-9. 2010
    ..Once secreted, it can be activated by enzymes produced by neutrophils and mast cells, which infiltrate early psoriasis lesions. These findings propose the chemerin/ChemR23 axis as a potential novel therapeutic target in psoriasis...
  6. ncbi request reprint Suppressor of cytokine signaling-1 inhibits interferon-gamma-induced activation of human keratinocytes
    Cristina Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, 00167 Rome, Italy
    Ann N Y Acad Sci 973:79-82. 2002
  7. ncbi request reprint A cytokine-to-chemokine axis between T lymphocytes and keratinocytes can favor Th1 cell accumulation in chronic inflammatory skin diseases
    C Albanesi
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Leukoc Biol 70:617-23. 2001
    ..Thus, keratinocytes appear considerably more sensitive to Th1- than to Th2-derived lymphokines in terms of chemokine release and can support the preferential accumulation of Th1 lymphocytes in the skin...
  8. doi request reprint Keratinocytes in allergic skin diseases
    Cristina Albanesi
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Curr Opin Allergy Clin Immunol 10:452-6. 2010
    ..The aim of the review is to provide up-to-date information on the multiple roles of epidermal keratinocytes in the immune reactions associated with allergic contact dermatitis and atopic dermatitis skin diseases...
  9. doi request reprint IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes
    Davide Pennino
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti di Creta 104, 00167 Rome, Italy
    J Immunol 184:4880-8. 2010
    ..Thus, IL-17 efficiently amplifies the allergic reaction by rendering virtually all of the T lymphocytes recruited at the site of skin inflammation capable to directly contribute to tissue damage...
  10. pmc Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment
    Cristina Albanesi
    Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico IRCCS, 00167 Rome, Italy
    J Exp Med 206:249-58. 2009
    ..These results support a role for the chemerin/ChemR23 axis in the early phases of psoriasis development...
  11. ncbi request reprint Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1
    Monica Federici
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 169:434-42. 2002
    ..Targeting keratinocyte SOCS1 may represent a novel therapeutic approach to IFN-gamma-dependent skin diseases...
  12. pmc Nitric oxide donors suppress chemokine production by keratinocytes in vitro and in vivo
    Maria Laura Giustizieri
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura e Carattere Scientifico, Rome, Italy
    Am J Pathol 161:1409-18. 2002
    ..Finally, NO donors inhibited nuclear factor-kappa B and STAT-1, but not AP-1 activities in transiently transfected keratinocytes. These results define NO donors as negative regulators of chemokine production by keratinocytes...
  13. doi request reprint The IFN-gamma-dependent suppressor of cytokine signaling 1 promoter activity is positively regulated by IFN regulatory factor-1 and Sp1 but repressed by growth factor independence-1b and Krüppel-like factor-4, and it is dysregulated in psoriatic keratinoc
    Stefania Madonna
    Laboratorio di Immunologia Sperimentale, Istituto Dermopatico dell Immacolata, Rome, Italy
    J Immunol 185:2467-81. 2010
    ..However, the SOCS1 increased levels in psoriatic keratinocytes are not sufficient to completely inhibit the expression of proinflammatory genes...
  14. ncbi request reprint IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines
    C Albanesi
    Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Immunol 165:1395-402. 2000
    ....
  15. ncbi request reprint Analysis of IFN-kappa expression in pathologic skin conditions: downregulation in psoriasis and atopic dermatitis
    Claudia Scarponi
    Laboratory of Immunology and Allergology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    J Interferon Cytokine Res 26:133-40. 2006
    ..Given the difference in IFN-kappa expression levels in the skin disorders examined, IFN-kappa presence or deficiency might have different pathogenetic consequences depending also on other disease-specific intrinsic alterations...
  16. doi request reprint STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
    Rosanna Sestito
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata Istituto di Ricovero e Cura a Carattere Scientifico, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 25:916-27. 2011
    ..In skin affected by psoriasis, SIRT1 is down-regulated by IFN-γ, which thus renders psoriatic keratinocytes more prone to respond to IL-22...
  17. doi request reprint Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses
    Stefania Madonna
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Rome, Italy
    Eur J Immunol 43:1883-95. 2013
    ..These data collectively indicate that PS-5 has an important therapeutic potential in the treatment of type-1 immune-mediated skin diseases. ..
  18. doi request reprint IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response
    Kilian Eyerich
    Laboratory of Immunology, IDI IRCCS, Rome, Italy
    J Allergy Clin Immunol 123:59-66.e4. 2009
    ..Recent studies show that an impaired IL-17 immune response results in diseases associated with chronic skin infections...
  19. ncbi request reprint Nickel-specific CD4(+) and CD8(+) T cells display distinct migratory responses to chemokines produced during allergic contact dermatitis
    Silvia Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 118:1052-8. 2002
    ..Our data indicate that distinct chemokines and cell types control the accumulation of CD8(+) and CD4(+) T cells within inflamed skin...
  20. ncbi request reprint Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity
    S Sebastiani
    Laboratory of Immunology, Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy
    J Immunol 166:996-1002. 2001
    ....
  21. doi request reprint Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation
    Stefania Madonna
    Laboratory of Immunology, IDI IRCCS, Via Monti di Creta, 104, 00167 Rome, Italy
    FASEB J 22:3287-97. 2008
    ..We hypothesize that SOCS1 functions as suppressor of IFN-gamma signaling, not only by inhibiting STAT1 activation but also by sustaining ERK1/2-dependent antiinflammatory pathways...
  22. ncbi request reprint H1 histamine receptor mediates inflammatory responses in human keratinocytes
    Maria Laura Giustizieri
    Istituto Dermopatica dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Via dei Monti de Creta 104, 00167 Rome, Italy
    J Allergy Clin Immunol 114:1176-82. 2004
    ..Little information is available on the effects of histamine on keratinocytes...
  23. ncbi request reprint Targeting tumor necrosis factor-alpha as a potential therapy in inflammatory skin diseases
    Giampiero Girolomoni
    Second Division of Dermatology and Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Via dei Monti di Creta 104, 001 67 Rome, Italy
    Curr Opin Investig Drugs 3:1590-5. 2002
    ....
  24. pmc Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells
    Angela Orecchia
    Molecular and Cell Biology Laboratory, IDI IRCCS, Rome, Italy
    PLoS ONE 6:e24307. 2011
    ..Altogether, these findings indicated that sirtuins may represent a promising therapeutic target for the treatment of inflammatory skin diseases characterized by a prominent microvessel involvement...
  25. ncbi request reprint The role of chemokines in allergic contact dermatitis
    Silvia Sebastiani
    Istituto Dermopatico dell Immacolata, IRCCS, Roma, Italy
    Arch Dermatol Res 293:552-9. 2002
    ..Targeting chemokines and chemokine receptors may offer new opportunities for therapeutic interventions in ACD and other chronic inflammatory skin diseases...
  26. ncbi request reprint T-cell subpopulations in the development of atopic and contact allergy
    G Girolomoni
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Via Monti di Creta 104, 00167, Roma, Italy
    Curr Opin Immunol 13:733-7. 2001
    ..In addition, studies are beginning to reveal the important contribution of skin resident cells to atopic dermatitis and the underlying molecular mechanisms...
  27. pmc Granulocyte macrophage colony-stimulating factor is overproduced by keratinocytes in atopic dermatitis. Implications for sustained dendritic cell activation in the skin
    S Pastore
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, 00167 Rome, Italy
    J Clin Invest 99:3009-17. 1997
    ....
  28. ncbi request reprint Regulatory activity of autocrine IL-10 on dendritic cell functions
    S Corinti
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy
    J Immunol 166:4312-8. 2001
    ..Moreover, IL-10R expression appears to be regulated by both transcriptional and posttranscriptional mechanisms. Endogenous IL-10 and IL-10R can be relevant targets for the manipulation of DC functions...
  29. ncbi request reprint Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses
    A Cavani
    Laboratory of Immunology, Istituto Dermopatico dell Immacolata, IRCCS, Rome, Italy
    J Invest Dermatol 114:295-302. 2000
    ..These inhibitory effects were completely prevented by IL-10, but not IL-5, neutralization. In aggregate, the results indicate that Tr1 cells can potently regulate the expression of Th1-mediated allergic diseases via release of IL-10...
  30. ncbi request reprint Pathobiology of chronic inflammatory skin diseases: interplay between keratinocytes and immune cells as a target for anti-inflammatory drugs
    C Albanesi
    Laboratory of Experimental Immunology, Istituto Dermopatico dell Immacolata IDI IRCCS, Roma, Italy
    Curr Drug Metab 11:210-27. 2010
    ....
  31. ncbi request reprint A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation
    C Albanesi
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma Tor Vergata, Rome, Italy
    Development 122:1291-302. 1996
    ..An immunoreactive protein of the same size can be produced in both eukaryotic and prokaryotic artificial expression systems...
  32. ncbi request reprint Regulatory effect of IFN-kappa, a novel type I IFN, on cytokine production by cells of the innate immune system
    Bernardetta Nardelli
    Human Genome Sciences, Rockville, MD 20850, USA
    J Immunol 169:4822-30. 2002
    ..The pattern of cytokines induced by IFN-kappa in monocytes, coupled with the unique induction of IFN-kappa mRNA by IFN-gamma, indicates a potential role for IFN-kappa in the regulation of immune cell functions...
  33. ncbi request reprint IL-4 and IL-13 negatively regulate TNF-alpha- and IFN-gamma-induced beta-defensin expression through STAT-6, suppressor of cytokine signaling (SOCS)-1, and SOCS-3
    Cristina Albanesi
    Laboratory of Immunologia and Allergology, Istituto Dermopatico dell Immacolata Instituti di Recovero e Cura a Carattere Scientifico, Roma, Italy
    J Immunol 179:984-92. 2007
    ....