Paola Torricelli

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. ncbi Osteoporosis and biomaterial osteointegration
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 58:487-93. 2004
  2. pmc In vitro tenocyte metabolism in aging and oestrogen deficiency
    P Torricelli
    Preclinical and Surgical Studies Laboratory, Codivilla Putti Research Institute, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Age (Dordr) 35:2125-36. 2013
  3. ncbi Characterization of bone defect repair in young and aged rat femur induced by xenogenic demineralized bone matrix
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Bologna, Italy
    J Periodontol 73:1003-9. 2002
  4. ncbi Effects of systemic glucocorticoid administration on tenocytes
    P Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, Bologna, Italy
    Biomed Pharmacother 60:380-5. 2006
  5. ncbi Intermittent exposure to ethanol vapor affects osteoblast behaviour more severely than estrogen deficiency does in vitro study on rat osteoblasts
    Paola Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicology 237:168-76. 2007
  6. ncbi Chronic alcohol abuse and endosseous implants: linkage of in vitro osteoblast dysfunction to titanium osseointegration rate
    Paola Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicology 243:138-44. 2008
  7. ncbi Biological glass coating on ceramic materials: in vitro evaluation using primary osteoblast cultures from healthy and osteopenic rat bone
    P Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti IOR, Bologna, Italy
    Biomaterials 22:2535-43. 2001
  8. ncbi Biomimetic PMMA-based bone substitutes: a comparative in vitro evaluation of the effects of pulsed electromagnetic field exposure
    Paola Torricelli
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, IOR Bologna, Italy
    J Biomed Mater Res A 64:182-8. 2003
  9. ncbi Human osteopenic bone-derived osteoblasts: essential amino acids treatment effects
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:35-46. 2003
  10. ncbi Osteoblasts cultured from osteoporotic bone: a comparative investigation on human and animal-derived cells
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:263-77. 2003

Collaborators

Detail Information

Publications73

  1. ncbi Osteoporosis and biomaterial osteointegration
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 58:487-93. 2004
    ..The use of pathological bone-derived cells and pathological animals is therefore recommended to test candidate orthopaedic materials...
  2. pmc In vitro tenocyte metabolism in aging and oestrogen deficiency
    P Torricelli
    Preclinical and Surgical Studies Laboratory, Codivilla Putti Research Institute, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Age (Dordr) 35:2125-36. 2013
    ..Our work improves the body of knowledge on the effects of senescence and oestrogen deficiency on tenocyte behaviour and allows further studies to find solution for the prevention of tendon injuries in aging and menopause. ..
  3. ncbi Characterization of bone defect repair in young and aged rat femur induced by xenogenic demineralized bone matrix
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Bologna, Italy
    J Periodontol 73:1003-9. 2002
    ..The aim of the present paper was to assess the effects of age on the healing of bone defects treated with demineralized bone matrix (DBM)...
  4. ncbi Effects of systemic glucocorticoid administration on tenocytes
    P Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, Bologna, Italy
    Biomed Pharmacother 60:380-5. 2006
    ....
  5. ncbi Intermittent exposure to ethanol vapor affects osteoblast behaviour more severely than estrogen deficiency does in vitro study on rat osteoblasts
    Paola Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicology 237:168-76. 2007
    ..Therefore, these in vitro data suggest that alcohol has even more deleterious effects on bone than estrogen deficiency does...
  6. ncbi Chronic alcohol abuse and endosseous implants: linkage of in vitro osteoblast dysfunction to titanium osseointegration rate
    Paola Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicology 243:138-44. 2008
    ..These in vitro data suggest that alcohol abuse affects bone repair and decreases the ability to form bone around standard cpTi. Innovative surfaces and adjuvant therapies could be useful when implants are required in alcoholics...
  7. ncbi Biological glass coating on ceramic materials: in vitro evaluation using primary osteoblast cultures from healthy and osteopenic rat bone
    P Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti IOR, Bologna, Italy
    Biomaterials 22:2535-43. 2001
    ..In particular, MTT significant higher values were detected in NB cultures on ZrO2-RKKP samples; ALP activity significantly increased in NB cultures on Al2O3-RKKP and in OB cultures on both coated samples...
  8. ncbi Biomimetic PMMA-based bone substitutes: a comparative in vitro evaluation of the effects of pulsed electromagnetic field exposure
    Paola Torricelli
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, IOR Bologna, Italy
    J Biomed Mater Res A 64:182-8. 2003
    ..The properties of PMMA+alpha-TCP look promising, and the present results support the use of PEMFs to improve tissue response to biomaterials implanted as bone substitutes...
  9. ncbi Human osteopenic bone-derived osteoblasts: essential amino acids treatment effects
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:35-46. 2003
    ..Therefore, administration of these amino acids may be useful in clinical treatment and prevention of osteoporosis...
  10. ncbi Osteoblasts cultured from osteoporotic bone: a comparative investigation on human and animal-derived cells
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:263-77. 2003
    ..Cells derived from osteopenic sheep behaved much more similarly to those from humans, except for a significant difference in terms of TGF-beta1 observed both under basal conditions and after stimulation...
  11. ncbi Isolation and characterization of osteoblast cultures from normal and osteopenic sheep for biomaterials evaluation
    P Torricelli
    Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli Servizio di Chirurgia Sperimentale, via di Barbiano 1 10 40136 Bologna, Italy
    J Biomed Mater Res 52:177-82. 2000
    ..05). These in vitro tests demonstrated that sheep osteoblast cultures can be useful when determining biocompatibility and osteointegration of orthopedic materials, and also when evaluating for the presence of osteoporosis...
  12. ncbi Human osteoblast cultures from osteoporotic and healthy bone: biochemical markers and cytokine expression in basal conditions and in response to 1,25(OH)2D3
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 30:219-27. 2002
    ..The current findings should be taken into account when cultures derived from human bone are used for in vitro experiments...
  13. ncbi Physical characterization of different-roughness titanium surfaces, with and without hydroxyapatite coating, and their effect on human osteoblast-like cells
    Veronica Borsari
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 75:359-68. 2005
    ..Surface morphology and the HA coating strongly affected cell behavior. However, ultrahigh values of roughness are not correctly seen by cells, and the presence of HA has no improving effects...
  14. ncbi Comparative in vitro study on a ultra-high roughness and dense titanium coating
    Veronica Borsari
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomaterials 26:4948-55. 2005
    ..In conclusion, the new ultra-high roughness and dense coating PG60 provided a good biological response, even though, at least in vitro, it behaved similarly to the coatings already used in orthopaedics...
  15. pmc Response of human chondrocytes and mesenchymal stromal cells to a decellularized human dermis
    Gianluca Giavaresi
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute IRCCS, Bologna, Italy
    BMC Musculoskelet Disord 14:12. 2013
    ..The aim of this study was to evaluate in vitro the biological influence of a newly developed decellularized human dermal extracellular matrix on two human primary cultures...
  16. ncbi In vitro and in vivo behaviour of biodegradable and injectable PLA/PGA copolymers related to different matrices
    M Tschon
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, Bologna Italy
    Int J Artif Organs 30:352-62. 2007
    ..The SL2-treated defects healed better at 12 weeks with a more similar microarchitecture of the newly formed bone to normal bone in comparison with other materials, as demonstrated by bone volume fraction and trabecular thickness values...
  17. ncbi In vitro and in vivo response to nanotopographically-modified surfaces of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone
    Gianluca Giavaresi
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, I 40136 Bologna, Italy
    J Biomater Sci Polym Ed 17:1405-23. 2006
    ....
  18. ncbi Mechanical and histomorphometric evaluations of titanium implants with different surface treatments inserted in sheep cortical bone
    Gianluca Giavaresi
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomaterials 24:1583-94. 2003
    ..However, further studies are required to investigate bone hardness and mineralization around implants...
  19. ncbi Early effects of extracorporeal shock wave treatment on osteoblast-like cells: a comparative study between electromagnetic and electrohydraulic devices
    Lucia Martini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Trauma 61:1198-206. 2006
    ....
  20. ncbi Primary osteoblasts response to shock wave therapy using different parameters
    Lucia Martini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:449-66. 2003
    ..The current study has demonstrated that one of the most important aspects to be considered is not the total number of impulses used but the energy level of the shock waves, thus confirming that ESWT has a dose-dependent effect on cells...
  21. ncbi In vitro behaviour of osteoblasts cultured on orthopaedic biomaterials with different surface roughness, uncoated and fluorohydroxyapatite-coated, relative to the in vivo osteointegration rate
    M Fini
    Experimental Surgery, Department Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 26:520-8. 2003
    ..Results suggest that collagen-I production could be useful in predicting the in vivo osteointegration rate of biocompatible biomaterials observed in previous studies...
  22. doi New PMMA-based composites for preparing spacer devices in prosthetic infections
    Gianluca Giavaresi
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute IRCCS, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Mater Sci Mater Med 23:1247-57. 2012
    ..These composites could be useful for preparing devices for prosthetic joint infections treatment also allowing the use of antibiotics solution at required concentrations...
  23. ncbi A bone substitute composed of polymethylmethacrylate and alpha-tricalcium phosphate: results in terms of osteoblast function and bone tissue formation
    Milena Fini
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:4523-31. 2002
    ....
  24. ncbi Bone tissue cultures: an in vitro model for the evaluation of bone defect healing after L-arginine and L-lysine administration
    P Torricelli
    Experimental Surgery Department, Research Institute Codivilla-Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 29:325-34. 2001
    ..The effect of Arg and Lys confirmed data of a previous study, where a faster healing of bone defect and fracture was observed in rabbits after Arg and Lys administration...
  25. doi Decellularized human dermis to treat massive rotator cuff tears: in vitro evaluations
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy
    Connect Tissue Res 53:298-306. 2012
    ..05). In vitro data showed that the decellularization technique enabled the development of a matrix with adequate biological and biomechanical properties...
  26. ncbi Role of obesity , alcohol and smoking on bone health
    Milena Fini
    Laboratory of Preclinical and Surgical Studies Rizzoli Orthopaedic Institute, Bologna, Italy
    Front Biosci (Elite Ed) 4:2686-706. 2012
    ..Health information campaigns against these harmful lifestyles should be strengthened by using available scientific information to increase awareness about their consequences on the bone...
  27. ncbi Lights and shadows concerning platelet products for musculoskeletal regeneration
    Matilde Tschon
    Laboratory of Surgical and Preclinical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Front Biosci (Elite Ed) 3:96-107. 2011
    ..The possibility of improving the knowledge on variables affecting therapeutic efficacy will surely help in addressing the best combination of factors implied in the different steps of PLT concentrate preparation and use...
  28. ncbi Effect of pulsed electromagnetic field stimulation on knee cartilage, subchondral and epyphiseal trabecular bone of aged Dunkin Hartley guinea pigs
    Milena Fini
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomed Pharmacother 62:709-15. 2008
    ..DXA confirmed the significantly higher bone density in SHAM-treated animals. Even in the presence of severe OA lesions PEMFs maintained a significant efficacy in reducing lesion progression...
  29. ncbi A biomimetic gelatin-calcium phosphate bone cement
    A Bigi
    Department of Chemistry G Ciamician, University of Bologna, Bologna, Italy
    Int J Artif Organs 27:664-73. 2004
    ..The remarkable improvement of the setting properties of the calcium phosphate cement due to the presence of gelatin suggest that the biomimetic composite material could be successfully applied as bone substitute...
  30. ncbi In vitro study comparing two collageneous membranes in view of their clinical application for rotator cuff tendon regeneration
    Milena Fini
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 25:98-107. 2007
    ..The obtained results support the conclusion that GJ is more suitable than SIS as a scaffold for in situ tissue engineering and for the in vitro bioengineering of tendons to heal massive tears of the rotator cuff tendon...
  31. ncbi Enhanced guided bone regeneration with a resorbable chamber containing demineralized bone matrix
    Roberto Giardino
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, University of Bologna, Bologna, Italy
    J Trauma 52:933-7. 2002
    ..The injection of bone marrow stem cells into the chamber had proven to enhance bone regeneration...
  32. ncbi Osseointegration of endosseous ceramic implants after postoperative low-power laser stimulation: an in vivo comparative study
    Gaetano A Guzzardella
    Department of Experimental Surgery Codivilla Putti Research Institute, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Oral Implants Res 14:226-32. 2003
    ..0005) and 6 weeks (P<0.001); a significant difference in bone microhardness was seen in the LPL group vs. the control group (P<0.01). These results suggest that LPL postoperative treatment enhances the bone-implant interface...
  33. pmc Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses
    Paola Torricelli
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Int Orthop 35:1569-76. 2011
    ....
  34. ncbi A new austenitic stainless steel with a negligible amount of nickel: an in vitro study in view of its clinical application in osteoporotic bone
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 71:30-7. 2004
    ..SEM images revealed no alteration in cell morphology. The current findings demonstrate that P558 promotes osteoblast proliferation, activation, and differentiation not only in normal bone, but also in osteopenic bone-derived osteoblasts...
  35. doi Role of moderate exercising on Achilles tendon collagen crimping patterns and proteoglycans
    Marco Franchi
    Department for Life Quality Studies, Faculty of Exercise and Sport Sciences, University of Bologna, Bologna, Italy
    Connect Tissue Res 54:267-74. 2013
    ....
  36. ncbi Alendronate-hydroxyapatite nanocomposites and their interaction with osteoclasts and osteoblast-like cells
    Elisa Boanini
    Department of Chemistry G Ciamician, University of Bologna, Bologna, Italy
    Biomaterials 29:790-6. 2008
    ..The osteoclast number on the composite nanocrystals decrease indicating that the bisphosphonate exerts its inhibitory effect on osteoclast proliferation even when incorporated into hydroxyapatite...
  37. ncbi In vitro models to test orthopedic biomaterials in view of their clinical application in osteoporotic bone
    P Torricelli
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 27:658-63. 2004
    ..Pathological cell culture models are able to demonstrate the different behavior of osteoblasts in response to biomaterials, when comparing normal and pathological conditions...
  38. ncbi Blood vessel formation after soft-tissue implantation of hyaluronan-based hydrogel supplemented with copper ions
    G Giavaresi
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomaterials 26:3001-8. 2005
    ....
  39. ncbi Biocompatibility and osseointegration in osteoporotic bone
    M Fini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 83:139-43. 2001
    ..Our findings suggest that osteopenic models may be used in vivo in the preclinical evaluation of orthopaedic biomaterials. We suggest that primary cell cultures from pathological models could be used as an experimental model in vitro...
  40. ncbi Combined effect of strontium and zoledronate on hydroxyapatite structure and bone cell responses
    Elisa Boanini
    Department of Chemistry G Ciamician, University of Bologna, Bologna, Italy
    Biomaterials 35:5619-26. 2014
    ....
  41. ncbi The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone: a morphologic and microstructural in vivo study
    Milena Fini
    J Orthop Res 20:756-63. 2002
    ..Both morphological and structural results demonstrated a positive therapeutic effect of PEMFs in accelerating HA osteointegration in trabecular bone...
  42. ncbi The role of different chemical modifications of superoxide dismutase in preventing a prolonged muscular ischemia/ reperfusion injury
    Roberto Giardino
    Surgical Pathophysiology, University of Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 30:189-98. 2002
    ..The outcomes obtained in terms of limb survival (p < 0.05), as well as histomorphologic studies (p < 0.0005), revealed a superior capacity of mPEG-SOD when compared with the other three substances...
  43. ncbi Improvement in zirconia osseointegration by means of a biological glass coating: An in vitro and in vivo investigation
    N Nicoli Aldini
    Experimental Surgery Department, Research Institute Codivilla Putti Rizzoli Orthopaedic Institute via di Barbiano 1 10, 40136, Bologna, Italy
    J Biomed Mater Res 61:282-9. 2002
    ..014) but only for coated ZrO(2.) These results suggest that RKKP bioglaze-coated ZrO(2) permits biocompatible devices with improved osseointegration properties to be manufactured...
  44. ncbi In vitro biocompatibility of titanium oxide for prosthetic devices nanostructured by low pressure metal-organic chemical vapor deposition
    G Giavaresi
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 26:774-80. 2003
    ....
  45. ncbi Pulsed electromagnetic fields reduce knee osteoarthritic lesion progression in the aged Dunkin Hartley guinea pig
    M Fini
    Department of Experimental Surgery, Codivilla Putti Research Institute, Rizzoli Institute of Orthopaedics, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Orthop Res 23:899-908. 2005
    ..The chondroprotective effect of PEMFs was demonstrated not only in the medial tibial plateau but also on the entire articular surface of the knee...
  46. ncbi Laser technology in orthopedics: preliminary study on low power laser therapy to improve the bone-biomaterial interface
    G A Guzzardella
    Experimental Surgery Department, Research Institute Codivilla Putti, Bologna, Italy
    Int J Artif Organs 24:898-902. 2001
    ..0005) and 8 weeks (p < 0.001). These preliminary positive results seem to support the hypothesis that LPL treatment can be considered a good tool to enhance the bone-implant interface in orthopedic surgery...
  47. ncbi Histomorphometric bone modifications induced by growth hormone treatment in a rabbit model of short bowel syndrome
    R Giardino
    Department of Experimental Surgery, Istituti Ortopedici Rizzoli, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 58:116-22. 2004
    ..05) in SBS Group than those of Control Group. The current findings are encouraging and suggest that GH administration in SBS animal model used may improve skeletal tissue remodelling...
  48. ncbi The ovariectomized ewe model in the evaluation of biomaterials for prosthetic devices in spinal fixation
    G Giavaresi
    Department of Experimental Surgery, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 24:814-20. 2001
    ..Such findings may be useful for future experimental investigations on biomaterials and prosthetic devices to be implanted in the osteopenic spine...
  49. ncbi Effect of L-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomed Pharmacother 55:213-20. 2001
    ..In osteopenic bone-derived osteoblasts this synthetic phase is preceded by an initial increase of cell proliferation...
  50. ncbi Laser biostimulation of cartilage: in vitro evaluation
    P Torricelli
    Experimental Surgery Department, Istituto di Ricerca Codivilla Putti, Bologna, Italy
    Biomed Pharmacother 55:117-20. 2001
    ..The results obtained with the Ga-Al-As diode laser using the above tested parameters for in vitro biostimulation of cartilage tissues provide a basis for a rational approach to the experimental and clinical use of this device...
  51. ncbi Laser stimulation on bone defect healing: an in vitro study
    G A Guzzardella
    Department of Experimental Surgery, Codivilla Putti Research Institute Rizzoli Orthopaedic Institute, Italy
    Lasers Med Sci 17:216-20. 2002
    ..0005) and in Ca in CG versus LG ( p<0.001). The healing rate of the defect area in the LG was higher than in the CG ( p=0.007). These in vitro results suggest that Ga-Al-As LPL treatment may play a positive role in bone defect healing...
  52. ncbi Natural and synthetic polyesters for musculoskeletal tissue repair: experimental in vitro and in vivo evaluations
    G Giavaresi
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 27:796-805. 2004
    ..D400G seems to be the most suitable material for biomedical application when tested in fibroblast cultures and in the subcutaneous tissue of rats...
  53. ncbi In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination
    D Dallari
    VII Orthopaedic and Traumatology Division, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    J Orthop Res 24:877-88. 2006
    ..05). These results showed that the combination of FDBA, BMSC and PRP permitted an acceleration in bone healing and bone remodeling processes...
  54. ncbi Current trends in the enhancement of biomaterial osteointegration: biophysical stimulation
    M Fini
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 27:681-90. 2004
    ....
  55. ncbi A new austenitic stainless steel with negligible nickel content: an in vitro and in vivo comparative investigation
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 24:4929-39. 2003
    ..55, ns). The current findings demonstrate P558 biocompatibility both in vitro and in vivo, and osteointegration processes are shown to be significantly improved by P558 as compared to the other materials tested...
  56. ncbi The healing of confined critical size cancellous defects in the presence of silk fibroin hydrogel
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomaterials 26:3527-36. 2005
    ..MAR and BFR/B.Pm presented significantly (p<0.05) higher values for SF hydrogel-treated defects in comparison with controls treated with a synthetic polymeric material, confirming that SF hydrogel accelerated remodelling processes...
  57. ncbi Low-power diode laser stimulation of surgical osteochondral defects: results after 24 weeks
    G A Guzzardella
    Department of Experimental Surgery, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 29:235-44. 2001
    ..Results obtained on the lased condyles showed good cell morphology and a regular aspect of the repaired osteocartilaginous tissue...
  58. ncbi Calcitonin release system in the treatment of experimental osteoporosis. Histomorphometric evaluation
    N N Aldini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, and University of Bologna, Italy
    J Orthop Res 19:955-61. 2001
    ..These data confirm a good in vivo behavior of the system, as well as a therapeutic effect of the released calcitonin in the osteopenic condition...
  59. ncbi Biomaterials in orthopedic surgery: effects of a nickel-reduced stainless steel on in vitro proliferation and activation of human osteoblasts
    P Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 26:952-7. 2003
    ..The current findings have demonstrated that P558 promotes osteoblast proliferation, activation and differentiation without negative effects and, thus, its good biocompatibility when used for orthopedic application...
  60. ncbi A resorbable biomaterial shaped as a tubular chamber and containing stem cells: a pilot study on artificial bone regeneration
    R Giardino
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna Italy
    Int J Artif Organs 23:331-7. 2000
    ..On the left side, progressive bone formation with reunion of the stumps was observed in the chamber. We conclude that stem cells can accelerate bone healing when contained in the tubular chamber...
  61. doi Co-electrospun gelatin-poly(L-lactic acid) scaffolds: modulation of mechanical properties and chondrocyte response as a function of composition
    Paola Torricelli
    Preclinical and Surgical Studies Laboratory, Codivilla Putti Research Institute, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy Laboratory of Biocompatibility, Innovative Technologies and Advanced Therapies Department Rizzoli Research, Innovation, Technology, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Mater Sci Eng C Mater Biol Appl 36:130-8. 2014
    ..Mineralization tests enable the deposition of a uniform layer of poorly crystalline apatite onto the scaffolds, suggesting potential applications involving cartilage as well as cartilage-bone interface tissue engineering. ..
  62. ncbi L-arginine and L-lysine stimulation on cultured human osteoblasts
    P Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Servizio di Chirurgia Sperimentale, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 56:492-7. 2002
    ..Arg and Lys show a positive effect on human osteoblasts, which is related partly to the production of those factors required for matrix synthesis, and partly to the direct or mediated activation of cell proliferation...
  63. ncbi Comparative interspecies investigation on osteoblast cultures: data on cell viability and synthetic activity
    P Torricelli
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Biomed Pharmacother 57:57-62. 2003
    ..Above all, the culture of sheep osteoblasts was seen to behave more similarly to that of primary human cells, mainly in terms of cell viability, osteocalcin, interleukin-6 and transforming growth factor-beta1 production...
  64. ncbi Pericellular partial oxygen pressure (pO2) measurement in osteopenic bone-derived osteoblast cultures
    M Fini
    Department of Experimental Surgery, Research Institute Codivilla-Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 29:213-23. 2001
    ....
  65. doi Alendronate and Pamidronate calcium phosphate bone cements: setting properties and in vitro response of osteoblast and osteoclast cells
    S Panzavolta
    Department of Chemistry G Ciamician, University of Bologna, Bologna, Italy
    J Inorg Biochem 103:101-6. 2009
    ..In particular, both Alendronate and Pamidronate promote osteoblast proliferation and differentiation, whereas they inhibit osteoclastogenesis and osteoclast function...
  66. ncbi Shock wave therapy as an innovative technology in skeletal disorders: study on transmembrane current in stimulated osteoblast-like cells
    L Martini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Via De Barbiano 1 10, 4 136 Bologna, Italy
    Int J Artif Organs 28:841-7. 2005
    ..05). These modifications of ion channels activity positively influence cell proliferation (MTT test, p<0.0001) without interfering with the normal synthesis activity of stimulated osteoblasts...
  67. ncbi Bacterial colonization of zirconia ceramic surfaces: an in vitro and in vivo study
    Lia Rimondini
    Department of Oral Pathology and Medicine, University of Milan, Milan, Italy
    Int J Oral Maxillofac Implants 17:793-8. 2002
    ..The microbial colonization of new ceramic materials developed for abutment manufacturing was assessed...
  68. doi An amidated carboxymethylcellulose hydrogel for cartilage regeneration
    Gemma Leone
    Department of Chemical and Biosystem Sciences and Technologies and C R I S M A, University of Siena, Via A Moro N 2, Siena 53100, Italy
    J Mater Sci Mater Med 19:2873-80. 2008
    ..The preliminary results pointed out that CMCA hydrogel could be considered as a potential compound for cartilage regeneration...
  69. doi The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model
    Adriana Bigi
    Department of Chemistry G Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy
    Biomaterials 29:1730-6. 2008
    ..The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti-Nb-Zr alloy with the HA coating on bone remodeling and maturation...
  70. ncbi Amidic alginate hydrogel for nucleus pulposus replacement
    Gemma Leone
    CRISMA, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy
    J Biomed Mater Res A 84:391-401. 2008
    ..In conclusion, the results achieved in this study demonstrated that the amidic alginate-based scaffold is a promising material to be utilized in the replacement of NP...
  71. ncbi Proliferative and re-defferentiative effects of photo-immobilized micro-patterned hyaluronan surfaces on chondrocyte cells
    Rolando Barbucci
    C R I S M A and Department of Chemical and Biosystems Sciences and Technologies, University of Siena, Via A Moro 2, 53100 Siena, Italy
    Biomaterials 26:7596-605. 2005
    ..Furthermore, the same surfaces induced chondrocyte differentiation, with a significant increase of aggrecan and collagen type II production, while homogeneous Hyal and pt-PET surfaces did not...
  72. ncbi Hyaluronic acid hydrogel added with ibuprofen-lysine for the local treatment of chondral lesions in the knee: in vitro and in vivo investigations
    Rolando Barbucci
    Department of Chemical and Biosystem Sciences and Technologies and C R I S M A, University of Siena, Siena, Italy
    J Biomed Mater Res B Appl Biomater 75:42-8. 2005
    ..The positive effects of Hyal 50% on chondral lesions were maintained in the presence of ibuprofen-lysine with the adjunctive effect of an increased limb usage, most likely due to less pain and discomfort...
  73. ncbi Nanocomposites of hydroxyapatite with aspartic acid and glutamic acid and their interaction with osteoblast-like cells
    Elisa Boanini
    Department of Chemistry G Ciamician, University of Bologna, Italy
    Biomaterials 27:4428-33. 2006
    ....