Lucia Savarino

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. ncbi request reprint Sister chromatid exchanges and ion release in patients wearing fracture fixation devices
    L Savarino
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res 50:21-6. 2000
  2. pmc Is wear debris responsible for failure in alumina-on-alumina implants?
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implant, Bologna, Italy
    Acta Orthop 80:162-7. 2009
  3. ncbi request reprint Anthraquinone-2,6-disulfonic acid as a disease-modifying osteoarthritis drug: an in vitro and in vivo study
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Clin Orthop Relat Res 461:231-7. 2007
  4. ncbi request reprint The performance of poly-epsilon-caprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biomaterials 28:3101-9. 2007
  5. ncbi request reprint Differences in ion release after ceramic-on-ceramic and metal-on-metal total hip replacement. Medium-term follow-up
    L Savarino
    The Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 88:472-6. 2006
  6. ncbi request reprint Enamel microhardness after in vitro demineralization and role of different restorative materials
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli Bologna, Italy
    J Biomater Sci Polym Ed 13:349-57. 2002
  7. ncbi request reprint Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 63:467-74. 2002
  8. ncbi request reprint Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 76:364-72. 2006
  9. ncbi request reprint A preliminary in vitro and in vivo study of the effects of new anthraquinones on neutrophils and bone remodeling
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 75:324-32. 2005
  10. ncbi request reprint Systemic cross-linked N-terminal telopeptide and procollagen I C-terminal extension peptide as markers of bone turnover after total hip arthroplasty
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:571-6. 2005

Detail Information

Publications59

  1. ncbi request reprint Sister chromatid exchanges and ion release in patients wearing fracture fixation devices
    L Savarino
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res 50:21-6. 2000
    ..In any case, it would be appropriate to remove the implant when fracture fixation is reached...
  2. pmc Is wear debris responsible for failure in alumina-on-alumina implants?
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implant, Bologna, Italy
    Acta Orthop 80:162-7. 2009
    ....
  3. ncbi request reprint Anthraquinone-2,6-disulfonic acid as a disease-modifying osteoarthritis drug: an in vitro and in vivo study
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Clin Orthop Relat Res 461:231-7. 2007
    ..Our data suggest anthraquinone-2,6-disulfonic acid is worth exploring for treating osteoarthritis...
  4. ncbi request reprint The performance of poly-epsilon-caprolactone scaffolds in a rabbit femur model with and without autologous stromal cells and BMP4
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Biomaterials 28:3101-9. 2007
    ..Finally, the BMP4-expressing BMSCs strongly favoured osteoinductivity of cellular constructs, as demonstrated by a more extensive bone/scaffold contact...
  5. ncbi request reprint Differences in ion release after ceramic-on-ceramic and metal-on-metal total hip replacement. Medium-term follow-up
    L Savarino
    The Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 88:472-6. 2006
    ..For this reason, the low corrosion level in a ceramic-on-ceramic coupling could be advantageous...
  6. ncbi request reprint Enamel microhardness after in vitro demineralization and role of different restorative materials
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli Bologna, Italy
    J Biomater Sci Polym Ed 13:349-57. 2002
    ..These demineralization processes may be responsible for marginal secondary caries and for restoration failures...
  7. ncbi request reprint Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 63:467-74. 2002
    ..In such a way a risk-to-benefit ratio for the patient could be established...
  8. ncbi request reprint Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 76:364-72. 2006
    ..The completion of the study and the evaluation of the ultimate clinical outcome are necessary in order to verify PG in vivo effects in orthopedic surgery...
  9. ncbi request reprint A preliminary in vitro and in vivo study of the effects of new anthraquinones on neutrophils and bone remodeling
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 75:324-32. 2005
    ..If it will be confirmed, they could be proposed in a variety of bone diseases, in particular, when acute inflammation is associated to osteolytic processes and, eventually, in the prevention and treatment of periprosthetic osteolysis...
  10. ncbi request reprint Systemic cross-linked N-terminal telopeptide and procollagen I C-terminal extension peptide as markers of bone turnover after total hip arthroplasty
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:571-6. 2005
    ..The NTx level could be used to indicate stability of the implant. However, further prospective, larger studies are necessary...
  11. ncbi request reprint Ion release in stable hip arthroplasties using metal-on-metal articulating surfaces: a comparison between short- and medium-term results
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res A 66:450-6. 2003
    ..This exposure should be carefully monitored, in order to clarify the biologic effects of ion dissemination and, consequently, to identify risks concerning long-term toxicity of metals...
  12. ncbi request reprint Biologic effects of surface roughness and fluorhydroxyapatite coating on osteointegration in external fixation systems: an in vivo experimental study
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna and UniversitĂ  di Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 66:652-61. 2003
    ..The authors emphasize the necessity for simultaneous evaluation of surface topography and chemistry as well as an improvement in plasma-spraying and post-processing techniques and in standard procedures for materials characterization...
  13. ncbi request reprint Ability of restorative and fluoride releasing materials to prevent marginal dentine demineralization
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Rizzoli Orthopaedic Institute and Department of Anatomical Sciences and Skeletal Muscle Pathophysiology, University of Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 25:1011-7. 2004
    ..On the contrary, composites did not show a protective effect, probably due to an insufficient marginal seal and the lack of fluoride release...
  14. ncbi request reprint Metal ion release from fracture fixation devices: a potential marker of implant failure
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 86:389-95. 2008
    ....
  15. ncbi request reprint Diagnosis of infection after total hip replacement
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, and 7th Division of Orthopaedic Surgery, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 70:139-45. 2004
    ..The inflammatory response to wear debris and the presence of superimposed, slowly growing bacteria could act synergically, both contributing to the pathogenesis of periprosthetic osteolysis...
  16. doi request reprint Potential role of tartrate-resistant acid phosphatase 5b (TRACP 5b) as a surrogate marker of late loosening in patients with total hip arthroplasty: a cohort study
    Lucia Savarino
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 28:887-92. 2010
    ..TRACP 5b has been proven a reliable marker, specifically related to resorbing-multinucleated cells, to ascertain late loosening in THA, and could support standard procedures, if confirmed by performing prospective studies...
  17. doi request reprint Pre-operative diagnosis of infection in total knee arthroplasty: an algorithm
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 17:667-75. 2009
    ..As a result an algorithm helpful to identify the cause of loosening has been developed. In our opinion, adherence to this algorithm could contribute to preoperatively define a rational surgical and antibiotic treatment strategy...
  18. ncbi request reprint Evaluation of restorative materials using a new perfusion system
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopedic Implants, Rizzoli Orthopedic Institute, Bologna, Italy
    J Adhes Dent 10:269-75. 2008
    ....
  19. doi request reprint Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty: 8-year minimum follow-up
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 26:1569-76. 2008
    ..On the contrary, due to the higher ion release, metal-on-metal coupling must be prudently considered, especially in young patients, in order to obtain definitive conclusions...
  20. doi request reprint The potential role of metal ion release as a marker of loosening in patients with total knee replacement: a cohort study
    L Savarino
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 92:634-8. 2010
    ..Measurement of the serum level of Cr ions may be of value for detecting failure due to loosening when the diagnosis is in doubt. The other metal ions studies did not have any diagnostic value...
  21. ncbi request reprint Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Exp Gerontol 36:327-39. 2001
    ..Consequently, a prospective and follow-up evaluation of Zn and Se could be proposed as a good index for a correct monitoring of the micronutrient deficiencies, that could represent an early sign of disease...
  22. ncbi request reprint Effects of metal ions on white blood cells of patients with failed total joint arthroplasties
    L Savarino
    Laboratory for Biocompatibility Research on Implant Materials, Instituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res 47:543-50. 1999
    ..These data suggest that the presence of metal ions, especially chromium, released from prosthesis components could be associated with changes of lymphocyte subpopulations in patients with loosening of joint prostheses...
  23. ncbi request reprint Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement
    Donatella Granchi
    Laboratorio dei Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Bone Joint Surg Br 85:758-64. 2003
    ....
  24. ncbi request reprint Bone cement extracts modulate the osteoprotegerin/osteoprotegerin-ligand expression in MG63 osteoblast-like cells
    Donatella Granchi
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:2359-65. 2002
    ..The ability of bone cements to induce the expression of OPG-L could be a co-factor in the development of osteolysis at the bone-cement interface...
  25. doi request reprint In vitro evaluation of freeze-dried bone allografts combined with platelet rich plasma and human bone marrow stromal cells for tissue engineering
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    J Mater Sci Mater Med 20:45-50. 2009
    ..In conclusion, the combination of FDBA and PRP had a favouring effect on the differentiation towards osteoblasts and allowed BMSC concentrated by simple centrifugation to differentiate as fast as BMSC purified by density gradient...
  26. pmc Does ion release differ between hip resurfacing and metal-on-metal THA?
    Antonio Moroni
    VI Division, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna, Italy
    Clin Orthop Relat Res 466:700-7. 2008
    ..Level of Evidence: Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence...
  27. ncbi request reprint Effects of bone cement extracts on the cell-mediated immune response
    Donatella Granchi
    Dipartimento Putti Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1033-41. 2002
    ..These findings show that the products released from bone cement are not able, by themselves, to elicit a specific immune response; on the contrary they hamper the function of lymphocytes activated by an exogenous stimulus...
  28. ncbi request reprint Plasma levels of platelet-derived growth factor BB and transforming growth factor in patients with failed hip prostheses
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, IT 40136 Bologna, Italy
    Acta Orthop 76:61-6. 2005
    ..We evaluated the levels of platelet-derived growth factor BB (PDGF-BB), transforming growth factors beta1 (TGF-beta1) and beta2 (TGF-beta2), both before and after activation, in patients with aseptic loosening of their hip prosthesis...
  29. pmc Do ion levels in metal-on-metal hip resurfacing differ from those in metal-on-metal THA at long-term followup?
    Lucia Savarino
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Clin Orthop Relat Res 471:2964-71. 2013
    ..Nevertheless, concerns remain regarding wear and corrosion of the bearing surfaces and the resulting systemic metal ion distribution...
  30. ncbi request reprint Plasma levels of coagulation inhibitors, fibrinolytic markers and platelet-derived growth factor-AB in patients with failed hip prosthesis
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Acta Orthop Scand 74:559-64. 2003
    ..PAI-1 and D-dimer assays in failed prostheses may be useful for the pathogenetic evaluation, because the continuous inflammatory stimulus associated with fibrin deposition may also affect the systemic levels...
  31. ncbi request reprint Interleukin-6 expression by osteoblast-like MG63 cells challenged with four acrylic bone cements
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 12:243-53. 2001
    ..We conclude that CMW 1 and CMW 2 increase the production of IL-6 in MG63 cells. The response to Sulfix-60 and CMW 3 is not significantly greater than the negative control...
  32. ncbi request reprint Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells
    D Dallari
    Seventh Division, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Am 89:2413-20. 2007
    ..We compared the osteogenic potential of lyophilized bone chips combined with platelet gel, or with platelet gel and bone marrow stromal cells, with that of lyophilized bone chips alone in the healing of a high tibial osteotomy...
  33. doi request reprint Relevance of deep decortication and vascularization in a case of post-traumatic femoral non-union treated with grafts, platelet gel and bone marrow stromal cells
    Dante Dallari
    Orthopaedic and Traumathological Department I, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 20:1834-8. 2012
    ..In addition to radiographs, two bone biopsies were retrieved: this allowed for a histological evaluation of the early response of host bone to the graft. To our knowledge, there is no report describing such early tissue response...
  34. doi request reprint Background and rationale of platelet gel in orthopaedic surgery
    Elisabetta Cenni
    Laboratorio di Fisiopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Bologna, Italy
    Musculoskelet Surg 94:1-8. 2010
    ..In experimental animals and in clinical application, the efficacy of platelet gel was increased by the combination with bone allografts, acting as scaffolds, and with bone marrow stromal cells...
  35. doi request reprint A prospective, randomised, controlled trial using a Mg-hydroxyapatite - demineralized bone matrix nanocomposite in tibial osteotomy
    Dante Dallari
    Orthopaedic and Traumathological Department I, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, Bologna, Italy
    Biomaterials 33:72-9. 2012
    ..More significant results could be obtained by continuing the clinical trial, by increasing the patient number and the study power. Eventually, the role of non-resorbed graft remnants is still unclear and requires further investigation...
  36. ncbi request reprint Thrombomodulin expression in endothelial cells after contact with bone cement
    Elisabetta Cenni
    Dipartimento Putti, Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:2159-65. 2002
    ..ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW 1 bone cement does not impair the expression of thrombomodulin in endothelial cells...
  37. ncbi request reprint The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation
    D Granchi
    Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 25:4037-45. 2004
    ..With regard to the inductive effect on the osteoclastogenesis, our results show that the Al(2)O(3) wear debris are less active...
  38. ncbi request reprint No effect of methacrylate-based bone cement CMW 1 on the plasmatic phase of coagulation, red blood cells and endothelial cells in vitro
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Acta Orthop Scand 72:86-93. 2001
    ....
  39. ncbi request reprint Expression of the CD69 activation antigen on lymphocytes of patients with hip prosthesis
    D Granchi
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 21:2059-65. 2000
    ..Activated lymphocytes in the peri-implant tissue are likely to elicit a localized immune response and contribute to maintain the inflammatory process evolving in the implant failure...
  40. ncbi request reprint Cytotoxic effect of bone cements in HL-60 cells: distinction between apoptosis and necrosis
    G Ciapetti
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res 52:338-45. 2000
    ..These findings provide potential leads for investigation into the molecular mechanisms of cell death, which are responsible for tissue damage by cements and intolerance of cemented prostheses...
  41. ncbi request reprint In vitro investigation of aluminum and fluoride release from compomers, conventional and resin-modified glass-ionomer cements: a standardized approach
    L Savarino
    Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 11:289-300. 2000
    ..We conclude that the biological assessment of dental cements can be performed only if a pre-evaluation of the leachables is obtained by applying a standardized protocol which allows a useful comparison between the different materials...
  42. ncbi request reprint Application of a combination of neutral red and amido black staining for rapid, reliable cytotoxicity testing of biomaterials
    G Ciapetti
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 17:1259-64. 1996
    ..These methods have been adjusted to a 96-well microplate cell culture system and re-evaluated as simple and reliable methods for the quantitative assessment of biomaterial effect on cells...
  43. ncbi request reprint Cytokine release in mononuclear cells of patients with Co-Cr hip prosthesis
    D Granchi
    Laboratory for Biocompatibility, Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 20:1079-86. 1999
    ....
  44. pmc Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm?
    A Moroni
    Department II of Orthopaedics and Traumatology, Bologna University, Rizzoli Orthopaedic Institute, Via G C Pupilli 1, 40136 Bologna, Italy
    Clin Orthop Relat Res 469:180-7. 2011
    ..Metal-on-metal Birmingham hip resurfacing (MOM-BHR) is an alternative to metal-on-metal total hip arthroplasty (MOM-THA), especially for young and/or active patients. However, wear resulting in increased serum ion levels is a concern...
  45. ncbi request reprint Evaluation of the effect of seven acrylic bone cements on erythrocytes and plasmatic phase of coagulation
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 22:1321-6. 2001
    ..It was concluded that the tested cement extracts do not induce haemolysis and do not activate the intrinsic pathway of coagulation, at least in the tests that were performed...
  46. ncbi request reprint Evaluation of tissue-factor production by human endothelial cells incubated with three acrylic bone cements
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 55:131-6. 2001
    ..The cements did not induce significant production of tissue factor and, therefore, did not activate the extrinsic pathway of coagulation within the limits of the mechanism considered...
  47. ncbi request reprint In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:617-27. 2002
    ..This study helps to gain more insight into the mechanism of cell death induced by PMMA-based cements and suggests apoptosis of osteoblasts as a part of the tissue reaction around cemented prostheses...
  48. ncbi request reprint Quantitative assessment of the response of osteoblast- and macrophage-like cells to particles of Ni-free Fe-base alloys
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 26:849-59. 2005
    ..In vitro mineralisation was achieved by osteoblasts in due time. The new alloys are well tolerated in in vitro systems, and, due to their chemical and mechanical characteristics, they are under development for surgical implants...
  49. ncbi request reprint Effect of CMW 1 bone cement on transforming growth factor-beta 1 expression by endothelial cells
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 12:1011-25. 2001
    ..Incubation with CMW 1 added with ATRA did not produce any changes in TGF-beta 1 synthesis. Incubation with cement extract after 7-day curing added with IL-beta 1 produced a significant reduction in TGF-beta 1 release...
  50. ncbi request reprint Gene expression of bone-associated cytokines in MG63 osteoblast-like cells incubated with acrylic bone cement extracts in minimum essential medium
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomater Sci Polym Ed 13:1283-94. 2002
    ....
  51. ncbi request reprint Biomechanical and histomorphometric investigations on two morphologically differing titanium surfaces with and without fluorohydroxyapatite coating: an experimental study in sheep tibiae
    M Fini
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 24:3183-92. 2003
    ..2%), and between LR+FHA and HR+FHA (-29.2%). The current findings suggest that LR surfaces significantly improve the osteointegration rate of implanted cortical screws independently of the FHA coating...
  52. ncbi request reprint Osteoblast growth and function in porous poly epsilon -caprolactone matrices for bone repair: a preliminary study
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40139, Bologna, Italy
    Biomaterials 24:3815-24. 2003
    ..It can be concluded that PCL is a promising material for three-dimensional scaffold for bone formation, and the presence of bone-like components improves osteoblast activity...
  53. ncbi request reprint Cytotoxicity testing of materials with limited in vivo exposure is affected by the duration of cell-material contact
    G Ciapetti
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 42:485-90. 1998
    ..We suggest that the experimental conditions of cytotoxicity testing have to be relevant to the in vivo situation; accordingly, the time of exposure should be designed carefully...
  54. ncbi request reprint In vitro sister chromatid exchange induced by glass ionomer cements
    S Stea
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 40:545-50. 1998
    ..The authors concluded that of the three cements tested the European cement Ketac Cem passed one of the tests suggested by the EEC standard for assessing genotoxicity...
  55. ncbi request reprint Effects of chromium extract on cytokine release by mononuclear cells
    D Granchi
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 19:283-91. 1998
    ..Moreover, chromium seems to inhibit the IL-2-dependent response of PBMCs, so that they are not able to trigger an efficient cell-mediated immune response...
  56. ncbi request reprint Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged >/=90 y
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, the Department of Angiology and Blood Coagulation, and the Division of Geriatric Medicine, University Hospital Sant Orsola Malpighi, Bologna, Italy
    Am J Clin Nutr 71:590-8. 2000
    ..Natural killer (NK) cells play a role in natural immunity against tumor and infected cells. Advanced aging is associated with functional impairment of NK cells and increased susceptibility to nutritional deficiencies...
  57. ncbi request reprint Effect of four acrylic bone cements on transforming growth factor-beta1 expression by osteoblast-like cells MG63
    Elisabetta Cenni
    Dipartimento Putti, Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:305-11. 2002
    ....
  58. ncbi request reprint Blood micronutrient and thyroid hormone concentrations in the oldest-old
    G Ravaglia
    Department of Internal Medicine, Cardioangiology, and Hepatology, University Hospital S Orsola Malpighi, Bologna, Italy
    J Clin Endocrinol Metab 85:2260-5. 2000
    ..011). In younger subjects, no significant association was found among thyroid variables and micronutrients. In conclusion, blood levels of specific micronutrients are associated with serum iodothyronine levels in extreme aging...
  59. ncbi request reprint Lipid peroxidation and antioxidant status in adults receiving lipid-based home parenteral nutrition
    L Pironi
    Department of Internal Medicine and Gastroenterology, Saint Orsola Malpighi Hospital, University of Bologna, Italy
    Am J Clin Nutr 68:888-93. 1998
    ....