Elizaveta Kon

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. doi request reprint Tissue engineering for total meniscal substitution: animal study in sheep model
    Elizaveta Kon
    Laboratorio di Biomeccanica, Rizzoli Orthopedic Institute, Bologna, Italy
    Tissue Eng Part A 14:1067-80. 2008
  2. doi request reprint Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper's knee
    Elizaveta Kon
    Biomechanics Laboratory, Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Injury 40:598-603. 2009
  3. doi request reprint Platelet-rich plasma (PRP) to treat sports injuries: evidence to support its use
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 19:516-27. 2011
  4. ncbi request reprint ACI and MACI
    Elizaveta Kon
    Biomechanics Laboratory III Orthopaedic Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Knee Surg 25:17-22. 2012
  5. ncbi request reprint Osteochondral regeneration using a novel aragonite-hyaluronate bi-phasic scaffold in a goat model
    E Kon
    III Clinic Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 22:1452-64. 2014
  6. pmc PRP For the Treatment of Cartilage Pathology
    Elizaveta Kon
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, 40136, Bologna, Italy
    Open Orthop J 7:120-8. 2013
  7. pmc Matrix assisted autologous chondrocyte transplantation for cartilage treatment: A systematic review
    E Kon
    Rizzoli Orthopaedic Institute, Biomechanics Laboratory and II Orthopaedic Clinic, Via di Barbiano n 1 10, Bologna 40136, Italy
    Bone Joint Res 2:18-25. 2013
  8. pmc Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review
    Alice Roffi
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, Bologna 40136, Italy
    BMC Musculoskelet Disord 14:330. 2013
  9. doi request reprint Clinical results and MRI evolution of a nano-composite multilayered biomaterial for osteochondral regeneration at 5 years
    Elizaveta Kon
    Elizaveta Kon, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10 40136 Bologna, Italy
    Am J Sports Med 42:158-65. 2014
  10. doi request reprint Biodegradable polyurethane meniscal scaffold for isolated partial lesions or as combined procedure for knees with multiple comorbidities: clinical results at 2 years
    Elizaveta Kon
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 22:128-34. 2014

Collaborators

Detail Information

Publications62

  1. doi request reprint Tissue engineering for total meniscal substitution: animal study in sheep model
    Elizaveta Kon
    Laboratorio di Biomeccanica, Rizzoli Orthopedic Institute, Bologna, Italy
    Tissue Eng Part A 14:1067-80. 2008
    ..Two different surgical implantation techniques in a sheep model were evaluated...
  2. doi request reprint Platelet-rich plasma: new clinical application: a pilot study for treatment of jumper's knee
    Elizaveta Kon
    Biomechanics Laboratory, Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Injury 40:598-603. 2009
    ..The results suggest that this method may be safely used for the treatment of jumper's knee, by aiding the regeneration of tissue which otherwise has low healing potential...
  3. doi request reprint Platelet-rich plasma (PRP) to treat sports injuries: evidence to support its use
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 19:516-27. 2011
    ..High-quality studies are required to confirm these preliminary results and provide scientific evidence to support its use...
  4. ncbi request reprint ACI and MACI
    Elizaveta Kon
    Biomechanics Laboratory III Orthopaedic Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Knee Surg 25:17-22. 2012
    ..The role of many variables that may influence the final outcome still need to be clarified to further improve the potential benefits of these biological regenerative procedures...
  5. ncbi request reprint Osteochondral regeneration using a novel aragonite-hyaluronate bi-phasic scaffold in a goat model
    E Kon
    III Clinic Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 22:1452-64. 2014
    ....
  6. pmc PRP For the Treatment of Cartilage Pathology
    Elizaveta Kon
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, 40136, Bologna, Italy
    Open Orthop J 7:120-8. 2013
    ..Based on current evidence, PRP treatment should only be indicated for low-grade cartilage degeneration and in case of failure of more traditional conservative approaches...
  7. pmc Matrix assisted autologous chondrocyte transplantation for cartilage treatment: A systematic review
    E Kon
    Rizzoli Orthopaedic Institute, Biomechanics Laboratory and II Orthopaedic Clinic, Via di Barbiano n 1 10, Bologna 40136, Italy
    Bone Joint Res 2:18-25. 2013
    ..The purpose of this systematic review is to document and analyse the available literature on the results of MACT in the treatment of chondral and osteochondral lesions of the knee...
  8. pmc Does PRP enhance bone integration with grafts, graft substitutes, or implants? A systematic review
    Alice Roffi
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, Bologna 40136, Italy
    BMC Musculoskelet Disord 14:330. 2013
    ....
  9. doi request reprint Clinical results and MRI evolution of a nano-composite multilayered biomaterial for osteochondral regeneration at 5 years
    Elizaveta Kon
    Elizaveta Kon, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10 40136 Bologna, Italy
    Am J Sports Med 42:158-65. 2014
    ....
  10. doi request reprint Biodegradable polyurethane meniscal scaffold for isolated partial lesions or as combined procedure for knees with multiple comorbidities: clinical results at 2 years
    Elizaveta Kon
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 22:128-34. 2014
    ..The aim of this study is to evaluate the safety and clinical efficacy of this novel polyurethane meniscal scaffold to treat partial meniscal loss...
  11. doi request reprint Treatment of knee osteochondritis dissecans with a cell-free biomimetic osteochondral scaffold: clinical and imaging evaluation at 2-year follow-up
    Giuseppe Filardo
    II Clinic Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Am J Sports Med 41:1786-93. 2013
    ..Unstable lesions must be treated surgically to reestablish the joint surface as anatomically as possible. Hypothesis/..
  12. ncbi request reprint Tissue engineering for total meniscal substitution: animal study in sheep model--results at 12 months
    Elizaveta Kon
    Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part A 18:1573-82. 2012
    ..The study suggests the potential of the novel hyaluronic acid/polycaprolactone scaffold for total meniscal substitution, although this approach has to be further improved before being applied into clinical practice...
  13. pmc New trends for knee cartilage regeneration: from cell-free scaffolds to mesenchymal stem cells
    Elizaveta Kon
    Nanobiotechnology Laboratory and III Orthopaedic Clinic, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Curr Rev Musculoskelet Med 5:236-43. 2012
    ..The first clinical trials have been published but further high quality research is needed to understand their mechanisms of action, their limits, and their clinical efficacy...
  14. doi request reprint Non-surgical management of early knee osteoarthritis
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 20:436-49. 2012
    ..Level of evidence IV...
  15. doi request reprint Second-generation autologous chondrocyte implantation: results in patients older than 40 years
    Elizaveta Kon
    III Clinic, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Am J Sports Med 39:1668-75. 2011
    ..Most studies on surgical procedures for cartilage focus on young patients because these procedures are generally not considered suitable for older patients...
  16. doi request reprint Novel nano-composite multilayered biomaterial for osteochondral regeneration: a pilot clinical trial
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Am J Sports Med 39:1180-90. 2011
    ..In recent years, there has been an increasing interest in and awareness of the importance of subchondral bone, for its role in the pathogenesis of articular surface damage and for the care that should be taken when treating such damage...
  17. pmc Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model
    Elizaveta Kon
    Biomechanics Laboratory Rizzoli Orthopaedic Institute, Bologna, Italy
    BMC Musculoskelet Disord 11:220. 2010
    ..The objective of this study was to investigate the regenerative potential of platelet-rich plasma (PRP) to enhance the repair process of a collagen-hydroxyapatite scaffold in osteochondral defects in a sheep model...
  18. doi request reprint Articular cartilage treatment in high-level male soccer players: a prospective comparative study of arthroscopic second-generation autologous chondrocyte implantation versus microfracture
    Elizaveta Kon
    Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Am J Sports Med 39:2549-57. 2011
    ..Articular cartilage lesions are difficult to treat, and the increased mechanical stress produced by this sport makes their management even more complex...
  19. doi request reprint Arthroscopic second-generation autologous chondrocyte implantation compared with microfracture for chondral lesions of the knee: prospective nonrandomized study at 5 years
    Elizaveta Kon
    Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy
    Am J Sports Med 37:33-41. 2009
    ..Various approaches have been proposed to treat articular cartilage lesions, which are plagued by inherent limited healing potential...
  20. doi request reprint Second generation issues in cartilage repair
    Elizaveta Kon
    Department of Orthopaedic and Traumatology, Biomechanics Lab, Rizzoli Orthopaedic Institute, Bologna University, Bologna, Italy
    Sports Med Arthrosc 16:221-9. 2008
    ....
  21. doi request reprint Orderly osteochondral regeneration in a sheep model using a novel nano-composite multilayered biomaterial
    Elizaveta Kon
    Laboratorio di Biomeccanica, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10 40136 Bologna, Italy
    J Orthop Res 28:116-24. 2010
    ..The comparable regeneration process observed with or without autologous chondrocytes suggests that the main mode of action of the scaffold is based on the recruitment of local cells...
  22. doi request reprint Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions
    Elizaveta Kon
    Department of Orthopaedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 18:472-9. 2010
    ..0005). The preliminary results indicate that the treatment with PRP injections is safe and has the potential to reduce pain and improve knee function and quality of live in younger patients with low degree of articular degeneration...
  23. pmc Novel nano-composite multi-layered biomaterial for the treatment of multifocal degenerative cartilage lesions
    Elizaveta Kon
    Department of Orthopaedic and Sports Trauma, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, Bologna 40136, Italy
    Knee Surg Sports Traumatol Arthrosc 17:1312-5. 2009
    ..MRI evaluation at 6 months showed that the implant gave a hyaline-like signal as well as a good restoration of the articular surface, with minimal subchondral bone oedema. Subchondral oedema was almost non-visible at 12 months...
  24. doi request reprint Scaffold-based repair for cartilage healing: a systematic review and technical note
    Giuseppe Filardo
    Biomechanics Lab, Rizzoli Orthopaedic Institute, Bologna, Italy
    Arthroscopy 29:174-86. 2013
    ....
  25. pmc Platelet-rich plasma vs hyaluronic acid to treat knee degenerative pathology: study design and preliminary results of a randomized controlled trial
    Giuseppe Filardo
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano n 1 10, Bologna 40136, Italy
    BMC Musculoskelet Disord 13:229. 2012
    ..The aim of this study is to show, through a randomized double blind prospective trial, the efficacy of this procedure, by comparing PRP to Hyaluronic Acid (HA) injections for the treatment of knee chondropathy or osteoarthritis (OA)...
  26. ncbi request reprint Arthroscopic second generation autologous chondrocyte implantation
    Maurilio Marcacci
    Department of Orthopedic and Sports Trauma, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 15:610-9. 2007
    ..This matrix autologous chondrocyte transplantation procedure simplifies the surgical procedure and can be performed arthroscopically, thus reducing surgical morbidity and recovery time...
  27. doi request reprint Does patient sex influence cartilage surgery outcome? Analysis of results at 5-year follow-up in a large cohort of patients treated with Matrix-assisted autologous chondrocyte transplantation
    Giuseppe Filardo
    Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Am J Sports Med 41:1827-34. 2013
    ..Sexual dimorphism in humans has already been documented at different levels, and preliminary findings also suggest the importance of patient sex on clinical outcome in the treatment of cartilage lesions...
  28. doi request reprint Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis
    Giuseppe Filardo
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 19:528-35. 2011
    ..The main purpose of this study was to investigate the persistence of the beneficial effects observed...
  29. doi request reprint Knee osteochondral autologous transplantation: long-term MR findings and clinical correlations
    Cecilia Tetta
    Radiology, Rizzoli Orthopedic Institute, Bologna, Italy
    Eur J Radiol 76:117-23. 2010
    ..003 and p=0.002). Contrastingly, overall MOCART showed no correlation with the Tegner score. MRI revealed to be a powerful tool for non-invasive long-term assessment of OAT...
  30. ncbi request reprint Arthroscopic second generation autologous chondrocytes implantation associated with bone grafting for the treatment of knee osteochondritis dissecans: Results at 6 years
    Giuseppe Filardo
    Biomechanics Laboratory, III Clinic, Rizzoli Orthopedic Institute, Bologna, Italy
    Knee 19:658-63. 2012
    ....
  31. pmc Use of platelet-rich plasma for the treatment of refractory jumper's knee
    Giuseppe Filardo
    Department of Orthopedic and Sports Trauma, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int Orthop 34:909-15. 2010
    ....
  32. ncbi request reprint Second-generation arthroscopic autologous chondrocyte implantation for the treatment of degenerative cartilage lesions
    Giuseppe Filardo
    III Clinic Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 20:1704-13. 2012
    ..The aim of this study is to analyze the clinical outcome obtained with the treatment for isolated degenerative knee cartilage lesions by second-generation arthroscopic autologous chondrocyte implantation (ACI)...
  33. doi request reprint Osteochondral tissue engineering approaches for articular cartilage and subchondral bone regeneration
    Silvia Panseri
    Laboratory of Nano Biotechnology, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 20:1182-91. 2012
    ..This review addresses the current surgical treatments and most promising tissue engineering approaches for articular cartilage and subchondral bone regeneration...
  34. doi request reprint Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis
    Elizaveta Kon
    Biomechanics Laboratory III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Arthroscopy 27:1490-501. 2011
    ..The aim of our study is to compare the efficacy of platelet-rich plasma (PRP) and viscosupplementation (hyaluronic acid [HA]) intra-articular injections for the treatment of knee cartilage degenerative lesions and osteoarthritis (OA)...
  35. ncbi request reprint Arthroscopic autologous osteochondral grafting for cartilage defects of the knee: prospective study results at a minimum 7-year follow-up
    Maurilio Marcacci
    Rizzoli Orthopedic Institute, Bologna, Italy
    Am J Sports Med 35:2014-21. 2007
    ..Various approaches have been proposed to treat these lesions; nevertheless, opinions on indications and clinical efficacy of these techniques are still controversial...
  36. doi request reprint Does intensive rehabilitation permit early return to sport without compromising the clinical outcome after arthroscopic autologous chondrocyte implantation in highly competitive athletes?
    Stefano Della Villa
    Education Research Department, Isokinetic Medical Group, Bologna, Italy
    Am J Sports Med 38:68-77. 2010
    ..The challenge of postoperative rehabilitation is to optimize return to preinjury activities without jeopardizing the graft...
  37. doi request reprint Scaffolds for cartilage repair of the ankle joint: The impact on surgical practice
    Francesca Vannini
    II Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, University of Bologna, Via GC Pupilli 1, 40136 Bologna, Italy
    Foot Ankle Surg 19:2-8. 2013
    ..Ideal management of osteochondral lesions in the ankle joint is still theme of debate. Scaffold-based repair is emerging as a new approach for regenerative treatment...
  38. ncbi request reprint Arthroscopic collagen meniscus implant results at 6 to 8 years follow up
    Stefano Zaffagnini
    Biomechanics Department, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 15:175-83. 2007
    ..Although the aspect of the implant was mostly abnormal, the implant may have helped reduce the deterioration of the knee joint at final observation time...
  39. pmc Platelet-rich plasma for the treatment of patellar tendinopathy: clinical and imaging findings at medium-term follow-up
    Giuseppe Filardo
    II Orthopaedic and Traumatology Clinic Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int Orthop 37:1583-9. 2013
    ....
  40. doi request reprint How to treat osteochondritis dissecans of the knee: surgical techniques and new trends: AAOS exhibit selection
    Elizaveta Kon
    III Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna 20136, Italy
    J Bone Joint Surg Am 94:e1(1-8). 2012
    ..Osteochondritis dissecans is a relatively common cause of knee pain. The aim of this study was to describe the outcomes of five different surgical techniques in a series of sixty patients with osteochondritis dissecans...
  41. ncbi request reprint Platelet-rich plasma intra-articular injections for cartilage degeneration and osteoarthritis: single- versus double-spinning approach
    Giuseppe Filardo
    Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 20:2082-91. 2012
    ..To compare the safety and efficacy of two different approaches of platelet-rich plasma (PRP) production methods as intra-articular injection treatment for knee cartilage degenerative lesions and osteoarthritis (OA)...
  42. ncbi request reprint Arthroscopic collagen meniscus implantation for partial lateral meniscal defects: a 2-year minimum follow-up study
    Stefano Zaffagnini
    Istituto Ortopedico Rizzoli, University of Bologna, Bologna, Italy
    Am J Sports Med 40:2281-8. 2012
    ..Loss of knee meniscal tissue often leads to increased pain and decreased function...
  43. doi request reprint Matrix-assisted autologous chondrocyte transplantation for the repair of cartilage defects of the knee: systematic clinical data review and study quality analysis
    Elizaveta Kon
    Department of Orthopedics and Traumatology, Biomechanics Lab, Rizzoli Orthopedic Institute, Bologna University, Bologna, Italy
    Am J Sports Med 37:156S-66S. 2009
    ....
  44. doi request reprint Arthroscopic second-generation autologous chondrocyte implantation: a prospective 7-year follow-up study
    Giuseppe Filardo
    III Clinic Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Am J Sports Med 39:2153-60. 2011
    ..The clinical application of the regenerative approach is well documented for different types of scaffold but mostly with an evaluation of the clinical outcome at short-term follow-up...
  45. pmc Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses
    Paola Torricelli
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Int Orthop 35:1569-76. 2011
    ....
  46. doi request reprint Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics
    Giuseppe Filardo
    Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 21:1717-29. 2013
    ..The aim of this systematic review is to examine the available clinical evidence in the literature to support mesenchymal stem cell (MSC) treatment strategies in orthopaedics for cartilage defect regeneration...
  47. doi request reprint Matrix-assisted autologous chondrocyte transplantation for cartilage regeneration in osteoarthritic knees: results and failures at midterm follow-up
    Giuseppe Filardo
    Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Am J Sports Med 41:95-100. 2013
    ..Young patients with osteoarthritic knees are a challenging population because of a combination of high functional demands and limited indication for joint replacement...
  48. ncbi request reprint Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up
    Maurilio Marcacci
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthroscopy 21:462-70. 2005
    ..To prospectively evaluate the mosaicplasty technique for treatment of femoral condyle cartilage lesions (Outerbridge grade IV) less than 2.5 cm2 in homogeneous group of young active patients...
  49. pmc Does platelet-rich plasma freeze-thawing influence growth factor release and their effects on chondrocytes and synoviocytes?
    Alice Roffi
    Nano Biotechnology Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano 1, 40136 Bologna, Italy
    Biomed Res Int 2014:692913. 2014
    ..PRP cryopreservation is a safe procedure, which sufficiently preserves PRP quality and its ability to induce proliferation and the production of ECM components in chondrocytes and synoviocytes. ..
  50. ncbi request reprint Is the clinical outcome after cartilage treatment affected by subchondral bone edema?
    Giuseppe Filardo
    Biomechanics Laboratory II Clinic, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Knee Surg Sports Traumatol Arthrosc 22:1337-44. 2014
    ..The aim of this study is to analyse the presence of edema after matrix-assisted autologous chondrocyte transplantation (MACT) for knee cartilage lesions at different follow-up times and its correlation with the clinical outcome...
  51. ncbi request reprint Lights and shadows concerning platelet products for musculoskeletal regeneration
    Matilde Tschon
    Laboratory of Surgical and Preclinical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Front Biosci (Elite Ed) 3:96-107. 2011
    ..The possibility of improving the knowledge on variables affecting therapeutic efficacy will surely help in addressing the best combination of factors implied in the different steps of PLT concentrate preparation and use...
  52. doi request reprint Treatment of "patellofemoral" cartilage lesions with matrix-assisted autologous chondrocyte transplantation: a comparison of patellar and trochlear lesions
    Giuseppe Filardo
    Luca Andriolo, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10 40136 Bologna, Italy
    Am J Sports Med 42:626-34. 2014
    ....
  53. ncbi request reprint Clinical profiling in cartilage regeneration: prognostic factors for midterm results of matrix-assisted autologous chondrocyte transplantation
    Giuseppe Filardo
    Berardo Di Matteo, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10 Bologna, 40136 Italy
    Am J Sports Med 42:898-905. 2014
    ..Although short-term/midterm results are now available for a small series of patients, the literature still lacks studies on large cohorts of patients evaluated at midterm/long-term follow-up...
  54. pmc New bio-ceramization processes applied to vegetable hierarchical structures for bone regeneration: an experimental model in sheep
    Giuseppe Filardo
    1 Laboratory of Biomechanics, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part A 20:763-73. 2014
    ....
  55. doi request reprint Treatment of cartilage lesions: what works and why?
    Maurilio Marcacci
    III Clinic, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Injury 44:S11-5. 2013
    ..Thus, the results obtained through the study of the authors' 20 years' experience in cartilage treatment were analyzed to give some indications on the potential and limits of different treatment approaches available in clinical practice...
  56. ncbi request reprint Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study
    Maurilio Marcacci
    Laboratorio di Biomeccanica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Tissue Eng 13:947-55. 2007
    ..We consider the obtained results very promising and propose the use of culture-expanded osteoprogenitor cells in conjunction with porous bioceramics as a real and significant improvement in the repair of critical-sized long bone defects...
  57. ncbi request reprint Chronic posttraumatic cartilage lesion of the knee treated with an acellular osteochondral-regenerating implant: case history with rehabilitation guidelines
    Elizaveta Kon
    III Clinic Biomechanics Laboratory, Rizzoli Orthopaedic Inst, Bologna, Italy
    J Sport Rehabil 23:270-5. 2014
    ..This scaffold was used on an Outerbridge grade IV medical condylar defect measuring ~2 cm2. At 24 mo follow-up, the articular surface appeared restored by MRI, and the patient returned to sports. ..
  58. ncbi request reprint Platelet-rich plasma affects bacterial growth in vitro
    Erminia Mariani
    Laboratory of Immunorheumatology and Tissue Regeneration RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Electronic address
    Cytotherapy 16:1294-304. 2014
    ..Microbicidal proteins released from activated P-PRP platelets were also determined...
  59. ncbi request reprint Platelet rich plasma: a valid augmentation for cartilage scaffolds? A systematic review
    Francesco Perdisa
    Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Histol Histopathol 29:805-14. 2014
    ..The aim of the present manuscript is to review systematically the current evidence in pre-clinical and clinical studies for the use of PRP augmented scaffolds to treat chondral or osteochondral disorders. ..
  60. doi request reprint Preparation method and growth factor content of platelet concentrate influence the osteogenic differentiation of bone marrow stromal cells
    Francesca Perut
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Rizzoli Orthopedic Institute, Bologna, Italy
    Cytotherapy 15:830-9. 2013
    ..The aim of this study was to determine whether different compositions of platelet concentrates may affect the osteogenic differentiation of bone marrow stromal cells (BMSC)...
  61. pmc Bone regeneration with mesenchymal stem cells
    Elizaveta Kon
    Biomechanics Laboratory, III Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Cases Miner Bone Metab 9:24-7. 2012
    ..Researchers have to perform more high quality studies in order to document results and increase the potential of MSCs use in clinical practice, to develop a minimally invasive treatment to favor high quality bone tissue regeneration...
  62. doi request reprint Nonoperative biological treatment approach for partial Achilles tendon lesion
    Giuseppe Filardo
    Department of Orthopedic and Sports Trauma, Biomechanics Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    Orthopedics 33:120-3. 2010
    ..This biological approach may represent a less-invasive therapeutic option even in cases where severe tendon lesions are candidates for surgical treatment...