Affiliation: Istituti Ortopedici Rizzoli
Gamberi G, Benassi M, Pompetti F, Ferrari C, Ragazzini P, Sollazzo M, et al
. Presence and expression of the simian virus-40 genome in human giant cell tumors of bone. Genes Chromosomes Cancer. 2000;28:23-30 pubmed
..001). These results show that SV40 DNA sequences and SV40 Tag are present in GCTs and might induce FOS activity. These data suggest that SV40 might play a role in the development and progression of some GCTs. ..
Gamberi G, Serra M, Ragazzini P, Magagnoli G, Pazzaglia L, Ponticelli F, et al
. Identification of markers of possible prognostic value in 57 giant cell tumors of bone. Oncol Rep. 2003;10:351-6 pubmed
..Therefore, the evaluation of the expression levels of these proteins at the time of diagnosis may be taken into consideration for a classification of GCT into categories characterized by a different risk to relapse. ..
Gamberi G, Benassi M, Ragazzini P, Pazzaglia L, Ponticelli F, Ferrari C, et al
. Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone. Ann Oncol. 2004;15:498-503 pubmed
..Morever, it appears that increased expression of the IL-6, u-PA, u-PAR and PAI1 proteins might not depend on mutation of the corresponding genes. ..
Gamberi G, Morandi L, Benini S, Resca A, Cocchi S, Magagnoli G, et al
. Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR). Pathol Res Pract. 2018;214:89-94 pubmed publisher
..We demonstrated that ASLNAqPCR is a quick, sensitive and reliable method to identify mutations of the H3F3A gene, in giant cell tumor of bone, to support diagnosis in morphologically ambiguous cases. ..
Righi A, Mancini I, Gambarotti M, Picci P, Gamberi G, Marraccini C, et al
. Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone. Hum Pathol. 2017;68:128-135 pubmed publisher
..Although the presence of H3F3A mutations does not exclude with certainty a diagnosis of sarcoma, the possibility of a malignant evolution of GCTB should also be considered. ..