Milena Fini

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. pmc Effect of training and sudden detraining on the patellar tendon and its enthesis in rats
    Antonio Frizziero
    Department of Histology, Embryology and Applied Biology, University of Bologna, Italy
    BMC Musculoskelet Disord 12:20. 2011
  2. doi request reprint Decellularized human dermis to treat massive rotator cuff tears: in vitro evaluations
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy
    Connect Tissue Res 53:298-306. 2012
  3. ncbi request reprint Histomorphometric and mechanical analysis of the hydroxyapatite-bone interface after electromagnetic stimulation: an experimental study in rabbits
    M Fini
    Experimental Surgery Laboratory, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 88:123-8. 2006
  4. ncbi request reprint Pulsed electromagnetic fields reduce knee osteoarthritic lesion progression in the aged Dunkin Hartley guinea pig
    M Fini
    Department of Experimental Surgery, Codivilla Putti Research Institute, Rizzoli Institute of Orthopaedics, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Orthop Res 23:899-908. 2005
  5. doi request reprint Ablation of bone cells by electroporation
    M Fini
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 92:1614-20. 2010
  6. ncbi request reprint Osteoporosis and biomaterial osteointegration
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 58:487-93. 2004
  7. ncbi request reprint A bone substitute composed of polymethylmethacrylate and alpha-tricalcium phosphate: results in terms of osteoblast function and bone tissue formation
    Milena Fini
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:4523-31. 2002
  8. ncbi request reprint Effects of pulsed electromagnetic fields on articular hyaline cartilage: review of experimental and clinical studies
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti Rizzoli, Orthopedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 59:388-94. 2005
  9. doi request reprint Harmful lifestyles on orthopedic implantation surgery: a descriptive review on alcohol and tobacco use
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Bone Miner Metab 29:633-44. 2011
  10. ncbi request reprint In vitro study comparing two collageneous membranes in view of their clinical application for rotator cuff tendon regeneration
    Milena Fini
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 25:98-107. 2007

Detail Information

Publications156 found, 100 shown here

  1. pmc Effect of training and sudden detraining on the patellar tendon and its enthesis in rats
    Antonio Frizziero
    Department of Histology, Embryology and Applied Biology, University of Bologna, Italy
    BMC Musculoskelet Disord 12:20. 2011
    ..Aim of the study was the assessment of training and especially detraining on the patellar tendon (PT) and its enthesis...
  2. doi request reprint Decellularized human dermis to treat massive rotator cuff tears: in vitro evaluations
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy
    Connect Tissue Res 53:298-306. 2012
    ..05). In vitro data showed that the decellularization technique enabled the development of a matrix with adequate biological and biomechanical properties...
  3. ncbi request reprint Histomorphometric and mechanical analysis of the hydroxyapatite-bone interface after electromagnetic stimulation: an experimental study in rabbits
    M Fini
    Experimental Surgery Laboratory, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 88:123-8. 2006
    ..0001; sigma(u), p < 0.0005)...
  4. ncbi request reprint Pulsed electromagnetic fields reduce knee osteoarthritic lesion progression in the aged Dunkin Hartley guinea pig
    M Fini
    Department of Experimental Surgery, Codivilla Putti Research Institute, Rizzoli Institute of Orthopaedics, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Orthop Res 23:899-908. 2005
    ..The chondroprotective effect of PEMFs was demonstrated not only in the medial tibial plateau but also on the entire articular surface of the knee...
  5. doi request reprint Ablation of bone cells by electroporation
    M Fini
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 92:1614-20. 2010
    ..It can be an effective treatment in bone and when used in combination with drugs, an option for the treatment of metastases...
  6. ncbi request reprint Osteoporosis and biomaterial osteointegration
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 58:487-93. 2004
    ..The use of pathological bone-derived cells and pathological animals is therefore recommended to test candidate orthopaedic materials...
  7. ncbi request reprint A bone substitute composed of polymethylmethacrylate and alpha-tricalcium phosphate: results in terms of osteoblast function and bone tissue formation
    Milena Fini
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:4523-31. 2002
    ....
  8. ncbi request reprint Effects of pulsed electromagnetic fields on articular hyaline cartilage: review of experimental and clinical studies
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti Rizzoli, Orthopedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomed Pharmacother 59:388-94. 2005
    ..In the present paper some recent experimental in vitro and in vivo data on the effect of PEMFs on articular cartilage were reviewed. These data strongly support the clinical use of PEMFs in OA patients...
  9. doi request reprint Harmful lifestyles on orthopedic implantation surgery: a descriptive review on alcohol and tobacco use
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Bone Miner Metab 29:633-44. 2011
    ....
  10. ncbi request reprint In vitro study comparing two collageneous membranes in view of their clinical application for rotator cuff tendon regeneration
    Milena Fini
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 25:98-107. 2007
    ..The obtained results support the conclusion that GJ is more suitable than SIS as a scaffold for in situ tissue engineering and for the in vitro bioengineering of tendons to heal massive tears of the rotator cuff tendon...
  11. ncbi request reprint Effect of L-lysine and L-arginine on primary osteoblast cultures from normal and osteopenic rats
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomed Pharmacother 55:213-20. 2001
    ..In osteopenic bone-derived osteoblasts this synthetic phase is preceded by an initial increase of cell proliferation...
  12. ncbi request reprint Effect of pulsed electromagnetic field stimulation on knee cartilage, subchondral and epyphiseal trabecular bone of aged Dunkin Hartley guinea pigs
    Milena Fini
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomed Pharmacother 62:709-15. 2008
    ..DXA confirmed the significantly higher bone density in SHAM-treated animals. Even in the presence of severe OA lesions PEMFs maintained a significant efficacy in reducing lesion progression...
  13. ncbi request reprint The ovariectomised sheep as a model for testing biomaterials and prosthetic devices in osteopenic bone: a preliminary study on iliac crest biopsies
    M Fini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 23:275-81. 2000
    ..In conclusion, OVX sheep showed a loss of trabecular bone starting at 12 months after ovariectomy. The developed osteopenic state may be considered as a useful tool when doing research on biomaterial osteointegration...
  14. ncbi request reprint Titanium alloy osseointegration in cancellous and cortical bone of ovariectomized animals: histomorphometric and bone hardness measurements
    Milena Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Oral Maxillofac Implants 17:28-37. 2002
    ....
  15. ncbi request reprint The healing of confined critical size cancellous defects in the presence of silk fibroin hydrogel
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    Biomaterials 26:3527-36. 2005
    ..MAR and BFR/B.Pm presented significantly (p<0.05) higher values for SF hydrogel-treated defects in comparison with controls treated with a synthetic polymeric material, confirming that SF hydrogel accelerated remodelling processes...
  16. ncbi request reprint Biological assessment of the bone-screw interface after insertion of uncoated and hydroxyapatite-coated pedicular screws in the osteopenic sheep
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 66:176-83. 2003
    ..However, osteopenia seems to greatly influence bone ingrowth processes around the implanted screws regardless of the characteristics of the material surface...
  17. ncbi request reprint A new austenitic stainless steel with negligible nickel content: an in vitro and in vivo comparative investigation
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 24:4929-39. 2003
    ..55, ns). The current findings demonstrate P558 biocompatibility both in vitro and in vivo, and osteointegration processes are shown to be significantly improved by P558 as compared to the other materials tested...
  18. ncbi request reprint The effect of pulsed electromagnetic fields on the osteointegration of hydroxyapatite implants in cancellous bone: a morphologic and microstructural in vivo study
    Milena Fini
    J Orthop Res 20:756-63. 2002
    ..Both morphological and structural results demonstrated a positive therapeutic effect of PEMFs in accelerating HA osteointegration in trabecular bone...
  19. ncbi request reprint Biomechanical and histomorphometric investigations on two morphologically differing titanium surfaces with and without fluorohydroxyapatite coating: an experimental study in sheep tibiae
    M Fini
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 24:3183-92. 2003
    ..2%), and between LR+FHA and HR+FHA (-29.2%). The current findings suggest that LR surfaces significantly improve the osteointegration rate of implanted cortical screws independently of the FHA coating...
  20. ncbi request reprint Osteointegration of titanium and hydroxyapatite rough surfaces in healthy and compromised cortical and trabecular bone: in vivo comparative study on young, aged, and estrogen-deficient sheep
    Veronica Borsari
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Orthop Res 25:1250-60. 2007
    ..9%) with no significant differences between groups. In conclusion, the performance of TI01 and HT01 surfaces was high not only in YOUNG, but also in OVX animals and, therefore, they might be useful for aged and osteoporotic patients...
  21. ncbi request reprint Chronic alcohol abuse and endosseous implants: linkage of in vitro osteoblast dysfunction to titanium osseointegration rate
    Paola Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicology 243:138-44. 2008
    ..These in vitro data suggest that alcohol abuse affects bone repair and decreases the ability to form bone around standard cpTi. Innovative surfaces and adjuvant therapies could be useful when implants are required in alcoholics...
  22. ncbi request reprint Alveolar ridge augmentation with titanium mesh and a combination of autogenous bone and anorganic bovine bone: a 2-year prospective study
    Francesco Pieri
    Department of Odontostomatological Sciences, University of Bologna, Bologna, Italy
    J Periodontol 79:2093-103. 2008
    ..The aim of this prospective study was to evaluate the clinical and radiographic parameters of implants placed in augmented ridges using a 70:30 mixture of autogenous bone and BBM in association with micro-mesh over a 2-year period...
  23. doi request reprint New PMMA-based composites for preparing spacer devices in prosthetic infections
    Gianluca Giavaresi
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute IRCCS, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Mater Sci Mater Med 23:1247-57. 2012
    ..These composites could be useful for preparing devices for prosthetic joint infections treatment also allowing the use of antibiotics solution at required concentrations...
  24. doi request reprint Immediate fixed implant rehabilitation of the atrophic edentulous maxilla after bilateral sinus floor augmentation: a 12-month pilot study
    Francesco Pieri
    Oral and Maxillo Facial Surgery Unit, Department of Dental Sciences, University of Bologna, Italy
    Clin Implant Dent Relat Res 14:e67-82. 2012
    ....
  25. ncbi request reprint Effect of a multiphasic anodic spark deposition coating on the improvement of implant osseointegration in the osteopenic trabecular bone of sheep
    Gianluca Giavaresi
    Laboratory of Experimental Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Oral Maxillofac Implants 23:659-68. 2008
    ....
  26. ncbi request reprint Physical characterization of different-roughness titanium surfaces, with and without hydroxyapatite coating, and their effect on human osteoblast-like cells
    Veronica Borsari
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 75:359-68. 2005
    ..Surface morphology and the HA coating strongly affected cell behavior. However, ultrahigh values of roughness are not correctly seen by cells, and the presence of HA has no improving effects...
  27. pmc Response of human chondrocytes and mesenchymal stromal cells to a decellularized human dermis
    Gianluca Giavaresi
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute IRCCS, Bologna, Italy
    BMC Musculoskelet Disord 14:12. 2013
    ..The aim of this study was to evaluate in vitro the biological influence of a newly developed decellularized human dermal extracellular matrix on two human primary cultures...
  28. doi request reprint Immediate functional loading of dental implants supporting a bar-retained maxillary overdenture: preliminary 12-month results
    Francesco Pieri
    Oral and Maxillofacial Surgery Unit, Department of Dental Sciences, University of Bologna, Bologna, Italy
    J Periodontol 80:1883-93. 2009
    ..The present study evaluated the efficacy of a treatment consisting of placing and immediately loading implants with a bar-retained overdenture in edentulous maxillae...
  29. ncbi request reprint Comparative in vitro study on a ultra-high roughness and dense titanium coating
    Veronica Borsari
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomaterials 26:4948-55. 2005
    ..In conclusion, the new ultra-high roughness and dense coating PG60 provided a good biological response, even though, at least in vitro, it behaved similarly to the coatings already used in orthopaedics...
  30. ncbi request reprint Intermittent exposure to ethanol vapor affects osteoblast behaviour more severely than estrogen deficiency does in vitro study on rat osteoblasts
    Paola Torricelli
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicology 237:168-76. 2007
    ..Therefore, these in vitro data suggest that alcohol has even more deleterious effects on bone than estrogen deficiency does...
  31. ncbi request reprint Influence of different implant surfaces on peri-implant osteogenesis: histomorphometric analysis in sheep
    Marco Franchi
    Department of Human Anatomical Sciences and Physiopathology of Locomotory Apparatus, University of Bologna, Bologna, Italy
    J Periodontol 78:879-88. 2007
    ..The present study investigated peri-implant osteogenesis and implant biologic fixation in different zirconia sandblasted endosseous titanium surfaces (SLA-60 and SLA-120) and a turned titanium surface (T) 2 and 4 weeks after surgery...
  32. ncbi request reprint In vivo experimental study on bone regeneration in critical bone defects using an injectable biodegradable PLA/PGA copolymer
    Lia Rimondini
    Research Institute Codivilla Putti, Bologna, Italy
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:148-54. 2005
    ..An assessment was done of the bone-healing rate after implantation of a polylactide/polyglycolide copolymer (PLA-PGA) 50/50 dispersed in aqueous solution of PGA and dextran, used as bone substitutes in an animal model...
  33. doi request reprint Early-term effect of adult chondrocyte transplantation in an osteoarthritis animal model
    Giovanna Desando
    Laboratory of Immunorheumatology and Tissue Regeneration, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part A 18:1617-27. 2012
    ..Thus, the transplantation of Chondrocytes+Hyaff-11 would seem to be advocated in the very early stage of the OA disease when a precocious action is mandatory...
  34. ncbi request reprint Osteointegration of hydroxyapatite-coated and uncoated titanium screws in long-term ovariectomized sheep
    Michele Rocca
    Experimental Surgery Department, Istituto di Ricerca Codivilla Putti, Rizzoli Orthopaedic Institute IOR, Bologna, Italy
    Biomaterials 23:1017-23. 2002
    ..The biomechanical and histomorphological results achieved suggest employing HA-coated screws in the presence of osteopenic cortical bone...
  35. ncbi request reprint In vitro and in vivo behaviour of biodegradable and injectable PLA/PGA copolymers related to different matrices
    M Tschon
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, Bologna Italy
    Int J Artif Organs 30:352-62. 2007
    ..The SL2-treated defects healed better at 12 weeks with a more similar microarchitecture of the newly formed bone to normal bone in comparison with other materials, as demonstrated by bone volume fraction and trabecular thickness values...
  36. doi request reprint Clinical use of bone marrow, bone marrow concentrate, and expanded bone marrow mesenchymal stem cells in cartilage disease
    Francesca Veronesi
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopedic Institute, Via Di Barbiano 1 10, Bologna, Italy
    Stem Cells Dev 22:181-92. 2013
    ..Although more standardized procedures are required, the length of follow-up and the number of patients observed should be augmented, and the design of trials should be implemented to achieve evidence-based results...
  37. doi request reprint Osteogenic protein-1 associated with mesenchymal stem cells promote bone allograft integration
    Claudia Di Bella
    Bone Regeneration Laboratory, Department of Muskulo Skeletal Oncology, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part A 16:2967-76. 2010
    ..These results demonstrated that the association of MSCs and OP-1 improve bone allograft integration promoting an almost complete bone restoring...
  38. ncbi request reprint Characterization of bone defect repair in young and aged rat femur induced by xenogenic demineralized bone matrix
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Bologna, Italy
    J Periodontol 73:1003-9. 2002
    ..The aim of the present paper was to assess the effects of age on the healing of bone defects treated with demineralized bone matrix (DBM)...
  39. doi request reprint Effect of mesenchymal stem cells and platelet-rich plasma on the healing of standardized bone defects in the alveolar ridge: a comparative histomorphometric study in minipigs
    Francesco Pieri
    Department of Odontostomatological Sciences, University of Bologna, Bologna, Italy
    J Oral Maxillofac Surg 67:265-72. 2009
    ....
  40. doi request reprint Magnesium and strontium doped octacalcium phosphate thin films by matrix assisted pulsed laser evaporation
    Elisa Boanini
    Department of Chemistry G Ciamician, University of Bologna, 40126 Bologna, Italy
    J Inorg Biochem 107:65-72. 2012
    ....
  41. doi request reprint Microbiological and pharmacological tests on new antibiotic-loaded PMMA-based composites for the treatment of osteomyelitis
    Gianluca Giavaresi
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute IRCCS, Via Di Barbiano 1 10, 40136, Bologna, Italy
    J Orthop Res 30:348-55. 2012
    ..These new porous PMMA composites, soaked in G-V solution in the operating room, might be an effective and useful drug delivery system for osteomyelitis treatment...
  42. doi request reprint Influence of a zirconia sandblasting treated surface on peri-implant bone healing: An experimental study in sheep
    Beatrice Bacchelli
    Human Anatomy Institute of the Department of Human Anatomical Sciences, University of Bologna, Italy
    Acta Biomater 5:2246-57. 2009
    ..The present work shows that the ZrO(2) treatment produces better results in peri-implant newly formed bone than Ti and TPS processing, whereas its performance is similar to the Al-SL surface treatment...
  43. doi request reprint Orderly osteochondral regeneration in a sheep model using a novel nano-composite multilayered biomaterial
    Elizaveta Kon
    Laboratorio di Biomeccanica, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10 40136 Bologna, Italy
    J Orthop Res 28:116-24. 2010
    ..The comparable regeneration process observed with or without autologous chondrocytes suggests that the main mode of action of the scaffold is based on the recruitment of local cells...
  44. doi request reprint Mesenchymal stem cells and platelet lysate in fibrin or collagen scaffold promote non-cemented hip prosthesis integration
    Barbara Dozza
    Bone Regeneration Laboratory, Rizzoli Orthopaedic Institute, 40136 Bologna, Italy
    J Orthop Res 29:961-8. 2011
    ..3 ± 3.1%) compared to the control group (mean 0.2 ± 0.1%). The results indicate that MSC and PL in a fibrin or collagen scaffold can promote NB formation around an uncemented hip prosthesis stem...
  45. ncbi request reprint Immediate occlusal loading of immediately placed implants supporting fixed restorations in completely edentulous arches: a 1-year prospective pilot study
    Francesco Pieri
    Department of Odontostomatological Sciences, University of Bologna, Bologna, Italy
    J Periodontol 80:411-21. 2009
    ....
  46. doi request reprint In vivo preclinical efficacy of a PDLLA/PGA porous copolymer for dental application
    Matilde Tschon
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 88:349-57. 2009
    ..At 30 days, GEL and SPONGE were degraded, and the sockets were filled with bone that, in terms of bone volume fraction, trabecular number, and separation, was not statistically different from normal bone...
  47. ncbi request reprint Total hip arthroplasty with shortening osteotomy in congenital major hip dislocation sequelae
    Dante Dallari
    Clinica Ortopedica e Traumatologica I, Istituto Ortopedico Rizzoli ed Università di Bologna, Bologna, Italy
    Orthopedics 34:e328-33. 2011
    ..Currently, the more complex Z osteotomy has been abandoned, because a modular stem prosthesis with metaphyseal sleeve allows the oblique osteotomy to be used with an easier and shorter surgical procedure...
  48. doi request reprint New perspectives in rotator cuff tendon regeneration: review of tissue engineered therapies
    Roberto Rotini
    Division of Orthopedic Surgery Section B, Istituti Ortopedici Rizzoli, Bologna, Italy
    Chir Organi Mov 91:87-92. 2008
    ..In our opinion the previously described literature revision showed the necessity for future studies in this area also because of recent advances in biological and bioactive scaffolds...
  49. doi request reprint Biofunctional alendronate-Hydroxyapatite thin films deposited by Matrix Assisted Pulsed Laser Evaporation
    Adriana Bigi
    Department of Chemistry G Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy
    Biomaterials 30:6168-77. 2009
    ..The successful deposition of alendronate modified hydroxyapatite thin films yields coatings with enhanced bioactivity, able to promote osteoblast differentiation and to inhibit osteoclast proliferation...
  50. ncbi request reprint In vitro and in vivo response to nanotopographically-modified surfaces of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone
    Gianluca Giavaresi
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, I 40136 Bologna, Italy
    J Biomater Sci Polym Ed 17:1405-23. 2006
    ....
  51. ncbi request reprint Primary osteoblasts response to shock wave therapy using different parameters
    Lucia Martini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:449-66. 2003
    ..The current study has demonstrated that one of the most important aspects to be considered is not the total number of impulses used but the energy level of the shock waves, thus confirming that ESWT has a dose-dependent effect on cells...
  52. ncbi request reprint Human osteopenic bone-derived osteoblasts: essential amino acids treatment effects
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:35-46. 2003
    ..Therefore, administration of these amino acids may be useful in clinical treatment and prevention of osteoporosis...
  53. ncbi request reprint Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/glass composite implant: in vivo mechanical and histomorphometric assessments
    G Giavaresi
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 27:674-80. 2004
    ..Finally, the biomimetic method applied to pHEMA needs to be further investigated in order to improve the positive effect of SBF on pHEMA and to enhance the coating adhesion...
  54. doi request reprint Electrochemotherapy is effective in the treatment of rat bone metastases
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Exp Metastasis 30:1033-45. 2013
    ..N; p < 0.0005 for BMD). These findings suggest that early ECT treatment of bone metastases is minimally invasive, safe and effective, thus providing pre-clinical evidence for its use in the treatment of human bone metastases...
  55. ncbi request reprint Role of obesity , alcohol and smoking on bone health
    Milena Fini
    Laboratory of Preclinical and Surgical Studies Rizzoli Orthopaedic Institute, Bologna, Italy
    Front Biosci (Elite Ed) 4:2686-706. 2012
    ..Health information campaigns against these harmful lifestyles should be strengthened by using available scientific information to increase awareness about their consequences on the bone...
  56. ncbi request reprint Preliminary 2-year report on treatment outcomes for 6-mm-long implants in posterior atrophic mandibles
    Francesco Pieri
    Department of Dental Sciences, University of Bologna, Bologna, Italy
    Int J Prosthodont 25:279-89. 2012
    ..The aim of this study was to prospectively evaluate clinical and radiographic outcomes of ultrashort implants (4-mm diameter, 6-mm length) supporting fixed partial dentures in severely atrophic posterior mandibles...
  57. doi request reprint The effect of zoledronate-hydroxyapatite nanocomposites on osteoclasts and osteoblast-like cells in vitro
    Elisa Boanini
    Department of Chemistry G Ciamician, University of Bologna, Italy
    Biomaterials 33:722-30. 2012
    ..Similarly, the reduction of osteoclast proliferation and the increase of Caspase 3 production are dramatically enhanced in co-cultures, which highlight an even greater influence of HA-ZOL than HA-AL on osteoclast apoptosis...
  58. ncbi request reprint A novel multiphase anodic spark deposition coating for the improvement of orthopedic implant osseointegration: an experimental study in cortical bone of sheep
    Gianluca Giavaresi
    Laboratory of Experimental Surgery, Rizzoli Orthopaedic Institute, Bologna Italy
    J Biomed Mater Res A 85:1022-31. 2008
    ..Data suggests that the TiSpark treatment produces a modification of the Ti surface, which presents good bioactivity and may be suitable for achieving a stable implant osseointegration...
  59. ncbi request reprint Medial-grade calcium sulfate hemihydrate (surgiplaster) in healing of a human extraction socket--histologic observation at 3 months: a case report
    Renzo Guarnieri
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Oral Maxillofac Implants 20:636-41. 2005
    ..The aim of this study was to investigate the influence of MGCSH on the histopathologic pattern of intrasocket regenerated bone and to evaluate histologically the healed MGCSH-grafted extraction socket site at 3 months postextraction...
  60. doi request reprint Osteoarthritis treated with mesenchymal stem cells on hyaluronan-based scaffold in rabbit
    Brunella Grigolo
    Laboratorio di Immunologia e Genetica, Istituto Ortopedico Rizzoli, Bologna, Italy
    Tissue Eng Part C Methods 15:647-58. 2009
    ....
  61. ncbi request reprint Lights and shadows concerning platelet products for musculoskeletal regeneration
    Matilde Tschon
    Laboratory of Surgical and Preclinical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Front Biosci (Elite Ed) 3:96-107. 2011
    ..The possibility of improving the knowledge on variables affecting therapeutic efficacy will surely help in addressing the best combination of factors implied in the different steps of PLT concentrate preparation and use...
  62. ncbi request reprint Osteoblasts cultured from osteoporotic bone: a comparative investigation on human and animal-derived cells
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 31:263-77. 2003
    ..Cells derived from osteopenic sheep behaved much more similarly to those from humans, except for a significant difference in terms of TGF-beta1 observed both under basal conditions and after stimulation...
  63. doi request reprint Bone regeneration potential of a soybean-based filler: experimental study in a rabbit cancellous bone defects
    Gianluca Giavaresi
    Laboratory of Surgical Preclinical Studies, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, Bologna, Italy
    J Mater Sci Mater Med 21:615-26. 2010
    ..05). Soybean-based biomaterials clearly promoted bone repair through a mechanism of action that is likely to involve both the scaffolding role of the biomaterial for osteoblasts and the induction of their differentiation...
  64. ncbi request reprint Basic fibroblast growth factor enhances in vitro mineralization of rat bone marrow stromal cells grown on non-woven hyaluronic acid based polymer scaffold
    G Lisignoli
    Laboratorio di Immunologia e Genetica. Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 22:2095-105. 2001
    ..Our in vitro results demonstrate that Hyaff 11 is a useful vehicle for growth, differentiation and mineralization of rat BMSC, and that it permits bone development...
  65. ncbi request reprint In vitro behaviour of osteoblasts cultured on orthopaedic biomaterials with different surface roughness, uncoated and fluorohydroxyapatite-coated, relative to the in vivo osteointegration rate
    M Fini
    Experimental Surgery, Department Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 26:520-8. 2003
    ..Results suggest that collagen-I production could be useful in predicting the in vivo osteointegration rate of biocompatible biomaterials observed in previous studies...
  66. ncbi request reprint Mechanical and histomorphometric evaluations of titanium implants with different surface treatments inserted in sheep cortical bone
    Gianluca Giavaresi
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Biomaterials 24:1583-94. 2003
    ..However, further studies are required to investigate bone hardness and mineralization around implants...
  67. pmc Histological, histomorphometric and microtomographic analyses of retrieval hip resurfacing arthroplasty failed at different times
    Francesca Salamanna
    Rizzoli Research Innovation Technology, Rizzoli Orthopaedic Institute, Bologna, Italy
    BMC Musculoskelet Disord 14:47. 2013
    ..The objective of the study was to examine by a specific quantitative histomorphometry and microtomography (micro-CT) method the characteristics of bone quality and its microarchitecture in retrieved metal-on-metal HR...
  68. pmc Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model
    Elizaveta Kon
    Biomechanics Laboratory Rizzoli Orthopaedic Institute, Bologna, Italy
    BMC Musculoskelet Disord 11:220. 2010
    ..The objective of this study was to investigate the regenerative potential of platelet-rich plasma (PRP) to enhance the repair process of a collagen-hydroxyapatite scaffold in osteochondral defects in a sheep model...
  69. doi request reprint Dose-dependent effect of adipose-derived adult stem cells on vertical bone regeneration in rabbit calvarium
    Francesco Pieri
    Department of Dental Sciences, University of Bologna, Via San Vitale 59, 40139 Bologna, Italy
    Biomaterials 31:3527-35. 2010
    ..This study suggests that the delivery of ASCs on ABB might effectively increase vertical bone regeneration and implant osseointegration, versus ABB alone...
  70. doi request reprint Preliminary investigations on a new gentamicin and vancomycin-coated PMMA nail for the treatment of bone and intramedullary infections: An experimental study in the rabbit
    Gianluca Giavaresi
    Laboratory of Experimental Surgery, Rizzoli Orthopaedic Institute, Via di Barbiano, 1 10, 40136 Bologna, Italy
    J Orthop Res 26:785-92. 2008
    ..The current findings showed that tested device might effectively lead to MRSA infection healing after surgical debridement and immediate implantation...
  71. ncbi request reprint Bone remodeling, humoral networks and smart biomaterial technology for osteoporosis
    Milena Fini
    Laboratory of Surgical and Preclinical Studies, Rizzoli Orthopaedic Institute, Bologna, Italy
    Front Biosci (Schol Ed) 2:468-82. 2010
    ..Furthermore, therapeutic interventions exploiting vulnerable nodes in these physiological networks will be posited. One exciting development in this area is the use of novel biomaterials...
  72. ncbi request reprint Early effects of extracorporeal shock wave treatment on osteoblast-like cells: a comparative study between electromagnetic and electrohydraulic devices
    Lucia Martini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Trauma 61:1198-206. 2006
    ....
  73. ncbi request reprint Comparison among three different biocoatings for orthopaedic prostheses. An experimental animal study
    M Rocca
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 21:553-8. 1998
    ..However, only at nine months did this difference reach statistical significance (p<0.005 comparing Groups A and B to C). The results of this study show that all the three coatings could be recommended for clinical applications...
  74. doi request reprint Functional tissue engineering in articular cartilage repair: is there a role for electromagnetic biophysical stimulation?
    Milena Fini
    Laboratory of Preclinical and Surgical Studies, Technological Innovations, and Advanced Therapies, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part B Rev 19:353-67. 2013
    ..PEMFs mediate an up-regulation of A2A adenosine receptors and a potentiation of their anti-inflammatory effects. ..
  75. doi request reprint Tissue engineering for total meniscal substitution: animal study in sheep model
    Elizaveta Kon
    Laboratorio di Biomeccanica, Rizzoli Orthopedic Institute, Bologna, Italy
    Tissue Eng Part A 14:1067-80. 2008
    ..Two different surgical implantation techniques in a sheep model were evaluated...
  76. doi request reprint Tissue engineering for total meniscal substitution: animal study in sheep model--results at 12 months
    Elizaveta Kon
    Laboratory of Biomechanics and Technology Innovation, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part A 18:1573-82. 2012
    ..The study suggests the potential of the novel hyaluronic acid/polycaprolactone scaffold for total meniscal substitution, although this approach has to be further improved before being applied into clinical practice...
  77. ncbi request reprint Bone tissue cultures: an in vitro model for the evaluation of bone defect healing after L-arginine and L-lysine administration
    P Torricelli
    Experimental Surgery Department, Research Institute Codivilla-Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 29:325-34. 2001
    ..The effect of Arg and Lys confirmed data of a previous study, where a faster healing of bone defect and fracture was observed in rabbits after Arg and Lys administration...
  78. ncbi request reprint A biomimetic gelatin-calcium phosphate bone cement
    A Bigi
    Department of Chemistry G Ciamician, University of Bologna, Bologna, Italy
    Int J Artif Organs 27:664-73. 2004
    ..The remarkable improvement of the setting properties of the calcium phosphate cement due to the presence of gelatin suggest that the biomimetic composite material could be successfully applied as bone substitute...
  79. doi request reprint Comparative in vivo evaluation of porous and dense duplex titanium and hydroxyapatite coating with high roughnesses in different implantation environments
    V Borsari
    Laboratory of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Biomed Mater Res A 89:550-60. 2009
    ..05). Data showed that high roughness and Ti and HA-coated surfaces are suitable for aged and osteoporotic patients. HA coatings represent the most successful strategy in trabecular bone...
  80. ncbi request reprint Pedicular fixation in the osteoporotic spine: a pilot in vivo study on long-term ovariectomized sheep
    N Nicoli Aldini
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, via di Bambino, 1110 40136 Bologna, Italy
    J Orthop Res 20:1217-24. 2002
    ..The HA coating has proven to improve bone purchase and bone-screw interface strength in healthy and osteopenic animals...
  81. pmc In vivo preclinical evaluation of the influence of osteoporosis on the anchorage of different pedicle screw designs
    Gianluca Giavaresi
    Laboratory of Preclinical and Surgical Studies, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Eur Spine J 20:1289-96. 2011
    ..1%, p < 0.05). These results suggest that both tested surface treatments of pedicular screws may provide an advantage in terms of bone quality and osseointegration, when implanted in osteoporotic vertebrae...
  82. doi request reprint The response of bone to nanocrystalline hydroxyapatite-coated Ti13Nb11Zr alloy in an animal model
    Adriana Bigi
    Department of Chemistry G Ciamician, University of Bologna, Via Selmi 2, 40126 Bologna, Italy
    Biomaterials 29:1730-6. 2008
    ..The study suggests that the HA coating on both alloys enhances bone response around implants and that there is a synergic effect of Ti-Nb-Zr alloy with the HA coating on bone remodeling and maturation...
  83. ncbi request reprint Histologic and histomorphometric evaluation of alveolar ridge augmentation using bone grafts and titanium micromesh in humans
    Giuseppe Corinaldesi
    Department of Odontostomatological Sciences, University of Bologna, Bologna, Italy
    J Periodontol 78:1477-84. 2007
    ....
  84. pmc Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses
    Paola Torricelli
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Int Orthop 35:1569-76. 2011
    ....
  85. ncbi request reprint Effects of pulsed electromagnetic stimulation on patients undergoing hip revision prostheses: a randomized prospective double-blind study
    Dante Dallari
    VII Division of Orthopaedic and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy
    Bioelectromagnetics 30:423-30. 2009
    ..05). This study showed that PEMF treatment aids clinical recovery and bone stock restoration...
  86. ncbi request reprint A new austenitic stainless steel with a negligible amount of nickel: an in vitro study in view of its clinical application in osteoporotic bone
    M Fini
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    J Biomed Mater Res B Appl Biomater 71:30-7. 2004
    ..SEM images revealed no alteration in cell morphology. The current findings demonstrate that P558 promotes osteoblast proliferation, activation, and differentiation not only in normal bone, but also in osteopenic bone-derived osteoblasts...
  87. ncbi request reprint Sandblasted titanium osteointegration in young, aged and ovariectomized sheep
    V Borsari
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 30:163-72. 2007
    ..Bone quality affected the biological response of bone to Ti/SA implants in both trabecular and cortical bone; consequently, strategies to maximize the bone osteogenic properties of osteoporotic patients should be adopted...
  88. ncbi request reprint Osseointegration of sandblasted or anodised hydrothermally-treated titanium implants: mechanical, histomorphometric and bone hardness measurements
    G Giavaresi
    Experimental Surgery Department, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Artif Organs 25:806-13. 2002
    ..05). In conclusion, present findings show that osseointegration may be accelerated by adequate surface roughness and bioactive ceramic coating such as current tested treatments which enhance bone interlocking and mineralization...
  89. ncbi request reprint Enhanced guided bone regeneration with a resorbable chamber containing demineralized bone matrix
    Roberto Giardino
    Experimental Surgery Department, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, University of Bologna, Bologna, Italy
    J Trauma 52:933-7. 2002
    ..The injection of bone marrow stem cells into the chamber had proven to enhance bone regeneration...
  90. doi request reprint The use of fluoride cement: preliminary experimental study and clinical application
    Claudia Di Bella
    V Orthopedic Ward, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna, Italy
    Chir Organi Mov 91:141-6. 2008
    ..Histological results in animals combined with long-term radiographic results in humans have shown the positive influence of fluoride in the cement, as it allows better integration of the cement with the surrounding bone...
  91. ncbi request reprint Human osteoblast cultures from osteoporotic and healthy bone: biochemical markers and cytokine expression in basal conditions and in response to 1,25(OH)2D3
    Paola Torricelli
    Experimental Surgery Department, Research Institute Codivilla Putti, Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 30:219-27. 2002
    ..The current findings should be taken into account when cultures derived from human bone are used for in vitro experiments...
  92. ncbi request reprint Calcitonin release system in the treatment of experimental osteoporosis. Histomorphometric evaluation
    N N Aldini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, and University of Bologna, Italy
    J Orthop Res 19:955-61. 2001
    ..These data confirm a good in vivo behavior of the system, as well as a therapeutic effect of the released calcitonin in the osteopenic condition...
  93. ncbi request reprint Detachment of titanium and fluorohydroxyapatite particles in unloaded endosseous implants
    D Martini
    Istituto di Anatomia Umana Normale, Via Irnerio 48, 40126, Bologna, Italy
    Biomaterials 24:1309-16. 2003
    ..The present findings suggest that the FHA coating may act as a barrier against the detachment of titanium debris stored in the medullary spaces near the implant surface...
  94. ncbi request reprint Osteointegration of bioactive glass-coated and uncoated zirconia in osteopenic bone: an in vivo experimental study
    N Nicoli Aldini
    Experimental Surgery Department, Research Institute Codivilla Putti Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy and University of Bologna Medical School, Bologna, Italy
    J Biomed Mater Res A 68:264-72. 2004
    ..The present results demonstrate that the RKKP bioactive glass used as a coating ensures a high osteointegration rate even in osteoporotic bone, which is already visible from postoperative day 30 and is still apparent on day 60...
  95. ncbi request reprint Transplantation of chondrocytes seeded on collagen-based scaffold in cartilage defects in rabbits
    Luciana De Franceschi
    Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 75:612-22. 2005
    ..These results advocate the use of this collagen-based scaffold for further in vivo studies on large size animals and, finally, in human clinical trials for the treatment of knee cartilage defects...
  96. doi request reprint Human dermal matrix scaffold augmentation for large and massive rotator cuff repairs: preliminary clinical and MRI results at 1-year follow-up
    Roberto Rotini
    Shoulder and Elbow Unit, Rizzoli Orthopaedic Institute, Via Pupilli 1, Bologna, Italy
    Musculoskelet Surg 95:S13-23. 2011
    ..The absence of adverse inflammatory or septic complications allows to continue this line of research with a prospective controlled study in order to define the real advantages and correct indications offered by scaffold application...
  97. ncbi request reprint Osteogenesis of large segmental radius defects enhanced by basic fibroblast growth factor activated bone marrow stromal cells grown on non-woven hyaluronic acid-based polymer scaffold
    G Lisignoli
    Laboratorio di Immunologia e Genetica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1043-51. 2002
    ..According to these in vivo findings, the Hyaff 11 scaffold is an appropriate carrier vehicle for the repair of bone defects; additionally, it can significantly accelerate bone mineralisation in combination with BMSCs and bFGF...
  98. ncbi request reprint In vitro models to test orthopedic biomaterials in view of their clinical application in osteoporotic bone
    P Torricelli
    Department of Experimental Surgery, Research Institute Codivilla Putti, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Artif Organs 27:658-63. 2004
    ..Pathological cell culture models are able to demonstrate the different behavior of osteoblasts in response to biomaterials, when comparing normal and pathological conditions...
  99. ncbi request reprint Biocompatibility and osseointegration in osteoporotic bone
    M Fini
    Experimental Surgery Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 83:139-43. 2001
    ..Our findings suggest that osteopenic models may be used in vivo in the preclinical evaluation of orthopaedic biomaterials. We suggest that primary cell cultures from pathological models could be used as an experimental model in vitro...
  100. ncbi request reprint Hemodynamic indices versus gastric tonometric measurements for prognosis of hemorrhagic shock: a porcine model
    Lucia Martini
    Servizio di Chirurgia Sperimentale, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano, 1 10, 40136, Bologna, Italy
    Comp Med 53:178-85. 2003
    ..On the basis of results of statistical analysis, only mean arterial pressure and SVR were good indicators of shock development, whereas pHi was not a significant factor in this experimental model...
  101. ncbi request reprint The role of different chemical modifications of superoxide dismutase in preventing a prolonged muscular ischemia/ reperfusion injury
    Roberto Giardino
    Surgical Pathophysiology, University of Bologna, Italy
    Artif Cells Blood Substit Immobil Biotechnol 30:189-98. 2002
    ..The outcomes obtained in terms of limb survival (p < 0.05), as well as histomorphologic studies (p < 0.0005), revealed a superior capacity of mPEG-SOD when compared with the other three substances...