Davide Donati

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. ncbi request reprint Bone grafting: historical and conceptual review, starting with an old manuscript by Vittorio Putti
    Davide Donati
    V Divisione Ortopedica, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Orthop 78:19-25. 2007
  2. ncbi request reprint Local and distant control in non-metastatic pelvic Ewing's sarcoma patients
    Davide Donati
    Orthopaedic Surgery, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Surg Oncol 96:19-25. 2007
  3. doi request reprint OP-1 application in bone allograft integration: preliminary results in sheep experimental surgery
    D Donati
    Bone Regeneration Laboratory, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Injury 39:S65-72. 2008
  4. pmc Allograft-prosthetic composite in the proximal tibia after bone tumor resection
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40126 Bologna, Italy
    Clin Orthop Relat Res 466:459-65. 2008
  5. ncbi request reprint Management of pelvic giant cell tumours involving the acetabular bone
    Davide Donati
    Musculoskeletal Oncology Department of the Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    Acta Orthop Belg 74:773-8. 2008
  6. pmc Surgical treatment of grade I central chondrosarcoma
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136, Bologna, Italy
    Clin Orthop Relat Res 468:581-9. 2010
  7. ncbi request reprint Knee arthrodesis with a temporary spacer performed in malignant tumor around the knee
    D Donati
    1st Clinic of the University, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Arch Orthop Trauma Surg 122:123-8. 2002
  8. ncbi request reprint Surgical treatment and outcome of conventional pelvic chondrosarcoma
    D Donati
    Orthopaedic Division, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:1527-30. 2005
  9. ncbi request reprint In vivo study on critical defects using the sheep model
    D Donati
    Dipartimento di Oncologia Muscolo scheletrica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Chir Organi Mov 90:31-9. 2005
  10. ncbi request reprint Osteosarcoma of the pelvis
    D Donati
    Department of Musculoskeletal Oncology and Orthopaedic Surgery, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Eur J Surg Oncol 30:332-40. 2004

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Bone grafting: historical and conceptual review, starting with an old manuscript by Vittorio Putti
    Davide Donati
    V Divisione Ortopedica, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Orthop 78:19-25. 2007
    ..f) The importance of functional exercise. These important experiences were achieved without Putti having any knowledge of immunology, vascular surgery, tissue preservation or non decalcified histology techniques...
  2. ncbi request reprint Local and distant control in non-metastatic pelvic Ewing's sarcoma patients
    Davide Donati
    Orthopaedic Surgery, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Surg Oncol 96:19-25. 2007
    ..The purpose of this study was to review our experience and evaluate the role of different local treatment in non-metastatic pelvic ES patients...
  3. doi request reprint OP-1 application in bone allograft integration: preliminary results in sheep experimental surgery
    D Donati
    Bone Regeneration Laboratory, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Injury 39:S65-72. 2008
    ..Massive bone allografts are frequently used in orthopaedic reconstructive surgery. However the failure rate at long term follow-up is around 25%...
  4. pmc Allograft-prosthetic composite in the proximal tibia after bone tumor resection
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40126 Bologna, Italy
    Clin Orthop Relat Res 466:459-65. 2008
    ..We believe the ideal candidate is the young patient with a benign aggressive or malignant low-grade tumor who has not undergone previous surgery...
  5. ncbi request reprint Management of pelvic giant cell tumours involving the acetabular bone
    Davide Donati
    Musculoskeletal Oncology Department of the Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    Acta Orthop Belg 74:773-8. 2008
    ..However, the possible complications of the different methods of pelvic reconstruction should always be considered...
  6. pmc Surgical treatment of grade I central chondrosarcoma
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136, Bologna, Italy
    Clin Orthop Relat Res 468:581-9. 2010
    ..Level of Evidence: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence...
  7. ncbi request reprint Knee arthrodesis with a temporary spacer performed in malignant tumor around the knee
    D Donati
    1st Clinic of the University, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Arch Orthop Trauma Surg 122:123-8. 2002
    ..In our institution, reconstruction with cement is still suggested for patients with a large tumor around the knee, when the quadriceps is completely sacrificed, and the patient prognosis is markedly unfavorable...
  8. ncbi request reprint Surgical treatment and outcome of conventional pelvic chondrosarcoma
    D Donati
    Orthopaedic Division, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:1527-30. 2005
    ..By contrast, grade 1 peripheral chondrosarcomas may be treated with contaminated margins in order to reduce operative morbidity, but without reducing survival...
  9. ncbi request reprint In vivo study on critical defects using the sheep model
    D Donati
    Dipartimento di Oncologia Muscolo scheletrica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Chir Organi Mov 90:31-9. 2005
    ..Metatarsal defect fixed with 7-hole DCP plate and protected with Scotchcast was the best surgical approach to avoid early or late implant failures, and provided good radiographic results after 4 months...
  10. ncbi request reprint Osteosarcoma of the pelvis
    D Donati
    Department of Musculoskeletal Oncology and Orthopaedic Surgery, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Eur J Surg Oncol 30:332-40. 2004
    ..To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment...
  11. ncbi request reprint Clear cell chondrosarcoma of bone: long time follow-up of 18 cases
    Davide Donati
    Orthopaedic Oncology of the Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Arch Orthop Trauma Surg 128:137-42. 2008
    ..We reviewed our cases of clear cell chondrosarcoma with the aim to assess the best diagnostic and curative approach to this rare tumor...
  12. doi request reprint Advance in the treatment of aneurysmal bone cyst of the sacrum
    Davide Donati
    II Orthopaedic and Traumatology Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Skeletal Radiol 40:1461-6. 2011
    ..The outcome of both procedures is reported. In addition, the treatment technique of CT-guided percutaneous injections of demineralized bone matrix mixed with bone marrow concentrate is described...
  13. ncbi request reprint Role of surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant chemotherapy
    Gaetano Bacci
    Section of Chemotherapy, Istituto Ortopedico Rizzoli, Via Pupilli 1, I 40136 Bologna, Italy
    Oncol Rep 11:111-20. 2004
    ..Our results indicate that surgery should always be considered in the local treatment of ES of the extremities. Postoperative radiation therapy must be added in case of inadequate surgical margins...
  14. ncbi request reprint Nonmetastatic osteosarcoma of the extremity with pathologic fracture at presentation: local and systemic control by amputation or limb salvage after preoperative chemotherapy
    Gaetano Bacci
    Department of Musculoskeletal Oncology of the Rizzoli Orthopaedic Institute, Bologna, Italy
    Acta Orthop Scand 74:449-54. 2003
    ....
  15. doi request reprint The posterior iliac crest outperforms the anterior iliac crest when obtaining mesenchymal stem cells from bone marrow
    Michela Pierini
    Osteoarticular Regeneration Laboratory, 2nd Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Am 95:1101-7. 2013
    ..In addition, we compared the expansion kinetics and multilineage differentiation potential of their culture-expanded progeny when processed to form mesenchymal stem cells...
  16. ncbi request reprint Multimodal therapy for the treatment of nonmetastatic Ewing sarcoma of pelvis
    Gaetano Bacci
    Chemotherapy Unit, Department of Musculoskeletal Oncology of the Rizzoli Orthopedic Institute, Bologna, Italy
    J Pediatr Hematol Oncol 25:118-24. 2003
    ..64% and 44% vs. 69%). Thus, despite associated chemotherapy, the outcome of ES localized in the pelvis remains poor, and new innovative methods for the treatment of this tumor are needed...
  17. doi request reprint Osteogenic protein-1 associated with mesenchymal stem cells promote bone allograft integration
    Claudia Di Bella
    Bone Regeneration Laboratory, Department of Muskulo Skeletal Oncology, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tissue Eng Part A 16:2967-76. 2010
    ..These results demonstrated that the association of MSCs and OP-1 improve bone allograft integration promoting an almost complete bone restoring...
  18. ncbi request reprint Neoadjuvant chemotherapy for osteosarcoma of the extremity: intensification of preoperative treatment does not increase the rate of good histologic response to the primary tumor or improve the final outcome
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzolo, Bologna, Italy
    J Pediatr Hematol Oncol 25:845-53. 2003
    ....
  19. ncbi request reprint Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: experience at Rizzoli on 1421 patients treated over the last 30 years
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Tumori 90:478-84. 2004
    ..The study evaluated the correlation between pretreatment serum lactate dehydrogenase (LDH) levels with the stage of disease and its clinical prognostic value...
  20. doi request reprint Effect of mesenchymal stem cells and platelet-rich plasma on the healing of standardized bone defects in the alveolar ridge: a comparative histomorphometric study in minipigs
    Francesco Pieri
    Department of Odontostomatological Sciences, University of Bologna, Bologna, Italy
    J Oral Maxillofac Surg 67:265-72. 2009
    ....
  21. ncbi request reprint Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity. Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor
    Gaetano Bacci
    Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 97:3068-75. 2003
    ..In primary central high-grade osteosarcoma, a number of distinct subtypes have been identified, but little is known about the response to chemotherapy...
  22. doi request reprint Mesenchymal stem cells and platelet lysate in fibrin or collagen scaffold promote non-cemented hip prosthesis integration
    Barbara Dozza
    Bone Regeneration Laboratory, Rizzoli Orthopaedic Institute, 40136 Bologna, Italy
    J Orthop Res 29:961-8. 2011
    ..3 ± 3.1%) compared to the control group (mean 0.2 ± 0.1%). The results indicate that MSC and PL in a fibrin or collagen scaffold can promote NB formation around an uncemented hip prosthesis stem...
  23. doi request reprint Efficient isolation and enrichment of mesenchymal stem cells from bone marrow
    Michela Pierini
    Bone Regeneration Laboratory, 2nd Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy
    Cytotherapy 14:686-93. 2012
    ..The BD Vacutainer® Cell Preparation Tube™ (CPT) was conceived to separate mononuclear cells from peripheral blood. The main goal of this study was to verify whether MSC could be isolated from BM using the CPT...
  24. pmc Alloprosthetic composite is a suitable reconstruction after periacetabular tumor resection
    Davide Donati
    Orthopaedic Surgery, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Clin Orthop Relat Res 469:1450-8. 2011
    ..However, while such composites restore anatomy and function of the pelvis the use of pelvic allografts is controversial and the durability is unknown...
  25. doi request reprint The use of fluoride cement: preliminary experimental study and clinical application
    Claudia Di Bella
    V Orthopedic Ward, Istituto Ortopedico Rizzoli, Via Pupilli 1, Bologna, Italy
    Chir Organi Mov 91:141-6. 2008
    ..Histological results in animals combined with long-term radiographic results in humans have shown the positive influence of fluoride in the cement, as it allows better integration of the cement with the surrounding bone...
  26. ncbi request reprint Recovery of stromal stem cells in bone sarcoma patients after chemotherapy: implication for cell-based therapy in bone defect reconstruction
    Amira Beccheroni
    Oncological Research Laboratory, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, I 40136 Bologna BO, Italy
    Oncol Rep 10:891-6. 2003
    ....
  27. doi request reprint Historical review of bone prefabrication
    Claudia Di Bella
    V Divisione di Oncologia Muscolo Scheletrica, Istituto Ortopedico Rizzoli, Bologna, Italy
    Chir Organi Mov 92:73-8. 2008
    ....
  28. ncbi request reprint Osteosarcoma of the limb. Amputation or limb salvage in patients treated by neoadjuvant chemotherapy
    G Bacci
    Department of Chemotherapy, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 84:88-92. 2002
  29. ncbi request reprint A rapid method for obtaining mesenchymal stem cells and platelets from bone marrow aspirate
    Barbara Dozza
    Bone Regeneration Laboratory, 2nd Clinic of Orthopaedics and Traumatology, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Tissue Eng Regen Med 8:483-92. 2014
    ..Isolated MSCs were further expanded in a laboratory and BM-MPRF was used clinically following BM withdrawal for rapid intra-operative cell therapy for the treatment of bone defects...
  30. pmc Injection of demineralized bone matrix with bone marrow concentrate improves healing in unicameral bone cyst
    Claudia Di Bella
    Department of Oncology Orthopaedic, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Orthop Relat Res 468:3047-55. 2010
    ..Various treatments have been proposed but there is no consensus regarding the best procedure...
  31. pmc Total knee replacement versus osteochondral allograft in proximal tibia bone tumours
    M Colangeli
    Bone Tumor Centre, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int Orthop 31:823-9. 2007
    ..An allograft, when optimal reconstruction is performed, gives better functional results...
  32. ncbi request reprint Platelet-derived growth factors enhance proliferation of human stromal stem cells
    Enrico Lucarelli
    Oncological Research Laboratory, Istituti Ortopedici Rizzoli, Via De Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 24:3095-100. 2003
    ..In conclusion, 10% PRP promotes SSC proliferation; cells expanded with 10% PRP can mineralize the extracellular matrix once PRP is withdrawn...
  33. ncbi request reprint Prognostic significance of serum alkaline phosphatase in osteosarcoma of the extremity treated with neoadjuvant chemotherapy: recent experience at Rizzoli Institute
    Gaetano Bacci
    Sezione di Chemioterapia, Istituti Ortopedici Rizzoli, I 40136 Bologna, Italy
    Oncol Rep 9:171-5. 2002
    ....
  34. doi request reprint CAD-CAM-generated hydroxyapatite scaffold to replace the mandibular condyle in sheep: preliminary results
    Leonardo Ciocca
    Department of Oral Science, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Biomater Appl 28:207-18. 2013
    ..This animal model was found to be appropriate for testing CAD-CAM customization and the biomechanical properties of porous, pure hydroxyapatite scaffolds used as joint prostheses. ..
  35. pmc Protein kinase B/AKT isoform 2 drives migration of human mesenchymal stem cells
    Zrinka Bulj
    Department of Biomedical Sciences, Cellular Signalling Laboratory, Bologna, Italy
    Int J Oncol 42:118-26. 2013
    ..Although preliminary, collectively our results indicate that AKT2 activation plays a critical role in enabling MSC migration...
  36. doi request reprint Mesenchymal stem cells and platelet-rich plasma enhance bone formation in sinus grafting: a histomorphometric study in minipigs
    Francesco Pieri
    Department of Odontostomatological Sciences, University of Bologna, Bologna, Italy
    J Clin Periodontol 35:539-46. 2008
    ..We investigated whether mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) seeded on a fluorohydroxyapatite (FH) scaffold can improve bone formation and bone-to-implant contact (BIC) in maxillary sinus grafting...
  37. doi request reprint Comparison of alternative mesenchymal stem cell sources for cell banking and musculoskeletal advanced therapies
    Carola Cavallo
    Immunorheumatology and Tissue Regeneration Laboratory RAMSES, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Cell Biochem 112:1418-30. 2011
    ..In vitro differentiation assays showed a higher osteogenic differentiation capacity of adipose tissue and BM MSCs, and a higher chondrogenic differentiation capacity of BM MSCs...
  38. pmc Comparison of allograft-prosthetic composite reconstruction and modular prosthetic replacement in proximal femur bone tumors: functional assessment by gait analysis in 20 patients
    Maria Grazia Benedetti
    Physical Medicine and Rehabilitation Unit, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Orthop 84:218-23. 2013
    ..In the allograft-prosthesis composite, the detached tendons are fixated to the graft. We assessed whether the latter procedure provides functional advantages regarding gait...
  39. doi request reprint Cell growth inhibition and apoptotic effect of the rexinoid 6-OH-11-O-hydroxyphenantrene on human osteosarcoma and mesenchymal stem cells
    Barbara Dozza
    Bone Regeneration Laboratory, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Toxicol In Vitro 26:142-9. 2012
    ..These results confirm that IIF may be an effective compound for anticancer treatment, including that of OS...
  40. ncbi request reprint Bone reconstruction of large defects using bone marrow derived autologous stem cells
    Enrico Lucarelli
    Regeneration and Tissue Engineering, Laboratory of the Musculoskeletal Tissue Bank, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Transfus Apher Sci 30:169-74. 2004
    ..In this report we outline the difficulties of working with SSC...
  41. ncbi request reprint Neoadjuvant chemotherapy for patients with synchronous multifocal osteosarcoma: results in eleven cases
    A Longhi
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 13:324-30. 2001
    ..This homogeneity supports the thesis that in synchronous multifocal osteosarcoma the tumors are not multicentric in origin but represent bone-to-bone metastases from a monocentric tumor...
  42. ncbi request reprint Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli
    G Bacci
    Departments of Musculo Skeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:4-11. 2000
    ..The identification of prognostic factors in patients with nonmetastatic Ewing's sarcoma could allow the use of risk-adapted therapeutic strategies of treatment...
  43. ncbi request reprint Muscle performance about the knee joint in patients who had distal femoral replacement after resection of a bone tumor. An objective study with use of gait analysis
    M G Benedetti
    Istituti Ortopedici Rizzoli, Bologna, Italy
    J Bone Joint Surg Am 82:1619-25. 2000
    ....
  44. ncbi request reprint Neoadjuvant chemotherapy for osteosarcoma of the extremity: long-term results of the Rizzoli's 4th protocol
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    Eur J Cancer 37:2030-9. 2001
    ..These results did not differ from those achieved in our previous study (IOR/OS-3) in which IFO was used only postoperatively in poor responders...
  45. ncbi request reprint A recently developed bifacial platelet-rich fibrin matrix
    E Lucarelli
    Bone Regeneration Laboratory, Dipartimento di Patologie Ortopediche Traumatologiche Specialistiche, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, I 40136 Bologna, Italy
    Eur Cell Mater 20:13-23. 2010
    ....
  46. ncbi request reprint Modular prosthetic replacement of the proximal femur after resection of a bone tumour a long-term follow-up
    D Donati
    V Division, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 83:1156-60. 2001
    ..Functional activity was satisfactory in 68% of the patients. A better system of reattachment of the soft tissues is needed to avoid pain and a persistent limp...
  47. ncbi request reprint High dose ifosfamide in combination with high dose methotrexate, adriamycin and cisplatin in the neoadjuvant treatment of extremity osteosarcoma: preliminary results of an Italian Sarcoma Group/Scandinavian Sarcoma Group pilot study
    G Bacci
    Sezione di Chemioterapia, Instituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 14:198-206. 2002
    ..On the basis of this study, in March 1997 the Italian and Scandinavian Sarcoma Groups started a new protocol for osteosarcoma of the extremities...
  48. ncbi request reprint Neoadjuvant chemotherapy for Ewing's tumour of bone: recent experience at the Rizzoli Orthopaedic Institute
    G Bacci
    Section of Chemotherapy, Rizzoli Orthopaedic Institute, Bologna, Italy
    Eur J Cancer 38:2243-51. 2002
    ....
  49. ncbi request reprint Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide
    G Bacci
    Section of Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Ann Oncol 14:1126-34. 2003
    ..Currently, little is known about patients with metastatic disease at presentation...
  50. ncbi request reprint Neoadjuvant chemotherapy for peripheral malignant neuroectodermal tumor of bone: recent experience at the istituto rizzoli
    G Bacci
    Departments of Chemotherapy and Pathology and Fifth Department of Orthopedic Surgery, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:885-92. 2000
    ..The results achieved in 44 patients with nonmetastatic peripheral neuroectodermal tumor (PNET) of bone treated with neoadjuvant chemotherapy are reported...
  51. ncbi request reprint Therapy and survival after recurrence of Ewing's tumors: the Rizzoli experience in 195 patients treated with adjuvant and neoadjuvant chemotherapy from 1979 to 1997
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    Ann Oncol 14:1654-9. 2003
    ..Many papers have reported the results achieved with combined therapy for Ewing's tumors, but little is known about the treatment and outcome of those 30-40% of patients who relapse...
  52. ncbi request reprint Long-term outcome for patients with non-metastatic Ewing's sarcoma treated with adjuvant and neoadjuvant chemotherapies. 402 patients treated at Rizzoli between 1972 and 1992
    G Bacci
    Sezione di Chemioterapia, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Eur J Cancer 40:73-83. 2004
    ..We conclude that since local or systemic relapses, treatment-complications and second malignancies are more common after 5 years or more from the beginning of treatment; a long-term follow-up is mandatory for patients with ES...
  53. ncbi request reprint Osteoarticular allograft reconstruction of the distal radius after bone tumour resection
    G Bianchi
    Istituto Ortopedico Rizzoli, Bologna, Italy
    J Hand Surg Br 30:369-73. 2005
    ..Subchondral bone alterations and joint narrowing were present in all cases but were painful in only one patient. The mean range of motion was 51 degrees of flexion and 37 degrees of extension...
  54. ncbi request reprint Nonmetastatic osteosarcoma of the extremity: results of a neoadjuvant chemotherapy protocol (IOR/OS-3) with high-dose methotrexate, intraarterial or intravenous cisplatin, doxorubicin, and salvage chemotherapy based on histologic tumor response
    S Ferrari
    Chemioterapia, I Clinica Ortopedica dell Università di Bologna, Italy
    Tumori 85:458-64. 1999
    ..Additional aims were to assess the role of the route of infusion (intraarterial or intravenous) of cisplatin on histologic response of the primary tumor and the use of ifosfamide as salvage chemotherapy in poor responders...
  55. pmc Conservative versus surgical treatment of osteogenesis imperfecta: a retrospective analysis of 29 patients
    Eugenio Chiarello
    Orthopaedic and Trauma Clinic II, University of Bologna, Rizzoli Orthopaedic Institute, Bologna, Italy
    Clin Cases Miner Bone Metab 9:191-4. 2012
    ..Nevertheless, bisphosphonate use can be considered a good adjuvant to both the conservative and surgical treatment of OI in order to reduce the rate of complications...
  56. ncbi request reprint Adult osteomyelitis: debridement versus debridement plus Osteoset T pellets
    Wang Chang
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    Acta Orthop Belg 73:238-43. 2007
    ..Osteoset T obviates the need for removal, which is the rule after implantation of gentamycin beads. Bony ingrowth is however limited...
  57. doi request reprint The use of unicondylar osteoarticular allografts in reconstructions around the knee
    Giuseppe Bianchi
    Istituti Ortopedici Rizzoli, 5th Division, Via Pupilli, 1 40136 Bologna, Italy
    Knee 16:1-5. 2009
    ..In selected cases of distal femoral and proximal tibial tumours, UOA reconstructions give good functional outcomes with relatively few major complications...
  58. ncbi request reprint Local and systemic control in Ewing's sarcoma of the femur treated with chemotherapy, and locally by radiotherapy and/or surgery
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Bone Joint Surg Br 85:107-14. 2003
    ..Further studies are needed to verify the impact of this strategy on overall survival...
  59. pmc In vitro biosafety profile evaluation of multipotent mesenchymal stem cells derived from the bone marrow of sarcoma patients
    Enrico Lucarelli
    Osteoarticolar Regeneration Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Transl Med 12:95. 2014
    ....
  60. ncbi request reprint Seven BMPs and all their receptors are simultaneously expressed in osteosarcoma cells
    Giuliana Gobbi
    Laboratory of Oncology Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Int J Oncol 20:143-7. 2002
    ..No mutations were detected in the BMPR-II cDNA. Our results suggest the presence of a mechanism involving the simultaneous activation of the BMPs and their receptors in osteosarcoma cell lines...