Elisabetta Cenni

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. ncbi Gene expression of bone-associated cytokines in MG63 osteoblast-like cells incubated with acrylic bone cement extracts in minimum essential medium
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomater Sci Polym Ed 13:1283-94. 2002
  2. ncbi Evaluation of endothelial cell integrins after in \ vitro contact with polyethylene terephthalate
    E Cenni
    Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Mater Sci Mater Med 12:345-9. 2001
  3. ncbi Interleukin-6 expression by cultured human endothelial cells in contact with carbon coated polyethylene terephthalate
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Mater Sci Mater Med 12:365-9. 2001
  4. ncbi Primitive and bone metastatic renal carcinoma cells promote osteoclastogenesis through endothelial cells
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 26:3065-9. 2006
  5. ncbi Effect of CMW 1 bone cement on transforming growth factor-beta 1 expression by endothelial cells
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 12:1011-25. 2001
  6. ncbi Platelet release of transforming growth factor-beta and beta-thromboglobulin after in vitro contact with acrylic bone cements
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1479-84. 2002
  7. ncbi Thrombomodulin expression in endothelial cells after contact with bone cement
    Elisabetta Cenni
    Dipartimento Putti, Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:2159-65. 2002
  8. ncbi Platelet activation after in vitro contact with seven acrylic bone cements
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 13:17-25. 2002
  9. ncbi Inhibition of angiogenic activity of renal carcinoma by an antisense oligonucleotide targeting fibroblast growth factor-2
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 25:1109-13. 2005
  10. ncbi Effects of activated platelet concentrates on human primary cultures of fibroblasts and osteoblasts
    E Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Rizzoli Orthopedic Institute, Bologna, Italy
    J Periodontol 76:323-8. 2005

Detail Information

Publications61

  1. ncbi Gene expression of bone-associated cytokines in MG63 osteoblast-like cells incubated with acrylic bone cement extracts in minimum essential medium
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomater Sci Polym Ed 13:1283-94. 2002
    ....
  2. ncbi Evaluation of endothelial cell integrins after in \ vitro contact with polyethylene terephthalate
    E Cenni
    Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Mater Sci Mater Med 12:345-9. 2001
    ..The increased expression of the vitronectin receptor, favoring the migration of smooth muscle cells, could give some information about the pathogenesis of intimal hyperplasia, which is a complication of vascular grafts...
  3. ncbi Interleukin-6 expression by cultured human endothelial cells in contact with carbon coated polyethylene terephthalate
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Mater Sci Mater Med 12:365-9. 2001
    ..We conclude that C-PET does not stimulate the synthesis of IL-6 and therefore does not favor inflammatory reaction through the release of this cytokine...
  4. ncbi Primitive and bone metastatic renal carcinoma cells promote osteoclastogenesis through endothelial cells
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 26:3065-9. 2006
    ..The contribution of angiogenesis to renal carcinoma bone metastases is virtually unknown...
  5. ncbi Effect of CMW 1 bone cement on transforming growth factor-beta 1 expression by endothelial cells
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 12:1011-25. 2001
    ..Incubation with CMW 1 added with ATRA did not produce any changes in TGF-beta 1 synthesis. Incubation with cement extract after 7-day curing added with IL-beta 1 produced a significant reduction in TGF-beta 1 release...
  6. ncbi Platelet release of transforming growth factor-beta and beta-thromboglobulin after in vitro contact with acrylic bone cements
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1479-84. 2002
    ..From the other side, activated platelets can release growth factors favoring bone formation...
  7. ncbi Thrombomodulin expression in endothelial cells after contact with bone cement
    Elisabetta Cenni
    Dipartimento Putti, Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:2159-65. 2002
    ..ATRA induced the increase of thrombomodulin also in cells incubated with cement extracts. These results suggest that CMW 1 bone cement does not impair the expression of thrombomodulin in endothelial cells...
  8. ncbi Platelet activation after in vitro contact with seven acrylic bone cements
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 13:17-25. 2002
    ..All cements determined a significant increase in beta-TG. CMW 3, Palacos, L.V.C., and Zimmer dough type determined a significant increase in TGF-beta1 compared with the negative control...
  9. ncbi Inhibition of angiogenic activity of renal carcinoma by an antisense oligonucleotide targeting fibroblast growth factor-2
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 25:1109-13. 2005
    ..Fibroblast growth factor-2 (FGF-2) induces angiogenesis, critical for the growth and metastatic spread of tumors...
  10. ncbi Effects of activated platelet concentrates on human primary cultures of fibroblasts and osteoblasts
    E Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Rizzoli Orthopedic Institute, Bologna, Italy
    J Periodontol 76:323-8. 2005
    ..The aim of this research was to assess the effect of platelet concentrates activated with thrombin on human gingival fibroblasts and human osteoblasts from trabecular bone...
  11. ncbi Plasma levels of platelet-derived growth factor BB and transforming growth factor in patients with failed hip prostheses
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, IT 40136 Bologna, Italy
    Acta Orthop 76:61-6. 2005
    ..We evaluated the levels of platelet-derived growth factor BB (PDGF-BB), transforming growth factors beta1 (TGF-beta1) and beta2 (TGF-beta2), both before and after activation, in patients with aseptic loosening of their hip prosthesis...
  12. ncbi Plasma levels of coagulation inhibitors, fibrinolytic markers and platelet-derived growth factor-AB in patients with failed hip prosthesis
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Acta Orthop Scand 74:559-64. 2003
    ..PAI-1 and D-dimer assays in failed prostheses may be useful for the pathogenetic evaluation, because the continuous inflammatory stimulus associated with fibrin deposition may also affect the systemic levels...
  13. ncbi Inhibition of angiogenesis via FGF-2 blockage in primitive and bone metastatic renal cell carcinoma
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 27:315-9. 2007
    ..Fibroblast growth factor-2 (FGF-2) has a role in the angiogenesis induced by renal carcinoma...
  14. ncbi Evaluation of tissue-factor production by human endothelial cells incubated with three acrylic bone cements
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 55:131-6. 2001
    ..The cements did not induce significant production of tissue factor and, therefore, did not activate the extrinsic pathway of coagulation within the limits of the mechanism considered...
  15. doi Platelet-rich plasma impairs osteoclast generation from human precursors of peripheral blood
    Elisabetta Cenni
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Orthop Res 28:792-7. 2010
    ..In conclusion, PRP at 10% interfered with the complete differentiation process of human osteoclast precursors. At higher concentration it impaired osteoclast formation also at an early stage of differentiation...
  16. ncbi Quantitative evaluation by image analysis of platelet morphological modifications after contact with polyvinylacetate
    E Cenni
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna
    Minerva Cardioangiol 48:1-8. 2000
    ....
  17. doi Background and rationale of platelet gel in orthopaedic surgery
    Elisabetta Cenni
    Laboratorio di Fisiopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Bologna, Italy
    Musculoskelet Surg 94:1-8. 2010
    ..In experimental animals and in clinical application, the efficacy of platelet gel was increased by the combination with bone allografts, acting as scaffolds, and with bone marrow stromal cells...
  18. doi Endothelial cells incubated with platelet-rich plasma express PDGF-B and ICAM-1 and induce bone marrow stromal cell migration
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 27:1493-8. 2009
    ....
  19. doi In vitro evaluation of freeze-dried bone allografts combined with platelet rich plasma and human bone marrow stromal cells for tissue engineering
    Elisabetta Cenni
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    J Mater Sci Mater Med 20:45-50. 2009
    ..In conclusion, the combination of FDBA and PRP had a favouring effect on the differentiation towards osteoblasts and allowed BMSC concentrated by simple centrifugation to differentiate as fast as BMSC purified by density gradient...
  20. ncbi Biocompatibility and performance in vitro of a hemostatic gelatin sponge
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 11:685-99. 2000
    ..In conclusion, Cutanplast Standard is neither cytotoxic nor genotoxic, while inducing platelet adhesion and release reaction when challenged with blood...
  21. ncbi Effect of four acrylic bone cements on transforming growth factor-beta1 expression by osteoblast-like cells MG63
    Elisabetta Cenni
    Dipartimento Putti, Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:305-11. 2002
    ....
  22. ncbi Evaluation of the effect of seven acrylic bone cements on erythrocytes and plasmatic phase of coagulation
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 22:1321-6. 2001
    ..It was concluded that the tested cement extracts do not induce haemolysis and do not activate the intrinsic pathway of coagulation, at least in the tests that were performed...
  23. ncbi No effect of methacrylate-based bone cement CMW 1 on the plasmatic phase of coagulation, red blood cells and endothelial cells in vitro
    E Cenni
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Bologna, Italy
    Acta Orthop Scand 72:86-93. 2001
    ....
  24. doi Biocompatibility of poly(D,L-lactide-co-glycolide) nanoparticles conjugated with alendronate
    Elisabetta Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 29:1400-11. 2008
    ..These results demonstrated that PLGA-ALE NPs had an acceptable degree of blood compatibility and were not cytotoxic; therefore, they may be considered suitable for intravenous administration...
  25. ncbi Isolation and characterization of a new cell line from a renal carcinoma bone metastasis
    Sofia Avnet
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Res 24:1705-11. 2004
    ..The use of cell lines isolated from metastases should enable the assessment of peculiar aspects of bone resorbing cytokine expression, as well as angiogenetic activity of renal carcinoma bone metastases...
  26. ncbi Serum levels of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand as markers of periprosthetic osteolysis
    Donatella Granchi
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Am 88:1501-9. 2006
    ..The aim of this study was to evaluate whether the circulating levels of OPG and RANKL, as well as their ratio, could be different in patients with aseptic loosening compared with patients with stable implants...
  27. ncbi Bone cement extracts modulate the osteoprotegerin/osteoprotegerin-ligand expression in MG63 osteoblast-like cells
    Donatella Granchi
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:2359-65. 2002
    ..The ability of bone cements to induce the expression of OPG-L could be a co-factor in the development of osteolysis at the bone-cement interface...
  28. ncbi Immunogenic properties of renal cell carcinoma and the pathogenesis of osteolytic bone metastases
    Francesca Perut
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Int J Oncol 34:1387-93. 2009
    ..Osteolysis in bone metastases, mediated by this pathway, may be further potentiated by the pro-angiogenic properties of RCC...
  29. ncbi Immunological changes in patients with primary osteoarthritis of the hip after total joint replacement
    Donatella Granchi
    Laboratorio dei Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Bone Joint Surg Br 85:758-64. 2003
    ....
  30. ncbi Sensitivity to implant materials in patients with total knee arthroplasties
    Donatella Granchi
    Laboratory for Pathophysiology of Orthopedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Biomaterials 29:1494-500. 2008
    ..On the contrary, the presence of symptoms of metal allergy before implantation should be taken into account as a potential risk factor for TKA failure...
  31. doi The effect of poly(d,l-lactide-co-glycolide)-alendronate conjugate nanoparticles on human osteoclast precursors
    Elisabetta Cenni
    a Laboratorio di Fisiopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    J Biomater Sci Polym Ed 23:1285-300. 2012
    ....
  32. ncbi Effects of bone cement extracts on the cell-mediated immune response
    Donatella Granchi
    Dipartimento Putti Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:1033-41. 2002
    ..These findings show that the products released from bone cement are not able, by themselves, to elicit a specific immune response; on the contrary they hamper the function of lymphocytes activated by an exogenous stimulus...
  33. doi Serum ion levels after ceramic-on-ceramic and metal-on-metal total hip arthroplasty: 8-year minimum follow-up
    Lucia Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Orthop Res 26:1569-76. 2008
    ..On the contrary, due to the higher ion release, metal-on-metal coupling must be prudently considered, especially in young patients, in order to obtain definitive conclusions...
  34. ncbi Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone marrow stromal cells
    D Dallari
    Seventh Division, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Am 89:2413-20. 2007
    ..We compared the osteogenic potential of lyophilized bone chips combined with platelet gel, or with platelet gel and bone marrow stromal cells, with that of lyophilized bone chips alone in the healing of a high tibial osteotomy...
  35. pmc In vitro models for the evaluation of angiogenic potential in bone engineering
    Elisabetta Cenni
    Laboratorio di Fisiopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Pharmacol Sin 32:21-30. 2011
    ..Platelet-rich plasma and recombinant growth factors may be useful for stimulating angiogenesis...
  36. ncbi Sensitivity to implant materials in patients undergoing total hip replacement
    Donatella Granchi
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 77:257-64. 2006
    ....
  37. ncbi Interleukin-6 expression by osteoblast-like MG63 cells challenged with four acrylic bone cements
    E Cenni
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomater Sci Polym Ed 12:243-53. 2001
    ..We conclude that CMW 1 and CMW 2 increase the production of IL-6 in MG63 cells. The response to Sulfix-60 and CMW 3 is not significantly greater than the negative control...
  38. pmc Idiopathic and secondary osteonecrosis of the femoral head show different thrombophilic changes and normal or higher levels of platelet growth factors
    Elisabetta Cenni
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Rizzoli Orthopaedic Institute, Bologna, Italy
    Acta Orthop 82:42-9. 2011
    ..As platelet-rich plasma has been proposed as an adjuvant in surgery, we also assessed whether platelet and serum growth factors were similar to those in healthy subjects...
  39. doi Growth factors in bone repair
    Valentina Devescovi
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, Bologna, Italy
    Chir Organi Mov 92:161-8. 2008
    ..In conclusion, GF are key components of functional bone regeneration: screening of basic research results and controlled clinical trials are accelerating the development of GF in orthopaedic surgery...
  40. pmc Recent highlights on bone stem cells: a report from Bone Stem Cells 2009, and not only…
    Elisabetta Cenni
    Laboratorio di Fisiopatologia Ortopedica e Medicina Rigenerativa, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Cell Mol Med 14:2614-21. 2010
    ..Further biological aspects of bone stem cells should be elucidated and a general consensus on the best models, protocols and proper use of scaffolds and growth factors should be achieved...
  41. ncbi Bone-targeted doxorubicin-loaded nanoparticles as a tool for the treatment of skeletal metastases
    M Salerno
    Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Istituto Ortopedico Rizzoli, Bologna, Italy
    Curr Cancer Drug Targets 10:649-59. 2010
    ..014, P = 0.040, respectively), possibly as a consequence of alendronate activity. In summary, NP may act effectively as a delivery system of anticancer drugs to the bone, and deserve further evaluation for the treatment of bone tumors...
  42. ncbi Modulation of pro- and anti-apoptotic genes in lymphocytes exposed to bone cements
    D Granchi
    Laboratorio di Fisiopotologia Degli Impianti Ortopedici, Bologna, Italy
    J Biomater Sci Polym Ed 11:633-46. 2000
    ....
  43. ncbi Cytotoxic effect of bone cements in HL-60 cells: distinction between apoptosis and necrosis
    G Ciapetti
    Dipartimento Putti, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res 52:338-45. 2000
    ..These findings provide potential leads for investigation into the molecular mechanisms of cell death, which are responsible for tissue damage by cements and intolerance of cemented prostheses...
  44. ncbi In vitro cytokine production by mononuclear cells exposed to bone cement extracts
    D Granchi
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 21:1789-95. 2000
    ..These findings allowed us to identify materials endowed with the highest inflammatory power...
  45. ncbi Osteoblast growth and function in porous poly epsilon -caprolactone matrices for bone repair: a preliminary study
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40139, Bologna, Italy
    Biomaterials 24:3815-24. 2003
    ..It can be concluded that PCL is a promising material for three-dimensional scaffold for bone formation, and the presence of bone-like components improves osteoblast activity...
  46. ncbi Apoptosis in peri-implant tissue
    S Stea
    Laboratory for Medical Technology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 21:1393-8. 2000
    ..Cell death by apoptosis may be important in implants which release metal ions by corrosion or wear and may have been underestimated up to now, as it is a 'clean' way of cell death, leading to limited damage in the surrounding tissues...
  47. ncbi Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Exp Gerontol 36:327-39. 2001
    ..Consequently, a prospective and follow-up evaluation of Zn and Se could be proposed as a good index for a correct monitoring of the micronutrient deficiencies, that could represent an early sign of disease...
  48. ncbi The influence of alumina and ultra-high molecular weight polyethylene particles on osteoblast-osteoclast cooperation
    D Granchi
    Laboratory of Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, Bologna 40136, Italy
    Biomaterials 25:4037-45. 2004
    ..With regard to the inductive effect on the osteoclastogenesis, our results show that the Al(2)O(3) wear debris are less active...
  49. ncbi Biologic effects of surface roughness and fluorhydroxyapatite coating on osteointegration in external fixation systems: an in vivo experimental study
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna and Università di Bologna, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res A 66:652-61. 2003
    ..The authors emphasize the necessity for simultaneous evaluation of surface topography and chemistry as well as an improvement in plasma-spraying and post-processing techniques and in standard procedures for materials characterization...
  50. ncbi Systemic cross-linked N-terminal telopeptide and procollagen I C-terminal extension peptide as markers of bone turnover after total hip arthroplasty
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:571-6. 2005
    ..The NTx level could be used to indicate stability of the implant. However, further prospective, larger studies are necessary...
  51. ncbi Ion release in stable hip arthroplasties using metal-on-metal articulating surfaces: a comparison between short- and medium-term results
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res A 66:450-6. 2003
    ..This exposure should be carefully monitored, in order to clarify the biologic effects of ion dissemination and, consequently, to identify risks concerning long-term toxicity of metals...
  52. ncbi Ion release in patients with metal-on-metal hip bearings in total joint replacement: a comparison with metal-on-polyethylene bearings
    L Savarino
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 63:467-74. 2002
    ..In such a way a risk-to-benefit ratio for the patient could be established...
  53. ncbi Evaluation of bone healing enhancement by lyophilized bone grafts supplemented with platelet gel: a standardized methodology in patients with tibial osteotomy for genu varus
    L Savarino
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Biomed Mater Res B Appl Biomater 76:364-72. 2006
    ..The completion of the study and the evaluation of the ultimate clinical outcome are necessary in order to verify PG in vivo effects in orthopedic surgery...
  54. ncbi Differences in ion release after ceramic-on-ceramic and metal-on-metal total hip replacement. Medium-term follow-up
    L Savarino
    The Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 88:472-6. 2006
    ..For this reason, the low corrosion level in a ceramic-on-ceramic coupling could be advantageous...
  55. ncbi In vivo study on the healing of bone defects treated with bone marrow stromal cells, platelet-rich plasma, and freeze-dried bone allografts, alone and in combination
    D Dallari
    VII Orthopaedic and Traumatology Division, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    J Orthop Res 24:877-88. 2006
    ..05). These results showed that the combination of FDBA, BMSC and PRP permitted an acceleration in bone healing and bone remodeling processes...
  56. ncbi Interferon-alpha inhibits in vitro osteoclast differentiation and renal cell carcinoma-induced angiogenesis
    S Avnet
    Laboratory for Pathophysiology of Orthopaedic Implants, Istituti Ortopedici Rizzoli, I 40136 Bologna, Italy
    Int J Oncol 30:469-76. 2007
    ....
  57. ncbi In vitro testing of the potential for orthopedic bone cements to cause apoptosis of osteoblast-like cells
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 23:617-27. 2002
    ..This study helps to gain more insight into the mechanism of cell death induced by PMMA-based cements and suggests apoptosis of osteoblasts as a part of the tissue reaction around cemented prostheses...
  58. ncbi Effects of chromium extract on cytokine release by mononuclear cells
    D Granchi
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    Biomaterials 19:283-91. 1998
    ..Moreover, chromium seems to inhibit the IL-2-dependent response of PBMCs, so that they are not able to trigger an efficient cell-mediated immune response...
  59. ncbi In vitro sister chromatid exchange induced by glass ionomer cements
    S Stea
    Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Biomed Mater Res 40:545-50. 1998
    ..The authors concluded that of the three cements tested the European cement Ketac Cem passed one of the tests suggested by the EEC standard for assessing genotoxicity...
  60. pmc Knee joint arthroplasty after tibial osteotomy
    Luca Amendola
    VII Department of Orthopaedic Surgery, Rizzoli Orthopaedic Institute, University of Bologna, Bologna, Italy
    Int Orthop 34:289-95. 2010
    ..Three patients underwent a further operation of secondary patella resurfacing for patella pain. The group without osteotomy reported a similar percentage of satisfactory results...
  61. ncbi Functionalization of poly-(L-lactic-co-epsilon-caprolactone): effects of surface modification on endothelial cell proliferation and hemocompatibility [corrected]
    Gabriele Perego
    Novamont S p A, Via G Fauser 8, 28100 Novara, Italy
    J Biomater Sci Polym Ed 14:1057-75. 2003
    ..Pre-cultured HMVEC seeding of the prosthesis by means of a rotation device resulted in an almost completely coverage of the graft inner surface...