Rosa Maria Borzi

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. pmc Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors
    Rosa Maria Borzi
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 62:2370-81. 2010
  2. ncbi request reprint Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha
    Ivana Stanic
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 206:138-46. 2006
  3. pmc Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes
    Eleonora Olivotto
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 58:227-39. 2008
  4. doi request reprint The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines
    Ivana Stanic'
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 219:109-16. 2009
  5. doi request reprint Sulforaphane protects human chondrocytes against cell death induced by various stimuli
    Annalisa Facchini
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 226:1771-9. 2011
  6. ncbi request reprint A role for chemokines in the induction of chondrocyte phenotype modulation
    Ilaria Mazzetti
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 50:112-22. 2004
  7. pmc IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation
    Eleonora Olivotto
    Laboratory of Immunorheumatology and Tissue Regeneration RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy
    PLoS ONE 8:e73024. 2013
  8. pmc Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1
    Marianna Penzo
    Centro Ricerca Biomedica Applicata CRBA, S Orsola Malpighi University Hospital, University of Bologna, Bologna, Italy
    J Cell Physiol 218:215-27. 2009
  9. doi request reprint Enhanced osteoblastogenesis of adipose-derived stem cells on spermine delivery via β-catenin activation
    Serena Guidotti
    Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy
    Stem Cells Dev 22:1588-601. 2013
  10. doi request reprint Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes
    Ivana Stanic
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 216:153-61. 2008

Collaborators

  • Andrea Facchini
  • Kenneth B Marcu
  • Giuseppe Filardo
  • Xiang Li
  • Benedetta Tantini
  • Jun Li
  • Miguel Otero
  • Simona Neri
  • Eleonora Olivotto
  • Flavio Flamigni
  • Ivana Stanic
  • Marianna Penzo
  • Claudio Stefanelli
  • Roberta Vitellozzi
  • Daniela Platano
  • Serena Guidotti
  • Silvia Cetrullo
  • Stefania Pagani
  • Mary B Goldring
  • Ivana Stanic'
  • Carlo Guarnieri
  • Ilaria Mazzetti
  • Manuela Minguzzi
  • Ermanno Martucci
  • Annalisa Astolfi
  • Giovanni Trisolino
  • Paul E Massa
  • Francesca Bianchi
  • Adedayo Hanidu
  • Elisabetta Falcieri
  • Michela Battistelli
  • Claudio Marcello Caldarera
  • Luca Cattini
  • Giorgia Magagnoli
  • Mariagrazia Uguccioni
  • Samantha Paoletti

Detail Information

Publications11

  1. pmc Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors
    Rosa Maria Borzi
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 62:2370-81. 2010
    ..To link matrix metalloproteinase 13 (MMP-13) activity and extracellular matrix (ECM) remodeling to alterations in regulatory factors leading to a disruption in chondrocyte homeostasis...
  2. ncbi request reprint Polyamine depletion inhibits apoptosis following blocking of survival pathways in human chondrocytes stimulated by tumor necrosis factor-alpha
    Ivana Stanic
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 206:138-46. 2006
    ..These results suggest that the intracellular depletion of polyamines in chondrocytes can inhibit both the death receptor pathway by reducing the level of procaspase-8, and the apoptotic mitochondrial pathway by activating Akt...
  3. pmc Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes
    Eleonora Olivotto
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 58:227-39. 2008
    ..This study was undertaken to investigate the differential roles of each IKK in chondrocyte differentiation and hypertrophy...
  4. doi request reprint The polyamine analogue N1,N11-diethylnorspermine can induce chondrocyte apoptosis independently of its ability to alter metabolism and levels of natural polyamines
    Ivana Stanic'
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 219:109-16. 2009
    ..In conclusion, the results suggest that DENSPM can favour apoptosis in chondrocytes independently of its effects on polyamine metabolism and levels...
  5. doi request reprint Sulforaphane protects human chondrocytes against cell death induced by various stimuli
    Annalisa Facchini
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 226:1771-9. 2011
    ....
  6. ncbi request reprint A role for chemokines in the induction of chondrocyte phenotype modulation
    Ilaria Mazzetti
    Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 50:112-22. 2004
    ....
  7. pmc IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation
    Eleonora Olivotto
    Laboratory of Immunorheumatology and Tissue Regeneration RAMSES, Rizzoli Orthopedic Research Institute, Bologna, Italy
    PLoS ONE 8:e73024. 2013
    ..Here, we have investigated the mechanism of action of IKKα as a novel effector of human and murine chondrocyte extracellular matrix (ECM) homeostasis and differentiation towards hypertrophy...
  8. pmc Sustained NF-kappaB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1
    Marianna Penzo
    Centro Ricerca Biomedica Applicata CRBA, S Orsola Malpighi University Hospital, University of Bologna, Bologna, Italy
    J Cell Physiol 218:215-27. 2009
    ....
  9. doi request reprint Enhanced osteoblastogenesis of adipose-derived stem cells on spermine delivery via β-catenin activation
    Serena Guidotti
    Laboratorio di Immunoreumatologia e Rigenerazione Tessutale, Istituto Ortopedico Rizzoli, Bologna, Italy
    Stem Cells Dev 22:1588-601. 2013
    ..The finding that spermine induces ASC to differentiate toward mature osteoblasts supports the use of these easily accessible mesenchymal stem cells coupled with PRP for orthopedic applications...
  10. doi request reprint Effect of the polyamine analogue N1,N11-diethylnorspermine on cell survival and susceptibility to apoptosis of human chondrocytes
    Ivana Stanic
    Dipartimento di Biochimica G Moruzzi, University of Bologna, Bologna, Italy
    J Cell Physiol 216:153-61. 2008
    ..Moreover, these results indicate that a reduction of polyamine levels not only leads to inhibition of cell proliferation, but also of caspase-mediated pathways of chondrocyte apoptosis...
  11. ncbi request reprint Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes
    Rosa Maria Borzi
    IRCCS Istituti Ortopedici Rizzoli, Bologna, Italy
    Arthritis Rheum 46:3201-11. 2002
    ....