F Bertoni

Summary

Affiliation: Istituti Ortopedici Rizzoli
Country: Italy

Publications

  1. ncbi request reprint Malignancy in giant cell tumor
    F Bertoni
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Skeletal Radiol 32:143-6. 2003
  2. ncbi request reprint Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute
    Franco Bertoni
    Surgical Pathology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 103:2373-82. 2005
  3. ncbi request reprint Malignancy in giant cell tumor of bone
    Franco Bertoni
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 97:2520-9. 2003
  4. ncbi request reprint Fibrous dysplasia with degenerative atypia: a benign lesion potentially mistaken for sarcoma
    Franco Bertoni
    Department of Surgical Pathology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Arch Pathol Lab Med 128:794-6. 2004
  5. ncbi request reprint Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report
    G Bacci
    Service of Chemotherapy, Laboratory of Pathology, Fifth Service of Orthopedic Surgery, and Laboratory of Oncologic Research, Department of Musculoskeletal Oncology, I F Goidanich of the Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:4016-27. 2000
  6. ncbi request reprint Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli
    G Bacci
    Departments of Musculo Skeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:4-11. 2000
  7. ncbi request reprint Local and systemic control for osteosarcoma of the extremity treated with neoadjuvant chemotherapy and limb salvage surgery: the Rizzoli experience
    G Bacci
    Sezione di Chemioterapia, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
    Oncol Rep 7:1129-33. 2000
  8. ncbi request reprint A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    Eur J Surg Oncol 27:98-104. 2001
  9. ncbi request reprint Neoadjuvant chemotherapy for peripheral malignant neuroectodermal tumor of bone: recent experience at the istituto rizzoli
    G Bacci
    Departments of Chemotherapy and Pathology and Fifth Department of Orthopedic Surgery, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:885-92. 2000
  10. ncbi request reprint Neoadjuvant chemotherapy for osseous malignant fibrous histiocytoma of the extremity: results in 18 cases and comparison with 112 contemporary osteosarcoma patients treated with the same chemotherapy regimen
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 9:293-9. 1997

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Malignancy in giant cell tumor
    F Bertoni
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Skeletal Radiol 32:143-6. 2003
    ..After curettage, the permanent histology slides showed areas of highly malignant osteosarcoma juxtaposed to areas of benign giant cell tumor. The patient was treated with chemotherapy and wide resection of the tumor...
  2. ncbi request reprint Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute
    Franco Bertoni
    Surgical Pathology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 103:2373-82. 2005
    ..The objective of this study was to analyze the clinicopathologic and radiographic features of a relatively large number of patients with DPOS in an attempt to define further the histologic and biologic behavior of this rare entity...
  3. ncbi request reprint Malignancy in giant cell tumor of bone
    Franco Bertoni
    Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 97:2520-9. 2003
    ..The goals of the current study were to define the clinicopathologic and histologic features of malignancy in giant cell tumors and to clarify the terminology...
  4. ncbi request reprint Fibrous dysplasia with degenerative atypia: a benign lesion potentially mistaken for sarcoma
    Franco Bertoni
    Department of Surgical Pathology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Arch Pathol Lab Med 128:794-6. 2004
    ..The differential diagnosis is discussed. When radiographic and other histologic findings suggest fibrous dysplasia, the atypical nuclear changes should not, by themselves, alter the diagnosis...
  5. ncbi request reprint Long-term outcome for patients with nonmetastatic osteosarcoma of the extremity treated at the istituto ortopedico rizzoli according to the istituto ortopedico rizzoli/osteosarcoma-2 protocol: an updated report
    G Bacci
    Service of Chemotherapy, Laboratory of Pathology, Fifth Service of Orthopedic Surgery, and Laboratory of Oncologic Research, Department of Musculoskeletal Oncology, I F Goidanich of the Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:4016-27. 2000
    ..To provide an estimate of long-term prognosis for patients with osteosarcoma of the extremity treated in a single institution with neoadjuvant chemotherapy and observed for at least 10 years...
  6. ncbi request reprint Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli
    G Bacci
    Departments of Musculo Skeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:4-11. 2000
    ..The identification of prognostic factors in patients with nonmetastatic Ewing's sarcoma could allow the use of risk-adapted therapeutic strategies of treatment...
  7. ncbi request reprint Local and systemic control for osteosarcoma of the extremity treated with neoadjuvant chemotherapy and limb salvage surgery: the Rizzoli experience
    G Bacci
    Sezione di Chemioterapia, Istituto Ortopedico Rizzoli, 40136 Bologna, Italy
    Oncol Rep 7:1129-33. 2000
    ....
  8. ncbi request reprint A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    Eur J Surg Oncol 27:98-104. 2001
    ..Our experience of pre-operative intraarterial (i.a.) vs intravenous (i.v.) infusion of cisplatinum (CDP) in a multiagent neo-adjuvant chemotherapy for osteosarcoma of the extremity is reported...
  9. ncbi request reprint Neoadjuvant chemotherapy for peripheral malignant neuroectodermal tumor of bone: recent experience at the istituto rizzoli
    G Bacci
    Departments of Chemotherapy and Pathology and Fifth Department of Orthopedic Surgery, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Clin Oncol 18:885-92. 2000
    ..The results achieved in 44 patients with nonmetastatic peripheral neuroectodermal tumor (PNET) of bone treated with neoadjuvant chemotherapy are reported...
  10. ncbi request reprint Neoadjuvant chemotherapy for osseous malignant fibrous histiocytoma of the extremity: results in 18 cases and comparison with 112 contemporary osteosarcoma patients treated with the same chemotherapy regimen
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 9:293-9. 1997
    ..The results of the present study seem to indicate that, in spite of a usually poor histologic response to preoperative treatment, neoadjuvant chemotherapy is very effective also in MFH of bone...
  11. ncbi request reprint Osteosarcoma of the extremities with synchronous lung metastases: long-term results in 44 patients treated with neoadjuvant chemotherapy
    G Bacci
    Chemotherapy Division, Rizzoli Orthopedic Institute, Bologna, Italy
    J Chemother 10:69-76. 1998
    ....
  12. ncbi request reprint Neoadjuvant chemotherapy for high grade osteosarcoma of the extremities: long-term results for patients treated according to the Rizzoli IOR/OS-3b protocol
    G Bacci
    Chemotherapy Division, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 13:93-9. 2001
    ..These results, however, are no better than those achieved in our previous study IOR/OS-3a, in which only poor responder patients received ifosfamide during the postoperative treatment...
  13. ncbi request reprint Telangiectatic osteosarcoma of the extremity: neoadjuvant chemotherapy in 24 cases
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Orthop Scand 72:167-72. 2001
    ..01) in the TO group. We conclude that TO, once considered a lethal tumor, seems to be even more sensitive to chemotherapy than conventional osteosarcoma, and that most of these patients may be cured without amputation...
  14. ncbi request reprint Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing's sarcoma of the extremities
    P Picci
    Department of Pathology, Rizzoli Orthopedic Institute, Bologna, Italy
    J Clin Oncol 15:1553-9. 1997
    ..This study was performed to assess the prognostic value of the proposed histopathologic method to evaluate the response of the primary tumor to preoperative chemotherapy in Ewing's sarcoma...
  15. ncbi request reprint Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide
    G Bacci
    Section of Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Ann Oncol 14:1126-34. 2003
    ..Currently, little is known about patients with metastatic disease at presentation...
  16. ncbi request reprint Intra-arterial versus intravenous cisplatinum (in addition to systemic Adriamycin and high dose methotrexate) in the neoadjuvant treatment of osteosarcoma of the extremities. results of a randomized study
    G Bacci
    Sezione di Chemioterapia dei Tumori Ossei, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 8:70-81. 1996
    ..In the IA group, however, there was only one local recurrence vs 5 in the IV group. The IA infusion of CDP is more active on the primary tumor than the IV infusion...
  17. ncbi request reprint Primary lymphoma of bone: long term results in patients treated with vincristine--adriamycin--cyclophosphamide and local radiation
    G Bacci
    Bone Tumor Center Istituto Rizzoli, Bologna, Italy
    J Chemother 3:189-93. 1991
    ..No local recurrences nor second tumor in the irradiated field were observed. We conclude that the addition of chemotherapy to radiotherapy results in an excellent cure rate for patients with PLB...
  18. ncbi request reprint Primary chemotherapy and delayed surgery (neoadjuvant chemotherapy) for telangiectatic osteogenic sarcoma of the extremities
    G Bacci
    Department of Internal Medicine and Medical Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Chemother 1:190-6. 1989
    ..Employing neoadjuvant chemotherapy a high percentage of patients with TOS can be cured and in most of them, limb sparing surgery is possible and safe...
  19. ncbi request reprint Neoadjuvant chemotherapy for Ewing's sarcoma of bone in patients older than thirty-nine years
    G Bacci
    Department of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Oncol 39:111-6. 2000
    ..We conclude that Ewing's sarcoma of bone in adults is no different from that occurring in children, and we therefore recommend the inclusion of all adult patients in multidisciplinary treatment trials of this tumor...
  20. ncbi request reprint Predictive factors of disease-free survival for non-metastatic osteosarcoma of the extremity: an analysis of 300 patients treated at the Rizzoli Institute
    S Ferrari
    Chemotherapy, Istituti Ortopedici Rizzoli, Bologna, Italy
    Ann Oncol 12:1145-50. 2001
    ..To identify predictive factors of disease-free survival (DFS) in patients with non-metastatic osteosarcoma of the extremity, treated with primary chemotherapy and delayed surgery...
  21. ncbi request reprint Pattern of relapse in 290 patients with nonmetastatic Ewing's sarcoma family tumors treated at a single institution with adjuvant and neoadjuvant chemotherapy between 1972 and 1999
    G Bacci
    Section of Chemotherapy, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Eur J Surg Oncol 32:974-9. 2006
    ..Evaluation of pattern of recurrences of 290 patients with an Ewing's sarcoma family tumor (ESFT), who relapsed after adjuvant or neoadjuvant chemotherapy...
  22. ncbi request reprint Alteration of pRb/p16/cdk4 regulation in human osteosarcoma
    M S Benassi
    Department of Musculoskeletal Oncology, Laboratory of Oncologic Research, Rizzoli Orthopedic Institute, Bologna, Italy
    Int J Cancer 84:489-93. 1999
    ..These data confirm the role of the pRb/p16/cdk4 pathway in OS development...
  23. ncbi request reprint Neoadjuvant chemotherapy for Ewing's tumour of bone: recent experience at the Rizzoli Orthopaedic Institute
    G Bacci
    Section of Chemotherapy, Rizzoli Orthopaedic Institute, Bologna, Italy
    Eur J Cancer 38:2243-51. 2002
    ....
  24. ncbi request reprint Twenty-year follow-up of osteosarcoma of the extremity treated with adjuvant chemotherapy
    A Longhi
    Chemotherapy, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Chemother 16:582-8. 2004
    ..Protracted medical follow-up and long-term updated results are useful to identify, at an early stage, late relapses and late treatment-related complications...
  25. ncbi request reprint Osteoid osteoma and osteoblastoma of the sacrum
    R Biagini
    Rizzoli Orthopedic Institute, Bologna, Italy
    Orthopedics 24:1061-4. 2001
    ..Radiotherapy as well as embolization of feeding arteries may be used for the most aggressive lesions. Prognosis is generally good with a low incidence of local recurrence (<10%)...
  26. ncbi request reprint Ewing's sarcoma of bone: relation between clinical characteristics and staging
    S Ferrari
    Sezione di Chemioterapia, Istituto Ortopedico Rizzoli, I 40136 Bologna, Italy
    Oncol Rep 8:553-6. 2001
    ..Only six patients were positive for five factors and all of them had metastases at presentation. The parameters identified are clinical markers of Ewing's sarcoma having a particularly aggressive metastatic behavior...
  27. ncbi request reprint Metalloproteinase expression and prognosis in soft tissue sarcomas
    M S Benassi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Ann Oncol 12:75-80. 2001
    ..This study assessed the prognostic role of MMP2, MMP9 metalloproteinases, and of the metalloproteinase inhibitor TIMP2, related to disease-free survival (DFS), in soft tissue sarcoma (STS) patients...
  28. ncbi request reprint Osteosarcoma of the pelvis
    D Donati
    Department of Musculoskeletal Oncology and Orthopaedic Surgery, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Eur J Surg Oncol 30:332-40. 2004
    ..To describe the outcomes of a large number of patients with pelvic osteosarcoma, and to define the guidelines for appropriate treatment...
  29. ncbi request reprint Dedifferentiated central chondrosarcoma
    Eric L Staals
    Fifth Orthopedic Division, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 106:2682-91. 2006
    ..The prognosis for patients who develop dedifferentiation of central chondrosarcoma traditionally has been poor. Because not much has been reported about this rare lesion, many uncertainties remain about prognostic factors...
  30. ncbi request reprint The Istituto Rizzoli experience with small cell osteosarcoma
    F Bertoni
    Istituto Orthopedico Rizzoli, Bologna, Italy
    Cancer 64:2591-9. 1989
    ..The lesion may mimic Ewing's tumor and other lesions in which round cells are seen. We report the clinical, radiologic, and pathologic features of this tumor, as well as the clinical outcome and response to therapy...
  31. ncbi request reprint Primary malignant myoepithelioma of the distal femur
    M Alberghini
    Department of Surgical Pathology, Rizzoli Institute, IRCCS, Bologna, Italy
    APMIS 115:376-80. 2007
    ..Primary malignant myoepithelioma of bone is an exceptionally rare neoplasm that should be considered in the differential diagnosis with the more aggressive myxoid spindle cell sarcomas...
  32. ncbi request reprint Surgical treatment and outcome of conventional pelvic chondrosarcoma
    D Donati
    Orthopaedic Division, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    J Bone Joint Surg Br 87:1527-30. 2005
    ..By contrast, grade 1 peripheral chondrosarcomas may be treated with contaminated margins in order to reduce operative morbidity, but without reducing survival...
  33. ncbi request reprint Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma
    P Ragazzini
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Histol Histopathol 19:401-11. 2004
    ..These two seem to have a more similar behavior than anaplastic and classic embryonal that are classified in the same subtype...
  34. ncbi request reprint Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma
    P Ragazzini
    Laboratory of Oncologic Research, Rizzoli Orthopedic Institute, Bologna, Italy
    Cancer Detect Prev 23:129-36. 1999
    ..SAS was found amplified in 15% of the samples. These findings indicate that these genes may be involved in tumorigenesis and progression of low-grade osteosarcoma...
  35. ncbi request reprint Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma
    M Alberghini
    Department of Surgical Pathology, Rizzoli Institute, Bologna, Italy
    Skeletal Radiol 30:350-3. 2001
    ..Immunohistochemistry and ultrastructural analysis are helpful in confirming the diagnosis. The recognition of this entity avoids unnecessary overtreatment of these patients...
  36. ncbi request reprint Histochemical and ultrastructural study of an elastofibroma dorsi coexisting with a high grade spindle cell sarcoma
    M Alberghini
    Anatomia Patologica, Istituti Ortopedici Rizzoli, via di Barbiano 1 10 40136 Bologna, Italy
    Eur J Histochem 48:173-8. 2004
    ..The results obtained suggest that the coexistence of the two pathological entities is conceivably coincidental...
  37. ncbi request reprint Giant cell tumor of the rib
    A Briccoli
    General Surgery, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    Skeletal Radiol 32:107-10. 2003
    ..When possible this type of tumor requires resection, instead of radiotherapy, since the majority of cases of malignant transformation are linked to prior radiation therapy...
  38. ncbi request reprint Nonmetastatic osteosarcoma of the extremity: results of a neoadjuvant chemotherapy protocol (IOR/OS-3) with high-dose methotrexate, intraarterial or intravenous cisplatin, doxorubicin, and salvage chemotherapy based on histologic tumor response
    S Ferrari
    Chemioterapia, I Clinica Ortopedica dell Università di Bologna, Italy
    Tumori 85:458-64. 1999
    ..Additional aims were to assess the role of the route of infusion (intraarterial or intravenous) of cisplatin on histologic response of the primary tumor and the use of ifosfamide as salvage chemotherapy in poor responders...
  39. ncbi request reprint May P-glycoprotein status be used to stratify high-grade osteosarcoma patients? Results from the Italian/Scandinavian Sarcoma Group 1 treatment protocol
    Massimo Serra
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Int J Oncol 29:1459-68. 2006
    ..P-glycoprotein evaluation can therefore constitute the basis for stratifying, at diagnosis, osteosarcoma patients for whom alternative treatments may be considered...
  40. ncbi request reprint Role of MMP-9 and its tissue inhibitor TIMP-1 in human osteosarcoma: findings in 42 patients followed for 1-16 years
    Cristina Ferrari
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, Bologna, Italy
    Acta Orthop Scand 75:487-91. 2004
    ..The activity of matrix metalloproteinases (MMPs) in degrading extracellular matrix is controlled by activation of proenzymes and inhibition of MMP tissue inhibitors (TIMPs)...
  41. ncbi request reprint Bone metastases in osteosarcoma patients treated with neoadjuvant or adjuvant chemotherapy: the Rizzoli experience in 52 patients
    Gaetano Bacci
    Section of Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Orthop 77:938-43. 2006
    ....
  42. ncbi request reprint Late relapse in osteosarcoma
    Stefano Ferrari
    Chemotherapy of the Department of Musculoskeletal Oncology at Istituti Ortopedici Rizzoli, Bologna, Italy
    J Pediatr Hematol Oncol 28:418-22. 2006
    ..No clinical predictive factors of late relapse were identified and a prolonged follow-up is recommended for all patients...
  43. ncbi request reprint Prognostic factors in non-metastatic Ewing's sarcoma tumor of bone: an analysis of 579 patients treated at a single institution with adjuvant or neoadjuvant chemotherapy between 1972 and 1998
    Gaetano Bacci
    Chemotherapy, Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Acta Oncol 45:469-75. 2006
    ..Criteria to stratify patients according to the risk of local or systemic relapse should not be based on a single prognostic factor, but should include all the variables that showed prognostic significance...
  44. ncbi request reprint Leiomyosarcoma of the spermatic cord: a light and ultrastructural description of one case
    Marco Alberghini
    Department of Surgical Pathology, IOR, Bologna, Italy
    Pathol Res Pract 200:487-91. 2004
    ....
  45. ncbi request reprint Neoadjuvant chemotherapy with high-dose Ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the Italian and Scandinavian Sarcoma Groups
    Stefano Ferrari
    Chemotherapy Division of Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Via C Pupilli 1, 40136 Bologna, Italy
    J Clin Oncol 23:8845-52. 2005
    ..To explore the effect of high-dose ifosfamide in first-line treatment for patients < or = 40 years of age with nonmetastatic osteosarcoma of the extremity...
  46. ncbi request reprint Grade of chemotherapy-induced necrosis as a predictor of local and systemic control in 881 patients with non-metastatic osteosarcoma of the extremities treated with neoadjuvant chemotherapy in a single institution
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    Eur J Cancer 41:2079-85. 2005
    ..Nonetheless, since they represent more than 70% of all osteosarcomas, we conclude that chemotherapy-induced necrosis has a significant prognostic value, regardless of the type of chemotherapy performed after surgery...
  47. ncbi request reprint No correlation between methotrexate serum level and histologic response in the pre-operative treatment of extremity osteosarcoma
    Gaetano Bacci
    Chemotherapy Research of the Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Anticancer Drugs 17:411-5. 2006
    ..Thus, increasing the dose of MTX increases the MTX serum peaks, but does not correlate with the histologic response of the tumor...
  48. ncbi request reprint Prognostic and therapeutic relevance of HER2 expression in osteosarcoma and Ewing's sarcoma
    Katia Scotlandi
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    Eur J Cancer 41:1349-61. 2005
    ..Therefore, the therapeutic potential of trastuzumab in these neoplasms may be better exploited in combined treatments with anti-IGF-IR approaches...
  49. ncbi request reprint Primary high-grade osteosarcoma: comparison between preadolescent and older patients
    Gaetano Bacci
    Department of Chemotherapy, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Pediatr Hematol Oncol 27:129-34. 2005
    ..89%), and good histologic response to preoperative treatment (65% vs. 63%) were essentially the same. The authors concluded that there is no need to employ different therapies for the two groups...
  50. ncbi request reprint The role of surgical margins in treatment of Ewing's sarcoma family tumors: experience of a single institution with 512 patients treated with adjuvant and neoadjuvant chemotherapy
    Gaetano Bacci
    Section of Chemotherapy, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Int J Radiat Oncol Biol Phys 65:766-72. 2006
    ..To evaluate the importance of surgical margins for local and systemic control of Ewing's sarcoma family tumors (ESFT)...
  51. ncbi request reprint Desmoplastic fibroblastoma: a light and ultrastructural description of two cases
    Marco Alberghini
    Department of Surgical Pathology, Rizzoli Institute, IRCCS, Bologna, Italy
    Ultrastruct Pathol 28:149-57. 2004
    ..Mitotic figures and necrotic areas were not identified. Immunohistochemistry showed positivity for vimentin and focal positivity for smooth and human muscle actin, and flow cytometry showed the tumoral cells to be diploid...
  52. ncbi request reprint Influence of local recurrence on survival in patients with extremity osteosarcoma treated with neoadjuvant chemotherapy: the experience of a single institution with 44 patients
    Gaetano Bacci
    Division of Chemotherapy, Institute Ortopedico Rizzoli, Bologna, Italy
    Cancer 106:2701-6. 2006
    ....
  53. ncbi request reprint Simultaneous osteosarcoma lung metastasis and second primary lung cancer
    Alessandra Longhi
    Chemotherapy, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Pediatr Hematol Oncol 26:457-61. 2004
    ..The occurrence of a primitive lung cancer together with lung metastases from osteosarcoma is even more unusual, and examination of all new lung nodules is highly recommended...
  54. ncbi request reprint Local and distant control in non-metastatic pelvic Ewing's sarcoma patients
    Davide Donati
    Orthopaedic Surgery, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Surg Oncol 96:19-25. 2007
    ..The purpose of this study was to review our experience and evaluate the role of different local treatment in non-metastatic pelvic ES patients...
  55. ncbi request reprint Evaluation of P-glycoprotein, HER-2/ErbB-2, p53, and Bcl-2 in primary tumor and metachronous lung metastases in patients with high-grade osteosarcoma
    Stefano Ferrari
    Chemotherapy Service, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Cancer 100:1936-42. 2004
    ..Investigation of the relation between primary tumor and metastatic disease is necessary for the identification of predictive factors for postrecurrence survival (PRS) in patients with recurrent osteosarcoma...
  56. ncbi request reprint Identification of markers of possible prognostic value in 57 giant cell tumors of bone
    Gabriella Gamberi
    Laboratory of Oncologic Research, Rizzoli Orthopaedic Institute, I 40136 Bologna, Italy
    Oncol Rep 10:351-6. 2003
    ..Therefore, the evaluation of the expression levels of these proteins at the time of diagnosis may be taken into consideration for a classification of GCT into categories characterized by a different risk to relapse...
  57. ncbi request reprint Multimodal therapy for the treatment of nonmetastatic Ewing sarcoma of pelvis
    Gaetano Bacci
    Chemotherapy Unit, Department of Musculoskeletal Oncology of the Rizzoli Orthopedic Institute, Bologna, Italy
    J Pediatr Hematol Oncol 25:118-24. 2003
    ..64% and 44% vs. 69%). Thus, despite associated chemotherapy, the outcome of ES localized in the pelvis remains poor, and new innovative methods for the treatment of this tumor are needed...
  58. ncbi request reprint Value of P-glycoprotein and clinicopathologic factors as the basis for new treatment strategies in high-grade osteosarcoma of the extremities
    Massimo Serra
    Laboratorio di Ricerca Oncologica, Sezione di Chemioterapia, Servizio di Anatomia Patologica, Va Divisione, and Unita di Chirurgia Generale, Istituti Ortopedici Rizzoli, Bologna, Italy
    J Clin Oncol 21:536-42. 2003
    ..To evaluate the prognostic value of P-glycoprotein and clinicopathologic parameters in a large series of high-grade osteosarcoma (OS) patients treated at the Rizzoli Institute...
  59. doi request reprint Spontaneous regression of lung metastasis from osteosarcoma: a case report
    Gaetano Bacci
    Division of Chemotherapy, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Pediatr Hematol Oncol 30:90-2. 2008
    ..The patient was followed up every 3 months and a spontaneous regression of the lesion was documented. Seven years after the diagnosis of lung metastases, no pulmonary nodules or other signs of relapse are present...
  60. doi request reprint High-grade surface osteosarcoma: a review of 25 cases from the Rizzoli Institute
    Eric L Staals
    Fifth Orthopedic Division, Rizzoli Orthopedic Institute, Bologna, Italy
    Cancer 112:1592-9. 2008
    ..High-grade surface osteosarcoma is a rare variant of surface osteosarcoma and is associated with a poor prognosis...
  61. ncbi request reprint Increased osteoclast activity is associated with aggressiveness of osteosarcoma
    Sofia Avnet
    Laboratory for Pathophysiology, Istituti Ortopedici Rizzoli, 40136 Bologna, Italy
    Int J Oncol 33:1231-8. 2008
    ..0117). In conclusion, tumor-infiltrating osteoclasts are frequently found in OS and increased serum TRACP 5b levels and the presence of active osteoclast at primary sites were positively associated with tumor aggressiveness...
  62. ncbi request reprint Management of pelvic giant cell tumours involving the acetabular bone
    Davide Donati
    Musculoskeletal Oncology Department of the Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136 Bologna, Italy
    Acta Orthop Belg 74:773-8. 2008
    ..However, the possible complications of the different methods of pelvic reconstruction should always be considered...
  63. pmc Surgical treatment of grade I central chondrosarcoma
    Davide Donati
    Musculoskeletal Oncology Department, Rizzoli Orthopaedic Institute, Via Pupilli 1, 40136, Bologna, Italy
    Clin Orthop Relat Res 468:581-9. 2010
    ..Level of Evidence: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence...
  64. ncbi request reprint Postrelapse survival in osteosarcoma of the extremities: prognostic factors for long-term survival
    Stefano Ferrari
    Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    J Clin Oncol 21:710-5. 2003
    ..To identify factors that influence postrelapse survival (PRS) in patients with nonmetastatic osteosarcoma of the extremity...
  65. ncbi request reprint Dedifferentiated chondrosarcomas arising in preexisting osteochondromas
    Eric L Staals
    Department of Musculoskeletal Oncology V Division E, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, Italy
    J Bone Joint Surg Am 89:987-93. 2007
    ..The purpose of the present study was to describe the specific clinical, radiographic, and histologic features of this lesion and to evaluate the oncologic outcome after different treatment strategies...
  66. ncbi request reprint Role of surgery in local treatment of Ewing's sarcoma of the extremities in patients undergoing adjuvant and neoadjuvant chemotherapy
    Gaetano Bacci
    Section of Chemotherapy, Istituto Ortopedico Rizzoli, Via Pupilli 1, I 40136 Bologna, Italy
    Oncol Rep 11:111-20. 2004
    ..Our results indicate that surgery should always be considered in the local treatment of ES of the extremities. Postoperative radiation therapy must be added in case of inadequate surgical margins...
  67. ncbi request reprint Neoadjuvant chemotherapy for osteosarcoma of the extremity: intensification of preoperative treatment does not increase the rate of good histologic response to the primary tumor or improve the final outcome
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzolo, Bologna, Italy
    J Pediatr Hematol Oncol 25:845-53. 2003
    ....
  68. ncbi request reprint Predictive factors of histologic response to primary chemotherapy in patients with Ewing sarcoma
    Stefano Ferrari
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Pediatr Hematol Oncol 29:364-8. 2007
    ..003). Female were more likely to achieve a GR (F 64% vs. M 42%, P<0.02). After multivariate analysis sex and age retained statistical significance. Age and sex influence the histologic response in patients with Ewing sarcoma...
  69. ncbi request reprint Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity. Histologic response to preoperative chemotherapy correlates with histologic subtype of the tumor
    Gaetano Bacci
    Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer 97:3068-75. 2003
    ..In primary central high-grade osteosarcoma, a number of distinct subtypes have been identified, but little is known about the response to chemotherapy...
  70. ncbi request reprint Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution
    Gaetano Bacci
    Chemotherapy, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    J Surg Oncol 96:118-23. 2007
    ..Indications and contraindications for limb salvage versus amputation for local treatment of osteosarcoma of the extremity are still controversial...
  71. ncbi request reprint C-kit receptor expression in Ewing's sarcoma: lack of prognostic value but therapeutic targeting opportunities in appropriate conditions
    Katia Scotlandi
    Laboratorio di Ricerca Oncologica and Servicio di Anatomia Patologica, Istituti Ortopedici Rizzoli, Via Di Barbiano 1 10, 40136 Bologna, Italy
    J Clin Oncol 21:1952-60. 2003
    ..Autocrine/paracrine stimulation of c-kit has been recently observed in Ewing's sarcoma (ES) cell lines. In this study, we tested the prognostic and therapeutic role of the receptor in this tumor...
  72. ncbi request reprint Clear cell chondrosarcoma of bone: long time follow-up of 18 cases
    Davide Donati
    Orthopaedic Oncology of the Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Arch Orthop Trauma Surg 128:137-42. 2008
    ..We reviewed our cases of clear cell chondrosarcoma with the aim to assess the best diagnostic and curative approach to this rare tumor...
  73. ncbi request reprint Primary osteogenic sarcoma of the clavicle. Case report
    S Paderni
    Clinica Ortopedica dell Università, Istituto Ortopedico Rizzoli, Bologna, Italy
    Chir Organi Mov 87:63-6. 2002
    ....
  74. ncbi request reprint Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone
    G Gamberi
    Laboratory of Oncologic Research, Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy
    Ann Oncol 15:498-503. 2004
    ..Few prognostic markers have been reported to predict the clinical outcome of GCT patients, so is very important to find the factor that can be implicated in its potential aggressiveness...
  75. ncbi request reprint Aneurysmal bone cyst of the mobile spine: report on 41 cases
    S Boriani
    Department of Orthopedics and Traumatology, Maggiore Hospital, Bologna, Italy
    Spine (Phila Pa 1976) 26:27-35. 2001
    ..Forty-one cases of aneurysmal bone cyst of the mobile spine were retrospectively reviewed...
  76. ncbi request reprint Mesenchymal chondrosarcoma. An analysis of patients treated at a single institution
    Marilena Cesari
    Chemotherapy, Department of Musculoskeletal Oncology, Istituti Ortopedici Rizzoli, Bologna, Italy
    Tumori 93:423-7. 2007
    ..Twenty-six patients (median age, 31 years) were identified using the Tumor Center and Chemotherapy Department database of the study institute...
  77. pmc The expression of ccn3(nov) gene in musculoskeletal tumors
    Maria Cristina Manara
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Am J Pathol 160:849-59. 2002
    ..Further studies will help to clarify the biological role of this protein in musculoskeletal neoplasms...
  78. ncbi request reprint Mesenchymal chondrosarcoma of the sacrum: a case report and review of the literature
    R Biagini
    First Orthopedic Clinic, Istituti Ortopedici Rizzoli, Bologna, Italy
    Tumori 86:75-8. 2000
    ..The authors present a case of mesenchymal chondrosarcoma located in the sacrum of a 23-year-old patient treated with radiotherapy and chemotherapy. A review of the literature on the topic is also reported...
  79. ncbi request reprint Osteosarcoma of the limb. Amputation or limb salvage in patients treated by neoadjuvant chemotherapy
    G Bacci
    Department of Chemotherapy, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Bone Joint Surg Br 84:88-92. 2002
  80. ncbi request reprint Post-traumatic osteolysis of the pubis: clinical case
    S Paderni
    I Divisione Ortopedia e Traumatologia, Istituto Ortopedico Rizzoli, Bologna, Italy
    Chir Organi Mov 88:435-40. 2003
  81. ncbi request reprint Osteosarcoma of the sternum: two case reports
    Antonio Briccoli
    Department of Surgical Oncology, Rizzoli Orthopaedic Institute, Bologna, Italy
    Tumori 88:160-2. 2002
    ..Since osteosarcoma of the sternum is a very rare entity, we have thought to explain the principal characteristics and the clinical and therapeutic approach based on our experience of two cases...
  82. ncbi request reprint Giant cell-rich osteosarcoma
    Franco Bertoni
    Servizio di Anatomia Patologica, Istituto Ortopedico Rizzoli, Bologna, Italy
    Orthopedics 26:179-81. 2003
  83. ncbi request reprint Focal myositis. Description of a case and review of the literature
    D Ferrari
    Divisione di Ortopedia e Traumatologia Pediatrica, Istituto Ortopedico Rizzoli, Bologna
    Chir Organi Mov 89:75-9. 2004
    ..Surgical excision of the lesion is the treatment of choice...
  84. ncbi request reprint Neurogenic arthropathy of the knee due to chronic alcoholism: two case reports
    A Sudanese
    I Divisione, Istituto Ortopedico Rizzoli, Bologna, Italy
    Chir Organi Mov 88:427-34. 2003
    ..The aim of the authors is to discuss the etiopathogenic theory (neurotraumatic or/and neurovascular) as well as the mechanism by which alcohol damages joints...
  85. ncbi request reprint Chondrosarcoma of the chest wall: a clinical analysis
    Antonio Briccoli
    Oncology Department, Rizzoli Orthopaedic Institute, Bologna, Italy
    Surg Today 32:291-6. 2002
    ..To discuss the management of different histological types of chondrosarcoma (CS) in the chest wall based on our clinical experience...
  86. ncbi request reprint Osteosarcoma associated with hyperparathyroidism
    Paul C Jutte
    Istituti Orthopedici Rizzoli, Via Pupilli 1, 40136, Bologna, Italy
    Skeletal Radiol 33:473-6. 2004
    ..The mechanism by which osteosarcoma is induced in humans cannot be explained based on current knowledge of mechanisms of action of parathyroid hormone...
  87. pmc Reconstruction with fascia lata allograft of the posterior vertebra elements after resection for aneurysmal bone cyst in a child
    Costantino Errani
    V Division Musculoskeletal Oncology Department, Rizzoli Institute, Via Pupilli n1, Bologna, Italy
    Eur Spine J 16:1531-5. 2007
    ....
  88. ncbi request reprint Severe suppression of Frzb/sFRP3 transcription in osteogenic sarcoma
    Deendayal Mandal
    Department of Orthopedic Research, Mayo Clinic and Foundation, 200 1st St SW, Rochester, MN 55905, USA
    Gene 386:131-8. 2007
    ..Together, these data suggest a tumor-suppressive potential for FRZB/sFRP3 in OGS...
  89. ncbi request reprint Imaging findings in desmoplastic fibroma of bone: distinctive T2 characteristics
    Matthew A Frick
    Department of Radiology, Mayo Clinic, West 2, 200 First Street, SW, Rochester, MN 55905, USA
    AJR Am J Roentgenol 184:1762-7. 2005
    ..CONCLUSION: Significant T2 shortening of a nonsclerotic fibroosseous lesion should place desmoplastic fibroma high among the diagnostic considerations...
  90. ncbi request reprint Radiographic, CT, and MR imaging features of dedifferentiated chondrosarcomas: a retrospective review of 174 de novo cases
    Laurel A Littrell
    Department of Radiologyy, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
    Radiographics 24:1397-409. 2004
    ..In the initial evaluation of patients with a primary bone tumor, thorough evaluation of the radiologic features of the entire tumor is critical...
  91. ncbi request reprint Expression of embryonic lethal abnormal vision (ELAV)-like protein HuR and cyclooxygenase-2 (COX-2) in Ewing sarcoma
    Sung Im Do
    Department of Pathology, Kyung Hee University School of Medicine, Seoul, Korea
    Tumori 94:347-50. 2008
    ..The aim of this study was to investigate the correlation between COX-2 and HuR in Ewing sarcoma...
  92. ncbi request reprint Ezrin in osteosarcoma: comparison between conventional high-grade and central low-grade osteosarcoma
    Hye Rim Park
    Department of Pathology, College of Medicine, Hallym University, Anyang, Republic of Korea
    Pathol Res Pract 202:509-15. 2006
    ..Taken together, ezrin appears to play a role in the progression of tumors, such as the metastasis of osteosarcoma. However, further data are needed before ezrin can be considered in clinical decision-making about osteosarcoma patients...
  93. ncbi request reprint Prognosis of radiation-induced bone sarcoma is similar to primary osteosarcoma
    Emanuela Palmerini
    Clin Orthop Relat Res 462:255; author reply 255-6. 2007
  94. ncbi request reprint Occupational factors and risk of adult bone sarcomas: a multicentric case-control study in Europe
    Franco Merletti
    Cancer Epidemiology Unit, CeRMS and Centre for Oncologic Prevention, University of Turin, Turin, Italy
    Int J Cancer 118:721-7. 2006
    ..76) and 1.44 (95% CI 0.43-4.85) for the first, second and third tertile of days of use of pesticides. Our study suggests that novel and previously reported (woodworking) occupational factors play a role in the aetiology of bone sarcomas...
  95. ncbi request reprint Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature
    Andrew L Folpe
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Am J Surg Pathol 28:1-30. 2004
    ..Recognition of PMTMCT is critical, as complete resection cures intractable OO. Immunohistochemistry and RT-PCR for FGF-23 confirm the role of this protein in PMTMCT-associated OO...
  96. ncbi request reprint Central low-grade osteosarcoma with pagetoid bone formation: a potential diagnostic pitfall
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 17:288-91. 2004
    ..Recognition of this variant of central low-grade osteosarcoma is based on the aggressive radiologic appearance and on adequate tumor sampling for histologic examination...
  97. ncbi request reprint Upregulation of the oncogenic helix-loop-helix protein Id2 in Ewing sarcoma
    Hye Rim Park
    Department of Pathology, College of Medicine, Hallym University, Anyang, Korea
    Tumori 92:236-40. 2006
    ..An enhanced expression of the Id2 gene in Ewing sarcoma cells was previously shown by gene array techniques. We investigated the expression of Id2 at the protein and gene level in Ewing sarcoma...
  98. ncbi request reprint Aggressive clear cell chondrosarcomas: do distinctive characteristics exist?: a report of 4 cases
    Domenico Corradi
    Department of Pathology and Laboratory Medicine, Pathology Section, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Arch Pathol Lab Med 130:1673-9. 2006
    ..Clear cell chondrosarcoma (CCC) is commonly considered to be a low-grade subtype of chondrosarcoma. However, a few cases of CCC behave as high-grade lesions (with early metastases or multiple/synchronous locations)...
  99. ncbi request reprint Long-term survival in high-grade axial osteosarcoma with bone and lung metastases treated with chemotherapy only
    Adalberto Brach del Prever
    Department of Pediatric Oncology, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    J Pediatr Hematol Oncol 27:42-5. 2005
    ..Although a surgical approach on the primary and secondary sites is fundamental, this case may be considered an indication of the efficacy of aggressive chemotherapy in treating osteosarcoma...
  100. ncbi request reprint Protein expression of KIT and gene mutation of c-kit and PDGFRs in Ewing sarcomas
    Ingu Do
    Department of Pathology, Kyung Hee University Hospital, 1 Hoegi dong, Dongdaemun Gu, Seoul 130 702, Republic of Korea
    Pathol Res Pract 203:127-34. 2007
    ..These findings imply other mechanisms for KIT activity and leave open the question of whether imatinib would be efficacious in the treatment of Ewing sarcoma...
  101. ncbi request reprint Epithelioid variant of myxofibrosarcoma: expanding the clinicomorphologic spectrum of myxofibrosarcoma in a series of 17 cases
    Alessandra F Nascimento
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Surg Pathol 31:99-105. 2007
    ..Its natural history seems more aggressive than usual high-grade MFS, with approximately 70% local recurrence and 50% metastases, even within a relatively short follow-up period...