G B Frisoni

Summary

Affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli
Country: Italy

Publications

  1. ncbi request reprint Radial width of the temporal horn: a sensitive measure in Alzheimer disease
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    AJNR Am J Neuroradiol 23:35-47. 2002
  2. pmc Imaging markers for Alzheimer disease: which vs how
    Giovanni B Frisoni
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS, S Giovanni di Dio, Fatebenefratelli Brescia, Italy
    Neurology 81:487-500. 2013
  3. doi request reprint Alzheimer's CSF markers in older schizophrenia patients
    Giovanni B Frisoni
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, Italy Psychogeriatric Ward, Italy
    Int J Geriatr Psychiatry 26:640-8. 2011
  4. doi request reprint Alzheimer's disease neuroimaging initiative in Europe
    Giovanni B Frisoni
    IRCCS Fatebenefratelli, The National Centre for Research and Care of Alzheimer s Disease, Brescia, Italy
    Alzheimers Dement 6:280-5. 2010
  5. ncbi request reprint Dementia: important advances in research in 2006
    Giovanni B Frisoni
    IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Lancet Neurol 6:4-5. 2007
  6. pmc The clinical use of structural MRI in Alzheimer disease
    Giovanni B Frisoni
    IRCCS Centro San Giovanni di Dio FBF, via Pilastroni 1, Brescia, Italy
    Nat Rev Neurol 6:67-77. 2010
  7. doi request reprint In vivo mapping of incremental cortical atrophy from incipient to overt Alzheimer's disease
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 256:916-24. 2009
  8. doi request reprint Preliminary evidence of validity of the revised criteria for Alzheimer disease diagnosis: report of 2 cases
    Giovanni B Frisoni
    Associazione Fatebenefratelli per la Ricerca Biomedica e Sanitaria, Rome, Italy
    Alzheimer Dis Assoc Disord 24:108-14. 2010
  9. pmc The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium
    Giovanni B Frisoni
    IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Alzheimers Dement 4:255-64. 2008
  10. ncbi request reprint Markers of Alzheimer's disease in a population attending a memory clinic
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Alzheimers Dement 5:307-17. 2009

Detail Information

Publications142 found, 100 shown here

  1. ncbi request reprint Radial width of the temporal horn: a sensitive measure in Alzheimer disease
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    AJNR Am J Neuroradiol 23:35-47. 2002
    ..The aim of this study was to explore the validity of a CT- and MR-based measure of MTL atrophy that would be feasible for routine clinical use...
  2. pmc Imaging markers for Alzheimer disease: which vs how
    Giovanni B Frisoni
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS, S Giovanni di Dio, Fatebenefratelli Brescia, Italy
    Neurology 81:487-500. 2013
    ..Standard operating procedures are key to biomarker use in the clinical routine and drug trials...
  3. doi request reprint Alzheimer's CSF markers in older schizophrenia patients
    Giovanni B Frisoni
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, Italy Psychogeriatric Ward, Italy
    Int J Geriatr Psychiatry 26:640-8. 2011
    ..Cognitive impairment is prevalent in older schizophrenia patients but its biological basis is unknown. Neuropathological studies have not revealed Alzheimer disease (AD) lesion burden but in vivo data are lacking...
  4. doi request reprint Alzheimer's disease neuroimaging initiative in Europe
    Giovanni B Frisoni
    IRCCS Fatebenefratelli, The National Centre for Research and Care of Alzheimer s Disease, Brescia, Italy
    Alzheimers Dement 6:280-5. 2010
    ....
  5. ncbi request reprint Dementia: important advances in research in 2006
    Giovanni B Frisoni
    IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Lancet Neurol 6:4-5. 2007
  6. pmc The clinical use of structural MRI in Alzheimer disease
    Giovanni B Frisoni
    IRCCS Centro San Giovanni di Dio FBF, via Pilastroni 1, Brescia, Italy
    Nat Rev Neurol 6:67-77. 2010
    ..The utility of structural imaging and other markers will be increased by standardization of acquisition and analysis methods, and by development of robust algorithms for automated assessment...
  7. doi request reprint In vivo mapping of incremental cortical atrophy from incipient to overt Alzheimer's disease
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 256:916-24. 2009
    ..These findings suggest that the polysynaptic hippocampal pathway is affected in iAD, the direct pathway and sensorimotor and visual networks are affected in moAD, and the sensorimotor network is affected in moAD...
  8. doi request reprint Preliminary evidence of validity of the revised criteria for Alzheimer disease diagnosis: report of 2 cases
    Giovanni B Frisoni
    Associazione Fatebenefratelli per la Ricerca Biomedica e Sanitaria, Rome, Italy
    Alzheimer Dis Assoc Disord 24:108-14. 2010
    ..We describe 2 very mild cases of MCI and their clinical outcome...
  9. pmc The pilot European Alzheimer's Disease Neuroimaging Initiative of the European Alzheimer's Disease Consortium
    Giovanni B Frisoni
    IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Alzheimers Dement 4:255-64. 2008
    ..A pilot study has been carried out in Europe to test the feasibility of the adoption of the ADNI platform (pilot E-ADNI)...
  10. ncbi request reprint Markers of Alzheimer's disease in a population attending a memory clinic
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Alzheimers Dement 5:307-17. 2009
    ..New marker-based criteria for the diagnosis of Alzheimer's disease (AD) were recently proposed. We describe their operational translation in 144 consecutive patients referred to our Memory Clinic...
  11. doi request reprint Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
    Brain 131:3266-76. 2008
    ..Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing...
  12. doi request reprint In vivo neuropathology of cortical changes in elderly persons with schizophrenia
    Giovanni B Frisoni
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
    Biol Psychiatry 66:578-85. 2009
    ..Magnetic resonance imaging (MRI) studies revealed brain structural abnormalities, but the pattern of cortical gray matter (GM) volume and its relationship with cognitive and behavioral symptoms are unknown...
  13. doi request reprint In vivo mapping of amyloid toxicity in Alzheimer disease
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    Neurology 72:1504-11. 2009
    ..To study the relationship between gray matter atrophy and amyloid deposition in Alzheimer disease (AD)...
  14. ncbi request reprint Neuroimaging outcomes in clinical trials in Alzheimer's disease
    G B Frisoni
    IRCCS Fatebenefratelli, Brescia, Italy
    J Nutr Health Aging 13:209-12. 2009
    ..Future testing of putative disease modifying drugs in valid animal models with valid imaging markers of disease progression will allow to maximize the predictability of their effect in phase II and III clinical trials...
  15. ncbi request reprint Interactive neuroimaging
    Giovanni B Frisoni
    Lancet Neurol 7:204. 2008
  16. ncbi request reprint Virtual imaging laboratories for marker discovery in neurodegenerative diseases
    Giovanni B Frisoni
    IRCCS Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Nat Rev Neurol 7:429-38. 2011
    ..In this article, we provide an overview of the currently available e-infrastructures and consider how computational neuroscience in neurodegenerative disease might evolve in the future...
  17. doi request reprint Harmonization of magnetic resonance-based manual hippocampal segmentation: a mandatory step for wide clinical use
    Giovanni B Frisoni
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Alzheimers Dement 7:171-4. 2011
    ..The task force will then validate the harmonized protocol, develop harmonized probabilistic hippocampal maps, and develop illustrative and educational material on the use of the harmonized protocol and maps...
  18. ncbi request reprint In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study
    G B Frisoni
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Neuroimage 32:104-10. 2006
    ..This study supports the possibility of carrying out in vivo macroscopic neuropathology of the hippocampus with MR imaging in the neurodegenerative dementias...
  19. doi request reprint MCI patients' EEGs show group differences between those who progress and those who do not progress to AD
    D V Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurobiol Aging 32:563-71. 2011
    ..EEG markers allow a mean correct percentage of correct classification up to 88.3%. Future prospective studies are needed to evaluate the sensitivity and specificity of these measures for predicting an AD outcome...
  20. doi request reprint Metabolic compensation and depression in Alzheimer's disease
    A Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Dement Geriatr Cogn Disord 29:37-45. 2010
    ..The aim of this study was to map metabolic compensation and depression in Alzheimer's disease (AD) on a voxel-by-voxel basis...
  21. ncbi request reprint Insight in dementia: when does it occur? Evidence for a nonlinear relationship between insight and cognitive status
    O Zanetti
    Alzheimer Disease Unit IRCCS, S Giovanni di Dio, S Cuore Fatebenefratelli Hospital, Brescia, Italy
    J Gerontol B Psychol Sci Soc Sci 54:P100-6. 1999
    ..The trilinear model of the association between insight and cognitive status reflects more closely the observable decline of insight and can provide estimates of when the decline of insight begins and ends...
  22. ncbi request reprint Topographic correspondence between white matter hyperintensities and brain atrophy
    R Rossi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 253:919-27. 2006
    ..Our findings suggest that frontal WMHs are associated with frontal gray matter damage while parietooccipital WMHs seem to have a weaker and more diffuse impact on gray matter...
  23. doi request reprint EEG markers discriminate among different subgroup of patients with mild cognitive impairment
    D V Moretti
    Neurophysiology, IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Am J Alzheimers Dis Other Demen 25:58-73. 2010
    ..Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%...
  24. pmc Medial temporal atrophy but not memory deficit predicts progression to dementia in patients with mild cognitive impairment
    C Geroldi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF The National Center for Research and Care of Alzheimer s Disease, via Pilastroni 4, 25125 Brescia, Italy
    J Neurol Neurosurg Psychiatry 77:1219-22. 2006
    ..The diagnosis of mild cognitive impairment (MCI) is clinically unhelpful, as many patients with MCI develop dementia but many do not...
  25. pmc Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer's disease in vivo
    M Pievani
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Neuroimage 45:1090-8. 2009
    ..002, ANOVA), in both early and late-onset patients (p<.05, ANOVA). We conclude that the epsilon4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability...
  26. ncbi request reprint Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease
    G B Frisoni
    IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurology 52:91-100. 1999
    ..To describe atrophic changes of the hippocampus and entorhinal cortex in frontotemporal dementia (FTD) and compare them with those of AD...
  27. ncbi request reprint Hippocampal atrophy and EEG markers in subjects with mild cognitive impairment
    D V Moretti
    IRCCS S Giovanni di Dio FBF, 25125, Brescia, Italy
    Clin Neurophysiol 118:2716-29. 2007
    ..The present study evaluates the potential relationship between hippocampal atrophy and EEG brain rhythmicity, as assessed by relative band power and alpha frequency indices in a cohort of subjects with mild cognitive impairment (MCI)...
  28. pmc The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort
    A Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Aging 31:1263-74. 2010
    ..FDG-PET started changing early in time and likely followed a linear decline. In conclusion, this study provides the first evidence in favor of the dynamic biomarker model which has recently been proposed...
  29. pmc The prevalence of apoE-epsilon4 in Alzheimer's disease is age dependent
    G B Frisoni
    Alzheimer s Unit, IRCCS San Giovanni di Dio, FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 65:103-6. 1998
    ..12 in the oldest age group. It is concluded that the relation of the epsilon4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages...
  30. doi request reprint Increase of theta/gamma ratio is associated with memory impairment
    D V Moretti
    IRCCS San Giovanni di Dio Fatebenefratelli, Department of Neurophysiology, 4, Pilastroni Road, 25125 Brescia, Italy
    Clin Neurophysiol 120:295-303. 2009
    ..In this study the theta/gamma ratio was investigated as early marker of cognitive decline...
  31. pmc Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    J Neurol Neurosurg Psychiatry 76:112-4. 2005
    ..To examine the brain structural correlates of age at onset in patients with Alzheimer's disease...
  32. doi request reprint Functional compensation in incipient Alzheimer's disease
    A Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS San Giovanni di Dio FBF, 25125 Brescia, Italy
    Neurobiol Aging 31:387-97. 2010
    ..These results help understand the reactive phenomena induced by the brain to try and counteract the pathological changes of AD...
  33. ncbi request reprint APOE and modulation of Alzheimer's and frontotemporal dementia
    M Boccardi
    Laboratory of Epidemiology and Neuroimaging L E N I, IRCCS San Giovanni di Dio FBF, Brescia 25125, Italy
    Neurosci Lett 356:167-70. 2004
    ..The epsilon4 allele of the APOE might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain...
  34. doi request reprint The new Alzheimer's criteria in a naturalistic series of patients with mild cognitive impairment
    S Galluzzi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine LENITEM, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 257:2004-14. 2010
    ..82, 95% CI 0.70-0.95). MT atrophy and abnormal CSF are the single most robust predictors of conversion to AD in MCI patients, and their combination enhances prediction. AD markers are not predictive of conversion to non-AD dementia...
  35. doi request reprint Hippocampal shape differences in dementia with Lewy bodies
    F Sabattoli
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Neuroimage 41:699-705. 2008
    ..The direct comparisons between LBD and AD patients showed that this pattern of local atrophy is different from that characteristic of AD. LBD pattern of hippocampal atrophy might be related to the peculiar neuropathology of the disease...
  36. ncbi request reprint Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease
    M Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    Neurosci Lett 335:139-43. 2002
    ..00005) showed that FTD amygdaloid volumes were intermediate between controls and AD. Behavioral and Klüver-Bucy-like symptoms, characteristic of FTD, cannot be explained by amygdaloid atrophy alone...
  37. ncbi request reprint Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment
    A Caroli
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 254:1698-707. 2007
    ..Aim of this study was to find cerebral perfusion correlates of conversion to dementia in patients with amnestic MCI...
  38. pmc Local amygdala structural differences with 3T MRI in patients with Alzheimer disease
    E Cavedo
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurology 76:727-33. 2011
    ..We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI...
  39. doi request reprint Enrichment through biomarkers in clinical trials of Alzheimer's drugs in patients with mild cognitive impairment
    M Lorenzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Aging 31:1443-51, 1451.e1. 2010
    ..Enrichment comes at the price of an often relevant proportion of screened out cases, and in clinical trial settings, the balance between enrichment of screened in and loss of screened out patients should be critically discussed...
  40. ncbi request reprint Validity of direct assessment of functional status as a tool for measuring Alzheimer's disease severity
    O Zanetti
    Alzheimer Unit, IRCCS, S Giovanni di Dio, S Cuore Fatebenefratelli Institute, via Pilastroni 4, 25123, Brescia, Italy
    Age Ageing 27:615-22. 1998
    ..to assess the validity of the Direct Assessment of Functional Status (DAFS) performance-based functional scale for the staging of dementia severity by comparing it with established clinical, functional and cognitive scales...
  41. ncbi request reprint Effects of estrogens on cognition and brain morphology: involvement of the cerebellum
    R Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Maturitas 54:222-8. 2006
    ..In the present study we investigated the effect of ERT on cognition and on brain morphology in healthy postmenopausal women, taking into account the distinction in current and past ERT users...
  42. ncbi request reprint Special care units for demented patients: a multicenter study
    G Bellelli
    Geriatric Research Group, Brescia, Italy
    Gerontologist 38:456-62. 1998
    ..The data show an overall reduction in behavioral disturbances and a decreased use of psychotropic drugs and physical restraints...
  43. ncbi request reprint Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Gerontol A Biol Sci Med Sci 56:M75-8. 2001
    ..Whether and which genetic factors affect human longevity is unclear. This study assesses the association between the epsilon2 allele of apolipoprotein E (APOE), a putative longevity gene, and extremely old age...
  44. ncbi request reprint Depressive symptoms of Alzheimer caregivers are mainly due to personal rather than patient factors
    O Zanetti
    Alzheimer s Dementia Unit, I R C C S S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Int J Geriatr Psychiatry 13:358-67. 1998
    ..To investigate the predictors of caregiver's depressive symptoms in a sample of community-dwelling Alzheimer's patients...
  45. ncbi request reprint An electronic memory aid to support prospective memory in patients in the early stages of Alzheimer's disease: a pilot study
    M Oriani
    Alzheimer Research and Care Unit, I R C C S, via Pilastroni 4, 25123 Brescia, Italy
    Aging Ment Health 7:22-7. 2003
    ..Future research that examines the value of using an EMA to help with tasks that are associated with prospective memory with a larger sample of patients within their own home context is suggested...
  46. pmc Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 73:657-64. 2002
    ..To test the applicability of an automated method of magnetic resonance image analysis (voxel based morphometry) to detect presence and severity of regional grey matter density reduction-a proxy of atrophy-in Alzheimer's disease...
  47. ncbi request reprint A comparison between the accuracy of voxel-based morphometry and hippocampal volumetry in Alzheimer's disease
    Cristina Testa
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Magn Reson Imaging 19:274-82. 2004
    ..To compare the accuracy of voxel-based morphometry (VBM) and region of interest (ROI)-based hippocampal volumetry to detect medial temporal lobe atrophy in Alzheimer's disease (AD)...
  48. ncbi request reprint Imaging, subjective complaints, and MCI: 30 years before
    S Galluzzi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    J Nutr Health Aging 12:80S-3S. 2008
    ....
  49. ncbi request reprint The dynamic marker hypothesis of Alzheimer's disease and its implications for clinical imaging
    E Cavedo
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Q J Nucl Med Mol Imaging 55:237-49. 2011
    ....
  50. pmc Volumetric differences in mapped hippocampal regions correlate with increase of high alpha rhythm in Alzheimer's disease
    D V Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, 4, Pilastroni Road, 25125 Brescia, Italy
    Int J Alzheimers Dis 2011:208218. 2011
    ..Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease. Conclusions. The findings confirm the possible diagnostic role of EEG markers...
  51. pmc Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 74:1371-81. 2003
    ....
  52. ncbi request reprint The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia
    Marina Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, via Pilastroni 4, I 25125, Brescia, Italy
    Neurobiol Aging 24:95-103. 2003
    ..To compare patterns of brain atrophy in fronto-temporal dementia (FTD) and Alzheimer's disease (AD) since atrophy in individual areas may not be sufficiently specific as diagnostic marker...
  53. ncbi request reprint The topography of grey matter involvement in early and late onset Alzheimer's disease
    Giovanni B Frisoni
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
    Brain 130:720-30. 2007
    ..These findings indicate that EOAD and LOAD differ in their typical topographic patterns of brain atrophy, suggesting different predisposing or aetiological factors...
  54. pmc Specific EEG changes associated with atrophy of hippocampus in subjects with mild cognitive impairment and Alzheimer's disease
    D V Moretti
    IRCCS Centro S Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
    Int J Alzheimers Dis 2012:253153. 2012
    ..This finding confirms the possible diagnostic role of EEG markers as diagnostic and prognostic factors in patient with prodromal and declared Alzheimer's disease...
  55. ncbi request reprint Neuroimaging outcomes for clinical trials
    G B Frisoni
    G B Frisoni, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Nutr Health Aging 11:348-52. 2007
    ..The reviewed techniques, except for the most recent amyloid imaging, are those applied to prospective studies investigating changes of imaging markers over time...
  56. doi request reprint The CST3 B haplotype is associated with frontotemporal lobar degeneration
    L Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Eur J Neurol 17:143-6. 2010
    ..Given the role of cystatin C in brain neurodegeneration and neuroregeneration, the aim of this study was to determine whether the cystatin C gene (CST3) was genetically associated with FTLD...
  57. ncbi request reprint Reality orientation therapy to delay outcomes of progression in patients with dementia. A retrospective study
    T Metitieri
    Geriartric Research Group, Brescia, Italy
    Clin Rehabil 15:471-8. 2001
    ..To evaluate the impact of continued Reality Orientation Therapy (ROT) in delaying the outcomes of dementia progression...
  58. doi request reprint Cardiac autonomic dysfunction is associated with white matter lesions in patients with mild cognitive impairment
    Samantha Galluzzi
    Laboratory of Epidemiology Neuroimaging and Telemedicine LENITEM, IRCCS San Giovanni di Dio FBF The National Center for Research and Care of Alzheimer s Disease, via Pilastroni 4, 25125, Brescia, Italy
    J Gerontol A Biol Sci Med Sci 64:1312-5. 2009
    ..Cardiac autonomic dysfunction has been associated with cognitive impairment, but the underlying pathogenesis is complex and cerebral white matter lesions (WMLs) might be implicated...
  59. ncbi request reprint Clinical and neuropsychological features associated with structural imaging patterns in patients with mild cognitive impairment
    Roberta Rossi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Dement Geriatr Cogn Disord 23:175-83. 2007
    ....
  60. ncbi request reprint White matter vascular lesions are related to parietal-to-frontal coupling of EEG rhythms in mild cognitive impairment
    Claudio Babiloni
    Dip Fisiologia Umana e Farmacologia, University La Sapienza, Rome, Italy
    Hum Brain Mapp 29:1355-67. 2008
    ..7). These results are interpreted as supporting the additive model according to which MCI state would result from the combination of cerebrovascular and neurodegenerative lesions...
  61. ncbi request reprint Electroencephalographic upper/low alpha frequency power ratio relates to cortex thinning in mild cognitive impairment
    D V Moretti
    IRCCS, S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurodegener Dis 14:18-30. 2014
    ..2014 S. Karger AG, Basel. ..
  62. ncbi request reprint The CT-based radial width of the temporal horn: pathological validation in AD without cerebrovascular disease
    R Rossi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Int J Geriatr Psychiatry 19:570-4. 2004
    ..Given the wide availability of the CT in the routine diagnostic assessment of patients with cognitive disturbances, a CT-based marker of AD might be clinically useful...
  63. ncbi request reprint Mild cognitive impairment: clinical features and review of screening instruments
    S Galluzzi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, Brescia, Italy
    Aging (Milano) 13:183-202. 2001
    ..We describe the most frequent clinical presentations of cognitive impairment in the pre-dementia stage, and review eleven screening tests to provide recommendations on which should be preferred in each setting...
  64. ncbi request reprint Clinical characteristics of frontotemporal patients with symmetric brain atrophy
    Marina Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, via Pilastroni 4, 25125 Brescia, Italy
    Eur Arch Psychiatry Clin Neurosci 252:235-9. 2002
    ..The presence of the epsilon4 allele is consistent with the hypothesis of greater vulnerability of the brain in epsilon4 carriers...
  65. ncbi request reprint Understanding information on clinical trials by persons with Alzheimer's dementia. A pilot study
    Corinna Porteri
    Bioethics Unit, IRCCS, Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 21:158-66. 2009
    ....
  66. ncbi request reprint Development of a CT-based weighted rating scale for subcortical cerebrovascular disease sensitive to mild clinical symptoms
    Cristina Geroldi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, Brescia 25125, Italy
    J Neurol Sci 203:241-5. 2002
    ..To devise and validate a CT-based visual rating scale sensitive to subcortical cerebrovascular disease (sCVD) in patients with cognitive impairment...
  67. doi request reprint Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurosci Lett 434:304-9. 2008
    ..This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve...
  68. doi request reprint White-matter vascular lesions correlate with alpha EEG sources in mild cognitive impairment
    Claudio Babiloni
    Department of Biomedical Sciences, University of Foggia, Foggia, Italy Casa di Cura San Raffaele Cassino, IRCCS San Raffaele Pisana, Rome, Italy
    Neuropsychologia 46:1707-20. 2008
    ..The present results are in line with the additive model of cognitive impairment postulating that this arises as the sum of neurodegenerative and cerebrovascular lesions...
  69. ncbi request reprint The added value of neuropsychologic tests and structural imaging for the etiologic diagnosis of dementia in italian expert centers
    Cristina Geroldi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, Scientific Institute for Research and Care IRCCS San Giovanni di Dio, FBF, Brescia, Italy
    Alzheimer Dis Assoc Disord 22:309-20. 2008
    ..4-29.1) and 4.1 (3.0 to 6.5) for AD and non-AD diagnoses. The added value of structural imaging and neuropsychologic testing in the routine clinical assessment of demented patients is substantial in both AD and non-AD cases...
  70. ncbi request reprint The radial width of the temporal horn in mild cognitive impairment
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF National Center for Research and Care of Alzheimer s Disease, via Pilastroni 4, 25125 Brescia, Italy
    J Neuroimaging 12:351-4. 2002
    ..The aim was to test the accuracy of a computed tomography-based (CT-based) marker of medial temporal lobe atrophy, the radial width of the temporal horn (rWTH), in MCI...
  71. doi request reprint Increase of theta/gamma and alpha3/alpha2 ratio is associated with amygdalo-hippocampal complex atrophy
    Davide Vito Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Alzheimers Dis 17:349-57. 2009
    ..The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state...
  72. doi request reprint Effect of memantine on resting state default mode network activity in Alzheimer's disease
    Marco Lorenzi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, Istituto di Ricerca e Cura a Carattere Scientifico San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Drugs Aging 28:205-17. 2011
    ..Importantly, the default mode network (DMN), which plays a key role in attention, is hypoactive in Alzheimer's disease and is under glutamatergic control...
  73. ncbi request reprint Validation study of the three-objects-three-places test: a screening test for Alzheimer's disease
    Annapaola Prestia
    Associazione Fatebenefratelli per la Ricerca, Rome, Italy
    Exp Aging Res 32:395-410. 2006
    ..The test is a valid instrument for the screening of AD...
  74. ncbi request reprint Diagnosis disclosure of prodromal Alzheimer disease-ethical analysis of two cases
    Corinna Porteri
    Bioethics Unit, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Can J Neurol Sci 37:67-75. 2010
    ..The use of the new proposed diagnostic criteria raises ethical issues and needs to be carefully evaluated...
  75. pmc Microstructural diffusion changes are independent of macrostructural volume loss in moderate to severe Alzheimer's disease
    Elisa Canu
    The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
    J Alzheimers Dis 19:963-76. 2010
    ..As such this work provides great understanding of the topography of pathological changes in AD that can be captured with imaging...
  76. ncbi request reprint Alzheimer's disease-associated disability: an ICF approach
    Rossella Muò
    Associazione Fatebenefratelli per la Ricerca AFaR, Italy
    Disabil Rehabil 27:1405-13. 2005
    ..The aim of the study is to provide a description of dementia-associated disability in Alzheimer's disease (AD) patients through the International Classification of Functioning, Disability and Health (ICF)...
  77. pmc Quantitative EEG Markers in Mild Cognitive Impairment: Degenerative versus Vascular Brain Impairment
    D V Moretti
    Centro San Giovanni di Dio Fatebenefratelli, TRccs, 25125 Brescia, Italy
    Int J Alzheimers Dis 2012:917537. 2012
    ..CVD and AHC damages are associated with specific EEG markers. So far, these EEG markers could have a prospective value in differential diagnosis between vascular and degenerative MCI...
  78. ncbi request reprint Mild cognitive deterioration with subcortical features: prevalence, clinical characteristics, and association with cardiovascular risk factors in community-dwelling older persons (The InCHIANTI Study)
    Cristina Geroldi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, Brescia, Italy
    J Am Geriatr Soc 51:1064-71. 2003
    ..To identify subjects with minimal or mild nonamnestic cognitive impairment with parkinsonian stance and gait and investigate vascular correlates of this condition...
  79. ncbi request reprint Regional brain atrophy in patients with mild Alzheimer's disease and delusions
    Cristina Geroldi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Int Psychogeriatr 14:365-78. 2002
    ..The aim of the study was to assess whether delusional AD patients have a specific pattern of regional brain atrophy...
  80. ncbi request reprint Distinctive clinical features of mild cognitive impairment with subcortical cerebrovascular disease
    Samantha Galluzzi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, IT 25125 Brescia, Italy
    Dement Geriatr Cogn Disord 19:196-203. 2005
    ....
  81. ncbi request reprint Validation study of a CT-based weighted rating scale for subcortical ischemic vascular disease in patients with mild cognitive deterioration
    Cristina Geroldi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Eur Neurol 49:193-209. 2003
    ..The aim of the study is to devise and validate a computed tomography (CT)-based visual rating scale sensitive to SIVD in patients with mild cognitive deterioration...
  82. doi request reprint Increasing hippocampal atrophy and cerebrovascular damage is differently associated with functional cortical coupling in MCI patients
    Davide Vito Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Alzheimer Dis Assoc Disord 23:323-32. 2009
    ..Our results show a lateralization (right hemisphere for cerebrovascular disease and left hemisphere for hippocampal atrophy) of the pathologic modifications of functional coupling...
  83. ncbi request reprint Effect of high climate temperature on the behavioral and psychological symptoms of dementia
    Cristina Cornali
    Alzheimer Rehabilitation Unit, Richiedei Medical Center, via Sgrazutti 1, 25036 Palazzolo s O, Brescia, Italy
    J Am Med Dir Assoc 5:161-6. 2004
    ..The objective of this study was to investigate if high climate temperature could have a negative effect on behavioral and psychological symptoms of dementia (BPSD)...
  84. doi request reprint Multi-center comparison of medial temporal atrophy in patients with Alzheimer's disease--data from the ICTUS study
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Dement Geriatr Cogn Disord 26:314-22. 2008
    ..To study multi-center variability of medial temporal lobe atrophy (MTA) in patients with Alzheimer's disease (AD) recruited in a European observational study of AD...
  85. ncbi request reprint Frontotemporal dementia as a neural system disease
    Marina Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Aging 26:37-44. 2005
    ..At P<0.001 uncorrected also the periaqueductal gray was atrophic. Atrophy outside the RLS was confined to a few voxels in the frontal and temporal gyri. FTD might be a neural-system disease where the RLS is predominantly damaged...
  86. ncbi request reprint Predictive role of single diseases and their combination on recovery of balance and gait in disabled elderly patients
    Ignazio Di Fazio
    Geriatric Evaluation and Rehabilitation Unit Richiedei Hospital, Palazzolo s O, and Geriatric Research Group, Brescia, Italy
    J Am Med Dir Assoc 7:208-11. 2006
    ..This study was designed to evaluate the role of single chronic diseases and of their combination on functional recovery after rehabilitative treatment in disabled elderly patients...
  87. ncbi request reprint Brain perfusion correlates of medial temporal lobe atrophy and white matter hyperintensities in mild cognitive impairment
    Anna Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS, S Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 254:1000-8. 2007
    ..To assess the association of Medial Temporal lobe Atrophy (MTA) and White Matter Hyperintensities (WMHs) with gray matter perfusion in Mild Cognitive Impairment (MCI)...
  88. ncbi request reprint Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    J Neurol 249:1423-32. 2002
    ..To identify non-demented individuals with cognitive impairment due to a cerebrovascular etiology among those coming to observation of a memory clinic and to describe their clinical features and outcome...
  89. doi request reprint Abnormal hippocampal shape in offenders with psychopathy
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Hum Brain Mapp 31:438-47. 2010
    ....
  90. ncbi request reprint Visual assessment of medial temporal atrophy on MR films in Alzheimer's disease: comparison with volumetry
    Lorena Bresciani
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Aging Clin Exp Res 17:8-13. 2005
    ..To test the agreement of a visual rating scale of medial temporal lobe atrophy (MTA) with linear and volumetric assessments, and to test its accuracy in discriminating between Alzheimer's disease (AD) patients and controls...
  91. ncbi request reprint Prescription practices of diagnostic imaging in dementia: a survey of 47 Alzheimer's Centres in Northern Italy
    R Riello
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Int J Geriatr Psychiatry 18:577-85. 2003
    ..To date, there are no data at the national or European level on the prescription practices of imaging (CT, MR, and SPET) in the diagnosis of cognitively impaired elderly patients...
  92. ncbi request reprint Treatment of Alzheimer's disease with acetylcholinesterase inhibitors: bridging the gap between evidence and practice
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol 248:551-7. 2001
    ..The gap between evidence and clinical practice might be closed with appropriately designed observational studies rather than randomized clinical trials...
  93. ncbi request reprint Differential associations of Head and Body Symptoms with depression and physical comorbidity in patients with cognitive impairment
    Roberta Riello
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Int J Geriatr Psychiatry 19:209-15. 2004
    ..To test the hypothesis that physical symptoms referred to the head might be specifically associated with depression in patients with cognitive impairment...
  94. ncbi request reprint The Italian Brain Normative Archive of structural MR scans: norms for medial temporal atrophy and white matter lesions
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 21:266-76. 2009
    ....
  95. doi request reprint Quantitative evaluation of Alzheimer's disease
    Anna Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Expert Rev Med Devices 6:569-88. 2009
    ....
  96. ncbi request reprint Hashimoto's encephalopathy in the elderly: relationship to cognitive impairment
    Samantha Galluzzi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Geriatr Psychiatry Neurol 15:175-9. 2002
    ..A review of cases of HE showing cognitive deterioration is also presented, and factors possibly related to characteristics of cognitive impairment and outcome after therapy are considered...
  97. doi request reprint Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE epsilon4 carriers
    Nicola Filippini
    LENITEM, Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS S Giovanni di Dio FBF, Brescia, Italy
    J Magn Reson Imaging 29:1021-6. 2009
    ..To investigate the possible effect of the APOE epsilon4 allele on age-related regional volume loss within the corpus callosum (CC) in healthy epsilon4 allele carriers compared with noncarriers...
  98. ncbi request reprint Influence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures: a volumetric MR study
    Nicola Filippini
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS S Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Eur J Hum Genet 14:443-9. 2006
    ..These findings should be considered preliminary and future replication is needed...
  99. ncbi request reprint Caregiver's distress is associated with delusions in Alzheimer's patients
    Roberta Riello
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, Brescia, Italy
    Behav Med 28:92-8. 2002
    ....
  100. ncbi request reprint Drug prescription in mild cognitive impairment: the physicians' perspective in Italy
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Int J Geriatr Psychiatry 21:1071-7. 2006
    ....
  101. doi request reprint Alexithymia in healthy women: a brain morphology study
    Genoveffa Borsci
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS S Giovanni di Dio, FBF, Brescia, Italy
    J Affect Disord 114:208-15. 2009
    ..Recent literature shows that specific structures process emotions. Aim of this study was to investigate whether alexithymia is associated with a specific cerebral morphology of candidate structures in healthy adults...