G B Frisoni

Summary

Affiliation: IRCCS San Giovanni di Dio-FBF
Country: Italy

Publications

  1. pmc Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 73:657-64. 2002
  2. pmc Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 74:1371-81. 2003
  3. ncbi request reprint Treatment of Alzheimer's disease with acetylcholinesterase inhibitors: bridging the gap between evidence and practice
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol 248:551-7. 2001
  4. ncbi request reprint Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    J Neurol 249:1423-32. 2002
  5. ncbi request reprint The radial width of the temporal horn in mild cognitive impairment
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF National Center for Research and Care of Alzheimer s Disease, via Pilastroni 4, 25125 Brescia, Italy
    J Neuroimaging 12:351-4. 2002
  6. pmc Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    J Neurol Neurosurg Psychiatry 76:112-4. 2005
  7. ncbi request reprint Prescription and choice of diagnostic imaging by physician specialty in Alzheimer's Centers (Unità di Valutazione Alzheimer - UVA) in Northern Italy
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Aging Clin Exp Res 17:14-9. 2005
  8. ncbi request reprint Topographic correspondence between white matter hyperintensities and brain atrophy
    R Rossi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 253:919-27. 2006
  9. ncbi request reprint Prescription patterns and efficacy of drugs for patients with dementia: physicians' perspective in Italy
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 19:349-55. 2007
  10. ncbi request reprint The topography of grey matter involvement in early and late onset Alzheimer's disease
    Giovanni B Frisoni
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
    Brain 130:720-30. 2007

Detail Information

Publications69

  1. pmc Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 73:657-64. 2002
    ..To test the applicability of an automated method of magnetic resonance image analysis (voxel based morphometry) to detect presence and severity of regional grey matter density reduction-a proxy of atrophy-in Alzheimer's disease...
  2. pmc Neuroimaging tools to rate regional atrophy, subcortical cerebrovascular disease, and regional cerebral blood flow and metabolism: consensus paper of the EADC
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 74:1371-81. 2003
    ....
  3. ncbi request reprint Treatment of Alzheimer's disease with acetylcholinesterase inhibitors: bridging the gap between evidence and practice
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Neurol 248:551-7. 2001
    ..The gap between evidence and clinical practice might be closed with appropriately designed observational studies rather than randomized clinical trials...
  4. ncbi request reprint Mild cognitive impairment with subcortical vascular features: clinical characteristics and outcome
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    J Neurol 249:1423-32. 2002
    ..To identify non-demented individuals with cognitive impairment due to a cerebrovascular etiology among those coming to observation of a memory clinic and to describe their clinical features and outcome...
  5. ncbi request reprint The radial width of the temporal horn in mild cognitive impairment
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF National Center for Research and Care of Alzheimer s Disease, via Pilastroni 4, 25125 Brescia, Italy
    J Neuroimaging 12:351-4. 2002
    ..The aim was to test the accuracy of a computed tomography-based (CT-based) marker of medial temporal lobe atrophy, the radial width of the temporal horn (rWTH), in MCI...
  6. pmc Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    J Neurol Neurosurg Psychiatry 76:112-4. 2005
    ..To examine the brain structural correlates of age at onset in patients with Alzheimer's disease...
  7. ncbi request reprint Prescription and choice of diagnostic imaging by physician specialty in Alzheimer's Centers (Unità di Valutazione Alzheimer - UVA) in Northern Italy
    Giovanni B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Aging Clin Exp Res 17:14-9. 2005
    ....
  8. ncbi request reprint Topographic correspondence between white matter hyperintensities and brain atrophy
    R Rossi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 253:919-27. 2006
    ..Our findings suggest that frontal WMHs are associated with frontal gray matter damage while parietooccipital WMHs seem to have a weaker and more diffuse impact on gray matter...
  9. ncbi request reprint Prescription patterns and efficacy of drugs for patients with dementia: physicians' perspective in Italy
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Aging Clin Exp Res 19:349-55. 2007
    ..The aim of this study was to assess the prescription practices and judgment of efficacy of physicians of drugs used for the cognitive and non-cognitive symptoms of dementia...
  10. ncbi request reprint The topography of grey matter involvement in early and late onset Alzheimer's disease
    Giovanni B Frisoni
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, The National Centre for Research and Care of Alzheimer s and Mental Diseases, Brescia, Italy
    Brain 130:720-30. 2007
    ..These findings indicate that EOAD and LOAD differ in their typical topographic patterns of brain atrophy, suggesting different predisposing or aetiological factors...
  11. ncbi request reprint The effect of white matter lesions on cognition in the elderly--small but detectable
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Nat Clin Pract Neurol 3:620-7. 2007
    ..This view has important implications for the development of drugs for the treatment and prevention of cognitive impairment and dementia...
  12. ncbi request reprint Drug prescription in mild cognitive impairment: the physicians' perspective in Italy
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Int J Geriatr Psychiatry 21:1071-7. 2006
    ....
  13. doi request reprint MCI patients' EEGs show group differences between those who progress and those who do not progress to AD
    D V Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurobiol Aging 32:563-71. 2011
    ..EEG markers allow a mean correct percentage of correct classification up to 88.3%. Future prospective studies are needed to evaluate the sensitivity and specificity of these measures for predicting an AD outcome...
  14. ncbi request reprint Insight in dementia: when does it occur? Evidence for a nonlinear relationship between insight and cognitive status
    O Zanetti
    Alzheimer Disease Unit IRCCS, S Giovanni di Dio, S Cuore Fatebenefratelli Hospital, Brescia, Italy
    J Gerontol B Psychol Sci Soc Sci 54:P100-6. 1999
    ..The trilinear model of the association between insight and cognitive status reflects more closely the observable decline of insight and can provide estimates of when the decline of insight begins and ends...
  15. doi request reprint EEG markers discriminate among different subgroup of patients with mild cognitive impairment
    D V Moretti
    Neurophysiology, IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Am J Alzheimers Dis Other Demen 25:58-73. 2010
    ..Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%...
  16. doi request reprint Metabolic compensation and depression in Alzheimer's disease
    A Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Dement Geriatr Cogn Disord 29:37-45. 2010
    ..The aim of this study was to map metabolic compensation and depression in Alzheimer's disease (AD) on a voxel-by-voxel basis...
  17. pmc Medial temporal atrophy but not memory deficit predicts progression to dementia in patients with mild cognitive impairment
    C Geroldi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF The National Center for Research and Care of Alzheimer s Disease, via Pilastroni 4, 25125 Brescia, Italy
    J Neurol Neurosurg Psychiatry 77:1219-22. 2006
    ..The diagnosis of mild cognitive impairment (MCI) is clinically unhelpful, as many patients with MCI develop dementia but many do not...
  18. pmc Mapping the effect of APOE epsilon4 on gray matter loss in Alzheimer's disease in vivo
    M Pievani
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Neuroimage 45:1090-8. 2009
    ..002, ANOVA), in both early and late-onset patients (p<.05, ANOVA). We conclude that the epsilon4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability...
  19. ncbi request reprint Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer's disease
    G B Frisoni
    IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurology 52:91-100. 1999
    ..To describe atrophic changes of the hippocampus and entorhinal cortex in frontotemporal dementia (FTD) and compare them with those of AD...
  20. doi request reprint Increase of theta/gamma ratio is associated with memory impairment
    D V Moretti
    IRCCS San Giovanni di Dio Fatebenefratelli, Department of Neurophysiology, 4, Pilastroni Road, 25125 Brescia, Italy
    Clin Neurophysiol 120:295-303. 2009
    ..In this study the theta/gamma ratio was investigated as early marker of cognitive decline...
  21. ncbi request reprint Hippocampal shape differences in dementia with Lewy bodies
    F Sabattoli
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Neuroimage 41:699-705. 2008
    ..The direct comparisons between LBD and AD patients showed that this pattern of local atrophy is different from that characteristic of AD. LBD pattern of hippocampal atrophy might be related to the peculiar neuropathology of the disease...
  22. pmc The prevalence of apoE-epsilon4 in Alzheimer's disease is age dependent
    G B Frisoni
    Alzheimer s Unit, IRCCS San Giovanni di Dio, FBF, Brescia, Italy
    J Neurol Neurosurg Psychiatry 65:103-6. 1998
    ..12 in the oldest age group. It is concluded that the relation of the epsilon4 allele with Alzheimer's disease is age dependent, indicating that other risk factors might be relevant in the younger and older ages...
  23. ncbi request reprint Hippocampal atrophy and EEG markers in subjects with mild cognitive impairment
    D V Moretti
    IRCCS S Giovanni di Dio FBF, 25125, Brescia, Italy
    Clin Neurophysiol 118:2716-29. 2007
    ..The present study evaluates the potential relationship between hippocampal atrophy and EEG brain rhythmicity, as assessed by relative band power and alpha frequency indices in a cohort of subjects with mild cognitive impairment (MCI)...
  24. doi request reprint The new Alzheimer's criteria in a naturalistic series of patients with mild cognitive impairment
    S Galluzzi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine LENITEM, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 257:2004-14. 2010
    ..82, 95% CI 0.70-0.95). MT atrophy and abnormal CSF are the single most robust predictors of conversion to AD in MCI patients, and their combination enhances prediction. AD markers are not predictive of conversion to non-AD dementia...
  25. ncbi request reprint Amygdaloid atrophy in frontotemporal dementia and Alzheimer's disease
    M Boccardi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    Neurosci Lett 335:139-43. 2002
    ..00005) showed that FTD amygdaloid volumes were intermediate between controls and AD. Behavioral and Klüver-Bucy-like symptoms, characteristic of FTD, cannot be explained by amygdaloid atrophy alone...
  26. ncbi request reprint APOE and modulation of Alzheimer's and frontotemporal dementia
    M Boccardi
    Laboratory of Epidemiology and Neuroimaging L E N I, IRCCS San Giovanni di Dio FBF, Brescia 25125, Italy
    Neurosci Lett 356:167-70. 2004
    ..The epsilon4 allele of the APOE might modulate the expression of degenerative dementias by enhancing the specific effects of neurodegenerative diseases on the brain...
  27. doi request reprint Functional compensation in incipient Alzheimer's disease
    A Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS San Giovanni di Dio FBF, 25125 Brescia, Italy
    Neurobiol Aging 31:387-97. 2010
    ..These results help understand the reactive phenomena induced by the brain to try and counteract the pathological changes of AD...
  28. pmc The dynamics of Alzheimer's disease biomarkers in the Alzheimer's Disease Neuroimaging Initiative cohort
    A Caroli
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Aging 31:1263-74. 2010
    ..FDG-PET started changing early in time and likely followed a linear decline. In conclusion, this study provides the first evidence in favor of the dynamic biomarker model which has recently been proposed...
  29. ncbi request reprint Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment
    A Caroli
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125, Brescia, Italy
    J Neurol 254:1698-707. 2007
    ..Aim of this study was to find cerebral perfusion correlates of conversion to dementia in patients with amnestic MCI...
  30. pmc Local amygdala structural differences with 3T MRI in patients with Alzheimer disease
    E Cavedo
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurology 76:727-33. 2011
    ..We aimed to assess in vivo local structural differences in the amygdala of patients with AD using high-field MRI...
  31. doi request reprint Enrichment through biomarkers in clinical trials of Alzheimer's drugs in patients with mild cognitive impairment
    M Lorenzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Aging 31:1443-51, 1451.e1. 2010
    ..Enrichment comes at the price of an often relevant proportion of screened out cases, and in clinical trial settings, the balance between enrichment of screened in and loss of screened out patients should be critically discussed...
  32. ncbi request reprint Validity of direct assessment of functional status as a tool for measuring Alzheimer's disease severity
    O Zanetti
    Alzheimer Unit, IRCCS, S Giovanni di Dio, S Cuore Fatebenefratelli Institute, via Pilastroni 4, 25123, Brescia, Italy
    Age Ageing 27:615-22. 1998
    ..to assess the validity of the Direct Assessment of Functional Status (DAFS) performance-based functional scale for the staging of dementia severity by comparing it with established clinical, functional and cognitive scales...
  33. ncbi request reprint Effects of estrogens on cognition and brain morphology: involvement of the cerebellum
    R Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Maturitas 54:222-8. 2006
    ..In the present study we investigated the effect of ERT on cognition and on brain morphology in healthy postmenopausal women, taking into account the distinction in current and past ERT users...
  34. ncbi request reprint Special care units for demented patients: a multicenter study
    G Bellelli
    Geriatric Research Group, Brescia, Italy
    Gerontologist 38:456-62. 1998
    ..The data show an overall reduction in behavioral disturbances and a decreased use of psychotropic drugs and physical restraints...
  35. ncbi request reprint Depressive symptoms of Alzheimer caregivers are mainly due to personal rather than patient factors
    O Zanetti
    Alzheimer s Dementia Unit, I R C C S S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Int J Geriatr Psychiatry 13:358-67. 1998
    ..To investigate the predictors of caregiver's depressive symptoms in a sample of community-dwelling Alzheimer's patients...
  36. ncbi request reprint In vivo neuropathology of the hippocampal formation in AD: a radial mapping MR-based study
    G B Frisoni
    LENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Neuroimage 32:104-10. 2006
    ..This study supports the possibility of carrying out in vivo macroscopic neuropathology of the hippocampus with MR imaging in the neurodegenerative dementias...
  37. doi request reprint In vivo mapping of amyloid toxicity in Alzheimer disease
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, I 25123 Brescia, Italy
    Neurology 72:1504-11. 2009
    ..To study the relationship between gray matter atrophy and amyloid deposition in Alzheimer disease (AD)...
  38. ncbi request reprint Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study
    G B Frisoni
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    J Gerontol A Biol Sci Med Sci 56:M75-8. 2001
    ..Whether and which genetic factors affect human longevity is unclear. This study assesses the association between the epsilon2 allele of apolipoprotein E (APOE), a putative longevity gene, and extremely old age...
  39. ncbi request reprint Imaging, subjective complaints, and MCI: 30 years before
    S Galluzzi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    J Nutr Health Aging 12:80S-3S. 2008
    ....
  40. pmc Volumetric differences in mapped hippocampal regions correlate with increase of high alpha rhythm in Alzheimer's disease
    D V Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, 4, Pilastroni Road, 25125 Brescia, Italy
    Int J Alzheimers Dis 2011:208218. 2011
    ..Results. Results show that the increase of alpha3/alpha2 power ratio is correlated with atrophy of mapped hippocampal regions in Alzheimer's disease. Conclusions. The findings confirm the possible diagnostic role of EEG markers...
  41. pmc Specific EEG changes associated with atrophy of hippocampus in subjects with mild cognitive impairment and Alzheimer's disease
    D V Moretti
    IRCCS Centro S Giovanni di Dio Fatebenefratelli, 25125 Brescia, Italy
    Int J Alzheimers Dis 2012:253153. 2012
    ..This finding confirms the possible diagnostic role of EEG markers as diagnostic and prognostic factors in patient with prodromal and declared Alzheimer's disease...
  42. ncbi request reprint The CST3 B haplotype is associated with frontotemporal lobar degeneration
    L Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Eur J Neurol 17:143-6. 2010
    ..Given the role of cystatin C in brain neurodegeneration and neuroregeneration, the aim of this study was to determine whether the cystatin C gene (CST3) was genetically associated with FTLD...
  43. ncbi request reprint The dynamic marker hypothesis of Alzheimer's disease and its implications for clinical imaging
    E Cavedo
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Q J Nucl Med Mol Imaging 55:237-49. 2011
    ....
  44. ncbi request reprint The CT-based radial width of the temporal horn: pathological validation in AD without cerebrovascular disease
    R Rossi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Int J Geriatr Psychiatry 19:570-4. 2004
    ..Given the wide availability of the CT in the routine diagnostic assessment of patients with cognitive disturbances, a CT-based marker of AD might be clinically useful...
  45. ncbi request reprint Reality orientation therapy to delay outcomes of progression in patients with dementia. A retrospective study
    T Metitieri
    Geriartric Research Group, Brescia, Italy
    Clin Rehabil 15:471-8. 2001
    ..To evaluate the impact of continued Reality Orientation Therapy (ROT) in delaying the outcomes of dementia progression...
  46. ncbi request reprint An electronic memory aid to support prospective memory in patients in the early stages of Alzheimer's disease: a pilot study
    M Oriani
    Alzheimer Research and Care Unit, I R C C S, via Pilastroni 4, 25123 Brescia, Italy
    Aging Ment Health 7:22-7. 2003
    ..Future research that examines the value of using an EMA to help with tasks that are associated with prospective memory with a larger sample of patients within their own home context is suggested...
  47. ncbi request reprint Mild cognitive impairment: clinical features and review of screening instruments
    S Galluzzi
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio, FBF, Brescia, Italy
    Aging (Milano) 13:183-202. 2001
    ..We describe the most frequent clinical presentations of cognitive impairment in the pre-dementia stage, and review eleven screening tests to provide recommendations on which should be preferred in each setting...
  48. ncbi request reprint Electroencephalographic upper/low alpha frequency power ratio relates to cortex thinning in mild cognitive impairment
    D V Moretti
    IRCCS, S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurodegener Dis 14:18-30. 2014
    ..The increase in EEG upper/low α frequency power ratio has been associated with AD converter MCI subjects. We investigated the association of the EEG upper/low α frequency power ratio with patterns of cortical thickness in MCI...
  49. ncbi request reprint Prescription practices of diagnostic imaging in dementia: a survey of 47 Alzheimer's Centres in Northern Italy
    R Riello
    Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Int J Geriatr Psychiatry 18:577-85. 2003
    ..To date, there are no data at the national or European level on the prescription practices of imaging (CT, MR, and SPET) in the diagnosis of cognitively impaired elderly patients...
  50. ncbi request reprint Neuroimaging outcomes for clinical trials
    G B Frisoni
    G B Frisoni, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Nutr Health Aging 11:348-52. 2007
    ..The reviewed techniques, except for the most recent amyloid imaging, are those applied to prospective studies investigating changes of imaging markers over time...
  51. pmc Quantitative EEG Markers in Mild Cognitive Impairment: Degenerative versus Vascular Brain Impairment
    D V Moretti
    Centro San Giovanni di Dio Fatebenefratelli, TRccs, 25125 Brescia, Italy
    Int J Alzheimers Dis 2012:917537. 2012
    ..CVD and AHC damages are associated with specific EEG markers. So far, these EEG markers could have a prospective value in differential diagnosis between vascular and degenerative MCI...
  52. ncbi request reprint Neuroimaging outcomes in clinical trials in Alzheimer's disease
    G B Frisoni
    IRCCS Fatebenefratelli, Brescia, Italy
    J Nutr Health Aging 13:209-12. 2009
    ..Future testing of putative disease modifying drugs in valid animal models with valid imaging markers of disease progression will allow to maximize the predictability of their effect in phase II and III clinical trials...
  53. ncbi request reprint The management of adverse clinical events in nursing homes: a 1-year survey study
    G Bellelli
    Geriatric Research Group, Brescia, Italy
    J Am Geriatr Soc 49:915-25. 2001
    ..CONCLUSIONS: NH residents frequently experience adverse clinical events; physician characteristics influence the rate of hospitalization and the quality of medical interventions...
  54. doi request reprint LCC-Demons: a robust and accurate symmetric diffeomorphic registration algorithm
    M Lorenzi
    Asclepios Research Project, INRIA Sophia Antipolis, 2004 Route des Lucioles BP 93, 06 902 Sophia Antipolis, France
    Neuroimage 81:470-83. 2013
    ..Without any additional optimization, it solves equally well intra & inter-subject registration problems, and compares favorably to state-of-the-art methods. ..
  55. doi request reprint Autonomic dysfunction in mild cognitive impairment: a transcranial Doppler study
    G P Anzola
    Service of Neurology, S Orsola Hospital, Brescia, Italy
    Acta Neurol Scand 124:403-9. 2011
    ..Aim of this study is to evaluate cerebrovascular reactivity (CVR) and cardiac autonomic function in patients with MCI by means of transcranial Doppler (TCD)...
  56. ncbi request reprint Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease
    F Nicosia
    Neurobiology Laboratory, Alzheimer s Unit, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, I 25123 Brescia, Italy
    Dement Geriatr Cogn Disord 12:305-8. 2001
    ..89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE epsilon4 status...
  57. ncbi request reprint Presenilin 1 protein directly interacts with Bcl-2
    A Alberici
    Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Centro S Giovanni di Dio, Neurobiology Laboratory, Alzheimer s Disease Unit, via Pilastroni 4, 25123 Brescia, Italy
    J Biol Chem 274:30764-9. 1999
    ..The results support the idea of cross-talk between these two proteins during apoptosis...
  58. ncbi request reprint Predicting clinical variable from MRI features: application to MMSE in MCI
    S Duchesne
    Montreal Neurological Institute MNI, McGill University, Montreal, Canada
    Med Image Comput Comput Assist Interv 8:392-9. 2005
    ..6955) with actual data. Prospective study of an independent cohort of patients is the next logical step towards establishing this promising technique for clinical use...
  59. doi request reprint MRI-based automated computer classification of probable AD versus normal controls
    S Duchesne
    Centre de recherche de l Université Laval Robert Giffard, Quebec, QC, G1J 2G3 Canada
    IEEE Trans Med Imaging 27:509-20. 2008
    ..The ability of cross-sectional MRI at detecting probable AD with high accuracy could have profound implications in the management of suspected AD candidates...
  60. pmc Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease
    F Portet
    Memory Research Resource Center for Alzheimer s Disease, Neurology B Department, Institut National de la Sante et de la Recherche Medicale, Montpellier Hospital, Montpellier, France
    J Neurol Neurosurg Psychiatry 77:714-8. 2006
    ....
  61. pmc A voxel based morphometry study on mild cognitive impairment
    C Pennanen
    Department of Neurology, Bldg 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
    J Neurol Neurosurg Psychiatry 76:11-4. 2005
    ..A number of volumetric magnetic resonance imaging (MRI) studies have detected atrophy of the medial temporal lobe in subjects with MCI, but for the other cerebral regions the results have been inconsistent...
  62. pmc Hippocampal MRI volumetry in cognitively discordant monozygotic twin pairs
    T Järvenpää
    Turku PET Centre and Department of Neurology, University of Turku, Turku, Finland
    J Neurol Neurosurg Psychiatry 75:116-20. 2004
    ..To investigate whether hippocampal atrophy, a proxy for incipient Alzheimer's disease, can be detected in non-demented monozygotic co-twins of demented twins by using volumetric magnetic resonance imaging (MRI)...
  63. ncbi request reprint Emotional withdrawal, CT abnormalities and drug response in late life depression
    A Carlo Altamura
    Department of Psychiatry and Clinical Sciences Luigi Sacco, University of Milan, Via G B Grassi 74, Milan 20157, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 28:349-54. 2004
    ..121, P<.03). The results from this study showed that patients with baseline emotional withdrawal and CT abnormalities have poorer outcome. Further investigations on larger samples are needed to confirm these findings...
  64. pmc Frontotemporal dementia: impact of P301L tau mutation on a healthy carrier
    A Alberici
    Neurobiology Lab, IRCCS S Giovanni di Dio FBF, 25123 Brescia, Italy
    J Neurol Neurosurg Psychiatry 75:1607-10. 2004
    ..We conclude that detection of these distinctive abnormalities should improve early diagnostic accuracy for FTD and help distinguish it from Alzheimer's disease...
  65. ncbi request reprint [Music therapy in Alzheimer's disease: is an evidence-based approach possible?]
    R Riello
    Laboratorio di Epidemiologia e Neuroimaging, IRCCS San Giovanni di Dio, Fatebenefratelli, Brescia
    Recenti Prog Med 92:317-21. 2001
    ..The aim of the study is to organize the present knowledge with a systematic approach so that further researches lead to base the application of music therapy on evidence instead of on singular clinical finding...
  66. ncbi request reprint The ICTUS Study: A Prospective longitudinal observational study of 1,380 AD patients in Europe. Study design and baseline characteristics of the cohort
    E Reynish
    INSERM, U558, Toulouse, France
    Neuroepidemiology 29:29-38. 2007
    ....
  67. pmc Executive dysfunction and depressive symptoms in cerebrovascular disease
    G Bellelli
    J Neurol Neurosurg Psychiatry 73:462-3. 2002
  68. ncbi request reprint Outcome measurement in mental health: the Italian experience in psychogeriatrics
    R Rozzini
    Br J Psychiatry 181:442-3. 2002
  69. ncbi request reprint Endpoints for trials in Alzheimer's disease: a European task force consensus
    Bruno Vellas
    INSERM U558, Toulouse, France
    Lancet Neurol 7:436-50. 2008
    ..A clear and consensual definition of endpoints is crucial for the success of further clinical trials in the field and will allow comparison of data across studies...