Research Topics
Genomes and Genes | Giuliano BinettiSummaryAffiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's diseaseCatia Scassellati
Genetics Unit, I R C C S Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Neurosci Lett 356:119-22. 2004..Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD...- Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and AmericansGiuliano Binetti
NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Patient Educ Couns 64:285-93. 2006.... 
Predictors of comprehensive stimulation program efficacy in patients with cognitive impairment. Clinical practice recommendationsGiuliano Binetti
NeuroBioGen Lab Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Int J Geriatr Psychiatry 28:26-33. 2013..The aim of the present study was to identify which factors may predict the best response to a comprehensive stimulation program in patients with dementia and mild cognitive impairment (MCI) as well as in their caregivers...- Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matterMarina Boccardi
LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
Neurosci Lett 434:304-9. 2008..This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve... - Progranulin Leu271LeufsX10 is one of the most common FTLD and CBS associated mutations worldwideLuisa Benussi
NeuroBioGen Lab Memory Clinic, IRCCS S Giovanni di Dio FBF, Brescia, Italy
Neurobiol Dis 33:379-85. 2009..The PGRN Leu271LeufsX10 mutation becomes one of the most common mutations worldwide, since it was identified in 38 patients belonging to 27 unrelated families... - Markers of Alzheimer's disease in a population attending a memory clinicGiovanni B Frisoni
Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
Alzheimers Dement 5:307-17. 2009..New marker-based criteria for the diagnosis of Alzheimer's disease (AD) were recently proposed. We describe their operational translation in 144 consecutive patients referred to our Memory Clinic... - Increasing hippocampal atrophy and cerebrovascular damage is differently associated with functional cortical coupling in MCI patientsDavide Vito Moretti
IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
Alzheimer Dis Assoc Disord 23:323-32. 2009..Our results show a lateralization (right hemisphere for cerebrovascular disease and left hemisphere for hippocampal atrophy) of the pathologic modifications of functional coupling... 
H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriersElisa Canu
LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
Eur J Hum Genet 17:287-94. 2009..The data suggest that H1 haplotype is associated with a particular cerebral morphology that may increase the susceptibility of the healthy carriers to develop neurodegenerative diseases such as sporadic tauopathies...- Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE epsilon4 carriersNicola Filippini
LENITEM, Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS S Giovanni di Dio FBF, Brescia, Italy
J Magn Reson Imaging 29:1021-6. 2009..To investigate the possible effect of the APOE epsilon4 allele on age-related regional volume loss within the corpus callosum (CC) in healthy epsilon4 allele carriers compared with noncarriers... - Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian studyRoberta Ghidoni
Proteomics Unit, IRCCS Centro S Giovanni di Dio Fatebenefratelli, Brescia, Italy
Neurodegener Dis 9:121-7. 2012.... - Increase of theta/gamma and alpha3/alpha2 ratio is associated with amygdalo-hippocampal complex atrophyDavide Vito Moretti
IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
J Alzheimers Dis 17:349-57. 2009..The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state... - Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's diseaseRoberta Ghidoni
Proteomics Unit, IRCCS, Centro S Giovanni di Dio Fatebenefratelli, Brescia, Italy
Neurobiol Aging 32:1435-42. 2011..A better understanding of the mechanisms involved in exosomal processing and release may have important implications for the fight against AD and other neurodegenerative diseases... - A novel deletion in progranulin gene is associated with FTDP-17 and CBSLuisa Benussi
NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
Neurobiol Aging 29:427-35. 2008..Despite the profound differences in the biological functions of the encoded proteins, it is not possible to define a clinical phenotype distinguishing the disease caused by mutations in MAPT and PGRN genes... - Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptidesRoberta Ghidoni
Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
J Alzheimers Dis 18:295-303. 2009..The AbetaPP T719P mutation is of particular interest because it is the only mutation located in close proximity to the AbetaPP epsilon-cleavage site... - Plasma cystatin C and risk of developing Alzheimer's disease in subjects with mild cognitive impairmentRoberta Ghidoni
Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
J Alzheimers Dis 22:985-91. 2010.... - HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humansElisa Canu
LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicin IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
J Neuroimaging 19:353-8. 2009..Similar effects were revealed also in healthy children but not in adult controls. The aim of this study was to investigate the role of the A218G polymorphism on the hindbrain structure of healthy adults... - Distinct cerebrospinal fluid amyloid-beta peptide signatures in cognitive decline associated with Alzheimer's disease and schizophreniaValentina Albertini
Proteomics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Electrophoresis 33:3738-44. 2012..These data suggests a dysmetabolism of amyloid precursor protein in older SCZ patients. Thus, the quite comparable reduction of CSF Aβ1-42 in AD and in elderly SCZ patients reflects different pathophysiological dynamics in ageing brain... - Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents beta-amyloid neurotoxicityDaniela Uberti
Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, Italy
Neuropsychopharmacology 32:872-80. 2007..Thus, these findings may give intracellular TRAIL pathway a role in AD pathophysiology, making DR5 receptor a possible candidate as a pharmacological target... - Association of blood pressure and genetic background with white matter lesions in patients with mild cognitive impairmentSamantha Galluzzi
LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
J Gerontol A Biol Sci Med Sci 63:510-7. 2008..03). Conclusions. BP and gene putative risk factors for cerebrovascular disease are differentially associated with WMLs in two MCI groups of different WML severity. WMLs might develop for the convergence of innate with acquired factors... - Estimating the age of the most common Italian GRN mutation: walking back to Canossa timesLuisa Benussi
NeuroBioGen Lab Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
J Alzheimers Dis 33:69-76. 2013..From a translational perspective, targeting mutation carriers offers a unique model to test disease-modifying drugs in clinical trials... - Cerebrovascular disease and hippocampal atrophy are differently linked to functional coupling of brain areas: an EEG coherence study in MCI subjectsDavide Vito Moretti
IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
J Alzheimers Dis 14:285-99. 2008..MCI-CVD patients performed worst on Trail Making Test battery whereas MCI-HIPP patients were impaired on Rey word list delayed recall and Rey figure recall... - Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's diseaseMariacarla Ventriglia
Genetics Unit, IRCCS S Giovanni di Dio, Ospedale Fatebenefratelli, Brescia, Italy
Aging Clin Exp Res 17:445-8. 2005..The object of this study was to investigate the association between this polymorphism of the MnSOD gene and AD in the Italian population... - Presenilin 2 mutations alter cystatin C trafficking in mouse primary neuronsRoberta Ghidoni
NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
Neurobiol Aging 28:371-6. 2007..The consequent reduction in the cystatin C extracellular levels might result in a failure of neuroregeneration. Understanding the interplay of PS2 and cystatin C in the pathogenesis of AD might highlight new therapeutic prospective... - Optimization protocol for amyloid-β peptides detection in human cerebrospinal fluid using SELDI TOF MSValentina Albertini
Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
Proteomics Clin Appl 4:352-7. 2010..The aim of the present work was to set up an optimized protocol for human cerebrospinal fluid amyloid-β (Aβ) profiling... - A window into the heterogeneity of human cerebrospinal fluid Aβ peptidesRoberta Ghidoni
Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
J Biomed Biotechnol 2011:697036. 2011..Finally, we suggest that Aβ peptides as well as other key signals in the central nervous system (CNS), mainly involved in learning and hence plasticity, may have a double-edged sword action on neuron survival and function... - Losing protein in the brain: the case of progranulinRoberta Ghidoni
Proteomics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
Brain Res 1476:172-82. 2012..This article is part of a Special Issue entitled: Brain Integration... - The H2 MAPT haplotype is associated with familial frontotemporal dementiaRoberta Ghidoni
NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
Neurobiol Dis 22:357-62. 2006..67, P = 0.001). Our results support idea that the MAPT H2 haplotype is a risk factor for FFTD. This locus could contain this or other inheritable genetic determinants contributing to increase risk of developing dementia... - Presenilin 2 is secreted in mouse primary neurons: a release enhanced by apoptosisRoberta Ghidoni
NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
Mech Ageing Dev 128:350-3. 2007..8-fold more than PS1. During apoptosis either proteins were colocalized especially within shedded vesicles. The present study suggest an active role for the presenilins CTF on putative target cells... - Preliminary evidence of validity of the revised criteria for Alzheimer disease diagnosis: report of 2 casesGiovanni B Frisoni
Associazione Fatebenefratelli per la Ricerca Biomedica e Sanitaria, Rome, Italy
Alzheimer Dis Assoc Disord 24:108-14. 2010..We describe 2 very mild cases of MCI and their clinical outcome... - Analysis of grey matter in thalamus and basal ganglia based on EEG α3/α2 frequency ratio reveals specific changes in subjects with mild cognitive impairmentDavide V Moretti
IRCCSS Centro Giovanni di Dio Fatebenefratelli, Brescia, Italy
ASN Neuro 4:e00103. 2012.... - Clinical and neuropsychological features associated with structural imaging patterns in patients with mild cognitive impairmentRoberta Rossi
Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
Dement Geriatr Cogn Disord 23:175-83. 2007.... - Effects of hormone therapy on brain morphology of healthy postmenopausal women: a Voxel-based morphometry studyMarina Boccardi
LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Menopause 13:584-91. 2006..The structures that exhibited greater volume in association with ET included the cerebellar and cerebral cortices and, typically involved in Alzheimer's disease, the medial temporal structures and the temporoparietal junction... - Predictors of cognitive improvement after reality orientation in Alzheimer's diseaseOrazio Zanetti
I R C C S S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
Age Ageing 31:193-6. 2002.... - Prevalence of TAU mutations in an Italian clinical series of familial frontotemporal patientsGiuliano Binetti
Neurobiology Laboratory, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
Neurosci Lett 338:85-7. 2003..6%); based on our results we could argue the existence of other mutations in regulatory regions in the TAU gene or, on the other hand, other genes might be responsible for the most cases of familial FTD... - Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humansEnzo Emanuele
Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
Neurosci Lett 353:201-4. 2003..011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD... - Atypical dementia associated with a novel presenilin-2 mutationGiuliano Binetti
Neurobiology Lab and Memory Clinic, IRCCS Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
Ann Neurol 54:832-6. 2003..These observations suggest the importance of still unknown biological and perhaps environmental factors in the disease determination... - Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementiaEnzo Emanuele
Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
Dement Geriatr Cogn Disord 18:189-96. 2004..Our results demonstrate that possession of at least one LMW apo(a) isoform is significantly associated with dementia and specifically offer new evidence of a strong association between the lipoprotein system and post-stroke dementia... - Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer diseaseClaudia Günther
Department of Human Genetics, University Hospital Hamburg Eppendorf, Butenfeld 42, 22529 Hamburg, Germany
Neurosci Lett 369:219-23. 2004..The findings suggest that a TFAM haplotype containing rs1937 G (for S12) may be a moderate risk factor for AD... - Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patientsDavide Seripa
Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
Neurobiol Aging 26:455-64. 2005.... - Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementiaMarta Giacomello
Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
Neurobiol Dis 18:638-48. 2005..A similar Ca2+ alteration occurred in HeLa and HEK293 cells transiently expressing PS2-T122R. Based on these data, the "Ca2+ overload" hypothesis in AD pathogenesis is here discussed and reformulated... - Tau missing from CSF: a case reportAntonella Alberici
J Neurol 254:107-9. 2007 - Apolipoprotein(a) null phenotype is related to a delayed age at onset of Alzheimer's diseaseEnzo Emanuele
Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
Neurosci Lett 357:45-8. 2004..We conclude that the expression of at least one apo(a) isoform may interact with other pathogenic mechanisms involved in controlling the age at onset of AD...