Giuliano Binetti

Summary

Affiliation: IRCCS Centro San Giovanni di Dio Fatebenefratelli
Country: Italy

Publications

  1. ncbi request reprint Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease
    Catia Scassellati
    Genetics Unit, I R C C S Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurosci Lett 356:119-22. 2004
  2. ncbi request reprint Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and Americans
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Patient Educ Couns 64:285-93. 2006
  3. doi request reprint Predictors of comprehensive stimulation program efficacy in patients with cognitive impairment. Clinical practice recommendations
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Int J Geriatr Psychiatry 28:26-33. 2013
  4. doi request reprint Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurosci Lett 434:304-9. 2008
  5. doi request reprint Progranulin Leu271LeufsX10 is one of the most common FTLD and CBS associated mutations worldwide
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Dis 33:379-85. 2009
  6. doi request reprint Increasing hippocampal atrophy and cerebrovascular damage is differently associated with functional cortical coupling in MCI patients
    Davide Vito Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Alzheimer Dis Assoc Disord 23:323-32. 2009
  7. doi request reprint Markers of Alzheimer's disease in a population attending a memory clinic
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Alzheimers Dement 5:307-17. 2009
  8. pmc H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers
    Elisa Canu
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Eur J Hum Genet 17:287-94. 2009
  9. doi request reprint Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE epsilon4 carriers
    Nicola Filippini
    LENITEM, Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS S Giovanni di Dio FBF, Brescia, Italy
    J Magn Reson Imaging 29:1021-6. 2009
  10. doi request reprint Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurodegener Dis 9:121-7. 2012

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease
    Catia Scassellati
    Genetics Unit, I R C C S Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurosci Lett 356:119-22. 2004
    ..Our results provide new insights on a possible involvement of the IL-10 gene in susceptibility to sporadic AD even though further functional and genetic investigations are necessary to clarify its role in AD...
  2. ncbi request reprint Areas of intervention for genetic counselling of dementia: cross-cultural comparison between Italians and Americans
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Patient Educ Couns 64:285-93. 2006
    ....
  3. doi request reprint Predictors of comprehensive stimulation program efficacy in patients with cognitive impairment. Clinical practice recommendations
    Giuliano Binetti
    NeuroBioGen Lab Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Int J Geriatr Psychiatry 28:26-33. 2013
    ..The aim of the present study was to identify which factors may predict the best response to a comprehensive stimulation program in patients with dementia and mild cognitive impairment (MCI) as well as in their caregivers...
  4. doi request reprint Effect of the XbaI polymorphism of estrogen receptor alpha on postmenopausal gray matter
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Neurosci Lett 434:304-9. 2008
    ..This allele might increase the susceptibility for senile neurodegenerative conditions, being associated to smaller cerebral reserve...
  5. doi request reprint Progranulin Leu271LeufsX10 is one of the most common FTLD and CBS associated mutations worldwide
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS S Giovanni di Dio FBF, Brescia, Italy
    Neurobiol Dis 33:379-85. 2009
    ..The PGRN Leu271LeufsX10 mutation becomes one of the most common mutations worldwide, since it was identified in 38 patients belonging to 27 unrelated families...
  6. doi request reprint Increasing hippocampal atrophy and cerebrovascular damage is differently associated with functional cortical coupling in MCI patients
    Davide Vito Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Alzheimer Dis Assoc Disord 23:323-32. 2009
    ..Our results show a lateralization (right hemisphere for cerebrovascular disease and left hemisphere for hippocampal atrophy) of the pathologic modifications of functional coupling...
  7. doi request reprint Markers of Alzheimer's disease in a population attending a memory clinic
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio FBF, Brescia, Italy
    Alzheimers Dement 5:307-17. 2009
    ..New marker-based criteria for the diagnosis of Alzheimer's disease (AD) were recently proposed. We describe their operational translation in 144 consecutive patients referred to our Memory Clinic...
  8. pmc H1 haplotype of the MAPT gene is associated with lower regional gray matter volume in healthy carriers
    Elisa Canu
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicine, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Eur J Hum Genet 17:287-94. 2009
    ..The data suggest that H1 haplotype is associated with a particular cerebral morphology that may increase the susceptibility of the healthy carriers to develop neurodegenerative diseases such as sporadic tauopathies...
  9. doi request reprint Regional atrophy of transcallosal prefrontal connections in cognitively normal APOE epsilon4 carriers
    Nicola Filippini
    LENITEM, Laboratory of Epidemiology, Neuroimaging, and Telemedicine IRCCS S Giovanni di Dio FBF, Brescia, Italy
    J Magn Reson Imaging 29:1021-6. 2009
    ..To investigate the possible effect of the APOE epsilon4 allele on age-related regional volume loss within the corpus callosum (CC) in healthy epsilon4 allele carriers compared with noncarriers...
  10. doi request reprint Optimal plasma progranulin cutoff value for predicting null progranulin mutations in neurodegenerative diseases: a multicenter Italian study
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurodegener Dis 9:121-7. 2012
    ....
  11. doi request reprint Increase of theta/gamma and alpha3/alpha2 ratio is associated with amygdalo-hippocampal complex atrophy
    Davide Vito Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Alzheimers Dis 17:349-57. 2009
    ..The alterations of the functional connections, inducing global network pathological changes, in the whole AHC could better explain MCI state...
  12. doi request reprint Distinct cerebrospinal fluid amyloid-beta peptide signatures in cognitive decline associated with Alzheimer's disease and schizophrenia
    Valentina Albertini
    Proteomics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Electrophoresis 33:3738-44. 2012
    ..These data suggests a dysmetabolism of amyloid precursor protein in older SCZ patients. Thus, the quite comparable reduction of CSF Aβ1-42 in AD and in elderly SCZ patients reflects different pathophysiological dynamics in ageing brain...
  13. ncbi request reprint The H2 MAPT haplotype is associated with familial frontotemporal dementia
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Dis 22:357-62. 2006
    ..67, P = 0.001). Our results support idea that the MAPT H2 haplotype is a risk factor for FFTD. This locus could contain this or other inheritable genetic determinants contributing to increase risk of developing dementia...
  14. ncbi request reprint Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
    Neurobiol Aging 28:371-6. 2007
    ..The consequent reduction in the cystatin C extracellular levels might result in a failure of neuroregeneration. Understanding the interplay of PS2 and cystatin C in the pathogenesis of AD might highlight new therapeutic prospective...
  15. doi request reprint Plasma cystatin C and risk of developing Alzheimer's disease in subjects with mild cognitive impairment
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Alzheimers Dis 22:985-91. 2010
    ....
  16. pmc Analysis of grey matter in thalamus and basal ganglia based on EEG α3/α2 frequency ratio reveals specific changes in subjects with mild cognitive impairment
    Davide V Moretti
    IRCCSS Centro Giovanni di Dio Fatebenefratelli, Brescia, Italy
    ASN Neuro 4:e00103. 2012
    ....
  17. pmc Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease
    Roberta Ghidoni
    Proteomics Unit, IRCCS, Centro S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Neurobiol Aging 32:1435-42. 2011
    ..A better understanding of the mechanisms involved in exosomal processing and release may have important implications for the fight against AD and other neurodegenerative diseases...
  18. doi request reprint Novel T719P AbetaPP mutation unbalances the relative proportion of amyloid-beta peptides
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Alzheimers Dis 18:295-303. 2009
    ..The AbetaPP T719P mutation is of particular interest because it is the only mutation located in close proximity to the AbetaPP epsilon-cleavage site...
  19. ncbi request reprint A novel deletion in progranulin gene is associated with FTDP-17 and CBS
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro San Giovanni di Dio Fatebenefratelli, via Pilastroni 4, 25125 Brescia, Italy
    Neurobiol Aging 29:427-35. 2008
    ..Despite the profound differences in the biological functions of the encoded proteins, it is not possible to define a clinical phenotype distinguishing the disease caused by mutations in MAPT and PGRN genes...
  20. doi request reprint HOXA1 A218G polymorphism is associated with smaller cerebellar volume in healthy humans
    Elisa Canu
    LENITEM Laboratory of Epidemiology, Neuroimaging, and Telemedicin IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Neuroimaging 19:353-8. 2009
    ..Similar effects were revealed also in healthy children but not in adult controls. The aim of this study was to investigate the role of the A218G polymorphism on the hindbrain structure of healthy adults...
  21. doi request reprint Estimating the age of the most common Italian GRN mutation: walking back to Canossa times
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Alzheimers Dis 33:69-76. 2013
    ..From a translational perspective, targeting mutation carriers offers a unique model to test disease-modifying drugs in clinical trials...
  22. ncbi request reprint Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents beta-amyloid neurotoxicity
    Daniela Uberti
    Department of Biomedical Sciences and Biotechnologies, University of Brescia Medical School, Brescia, Italy
    Neuropsychopharmacology 32:872-80. 2007
    ..Thus, these findings may give intracellular TRAIL pathway a role in AD pathophysiology, making DR5 receptor a possible candidate as a pharmacological target...
  23. doi request reprint Losing protein in the brain: the case of progranulin
    Roberta Ghidoni
    Proteomics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    Brain Res 1476:172-82. 2012
    ..This article is part of a Special Issue entitled: Brain Integration...
  24. ncbi request reprint Cerebrovascular disease and hippocampal atrophy are differently linked to functional coupling of brain areas: an EEG coherence study in MCI subjects
    Davide Vito Moretti
    IRCCS S Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Alzheimers Dis 14:285-99. 2008
    ..MCI-CVD patients performed worst on Trail Making Test battery whereas MCI-HIPP patients were impaired on Rey word list delayed recall and Rey figure recall...
  25. ncbi request reprint Association of blood pressure and genetic background with white matter lesions in patients with mild cognitive impairment
    Samantha Galluzzi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
    J Gerontol A Biol Sci Med Sci 63:510-7. 2008
    ..03). Conclusions. BP and gene putative risk factors for cerebrovascular disease are differentially associated with WMLs in two MCI groups of different WML severity. WMLs might develop for the convergence of innate with acquired factors...
  26. ncbi request reprint Lack of association between MnSOD gene polymorphism and sporadic Alzheimer's disease
    Mariacarla Ventriglia
    Genetics Unit, IRCCS S Giovanni di Dio, Ospedale Fatebenefratelli, Brescia, Italy
    Aging Clin Exp Res 17:445-8. 2005
    ..The object of this study was to investigate the association between this polymorphism of the MnSOD gene and AD in the Italian population...
  27. ncbi request reprint Optimization protocol for amyloid-β peptides detection in human cerebrospinal fluid using SELDI TOF MS
    Valentina Albertini
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    Proteomics Clin Appl 4:352-7. 2010
    ..The aim of the present work was to set up an optimized protocol for human cerebrospinal fluid amyloid-β (Aβ) profiling...
  28. pmc A window into the heterogeneity of human cerebrospinal fluid Aβ peptides
    Roberta Ghidoni
    Proteomics Unit, IRCCS Centro S Giovanni di Dio FBF, Brescia, Italy
    J Biomed Biotechnol 2011:697036. 2011
    ..Finally, we suggest that Aβ peptides as well as other key signals in the central nervous system (CNS), mainly involved in learning and hence plasticity, may have a double-edged sword action on neuron survival and function...
  29. ncbi request reprint Presenilin 2 is secreted in mouse primary neurons: a release enhanced by apoptosis
    Roberta Ghidoni
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, AFaR, Brescia, Italy
    Mech Ageing Dev 128:350-3. 2007
    ..8-fold more than PS1. During apoptosis either proteins were colocalized especially within shedded vesicles. The present study suggest an active role for the presenilins CTF on putative target cells...
  30. doi request reprint Preliminary evidence of validity of the revised criteria for Alzheimer disease diagnosis: report of 2 cases
    Giovanni B Frisoni
    Associazione Fatebenefratelli per la Ricerca Biomedica e Sanitaria, Rome, Italy
    Alzheimer Dis Assoc Disord 24:108-14. 2010
    ..We describe 2 very mild cases of MCI and their clinical outcome...
  31. ncbi request reprint Clinical and neuropsychological features associated with structural imaging patterns in patients with mild cognitive impairment
    Roberta Rossi
    Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Dement Geriatr Cogn Disord 23:175-83. 2007
    ....
  32. ncbi request reprint Interaction between tau and alpha-synuclein proteins is impaired in the presence of P301L tau mutation
    Luisa Benussi
    NeuroBioGen Lab Memory Clinic, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Exp Cell Res 308:78-84. 2005
    ..We restored the impaired interaction by inducing heat shock proteins 70 and 90. In addition, we show that P301L tau mutation strongly affects tau and alpha-synuclein neuronal distribution...
  33. ncbi request reprint Effects of hormone therapy on brain morphology of healthy postmenopausal women: a Voxel-based morphometry study
    Marina Boccardi
    LENITEM Laboratory of Epidemiology, Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, Brescia, Italy
    Menopause 13:584-91. 2006
    ..The aim of this study was to evaluate the potential effects of estrogen therapy (ET) on human gray matter volume in vivo...
  34. ncbi request reprint Predictors of cognitive improvement after reality orientation in Alzheimer's disease
    Orazio Zanetti
    I R C C S S Giovanni di Dio, Fatebenefratelli, Brescia, Italy
    Age Ageing 31:193-6. 2002
    ....
  35. ncbi request reprint Apolipoprotein(a) null phenotype is related to a delayed age at onset of Alzheimer's disease
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
    Neurosci Lett 357:45-8. 2004
    ..We conclude that the expression of at least one apo(a) isoform may interact with other pathogenic mechanisms involved in controlling the age at onset of AD...
  36. ncbi request reprint Prevalence of TAU mutations in an Italian clinical series of familial frontotemporal patients
    Giuliano Binetti
    Neurobiology Laboratory, IRCCS Centro S Giovanni di Dio FBF, via Pilastroni 4, 25123 Brescia, Italy
    Neurosci Lett 338:85-7. 2003
    ..6%); based on our results we could argue the existence of other mutations in regulatory regions in the TAU gene or, on the other hand, other genes might be responsible for the most cases of familial FTD...
  37. ncbi request reprint Association between small apolipoprotein(a) isoforms and frontotemporal dementia in humans
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, Piazzale Golgi 2, University of Pavia, 27100 Pavia, Italy
    Neurosci Lett 353:201-4. 2003
    ..011 and P=0.025, respectively). Our data suggest a role of apo(a) phenotypes of low MW in mediating susceptibility to FTD...
  38. ncbi request reprint Atypical dementia associated with a novel presenilin-2 mutation
    Giuliano Binetti
    Neurobiology Lab and Memory Clinic, IRCCS Fatebenefratelli, via Pilastroni 4, 25123 Brescia, Italy
    Ann Neurol 54:832-6. 2003
    ..These observations suggest the importance of still unknown biological and perhaps environmental factors in the disease determination...
  39. ncbi request reprint Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia
    Marta Giacomello
    Department of Biomedical Sciences, University of Padova, Via G Colombo, 3, 35121 Padova, Italy
    Neurobiol Dis 18:638-48. 2005
    ..A similar Ca2+ alteration occurred in HeLa and HEK293 cells transiently expressing PS2-T122R. Based on these data, the "Ca2+ overload" hypothesis in AD pathogenesis is here discussed and reformulated...
  40. ncbi request reprint Possible association of mitochondrial transcription factor A (TFAM) genotype with sporadic Alzheimer disease
    Claudia Günther
    Department of Human Genetics, University Hospital Hamburg Eppendorf, Butenfeld 42, 22529 Hamburg, Germany
    Neurosci Lett 369:219-23. 2004
    ..The findings suggest that a TFAM haplotype containing rs1937 G (for S12) may be a moderate risk factor for AD...
  41. ncbi request reprint Genotypes and haplotypes in the IL-1 gene cluster: analysis of two genetically and diagnostically distinct groups of Alzheimer patients
    Davide Seripa
    Laboratory of Gene Therapy, I R C C S Casa Sollievo della Sofferenza, Padre Pio da Pietrelcina Foundation, San Giovanni Rotondo, FG, Italy
    Neurobiol Aging 26:455-64. 2005
    ....
  42. ncbi request reprint Tau missing from CSF: a case report
    Antonella Alberici
    J Neurol 254:107-9. 2007
  43. ncbi request reprint Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementia
    Enzo Emanuele
    Molecular Medicine Laboratory, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy
    Dement Geriatr Cogn Disord 18:189-96. 2004
    ..Our results demonstrate that possession of at least one LMW apo(a) isoform is significantly associated with dementia and specifically offer new evidence of a strong association between the lipoprotein system and post-stroke dementia...