Research Topics
| David PimSummaryAffiliation: International Centre for Genetic Engineering and Biotechnology Country: Italy Publications
| Collaborators
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Detail Information
Publications
Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cellsLuisa Accardi
Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
BMC Cancer 11:17. 2011....
p53 polymorphic variants at codon 72 exert different effects on cell cycle progressionDavid Pim
International Center for Genetic Engineering and Biotechnology, Trieste, Italy
Int J Cancer 108:196-9. 2004..In contrast, the Pro72 form appears to induce a higher level of G1 arrest than the Arg72 form. These results demonstrate significant differences in how the codon 72 polymorphism affects the biological activity of p53...- Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2ADavid Pim
International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
Oncogene 24:7830-8. 2005.... - The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 proteinDavid Pim
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
J Virol 83:9863-74. 2009.... 
Interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomavirusesDavid Pim
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
APMIS 118:471-93. 2010....- The stability of the human papillomavirus E6 oncoprotein is E6AP dependentVjekoslav Tomaic
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
Virology 393:7-10. 2009..These results demonstrate that the stability of HPV E6 is critically dependent upon the presence of E6AP... - Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDDVjekoslav Tomaic
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
J Virol 85:3120-7. 2011.... - Interactions between E6AP and E6 proteins from alpha and beta HPV typesMiranda Thomas
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34149, Italy
Virology 435:357-62. 2013..These results define important differences and commonalities in how HPV E6 proteins of mucosal and cutaneous origin interact with cellular ubiquitin-protein ligases... - Human papillomaviruses and the specificity of PDZ domain targetingDavid Pim
International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
FEBS J 279:3530-7. 2012..In this review, we highlight aspects of E6 function and biology that help to answer this question, and thereby provide insight into the role of these substrates during development of HPV-induced malignancy... - HPV-18 E6*I modulates HPV-18 full-length E6 functions in a cell cycle dependent mannerErnesto Guccione
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy
Int J Cancer 110:928-33. 2004.... - Viruses and the 26S proteasome: hacking into destructionLawrence Banks
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
Trends Biochem Sci 28:452-9. 2003.... - Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteinsDavid Pim
International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, I 34012, Trieste, Italy
Oncogene 21:8140-8. 2002..These results demonstrate significant differences, both between mucosal and cutaneous HPV E6 proteins and in the pathways required for Dlg and MAGI-1 degradation... - Human tumour viruses and the deregulation of cell polarity in cancerLawrence Banks
The International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
Nat Rev Cancer 12:877-86. 2012..However, a body of data from human tumour viruses is now providing compelling evidence of a central role for the perturbation of cell polarity in the development of cancer...