David Pim

Summary

Affiliation: International Centre for Genetic Engineering and Biotechnology
Country: Italy

Publications

  1. pmc Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells
    Luisa Accardi
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    BMC Cancer 11:17. 2011
  2. doi request reprint Interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomaviruses
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    APMIS 118:471-93. 2010
  3. ncbi request reprint p53 polymorphic variants at codon 72 exert different effects on cell cycle progression
    David Pim
    International Center for Genetic Engineering and Biotechnology, Trieste, Italy
    Int J Cancer 108:196-9. 2004
  4. ncbi request reprint Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Oncogene 24:7830-8. 2005
  5. pmc The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 protein
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    J Virol 83:9863-74. 2009
  6. doi request reprint The stability of the human papillomavirus E6 oncoprotein is E6AP dependent
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Virology 393:7-10. 2009
  7. doi request reprint Interaction of HPV E6 oncoproteins with specific proteasomal subunits
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
    Virology 446:389-96. 2013
  8. pmc Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
    J Virol 85:3120-7. 2011
  9. doi request reprint Interactions between E6AP and E6 proteins from alpha and beta HPV types
    Miranda Thomas
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34149, Italy
    Virology 435:357-62. 2013
  10. doi request reprint Human papillomaviruses and the specificity of PDZ domain targeting
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    FEBS J 279:3530-7. 2012

Collaborators

Detail Information

Publications14

  1. pmc Retinoblastoma-independent antiproliferative activity of novel intracellular antibodies against the E7 oncoprotein in HPV 16-positive cells
    Luisa Accardi
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    BMC Cancer 11:17. 2011
    ....
  2. doi request reprint Interaction of viral oncoproteins with cellular target molecules: infection with high-risk vs low-risk human papillomaviruses
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    APMIS 118:471-93. 2010
    ....
  3. ncbi request reprint p53 polymorphic variants at codon 72 exert different effects on cell cycle progression
    David Pim
    International Center for Genetic Engineering and Biotechnology, Trieste, Italy
    Int J Cancer 108:196-9. 2004
    ..In contrast, the Pro72 form appears to induce a higher level of G1 arrest than the Arg72 form. These results demonstrate significant differences in how the codon 72 polymorphism affects the biological activity of p53...
  4. ncbi request reprint Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Oncogene 24:7830-8. 2005
    ....
  5. pmc The human papillomavirus (HPV) E6* proteins from high-risk, mucosal HPVs can direct degradation of cellular proteins in the absence of full-length E6 protein
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    J Virol 83:9863-74. 2009
    ....
  6. doi request reprint The stability of the human papillomavirus E6 oncoprotein is E6AP dependent
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Virology 393:7-10. 2009
    ..These results demonstrate that the stability of HPV E6 is critically dependent upon the presence of E6AP...
  7. doi request reprint Interaction of HPV E6 oncoproteins with specific proteasomal subunits
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
    Virology 446:389-96. 2013
    ..These results suggest a complex interplay between E6 and the proteasome, only some aspects of which are dependent upon the E6AP ubiquitin ligase. ..
  8. pmc Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
    J Virol 85:3120-7. 2011
    ....
  9. doi request reprint Interactions between E6AP and E6 proteins from alpha and beta HPV types
    Miranda Thomas
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34149, Italy
    Virology 435:357-62. 2013
    ..These results define important differences and commonalities in how HPV E6 proteins of mucosal and cutaneous origin interact with cellular ubiquitin-protein ligases...
  10. doi request reprint Human papillomaviruses and the specificity of PDZ domain targeting
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    FEBS J 279:3530-7. 2012
    ..In this review, we highlight aspects of E6 function and biology that help to answer this question, and thereby provide insight into the role of these substrates during development of HPV-induced malignancy...
  11. ncbi request reprint HPV-18 E6*I modulates HPV-18 full-length E6 functions in a cell cycle dependent manner
    Ernesto Guccione
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Int J Cancer 110:928-33. 2004
    ....
  12. ncbi request reprint Viruses and the 26S proteasome: hacking into destruction
    Lawrence Banks
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Trends Biochem Sci 28:452-9. 2003
    ....
  13. ncbi request reprint Chimaeric HPV E6 proteins allow dissection of the proteolytic pathways regulating different E6 cellular target proteins
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, I 34012, Trieste, Italy
    Oncogene 21:8140-8. 2002
    ..These results demonstrate significant differences, both between mucosal and cutaneous HPV E6 proteins and in the pathways required for Dlg and MAGI-1 degradation...
  14. doi request reprint Human tumour viruses and the deregulation of cell polarity in cancer
    Lawrence Banks
    The International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
    Nat Rev Cancer 12:877-86. 2012
    ..However, a body of data from human tumour viruses is now providing compelling evidence of a central role for the perturbation of cell polarity in the development of cancer...