Ramiro Mendoza-Maldonado

Summary

Affiliation: International Centre for Genetic Engineering and Biotechnology
Country: Italy

Publications

  1. ncbi The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation
    Ramiro Mendoza-Maldonado
    International Centre for Genetic Engineering and Biotechnology Padriciano 99, 34149 Trieste, Italy
    Mol Cancer 10:83. 2011
  2. ncbi A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
    Bojana Lucic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Nucleic Acids Res 39:1703-17. 2011
  3. ncbi Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation
    Saravanabhavan Thangavel
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Mol Cell Biol 30:1382-96. 2010

Collaborators

Detail Information

Publications3

  1. ncbi The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation
    Ramiro Mendoza-Maldonado
    International Centre for Genetic Engineering and Biotechnology Padriciano 99, 34149 Trieste, Italy
    Mol Cancer 10:83. 2011
    ..Current data show that the specific depletion of the human RECQ1 helicase leads to mitotic catastrophe in cancer cells and inhibition of tumor growth in mice...
  2. ncbi A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
    Bojana Lucic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Nucleic Acids Res 39:1703-17. 2011
    ..Interestingly, two independent protein-protein contacts are required for tetramer formation, one involves the β-hairpin and the other the N-terminus of RECQ1, suggesting a non-hierarchical mechanism of tetramer assembly...
  3. ncbi Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation
    Saravanabhavan Thangavel
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Mol Cell Biol 30:1382-96. 2010
    ..These results indicate that RECQ1 and RECQ4 are integral components of the human replication complex and play distinct roles in DNA replication initiation and replication fork progression in vivo...