Paola Massimi

Summary

Affiliation: International Centre for Genetic Engineering and Biotechnology
Country: Italy

Publications

  1. ncbi Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Exp Cell Res 314:3306-17. 2008
  2. ncbi The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins
    Miranda Thomas
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Oncogene 24:6222-30. 2005
  3. ncbi Regulation of human papillomavirus type 16 E7 activity through direct protein interaction with the E2 transcriptional activator
    Noor Gammoh
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34012, Italy
    J Virol 80:1787-97. 2006
  4. ncbi Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Virology 371:374-9. 2008
  5. ncbi CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability
    Nisha Narayan
    Tumour Virology Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    J Cell Sci 122:65-74. 2009
  6. ncbi HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradation
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste I-34012, Italy
    Oncogene 23:8033-9. 2004
  7. ncbi The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity
    Vanitha Krishna Subbaiah
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    PLoS Pathog 8:e1002543. 2012
  8. ncbi Human papillomaviruses and the specificity of PDZ domain targeting
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    FEBS J 279:3530-7. 2012
  9. ncbi Transformation assays for HPV oncoproteins
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Methods Mol Med 119:381-95. 2005
  10. ncbi Regulation of the DLG tumor suppressor by β-catenin
    Vanitha Krishna Subbaiah
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    Int J Cancer 131:2223-33. 2012

Collaborators

Detail Information

Publications17

  1. ncbi Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Exp Cell Res 314:3306-17. 2008
    ..This is the first detailed analysis of the co-localisation and function of the hScrib complex in mammalian cells and demonstrates a direct link between the control of the hScrib complex and vesicle transport pathways...
  2. ncbi The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins
    Miranda Thomas
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Oncogene 24:6222-30. 2005
    ....
  3. ncbi Regulation of human papillomavirus type 16 E7 activity through direct protein interaction with the E2 transcriptional activator
    Noor Gammoh
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34012, Italy
    J Virol 80:1787-97. 2006
    ..These results demonstrate a direct role for E2 in regulating the function of E7 and suggest an important role for E2 in directing E7 localization during mitosis...
  4. ncbi Comparative transforming potential of different human papillomaviruses associated with non-melanoma skin cancer
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    Virology 371:374-9. 2008
    ..These results provide molecular support for a role of these viruses in the development of certain human malignancies...
  5. ncbi CDK phosphorylation of the discs large tumour suppressor controls its localisation and stability
    Nisha Narayan
    Tumour Virology Laboratory, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    J Cell Sci 122:65-74. 2009
    ..These findings establish phosphorylation events as key regulators of DLG1 localisation and function...
  6. ncbi HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradation
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste I-34012, Italy
    Oncogene 23:8033-9. 2004
    ..These results suggest that in the context of HPV-induced transformation Dlg, MAGI-1 and MUPP1 can function as tumour suppressors...
  7. ncbi The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity
    Vanitha Krishna Subbaiah
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    PLoS Pathog 8:e1002543. 2012
    ..These studies demonstrate that hDlg has a distinct oncogenic function in the context of HPV induced malignancy, one of the outcomes of which is increased RhoG activity and increased invasive capacity...
  8. ncbi Human papillomaviruses and the specificity of PDZ domain targeting
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    FEBS J 279:3530-7. 2012
    ..In this review, we highlight aspects of E6 function and biology that help to answer this question, and thereby provide insight into the role of these substrates during development of HPV-induced malignancy...
  9. ncbi Transformation assays for HPV oncoproteins
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy
    Methods Mol Med 119:381-95. 2005
    ..In this chapter we describe how the transforming activities of the HPV oncoproteins can be assessed...
  10. ncbi Regulation of the DLG tumor suppressor by β-catenin
    Vanitha Krishna Subbaiah
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    Int J Cancer 131:2223-33. 2012
    ..Taken together these studies suggest that one mechanism by which deregulated β-catenin can contribute to tumorigenesis is through enhancing DLG degradation...
  11. ncbi Regulation of the human papillomavirus type 18 E6/E6AP ubiquitin ligase complex by the HECT domain-containing protein EDD
    Vjekoslav Tomaic
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34149 Trieste, Italy
    J Virol 85:3120-7. 2011
    ....
  12. ncbi Crosstalk between the human papillomavirus E2 transcriptional activator and the E6 oncoprotein
    Helena Sterlinko Grm
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Oncogene 24:5149-64. 2005
    ....
  13. ncbi The Mdm2 ubiquitin ligase enhances transcriptional activity of human papillomavirus E2
    Noor Gammoh
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    J Virol 83:1538-43. 2009
    ..We also show that HPV E2 recruits Mdm2 onto HPV promoter sequences, providing an explanation for this cooperative activity...
  14. ncbi Redistribution of the discs large tumor suppressor protein during mitosis
    Paola Massimi
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy
    Exp Cell Res 290:265-74. 2003
    ..We conclude that localisation of Dlg to the midbody indicates a role for Dlg at this critical point in cytokinesis...
  15. ncbi Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A
    David Pim
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Oncogene 24:7830-8. 2005
    ....
  16. ncbi Complementation of a p300/CBP defective-binding mutant of adenovirus E1a by human papillomavirus E6 proteins
    Agnieszka Bernat
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I 34012 Trieste, Italy
    J Gen Virol 83:829-33. 2002
    ..In contrast, a mutant of HPV-16 E6 which does not bind p300 failed to rescue the E1a mutant. These results suggest that the E6-p300 interaction may be important for the ability of HPV E6 to contribute towards cell transformation...
  17. ncbi Comparative analysis of the intracellular location of the high- and low-risk human papillomavirus oncoproteins
    Ernesto Guccione
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy
    Virology 293:20-5. 2002
    ..These results demonstrate fundamental differences in the localization of these viral oncoproteins within the cell and offer alternative explanations for their respective differences in pathology...