- Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behaviorFabian Feiguin
International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
FEBS Lett 583:1586-92. 2009..Our results demonstrate the role of this protein in vivo and suggest an alternative explanation to ALS pathogenesis that may be more due to the lack of TDP 43 function than to the toxicity of the aggregates...
- TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organizationVinay K Godena
International Center for Genetic Engineering and Biotechnology, Trieste, Italy
PLoS ONE 6:e17808. 2011..Moreover, we observed that TDP-43 physically interacts with futsch mRNA and that its RNA binding capacity is required to prevent futsch down regulation and synaptic defects...