Fabian Feiguin

Summary

Affiliation: International Centre for Genetic Engineering and Biotechnology
Country: Italy

Publications

  1. doi request reprint Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
    Fabian Feiguin
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    FEBS Lett 583:1586-92. 2009
  2. doi request reprint Chronological requirements of TDP-43 function in synaptic organization and locomotive control
    Giulia Romano
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Neurobiol Dis 71:95-109. 2014
  3. pmc TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization
    Vinay K Godena
    International Center for Genetic Engineering and Biotechnology, Trieste, Italy
    PLoS ONE 6:e17808. 2011
  4. doi request reprint Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye
    Lucia Cragnaz
    ICGEB International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Neurobiol Dis 71:74-80. 2014
  5. doi request reprint Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates
    Chiara Appocher
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34149, Italy
    Hum Mol Genet 23:6762-72. 2014

Collaborators

  • Patrik Verstreken
  • Raffaella Klima
  • Chiara Appocher
  • Francisco E Baralle
  • Giulia Romano
  • Lucia Cragnaz
  • Emanuele Buratti
  • Vinay K Godena
  • Raffaela Klima
  • Mauricio Budini
  • Natasa Skoko
  • Maurizio Romano

Detail Information

Publications5

  1. doi request reprint Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
    Fabian Feiguin
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    FEBS Lett 583:1586-92. 2009
    ..Our results demonstrate the role of this protein in vivo and suggest an alternative explanation to ALS pathogenesis that may be more due to the lack of TDP 43 function than to the toxicity of the aggregates...
  2. doi request reprint Chronological requirements of TDP-43 function in synaptic organization and locomotive control
    Giulia Romano
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Neurobiol Dis 71:95-109. 2014
    ..These observations suggest that late therapeutic approaches based on TDP-43 functionality may also be successful for the human pathology. ..
  3. pmc TDP-43 regulates Drosophila neuromuscular junctions growth by modulating Futsch/MAP1B levels and synaptic microtubules organization
    Vinay K Godena
    International Center for Genetic Engineering and Biotechnology, Trieste, Italy
    PLoS ONE 6:e17808. 2011
    ..Moreover, we observed that TDP-43 physically interacts with futsch mRNA and that its RNA binding capacity is required to prevent futsch down regulation and synaptic defects...
  4. doi request reprint Aggregate formation prevents dTDP-43 neurotoxicity in the Drosophila melanogaster eye
    Lucia Cragnaz
    ICGEB International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy
    Neurobiol Dis 71:74-80. 2014
    ..This is an important indication for the possible pathological mechanism in action on ALS patients. ..
  5. doi request reprint Functional screening in Drosophila reveals the conserved role of REEP1 in promoting stress resistance and preventing the formation of Tau aggregates
    Chiara Appocher
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste 34149, Italy
    Hum Mol Genet 23:6762-72. 2014
    ..These studies identify a new function for the REEP1 protein in vivo and a novel cellular mechanism to prevent Tau toxicity. ..