L Zecca

Summary

Affiliation: Institute of Biomedical Technologies
Country: Italy

Publications

  1. pmc New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
    Luigi Zecca
    Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Milan, Italy
    Proc Natl Acad Sci U S A 105:17567-72. 2008
  2. doi request reprint Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease
    Luigi Zecca
    Institute of Biomedical Technologies Italian National Research Council, Milano, Italy
    J Neurochem 106:1866-75. 2008
  3. ncbi request reprint A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease
    L Zecca
    Institute of Biomedical Technologies Italian Research Council, Segrate, Milano, Italy
    Neurology 67:S8-11. 2006
  4. ncbi request reprint Iron, brain ageing and neurodegenerative disorders
    Luigi Zecca
    Institute of Biomedical Technologies Italian National Research Council, 20090 Segrate, Milano, Italy
    Nat Rev Neurosci 5:863-73. 2004
  5. pmc The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
    Luigi Zecca
    Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Italy
    Proc Natl Acad Sci U S A 101:9843-8. 2004
  6. ncbi request reprint Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
    Luigi Zecca
    Institute of Biomedical Technologies National Council of Research, Segrate, Italy
    Trends Neurosci 26:578-80. 2003
  7. ncbi request reprint Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes
    L Zecca
    Institute of Advanced Biomedical Technologies CNR, Segrate, Italy
    J Neurochem 76:1766-73. 2001
  8. ncbi request reprint The neuromelanin of human substantia nigra and its interaction with metals
    L Zecca
    Institute of Biomedical Technologies CNR, Segrate, Milano, Italy
    J Neural Transm 109:663-72. 2002
  9. ncbi request reprint A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds
    M G Sacco
    Institute of Advanced Biomedical Technologies, National Research Council, Milan, Italy
    Nat Biotechnol 15:1392-7. 1997
  10. doi request reprint Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
    David Sulzer
    Department of Neurology, Columbia University, New York, NY 10036, USA
    J Neurochem 106:24-36. 2008

Collaborators

Detail Information

Publications21

  1. pmc New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
    Luigi Zecca
    Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Milan, Italy
    Proc Natl Acad Sci U S A 105:17567-72. 2008
    ..Furthermore, the resulting melanic component serves an additional protective role through its ability to chelate and accumulate metals, including environmentally toxic metals such as mercury and lead...
  2. doi request reprint Neuromelanin can protect against iron-mediated oxidative damage in system modeling iron overload of brain aging and Parkinson's disease
    Luigi Zecca
    Institute of Biomedical Technologies Italian National Research Council, Milano, Italy
    J Neurochem 106:1866-75. 2008
    ..This occurs in PD when extraneuronal iron-neuromelanin is phagocytosed by microglia and iron-neuromelanin degradation releases reactive/toxic iron...
  3. ncbi request reprint A proposed dual role of neuromelanin in the pathogenesis of Parkinson's disease
    L Zecca
    Institute of Biomedical Technologies Italian Research Council, Segrate, Milano, Italy
    Neurology 67:S8-11. 2006
    ..Neuromelanin appears to be a suitable target for devising chemical agents that might modify the course of these diseases...
  4. ncbi request reprint Iron, brain ageing and neurodegenerative disorders
    Luigi Zecca
    Institute of Biomedical Technologies Italian National Research Council, 20090 Segrate, Milano, Italy
    Nat Rev Neurosci 5:863-73. 2004
    ..By studying the accumulation and cellular distribution of iron during ageing, we should be able to increase our understanding of these neurodegenerative disorders and develop new therapeutic strategies...
  5. pmc The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging
    Luigi Zecca
    Institute of Biomedical Technologies, Italian National Research Council, 20090 Segrate, Italy
    Proc Natl Acad Sci U S A 101:9843-8. 2004
    ..Manganese-SOD and copper/zinc-SOD had similar age trend in LC and SN. These results may explain at least one of the reasons underlying lower vulnerability of LC compared to SN in Parkinsonian syndromes...
  6. ncbi request reprint Neuromelanin of the substantia nigra: a neuronal black hole with protective and toxic characteristics
    Luigi Zecca
    Institute of Biomedical Technologies National Council of Research, Segrate, Italy
    Trends Neurosci 26:578-80. 2003
    ..However, dying neurons in Parkinson's disease that release neuromelanin might induce a vicious cycle of chronic neuroinflammation and neuronal loss...
  7. ncbi request reprint Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes
    L Zecca
    Institute of Advanced Biomedical Technologies CNR, Segrate, Italy
    J Neurochem 76:1766-73. 2001
    ..Based on this data and on the low H- and L-ferritin content in neurones it is concluded that neuromelanin is the major iron storage in substantia nigra neurones in normal individuals...
  8. ncbi request reprint The neuromelanin of human substantia nigra and its interaction with metals
    L Zecca
    Institute of Biomedical Technologies CNR, Segrate, Milano, Italy
    J Neural Transm 109:663-72. 2002
    ..The overloading of NM with iron and other metals in neurons may trigger inflammatory and degenerative processes aggravating the underlying pathological condition...
  9. ncbi request reprint A transgenic mouse model for the detection of cellular stress induced by toxic inorganic compounds
    M G Sacco
    Institute of Advanced Biomedical Technologies, National Research Council, Milan, Italy
    Nat Biotechnol 15:1392-7. 1997
    ..Transgenic mice injected intraperitoneally with sodium arsenite, cadmium chloride, copper sulphate, or methylmercurium chloride showed significant hGH levels in plasma...
  10. doi request reprint Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
    David Sulzer
    Department of Neurology, Columbia University, New York, NY 10036, USA
    J Neurochem 106:24-36. 2008
    ....
  11. doi request reprint Human neuromelanin induces neuroinflammation and neurodegeneration in the rat substantia nigra: implications for Parkinson's disease
    Luigi Zecca
    Institute of Biomedical Technologies, Via Fratelli Cervi 93, 20090, Segrate Milan, Italy
    Acta Neuropathol 116:47-55. 2008
    ..This may be highly relevant to the elucidation of therapeutic strategies in PD...
  12. ncbi request reprint The absolute concentration of nigral neuromelanin, assayed by a new sensitive method, increases throughout the life and is dramatically decreased in Parkinson's disease
    Luigi Zecca
    Institute of Biomedical Technologies CNR, Segrate, Italy
    FEBS Lett 510:216-20. 2002
    ..These data demonstrate a continuous NM accumulation in SNPC neurons during aging, the presence of large amounts of NM in SNPC and severe depletion of NM in Parkinson's disease...
  13. ncbi request reprint The structure of neuromelanin as studied by chemical degradative methods
    Kazumasa Wakamatsu
    Department of Chemistry, Fujita Health University School of Health Sciences, Toyoake, Aichi, Japan
    J Neurochem 86:1015-23. 2003
    ..The involvement of DA and CysDA as building blocks of NM demonstrates the detoxifying role of NM synthesis, since it prevents the intraneuronal accumulation of DA and CysDA, which would cause toxic effects...
  14. ncbi request reprint In vivo detection of iron and neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage
    Luigi Zecca
    Institute of Biomedical Technologies CNR, Segrate Milano, Italy
    Mov Disord 20:1278-85. 2005
    ....
  15. ncbi request reprint The neuromelanin of human substantia nigra: physiological and pathogenic aspects
    Fabio A Zucca
    Institute of Biomedical Technologies CNR 20090 Segrate Milano, Italy
    Pigment Cell Res 17:610-7. 2004
    ..On the other hand, experiments in cell culture indicate that NM can activate microglia, eliciting the release of cytotoxic factors that can induce neurodegeneration...
  16. ncbi request reprint Neuromelanin and its interaction with iron as a potential risk factor for dopaminergic neurodegeneration underlying Parkinson's disease
    Manfred Gerlach
    Clinical Neurochemistry, Department of Child and Youth Psychiatry and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, D 97080 Wurzburg, Germany
    Neurotox Res 5:35-44. 2003
    ..The resultant radical-mediated cytotoxicity may contribute to cellular damage observed in PD...
  17. ncbi request reprint Iron-binding characteristics of neuromelanin of the human substantia nigra
    Kay L Double
    Prince of Wales Medical Research Institute, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia
    Biochem Pharmacol 66:489-94. 2003
    ..The interaction between NM and iron has implications for disorders such as Parkinson's disease where an increase in iron in the SN is associated with increased indices of oxidative stress...
  18. ncbi request reprint Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    Michelle L Block
    Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Nat Rev Neurosci 8:57-69. 2007
    ....
  19. ncbi request reprint Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain
    Weslyn C Ward
    Department of Chemistry, Duke University, Durham, NC, USA
    J Lipid Res 48:1457-62. 2007
    ..The distribution of dol-CA chains lengths in NM also differed from that of dol, suggesting that the enzyme(s) responsible for the conversion of dol to dol-CA prefer a dolichol substrate containing 19 isoprene units...
  20. ncbi request reprint Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen-activated protein kinase: implications for Parkinson's disease
    Henrik Wilms
    Klinik fur Neurologie, Christian Albrechts Universitat zu Kiel, 24105 Kiel, Germany
    FASEB J 17:500-2. 2003
    ..The antagonization of microglial activation by a pharmacological intervention targeting microglial NF-kappaB or p38 MAPK could point to additional venues in the treatment of PD...
  21. pmc The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface
    William D Bush
    Department of Chemistry, Duke University, Durham, NC 27708, USA
    Proc Natl Acad Sci U S A 103:14785-9. 2006
    ..Such a kinetic model would predict a structural motif with pheomelanin at the core and eumelanin at the surface, which is consistent with the measured surface oxidation potential of the approximately 30-nm constituents of NM granules...