Affiliation: Institute of Genetics and Biophysics
- Deciphering AP-1 function in tumorigenesis: fra-ternizing on target promotersPasquale Verde
Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
Cell Cycle 6:2633-9. 2007..Here, we focus on the Fra-1 protein in tumorigenesis, which offers an illustrative example of this helter-skelter voyage...
- Fra-1 promotes growth and survival in RAS-transformed thyroid cells by controlling cyclin A transcriptionLaura Casalino
A Buzzati Traverso Institute of Genetics and Biophysics, CNR, Naples, Italy
EMBO J 26:1878-90. 2007..Fra-1 also induced the expression of JunB, which in turn interacts with the cyclin A promoter. Hence, Fra-1 induction is important in thyroid tumorigenesis, critically regulating cyclin expression and cell-cycle progression...
- Accumulation of Fra-1 in ras-transformed cells depends on both transcriptional autoregulation and MEK-dependent posttranslational stabilizationLaura Casalino
Institute of Genetics and Biophysics A Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80125 Naples, Italy
Mol Cell Biol 23:4401-15. 2003..These data show that the alteration of multiple regulatory mechanisms is required for the constitutive activation of Fra-1 as a nuclear target of ras transformation...