Research Topics
| Cinzia VerdeSummaryAffiliation: Institute of Protein Biochemistry Country: Italy Publications
| Collaborators
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Detail Information
Publications
The adaptation of polar fishes to climatic changes: Structure, function and phylogeny of haemoglobinCinzia Verde
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, Naples, Italy
IUBMB Life 60:29-40. 2008..Current climate change may disturb adaptation, calling for strategies aimed at neutralising threats to biodiversity...- ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinusDaniela Coppola
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
Mol Biosyst 8:3295-304. 2012..maclovinus, whose life-style varies according to changes in habitat, the mechanisms that regulate O(2) affinity and the ATP-induced Root effect differ from those of high-Antarctic Notothenioids... 
Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutesDaniela Coppola
Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy
BMC Biochem 12:66. 2011..These recent findings call for the biotechnological development of stable, low-affinity PEGylated hemoglobins with low NO dioxygenase reactivity...
The hemoglobins of fishes living at polar latitudes - current knowledge on structural adaptations in a changing environmentCinzia Verde
Institute of Protein Biochemistry, Naples, Italy
Curr Protein Pept Sci 9:578-90. 2008..The occurrence of bis-histidyl and penta-coordinate states in ferric forms of polar fish hemoglobins suggests additional redox properties...- The evolution of thermal adaptation in polar fishCinzia Verde
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
Gene 385:137-45. 2006.... - Correlation between hemichrome stability and the root effect in tetrameric hemoglobinsAlessandro Vergara
Department of Chemistry, University of Naples Federico II, Complesso Universitario Monte S Angelo, Naples, Italy
Biophys J 97:866-74. 2009.... - Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatusDaniela Giordano
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
Gene 406:58-68. 2007..Close phylogenetic relationships between Cottoidei and Notothenioidei, together with their life style, seem to be the main factor driving the globin-sequence evolution... - Structure, function and molecular adaptations of haemoglobins of the polar cartilaginous fish Bathyraja eatonii and Raja hyperboreaCinzia Verde
Institute of Protein Biochemistry, CNR, Via Marconi 12, I-80125 Naples, Italy
Biochem J 389:297-306. 2005..Such evidence suggests that, in temperate and polar habitats, physiological adaptations have evolved along distinct pathways, whereas, in this case, the effect of the differences characterizing the two polar environments is negligible... - Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense stateLuigi Vitagliano
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I 80134 Naples, Italy
J Am Chem Soc 130:10527-35. 2008..The implications of the present findings have also been discussed in the wider context of tetrameric Hbs... - Biogeography and adaptation of Notothenioid fish: hemoglobin function and globin-gene evolutionGuido Di Prisco
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
Gene 398:143-55. 2007..Adaptation of the oxygen-transport system in notothenioids seems to be based on evolutionary changes involving levels of biological organisation higher than the structure of hemoglobin... - Minimal structural requirements for root effect: crystal structure of the cathodic hemoglobin isolated from the antarctic fish Trematomus newnesiLelio Mazzarella
Dipartimento di Chimica, Universita degli Studi di Napoli Federico II, Naples, Italy
Proteins 62:316-21. 2006.... - Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobinsAlessandro Vergara
Department of Chemistry and Consorzio Bioteknet, University of Naples Federico II, Naples, Italy
Methods Enzymol 436:425-44. 2008..Here we review the methodological approaches adopted to achieve these results, the main structural features of these states, and the current hypotheses on their possible functional implications... - The evolution of polar fish hemoglobin: a phylogenetic analysis of the ancestral amino acid residues linked to the root effectCinzia Verde
Institute of Protein Biochemistry, CNR, Via Marconi 12, 1-80125 Naples, Italy
J Mol Evol 57:S258-67. 2003.... - The oxygen transport system in three species of the boreal fish family Gadidae. Molecular phylogeny of hemoglobinCinzia Verde
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I-80131 Naples, Italy
J Biol Chem 281:22073-84. 2006.... - Ligand- and proton-linked conformational changes of the ferrous 2/2 hemoglobin of Pseudoalteromonas haloplanktis TAC125Daniela Giordano
Institute of Protein Biochemistry, CNR, Naples, Italy
IUBMB Life 63:566-73. 2011..In addition, at temperatures above the physiological temperature of 1 °C, an enhanced tendency of the protein to oxidize is observed... - The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species--oxygen-binding equilibria, kinetics and molecular dynamicsDaniela Giordano
Institute of Protein Biochemistry, National Research Council CNR, Naples, Italy
FEBS J 276:2266-77. 2009..Molecular dynamic simulations of C. gobio Hb1 were performed on the dimeric protein in order to obtain a better understanding of the molecular basis of structure/function relationships... - Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhuaAlessia Riccio
Institute of Protein Biochemistry, CNR, Naples, Italy
IUBMB Life 63:346-54. 2011..The widespread occurrence of the polymerization phenomenon displayed by hemoglobins of Arctic fish supports the hypothesis that this feature may bea response to stressful environmental conditions... - Structure and function of the Gondwanian hemoglobin of Pseudaphritis urvillii, a primitive notothenioid fish of temperate latitudesCinzia Verde
Institute of Protein Biochemistry, National Research Council, Naples, Italy
Protein Sci 13:2766-81. 2004..This conformation may lead to the hemichrome form identified by spectroscopy in the Met state, which likely fulfils a potentially important physiological role... - The truncated hemoglobins in the Antarctic psychrophilic bacterium Pseudoalteromonas haloplanktis TAC125Daniela Giordano
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
Gene 398:69-77. 2007..Phylogenetic analyses show that two truncated globins encoded by the PSHAa0030 and PSHAa2217 genes belong to group II, and the third one encoded by PSHAa0458 to group I... - Molecular adaptations in Antarctic fish and marine microorganismsDaniela Giordano
Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
Mar Genomics 6:1-6. 2012.... - Structure/function and phylogeny of hemoglobins of polar fishesCinzia Verde
Institute of Protein Biochemistry, CNR, Via Marconi 12, I-80125 Naples, Italy
Micron 35:77-80. 2004.... - The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minorCinzia Verde
Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche, Via Marconi 12, I-80125 Naples, Italy
J Biol Chem 277:36312-20. 2002..The oxygen transport system of A. minor differs remarkably from those of Antarctic Notothenioidei, indicating distinct evolutionary pathways in the regulatory mechanisms of the fish respiratory system in the two polar environments... - Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobinDaniela Giordano
Institute of Protein Biochemistry, CNR, Naples, Italy
PLoS ONE 7:e44508. 2012..Despite subtle differences, the adaptation of Antarctic fish neuroglobins does not seem to parallel the dramatic adaptation of the oxygen carrying globins, hemoglobin and myoglobin, in the same organisms... - Understanding and protecting the world's biodiversity: the role and legacy of the SCAR programme "Evolution and Biodiversity in the Antarctic"Guido Di Prisco
Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
Mar Genomics 8:3-8. 2012..These programmes are the legacy of EBA, and they are key to understanding and protect Antarctic biodiversity... - Inferring evolution of fish proteins: the globin case studyAgnes Dettai
UMR, Departement Systematique et Evolution, Museum national d histoire naturelle, Paris, France
Methods Enzymol 436:539-70. 2008..These residues, mapped on the three-dimensional Hb structure, can provide insights into functional and structural divergence... - Comparative and evolutionary genomics of globin genes in fishEnrico Negrisolo
Department of Public Health, Comparative Pathology, and Veterinary Hygiene, University of Padova, Legnaro, Italy
Methods Enzymol 436:511-38. 2008..Internet resources for analyzing sequence alignments and annotations and new bioinformatic tools to address critical problems are thoroughly discussed... - Structural characterization of ferric hemoglobins from three antarctic fish species of the suborder notothenioideiAlessandro Vergara
Department of Chemistry, University of Naples Federico II, Complesso Universitario Monte S Angelo, I 80126 Naples, Italy
Biophys J 93:2822-9. 2007..Altogether the data show that ferric states commonly associated with monomeric and dimeric Hbs are also found in tetrameric Hbs... - High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: the role of histidine residues in modulating the strength of the root effectLelio Mazzarella
Dipartimento di Chimica, Universita degli Studi di Napoli Federico II, Complesso Universitario di Monte S Angelo, Via Cinthia, I 80126 Naples, Italy
Proteins 65:490-8. 2006.... - Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding siteMariagiuseppina Pellegrini
Department of Sciences Applied to Biosystems, University of Cagliari, Cittadella Universitaria, I 09042 Monserrato Ca, Italy
Biochem J 372:679-86. 2003....