Cinzia Verde

Summary

Affiliation: Institute of Protein Biochemistry
Country: Italy

Publications

  1. doi request reprint The adaptation of polar fishes to climatic changes: Structure, function and phylogeny of haemoglobin
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, Naples, Italy
    IUBMB Life 60:29-40. 2008
  2. pmc Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutes
    Daniela Coppola
    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy
    BMC Biochem 12:66. 2011
  3. ncbi request reprint The hemoglobins of fishes living at polar latitudes - current knowledge on structural adaptations in a changing environment
    Cinzia Verde
    Institute of Protein Biochemistry, Naples, Italy
    Curr Protein Pept Sci 9:578-90. 2008
  4. ncbi request reprint The evolution of thermal adaptation in polar fish
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Gene 385:137-45. 2006
  5. doi request reprint ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus
    Daniela Coppola
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Mol Biosyst 8:3295-304. 2012
  6. pmc Correlation between hemichrome stability and the root effect in tetrameric hemoglobins
    Alessandro Vergara
    Department of Chemistry, University of Naples Federico II, Complesso Universitario Monte S Angelo, Naples, Italy
    Biophys J 97:866-74. 2009
  7. ncbi request reprint Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatus
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Gene 406:58-68. 2007
  8. doi request reprint The globins of cold-adapted Pseudoalteromonas haloplanktis TAC125: from the structure to the physiological functions
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Naples, Italy
    Adv Microb Physiol 63:329-89. 2013
  9. doi request reprint Ligand-rebinding kinetics of 2/2 hemoglobin from the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
    Roberta Russo
    Institute of Protein Biochemistry, Naples, Italy
    Biochim Biophys Acta 1834:1932-8. 2013
  10. pmc Structure, function and molecular adaptations of haemoglobins of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Marconi 12, I 80125 Naples, Italy
    Biochem J 389:297-306. 2005

Collaborators

Detail Information

Publications33

  1. doi request reprint The adaptation of polar fishes to climatic changes: Structure, function and phylogeny of haemoglobin
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, Naples, Italy
    IUBMB Life 60:29-40. 2008
    ..Current climate change may disturb adaptation, calling for strategies aimed at neutralising threats to biodiversity...
  2. pmc Low affinity PEGylated hemoglobin from Trematomus bernacchii, a model for hemoglobin-based blood substitutes
    Daniela Coppola
    Department of Biochemistry and Molecular Biology, University of Parma, Parma, Italy
    BMC Biochem 12:66. 2011
    ..These recent findings call for the biotechnological development of stable, low-affinity PEGylated hemoglobins with low NO dioxygenase reactivity...
  3. ncbi request reprint The hemoglobins of fishes living at polar latitudes - current knowledge on structural adaptations in a changing environment
    Cinzia Verde
    Institute of Protein Biochemistry, Naples, Italy
    Curr Protein Pept Sci 9:578-90. 2008
    ..The occurrence of bis-histidyl and penta-coordinate states in ferric forms of polar fish hemoglobins suggests additional redox properties...
  4. ncbi request reprint The evolution of thermal adaptation in polar fish
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Gene 385:137-45. 2006
    ....
  5. doi request reprint ATP regulation of the ligand-binding properties in temperate and cold-adapted haemoglobins. X-ray structure and ligand-binding kinetics in the sub-Antarctic fish Eleginops maclovinus
    Daniela Coppola
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Mol Biosyst 8:3295-304. 2012
    ..maclovinus, whose life-style varies according to changes in habitat, the mechanisms that regulate O(2) affinity and the ATP-induced Root effect differ from those of high-Antarctic Notothenioids...
  6. pmc Correlation between hemichrome stability and the root effect in tetrameric hemoglobins
    Alessandro Vergara
    Department of Chemistry, University of Naples Federico II, Complesso Universitario Monte S Angelo, Naples, Italy
    Biophys J 97:866-74. 2009
    ....
  7. ncbi request reprint Hemoglobin structure/function and globin-gene evolution in the Arctic fish Liparis tunicatus
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Gene 406:58-68. 2007
    ..Close phylogenetic relationships between Cottoidei and Notothenioidei, together with their life style, seem to be the main factor driving the globin-sequence evolution...
  8. doi request reprint The globins of cold-adapted Pseudoalteromonas haloplanktis TAC125: from the structure to the physiological functions
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Naples, Italy
    Adv Microb Physiol 63:329-89. 2013
    ....
  9. doi request reprint Ligand-rebinding kinetics of 2/2 hemoglobin from the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
    Roberta Russo
    Institute of Protein Biochemistry, Naples, Italy
    Biochim Biophys Acta 1834:1932-8. 2013
    ..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  10. pmc Structure, function and molecular adaptations of haemoglobins of the polar cartilaginous fish Bathyraja eatonii and Raja hyperborea
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Marconi 12, I 80125 Naples, Italy
    Biochem J 389:297-306. 2005
    ..Such evidence suggests that, in temperate and polar habitats, physiological adaptations have evolved along distinct pathways, whereas, in this case, the effect of the differences characterizing the two polar environments is negligible...
  11. doi request reprint Spectroscopic and crystallographic characterization of a tetrameric hemoglobin oxidation reveals structural features of the functional intermediate relaxed/tense state
    Luigi Vitagliano
    Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, I 80134 Naples, Italy
    J Am Chem Soc 130:10527-35. 2008
    ..The implications of the present findings have also been discussed in the wider context of tetrameric Hbs...
  12. ncbi request reprint Biogeography and adaptation of Notothenioid fish: hemoglobin function and globin-gene evolution
    Guido Di Prisco
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Gene 398:143-55. 2007
    ..Adaptation of the oxygen-transport system in notothenioids seems to be based on evolutionary changes involving levels of biological organisation higher than the structure of hemoglobin...
  13. pmc Biophysical characterisation of neuroglobin of the icefish, a natural knockout for hemoglobin and myoglobin. Comparison with human neuroglobin
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Naples, Italy
    PLoS ONE 7:e44508. 2012
    ..Despite subtle differences, the adaptation of Antarctic fish neuroglobins does not seem to parallel the dramatic adaptation of the oxygen carrying globins, hemoglobin and myoglobin, in the same organisms...
  14. doi request reprint Spectroscopic and crystallographic characterization of bis-histidyl adducts in tetrameric hemoglobins
    Alessandro Vergara
    Department of Chemistry and Consorzio Bioteknet, University of Naples Federico II, Naples, Italy
    Methods Enzymol 436:425-44. 2008
    ..Here we review the methodological approaches adopted to achieve these results, the main structural features of these states, and the current hypotheses on their possible functional implications...
  15. doi request reprint The hemoglobins of the sub-Antarctic fish Cottoperca gobio, a phyletically basal species--oxygen-binding equilibria, kinetics and molecular dynamics
    Daniela Giordano
    Institute of Protein Biochemistry, National Research Council CNR, Naples, Italy
    FEBS J 276:2266-77. 2009
    ..Molecular dynamic simulations of C. gobio Hb1 were performed on the dimeric protein in order to obtain a better understanding of the molecular basis of structure/function relationships...
  16. doi request reprint Ligand- and proton-linked conformational changes of the ferrous 2/2 hemoglobin of Pseudoalteromonas haloplanktis TAC125
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Naples, Italy
    IUBMB Life 63:566-73. 2011
    ..In addition, at temperatures above the physiological temperature of 1 °C, an enhanced tendency of the protein to oxidize is observed...
  17. ncbi request reprint The oxygen transport system in three species of the boreal fish family Gadidae. Molecular phylogeny of hemoglobin
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    J Biol Chem 281:22073-84. 2006
    ....
  18. ncbi request reprint The evolution of polar fish hemoglobin: a phylogenetic analysis of the ancestral amino acid residues linked to the root effect
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Marconi 12, 1 80125 Naples, Italy
    J Mol Evol 57:S258-67. 2003
    ....
  19. ncbi request reprint Minimal structural requirements for root effect: crystal structure of the cathodic hemoglobin isolated from the antarctic fish Trematomus newnesi
    Lelio Mazzarella
    Dipartimento di Chimica, Universita degli Studi di Napoli Federico II, Naples, Italy
    Proteins 62:316-21. 2006
    ....
  20. ncbi request reprint The truncated hemoglobins in the Antarctic psychrophilic bacterium Pseudoalteromonas haloplanktis TAC125
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Gene 398:69-77. 2007
    ..Phylogenetic analyses show that two truncated globins encoded by the PSHAa0030 and PSHAa2217 genes belong to group II, and the third one encoded by PSHAa0458 to group I...
  21. doi request reprint Antarctic bacterial haemoglobin and its role in the protection against nitrogen reactive species
    Daniela Coppola
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, Naples, Italy
    Biochim Biophys Acta 1834:1923-31. 2013
    ..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  22. doi request reprint Polymerization of hemoglobins in Arctic fish: Lycodes reticulatus and Gadus morhua
    Alessia Riccio
    Institute of Protein Biochemistry, CNR, Naples, Italy
    IUBMB Life 63:346-54. 2011
    ..The widespread occurrence of the polymerization phenomenon displayed by hemoglobins of Arctic fish supports the hypothesis that this feature may bea response to stressful environmental conditions...
  23. pmc Structure and function of the Gondwanian hemoglobin of Pseudaphritis urvillii, a primitive notothenioid fish of temperate latitudes
    Cinzia Verde
    Institute of Protein Biochemistry, National Research Council, Naples, Italy
    Protein Sci 13:2766-81. 2004
    ..This conformation may lead to the hemichrome form identified by spectroscopy in the Met state, which likely fulfils a potentially important physiological role...
  24. doi request reprint Molecular adaptations in Antarctic fish and marine microorganisms
    Daniela Giordano
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, I 80131 Naples, Italy
    Mar Genomics 6:1-6. 2012
    ....
  25. ncbi request reprint Structure/function and phylogeny of hemoglobins of polar fishes
    Cinzia Verde
    Institute of Protein Biochemistry, CNR, Via Marconi 12, I 80125 Naples, Italy
    Micron 35:77-80. 2004
    ....
  26. doi request reprint Hemoglobin is present as a canonical α2β2 tetramer in dopaminergic neurons
    Roberta Russo
    Institute of Protein Biochemistry, CNR, Via Pietro Castellino 111, Naples, Italy
    Biochim Biophys Acta 1834:1939-43. 2013
    ..This article is part of a Special Issue entitled: Oxygen Binding and Sensing Proteins. ..
  27. ncbi request reprint The functionally distinct hemoglobins of the Arctic spotted wolffish Anarhichas minor
    Cinzia Verde
    Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche, Via Marconi 12, I 80125 Naples, Italy
    J Biol Chem 277:36312-20. 2002
    ..The oxygen transport system of A. minor differs remarkably from those of Antarctic Notothenioidei, indicating distinct evolutionary pathways in the regulatory mechanisms of the fish respiratory system in the two polar environments...
  28. doi request reprint Understanding and protecting the world's biodiversity: the role and legacy of the SCAR programme "Evolution and Biodiversity in the Antarctic"
    Guido Di Prisco
    Institute of Protein Biochemistry, National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy
    Mar Genomics 8:3-8. 2012
    ..These programmes are the legacy of EBA, and they are key to understanding and protect Antarctic biodiversity...
  29. doi request reprint Comparative and evolutionary genomics of globin genes in fish
    Enrico Negrisolo
    Department of Public Health, Comparative Pathology, and Veterinary Hygiene, University of Padova, Legnaro, Italy
    Methods Enzymol 436:511-38. 2008
    ..Internet resources for analyzing sequence alignments and annotations and new bioinformatic tools to address critical problems are thoroughly discussed...
  30. pmc Structural characterization of ferric hemoglobins from three antarctic fish species of the suborder notothenioidei
    Alessandro Vergara
    Department of Chemistry, University of Naples Federico II, Complesso Universitario Monte S Angelo, I 80126 Naples, Italy
    Biophys J 93:2822-9. 2007
    ..Altogether the data show that ferric states commonly associated with monomeric and dimeric Hbs are also found in tetrameric Hbs...
  31. doi request reprint Inferring evolution of fish proteins: the globin case study
    Agnes Dettai
    UMR, Departement Systematique et Evolution, Museum national d histoire naturelle, Paris, France
    Methods Enzymol 436:539-70. 2008
    ..These residues, mapped on the three-dimensional Hb structure, can provide insights into functional and structural divergence...
  32. ncbi request reprint High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: the role of histidine residues in modulating the strength of the root effect
    Lelio Mazzarella
    Dipartimento di Chimica, Universita degli Studi di Napoli Federico II, Complesso Universitario di Monte S Angelo, Via Cinthia, I 80126 Naples, Italy
    Proteins 65:490-8. 2006
    ....
  33. pmc Structural-functional characterization of the cathodic haemoglobin of the conger eel Conger conger: molecular modelling study of an additional phosphate-binding site
    Mariagiuseppina Pellegrini
    Department of Sciences Applied to Biosystems, University of Cagliari, Cittadella Universitaria, I 09042 Monserrato Ca, Italy
    Biochem J 372:679-86. 2003
    ....