Gian Luigi Russo

Summary

Affiliation: Institute of Food Science
Country: Italy

Publications

  1. pmc Ovothiol isolated from sea urchin oocytes induces autophagy in the Hep-G2 cell line
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, Avellino 83100, Italy
    Mar Drugs 12:4069-85. 2014
  2. pmc Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation
    C Spagnuolo
    Institute of Food Sciences, National Research Council, 83100 Avellino 83100 Avellino, Italy
    Br J Cancer 105:221-30. 2011
  3. pmc Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients
    M Russo
    Institute of Food Sciences, National Research Council, Avellino 83100, Italy
    Br J Cancer 103:642-8. 2010
  4. doi request reprint Quercetin: a pleiotropic kinase inhibitor against cancer
    Gian Luigi Russo
    Istituto Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, 83100, Avellino, Italy
    Cancer Treat Res 159:185-205. 2014
  5. ncbi request reprint AMP-activated protein kinase: a target for old drugs against diabetes and cancer
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 86:339-50. 2013
  6. ncbi request reprint Ins and outs of apoptosis in cardiovascular diseases
    G L Russo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Nutr Metab Cardiovasc Dis 13:291-300. 2003
  7. ncbi request reprint Ins and outs of dietary phytochemicals in cancer chemoprevention
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 74:533-44. 2007
  8. ncbi request reprint Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 77:937-46. 2009
  9. doi request reprint The flavonoid quercetin in disease prevention and therapy: facts and fancies
    Maria Russo
    Institute of Food Sciences, National Research Council, Avellino, Italy
    Biochem Pharmacol 83:6-15. 2012
  10. doi request reprint ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation
    Maria Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 85:927-36. 2013

Collaborators

Detail Information

Publications22

  1. pmc Ovothiol isolated from sea urchin oocytes induces autophagy in the Hep-G2 cell line
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, Avellino 83100, Italy
    Mar Drugs 12:4069-85. 2014
    ..The proliferation of normal human embryonic lung cells is not affected by ovothiol A. These results hint at ovothiol as a promising bioactive molecule from marine organisms able to inhibit cell proliferation in cancer cells. ..
  2. pmc Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation
    C Spagnuolo
    Institute of Food Sciences, National Research Council, 83100 Avellino 83100 Avellino, Italy
    Br J Cancer 105:221-30. 2011
    ..Therefore, we investigate here whether the sensitising activity of this flavonoid, which leads to increased apoptosis in both cell lines and CLL, could be related to Mcl-1 expression and stability...
  3. pmc Quercetin induced apoptosis in association with death receptors and fludarabine in cells isolated from chronic lymphocytic leukaemia patients
    M Russo
    Institute of Food Sciences, National Research Council, Avellino 83100, Italy
    Br J Cancer 103:642-8. 2010
    ....
  4. doi request reprint Quercetin: a pleiotropic kinase inhibitor against cancer
    Gian Luigi Russo
    Istituto Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, 83100, Avellino, Italy
    Cancer Treat Res 159:185-205. 2014
    ..Among the different substrates triggered by quercetin, we have reviewed the ability of the molecule to inhibit protein kinases involved in deregulated cell growth in cancer cells. ..
  5. ncbi request reprint AMP-activated protein kinase: a target for old drugs against diabetes and cancer
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 86:339-50. 2013
    ..We also discuss how the activation of AMPK by naturally occurring compounds could help to prevent the development of numerous chronic diseases contributing in such a way to the well-being of ageing population. ..
  6. ncbi request reprint Ins and outs of apoptosis in cardiovascular diseases
    G L Russo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Nutr Metab Cardiovasc Dis 13:291-300. 2003
    ..The aim of this paper is to review the most recent data concerning the role of apoptosis in CVD, concentrating on the key apoptotic pathways in cardiomyocytes that may represent potential targets for therapeutic interventions...
  7. ncbi request reprint Ins and outs of dietary phytochemicals in cancer chemoprevention
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 74:533-44. 2007
    ..Single molecules may evolve in perfect chemopreventive agents, as in the case of tamoxifen, or generate ambiguity. Resveratrol and quercetin represent two paradoxes, discussed here...
  8. ncbi request reprint Dietary n-6 and n-3 polyunsaturated fatty acids: from biochemistry to clinical implications in cardiovascular prevention
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 77:937-46. 2009
    ....
  9. doi request reprint The flavonoid quercetin in disease prevention and therapy: facts and fancies
    Maria Russo
    Institute of Food Sciences, National Research Council, Avellino, Italy
    Biochem Pharmacol 83:6-15. 2012
    ..The design of specific clinical trials is extremely warranted to depict possible applications of quercetin in adjuvant cancer therapy...
  10. doi request reprint ABT-737 resistance in B-cells isolated from chronic lymphocytic leukemia patients and leukemia cell lines is overcome by the pleiotropic kinase inhibitor quercetin through Mcl-1 down-regulation
    Maria Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 85:927-36. 2013
    ..The same mechanism was confirmed in B-cells. These results may open new clinical perspectives based on a translational approach in CLL therapy...
  11. doi request reprint Dietary polyphenols in cancer prevention: the example of the flavonoid quercetin in leukemia
    Carmela Spagnuolo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Ann N Y Acad Sci 1259:95-103. 2012
    ..Considering the low toxicity of the flavonoids toward normal peripheral blood cells, our experimental results are in favor of a potential use of quercetin in adjuvant chemotherapy in CLL or other types of cancer...
  12. ncbi request reprint Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Calpha
    Maria Russo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy
    Oncogene 22:3330-42. 2003
    ..Our data confirm the involvement of specific PKC isoforms in CD95 signaling and suggest, for the first time, that quercetin targets this pathway increasing apoptogenic response in a cell line resistant to CD95-mediated apoptosis...
  13. pmc Phytochemicals in cancer prevention and therapy: truth or dare?
    Maria Russo
    Institute of Food Sciences, National Research Council, 83100, Avellino, Italy
    Toxins (Basel) 2:517-51. 2010
    ..Nevertheless, the preliminary results are promising and raise solid foundations for future investigations...
  14. ncbi request reprint Antioxidant and cytotoxic properties of lyophilized beer extracts on HL-60 cell line
    Idolo Tedesco
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Nutr Cancer 52:74-83. 2005
    ..These data, together with the low in vivo beer toxicity reported in the literature, suggest a possible chemopreventive role for this beverage that requires further studies in animal models...
  15. doi request reprint Exploring death receptor pathways as selective targets in cancer therapy
    Maria Russo
    Institute of Food Sciences, National Research Council, 83100 Avellino, Italy
    Biochem Pharmacol 80:674-82. 2010
    ..The present review focuses on new insights in the signalling and clinical application of TNF, CD95 and TRAIL receptors...
  16. ncbi request reprint Toxicity of melanin-free ink of Sepia officinalis to transformed cell lines: identification of the active factor as tyrosinase
    Gian Luigi Russo
    Institute of Food Science, National Research Council, Avellino, Italy
    Biochem Biophys Res Commun 308:293-9. 2003
    ..Overall, these results disclose a hitherto unrecognized property of tyrosinase that may lead to a reappraisal of its biological significance beyond that of a mere pigment producing enzyme...
  17. doi request reprint Cellular adaptive response to chronic radiation exposure in interventional cardiologists
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, Via Roma 64, Avellino, Italy
    Eur Heart J 33:408-14. 2012
    ....
  18. ncbi request reprint The effects of radiation exposure on interventional cardiologists
    Gian Luigi Russo
    Institute of FoodSciences, National Research Council, Avellino, Italy
    Eur Heart J 33:423-4. 2012
    ..Professional exposure of interventional cardiologist to low-dose radiation prompts cellular changes that may protect from harm...
  19. doi request reprint Commentary on 'resveratrol commonly displays hormesis: occurrence and biomedical significance'
    Idolo Tedesco
    Institute of Food Sciences, National Research Council, Avellino, Italy
    Hum Exp Toxicol 29:1029-31. 2010
    ..Overall, we encourage colleagues working in this field to read the present review and consider its relevant biological implications. The vision of Calabrese et al. is far too important to be ignored...
  20. ncbi request reprint Valproic acid sensitizes K562 erythroleukemia cells to TRAIL/Apo2L-induced apoptosis
    Giuseppe Iacomino
    Institute of Food Sciences, National Research Council, Avellino, Italy
    Anticancer Res 28:855-64. 2008
    ..In recent years, the clinical application of HDACi has been largely explored for their ability to modulate gene transcription, block cell division cycle, inhibit cell proliferation, induce cellular differentiation and apoptosis...
  21. ncbi request reprint Effects of histone deacetylase inhibitors on p55CDC/Cdc20 expression in HT29 cell line
    Giuseppe Iacomino
    Institute of Food Sciences, National Research Council, 83100, Avellino, Italy
    J Cell Biochem 99:1122-31. 2006
    ..Taken together, these results suggest that targeting molecules involved in spindle mitotic checkpoint, such as p55CDC/Cdc20, might account for the high cytotoxicity of HDAC inhibitors versus malignant cells...
  22. ncbi request reprint A marine diatom-derived aldehyde induces apoptosis in copepod and sea urchin embryos
    Giovanna Romano
    Stazione Zoologica Anton Dohrn Villa Comunale, I 80121 Naples, Italy
    J Exp Biol 206:3487-94. 2003
    ....