Affiliation: Institute for Cancer Research and Treatment
- Apoptosis to necrosis switching downstream of apoptosome formation requires inhibition of both glycolysis and oxidative phosphorylation in a BCL-X(L)- and PKB/AKT-independent fashionD Gramaglia
Division of Molecular Oncology, Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
Cell Death Differ 11:342-53. 2004..Apoptosis is not blocked per se by ATP depletion, as engagement of the Fas receptor directly activates caspases, thus bypassing ddFSK inhibition...
- Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatinAndrea Rasola
Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
Cancer Res 64:1744-50. 2004..This suggests that HGF may be used to improve response to chemotherapy in a set of human ovarian carcinomas molecularly classified based on the MET oncogene expression...
- Genes regulated by hepatocyte growth factor as targets to sensitize ovarian cancer cells to cisplatinMartina Olivero
Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Torino School of Medicine, SP 142, Km 3 95, 10060, Candiolo Torino, Italy
Mol Cancer Ther 5:1126-35. 2006..We also provide the proof-of-concept that the identified genes might be targeted to either increase the efficacy of chemotherapeutics or revert chemotherapy resistance...
- p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosisNadia Coltella
Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Italy
Int J Cancer 118:2981-90. 2006..Therefore, the p38 MAPK pathway might be a suitable target to improve response to conventional chemotherapy in human ovarian cancer...
- Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosisMichela Fassetta
Division of Molecular Oncology, University of Torino Medical School, Candiolo, Italy
Cell Signal 18:1967-76. 2006..Both p38 MAPK and HGF/HGFR signaling constitute potential molecular targets for inhibiting colorectal carcinogenesis...
- A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activityFederica Chiara
Ludwig Institute for Cancer Research, Box 595, Uppsala S 751 24, Sweden
J Biol Chem 279:42516-27. 2004..Our findings support a model whereby an activating point mutation results in a deregulated PDGFRbeta with oncogenic predisposition...
- The mitochondrial permeability transition pore and its involvement in cell death and in disease pathogenesisAndrea Rasola
CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padua, Italy
Apoptosis 12:815-33. 2007..Here we review basic concepts about PTP structure, function and regulation within the framework of intracellular death signalling, and its role in disease pathogenesis...
- Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitroMauricio G Martin
VIB and Department of Human Genetics, Catholic University of Leuven, B 3000 Leuven, Belgium
Mol Biol Cell 19:2101-12. 2008....
- Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channelsFederica Chiara
CNR Institute of Neuroscience and Department of Biomedical Sciences, University of Padova, Padova, Italy
PLoS ONE 3:e1852. 2008..These findings have profound implications for our understanding of the pathways of outer mitochondrial membrane permeabilization and their inactivation in tumors...