Research Topics
Genomes and Genes
| Luca PrimoSummaryAffiliation: Institute for Cancer Research and Treatment Country: Italy Publications
| Collaborators
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Detail Information
Publications
Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membraneLuca Primo
Department of Clinical and Biological Sciences and Oncological Sciences, University of Torino, and Institute for Cancer Research and Treatment, Candiolo, Turin, Italy
Cancer Res 70:5759-69. 2010....
Identification of CD36 molecular features required for its in vitro angiostatic activityLuca Primo
Institute for Cancer Research and Treatment, Candiolo, and School of Medicine, University of Torino, Italy
FASEB J 19:1713-5. 2005..These results identify specific amino acids of the C-terminal cytoplasmic tail of CD36 crucial for the in vitro angiostatic activity of TSP-1 and extend our knowledge of regulation of VEGFR-2-mediated biological activities on ECs...
Essential role of PDK1 in regulating endothelial cell migrationLuca Primo
Department of Oncological Sciences, University of Torino, 10060 Candiolo, Italy
J Cell Biol 176:1035-47. 2007..These findings establish a mechanism for the spatial localization of PDK1 and its substrate Akt to regulate directional migration...- 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent mannerPaolo Armando Gagliardi
Institute for Cancer Research and Treatment, Candiolo, Italy
Neoplasia 14:719-31. 2012..In summary, these results suggest that PDK1 may contribute to breast cancer, even in the absence of PI3K oncogenic mutations and through both Akt-dependent and Akt-independent mechanisms... - The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85βRoberto Sessa
Institute for Cancer Research and Treatment, Candiolo, Italy
Biochim Biophys Acta 1823:1925-35. 2012..Our findings suggest that miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation... - Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2Alessio Noghero
Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
Arterioscler Thromb Vasc Biol 32:2280-8. 2012..In the endothelium, perturbations of cell cholesterol have an impact on fundamental processes. We, therefore, assessed the effects of LXR activation on endothelial functions related to angiogenesis in vitro and in vivo... - Protein kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and endothelial cell migrationLaura di Blasio
Institute for Cancer Research and Treatment, Candiolo, Italy
Traffic 11:1107-18. 2010..These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions... - Class 3 semaphorins control vascular morphogenesis by inhibiting integrin functionGuido Serini
Division of Molecular Angiogenesis, IRCC, Institute for Cancer Research and Treatment, and Department of Oncological Sciences, University of Torino School of Medicine, 10060 Candiolo, TO, Italy
Nature 424:391-7. 2003..Sema3a null mice show vascular defects as well. Thus during angiogenesis endothelial SEMA3 proteins endow the vascular system with the plasticity required for its reshaping by controlling integrin function... - Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanismCristina Roca
Department of Oncological Sciences, School of Medicine, University of Torino, 10060 Candiolo, Italy
Cancer Res 63:1500-7. 2003..These results indicate that heat-mediated PAI-1 induction is an important pathway by which HT exerts its antitumor activity and may represent a rationale for a combined cancer therapy based on HT associated with antiangiogenic molecules... - Unraveling the influence of endothelial cell density on VEGF-A signalingLucia Napione
Institute for Cancer Research and Treatment, Torino, Italy
Blood 119:5599-607. 2012..Our data-based mathematical model quantitatively describes VEGF signaling in quiescent and angiogenic endothelium and is suitable to identify new molecular determinants and therapeutic targets... - Vasculogenic potential of long term repopulating cord blood progenitorsSara Droetto
Division of Molecular Angiogenesis, I R C C, Strada Provinciale 142, Km 3 95, Candiolo TO, Italy
FASEB J 18:1273-5. 2004.... - IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanismLucia Napione
Department of Oncological Sciences, Institute for Cancer Research and Treatment, University of Torino, 10060, Candiolo, Torino, Italy
Angiogenesis 15:713-25. 2012.... - Amphoteric agmatine containing polyamidoamines as carriers for plasmid DNA in vitro and in vivo deliveryRoberta Cavalli
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, via P Giuria 9, Turin, Italy
Biomacromolecules 11:2667-74. 2010..DNA/AGMA10 polyplex intravenously administered to mice promoted gene expression in liver but not in other organs without detectable toxic side effects... - Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope proteinSerena Marchio
Division of Molecular Angiogenesis, Department of Oncological Sciences, University of Turin Medicine School, Institute for Cancer Research and Treatment, SP 142, km 3 95 10060 Candiolo TO Italy
Blood 105:2802-11. 2005..Our data demonstrate that membrane-associated Tat is a novel modulator of virus entry and suggest that the Tat-gp120 interaction represents a critical step in HIV-1 spreading during the course of infection... - Gorham-Stout syndrome: a monocyte-mediated cytokine propelled diseaseSilvia Colucci
Istituto di Anatomia Umana Normale, , Bari, Italy
J Bone Miner Res 21:207-18. 2006..These data suggest that cells of monocyte-macrophage lineage play an essential role in the pathogenesis of Gorham-Stout disease, whose progression is propelled by cytokine circuits that accelerate angiogenesis and osteoclastogenesis...