Luca Primo

Summary

Affiliation: Institute for Cancer Research and Treatment
Country: Italy

Publications

  1. doi request reprint Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membrane
    Luca Primo
    Department of Clinical and Biological Sciences and Oncological Sciences, University of Torino, and Institute for Cancer Research and Treatment, Candiolo, Turin, Italy
    Cancer Res 70:5759-69. 2010
  2. ncbi request reprint Identification of CD36 molecular features required for its in vitro angiostatic activity
    Luca Primo
    Institute for Cancer Research and Treatment, Candiolo, and School of Medicine, University of Torino, Italy
    FASEB J 19:1713-5. 2005
  3. pmc Essential role of PDK1 in regulating endothelial cell migration
    Luca Primo
    Department of Oncological Sciences, University of Torino, 10060 Candiolo, Italy
    J Cell Biol 176:1035-47. 2007
  4. pmc 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner
    Paolo Armando Gagliardi
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Neoplasia 14:719-31. 2012
  5. ncbi request reprint The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β
    Roberto Sessa
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Biochim Biophys Acta 1823:1925-35. 2012
  6. doi request reprint Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2
    Alessio Noghero
    Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
    Arterioscler Thromb Vasc Biol 32:2280-8. 2012
  7. doi request reprint Modeling human tumor angiogenesis in a three-dimensional culture system
    Giorgio Seano
    Institute for Cancer Research and Treatment at Candiolo, University of Torino, Turin, Italy
    Blood 121:e129-37. 2013
  8. doi request reprint Protein kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and endothelial cell migration
    Laura di Blasio
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Traffic 11:1107-18. 2010
  9. ncbi request reprint Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
    Guido Serini
    Division of Molecular Angiogenesis, IRCC, Institute for Cancer Research and Treatment, and Department of Oncological Sciences, University of Torino School of Medicine, 10060 Candiolo, TO, Italy
    Nature 424:391-7. 2003
  10. ncbi request reprint Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism
    Cristina Roca
    Department of Oncological Sciences, School of Medicine, University of Torino, 10060 Candiolo, Italy
    Cancer Res 63:1500-7. 2003

Collaborators

Detail Information

Publications16

  1. doi request reprint Increased expression of alpha6 integrin in endothelial cells unveils a proangiogenic role for basement membrane
    Luca Primo
    Department of Clinical and Biological Sciences and Oncological Sciences, University of Torino, and Institute for Cancer Research and Treatment, Candiolo, Turin, Italy
    Cancer Res 70:5759-69. 2010
    ....
  2. ncbi request reprint Identification of CD36 molecular features required for its in vitro angiostatic activity
    Luca Primo
    Institute for Cancer Research and Treatment, Candiolo, and School of Medicine, University of Torino, Italy
    FASEB J 19:1713-5. 2005
    ..These results identify specific amino acids of the C-terminal cytoplasmic tail of CD36 crucial for the in vitro angiostatic activity of TSP-1 and extend our knowledge of regulation of VEGFR-2-mediated biological activities on ECs...
  3. pmc Essential role of PDK1 in regulating endothelial cell migration
    Luca Primo
    Department of Oncological Sciences, University of Torino, 10060 Candiolo, Italy
    J Cell Biol 176:1035-47. 2007
    ..These findings establish a mechanism for the spatial localization of PDK1 and its substrate Akt to regulate directional migration...
  4. pmc 3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner
    Paolo Armando Gagliardi
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Neoplasia 14:719-31. 2012
    ..In summary, these results suggest that PDK1 may contribute to breast cancer, even in the absence of PI3K oncogenic mutations and through both Akt-dependent and Akt-independent mechanisms...
  5. ncbi request reprint The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85β
    Roberto Sessa
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Biochim Biophys Acta 1823:1925-35. 2012
    ..Our findings suggest that miR-126-mediated phosphoinositide-3-kinase regulation, not only fine-tunes VEGF-signaling, but it strongly enhances the activities of Ang-1 on vessel stabilization and maturation...
  6. doi request reprint Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2
    Alessio Noghero
    Institute for Cancer Research and Treatment IRCC, Candiolo, Italy
    Arterioscler Thromb Vasc Biol 32:2280-8. 2012
    ..In the endothelium, perturbations of cell cholesterol have an impact on fundamental processes. We, therefore, assessed the effects of LXR activation on endothelial functions related to angiogenesis in vitro and in vivo...
  7. doi request reprint Modeling human tumor angiogenesis in a three-dimensional culture system
    Giorgio Seano
    Institute for Cancer Research and Treatment at Candiolo, University of Torino, Turin, Italy
    Blood 121:e129-37. 2013
    ..The human arterial ring assay bridges the gap between in vitro endothelial cell and animal model, and is a powerful system for identification of genes and drugs that regulate human angiogenesis...
  8. doi request reprint Protein kinase D1 regulates VEGF-A-induced alphavbeta3 integrin trafficking and endothelial cell migration
    Laura di Blasio
    Institute for Cancer Research and Treatment, Candiolo, Italy
    Traffic 11:1107-18. 2010
    ..These results suggest that PKD1-regulated alphavbeta3 trafficking contributes to the angiogenesis process by integrating VEGF-A signaling with extracellular matrix interactions...
  9. ncbi request reprint Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function
    Guido Serini
    Division of Molecular Angiogenesis, IRCC, Institute for Cancer Research and Treatment, and Department of Oncological Sciences, University of Torino School of Medicine, 10060 Candiolo, TO, Italy
    Nature 424:391-7. 2003
    ..Sema3a null mice show vascular defects as well. Thus during angiogenesis endothelial SEMA3 proteins endow the vascular system with the plasticity required for its reshaping by controlling integrin function...
  10. ncbi request reprint Hyperthermia inhibits angiogenesis by a plasminogen activator inhibitor 1-dependent mechanism
    Cristina Roca
    Department of Oncological Sciences, School of Medicine, University of Torino, 10060 Candiolo, Italy
    Cancer Res 63:1500-7. 2003
    ..These results indicate that heat-mediated PAI-1 induction is an important pathway by which HT exerts its antitumor activity and may represent a rationale for a combined cancer therapy based on HT associated with antiangiogenic molecules...
  11. doi request reprint Unraveling the influence of endothelial cell density on VEGF-A signaling
    Lucia Napione
    Institute for Cancer Research and Treatment, Torino, Italy
    Blood 119:5599-607. 2012
    ..Our data-based mathematical model quantitatively describes VEGF signaling in quiescent and angiogenic endothelium and is suitable to identify new molecular determinants and therapeutic targets...
  12. ncbi request reprint Vasculogenic potential of long term repopulating cord blood progenitors
    Sara Droetto
    Division of Molecular Angiogenesis, I R C C, Strada Provinciale 142, Km 3 95, Candiolo TO, Italy
    FASEB J 18:1273-5. 2004
    ....
  13. doi request reprint IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism
    Lucia Napione
    Department of Oncological Sciences, Institute for Cancer Research and Treatment, University of Torino, 10060, Candiolo, Torino, Italy
    Angiogenesis 15:713-25. 2012
    ....
  14. doi request reprint Amphoteric agmatine containing polyamidoamines as carriers for plasmid DNA in vitro and in vivo delivery
    Roberta Cavalli
    Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, via P Giuria 9, Turin, Italy
    Biomacromolecules 11:2667-74. 2010
    ..DNA/AGMA10 polyplex intravenously administered to mice promoted gene expression in liver but not in other organs without detectable toxic side effects...
  15. ncbi request reprint Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein
    Serena Marchio
    Division of Molecular Angiogenesis, Department of Oncological Sciences, University of Turin Medicine School, Institute for Cancer Research and Treatment, SP 142, km 3 95 10060 Candiolo TO Italy
    Blood 105:2802-11. 2005
    ..Our data demonstrate that membrane-associated Tat is a novel modulator of virus entry and suggest that the Tat-gp120 interaction represents a critical step in HIV-1 spreading during the course of infection...
  16. ncbi request reprint Gorham-Stout syndrome: a monocyte-mediated cytokine propelled disease
    Silvia Colucci
    Istituto di Anatomia Umana Normale, Universita di Bari, Bari, Italy
    J Bone Miner Res 21:207-18. 2006
    ..We found that these cells belonged to a monocytic lineage with some characteristics of immature osteoclasts and were able to release large amounts of osteoclastogenic and angiogenic molecules that may contribute to disease progression...