Claudio Passino

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi request reprint Right heart overload contributes to cardiac natriuretic hormone elevation in patients with heart failure
    Claudio Passino
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Int J Cardiol 104:39-45. 2005
  2. ncbi request reprint Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP immunoassays in chronic and acute heart failure: a systematic review
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, Department of Cardiovascular Medicine, Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 53:813-22. 2007
  3. doi request reprint Abnormal hyperventilation in patients with hepatic cirrhosis: role of enhanced chemosensitivity to carbon dioxide
    Claudio Passino
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 154:22-6. 2012
  4. ncbi request reprint C-type natriuretic peptide expression in patients with chronic heart failure: effects of aerobic training
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    Eur J Cardiovasc Prev Rehabil 15:168-72. 2008
  5. ncbi request reprint Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    J Am Coll Cardiol 47:1835-9. 2006
  6. ncbi request reprint Persistence of baroreceptor control of cerebral blood flow velocity at a simulated altitude of 5000 m
    Claudio Passino
    Department of Internal Medicine, University of Pavia and IRCCS S Matteo, Pavia, and Department of Internal Medicine, Unita Ospedaliera S Maria Nuova, Firenze, Italy
    J Hypertens 25:1862-70. 2007
  7. ncbi request reprint Neuro-hormonal activation predicts ventilatory response to exercise and functional capacity in patients with heart failure
    Claudio Passino
    CNR Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy
    Eur J Heart Fail 8:46-53. 2006
  8. ncbi request reprint Ventricular repolarization in hypertension: beyond Bazett
    Claudio Passino
    Department of Cardiovascular Medicine, CNR Institute of Clinical Physiology, Pisa, Italy
    Am J Hypertens 21:9. 2008
  9. doi request reprint Clinical relevance of non-cardiac determinants of natriuretic peptide levels
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 46:1515-23. 2008
  10. ncbi request reprint Abnormal ventricular repolarization in hypertensive patients: role of sympatho-vagal imbalance and left ventricular hypertrophy
    Claudio Passino
    Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy
    Int J Cardiol 97:57-62. 2004

Detail Information

Publications76

  1. ncbi request reprint Right heart overload contributes to cardiac natriuretic hormone elevation in patients with heart failure
    Claudio Passino
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Int J Cardiol 104:39-45. 2005
    ..We assessed the hypothesis that right ventricular (RV) overload might significantly contribute to plasma elevation of cardiac natriuretic hormones in patients with heart failure...
  2. ncbi request reprint Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP immunoassays in chronic and acute heart failure: a systematic review
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, Department of Cardiovascular Medicine, Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 53:813-22. 2007
    ..We used evidence-based laboratory medicine principles to compare the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terminal part of the propeptide of BNP (NT-proBNP) assays for the diagnosis of heart failure...
  3. doi request reprint Abnormal hyperventilation in patients with hepatic cirrhosis: role of enhanced chemosensitivity to carbon dioxide
    Claudio Passino
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 154:22-6. 2012
    ..The aim of the study was to determine whether altered chemosensitivity either to hypoxia or hypercapnia could underlie inappropriate hyperventilation in cirrhotic patients...
  4. ncbi request reprint C-type natriuretic peptide expression in patients with chronic heart failure: effects of aerobic training
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    Eur J Cardiovasc Prev Rehabil 15:168-72. 2008
    ..Endothelial dysfunction, commonly observed in chronic heart failure (HF) patients is positively affected by physical training...
  5. ncbi request reprint Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure
    Claudio Passino
    Cardiovascular Medicine Department, CNR Institute of Clinical Physiology, Pisa, Italy
    J Am Coll Cardiol 47:1835-9. 2006
    ..We sought to evaluate the effect of physical training on neurohormonal activation in patients with heart failure (HF)...
  6. ncbi request reprint Persistence of baroreceptor control of cerebral blood flow velocity at a simulated altitude of 5000 m
    Claudio Passino
    Department of Internal Medicine, University of Pavia and IRCCS S Matteo, Pavia, and Department of Internal Medicine, Unita Ospedaliera S Maria Nuova, Firenze, Italy
    J Hypertens 25:1862-70. 2007
    ..To assess the effects of acute exposure to simulated high altitude on baroreflex control of mean cerebral blood flow velocity (MCFV)...
  7. ncbi request reprint Neuro-hormonal activation predicts ventilatory response to exercise and functional capacity in patients with heart failure
    Claudio Passino
    CNR Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy
    Eur J Heart Fail 8:46-53. 2006
    ..Heart failure (HF) is characterised by reduced tolerance to effort, associated with progressive fatigue and dyspnoea. Neuro-hormonal activation is a hallmark of HF and influences its clinical evolution...
  8. ncbi request reprint Ventricular repolarization in hypertension: beyond Bazett
    Claudio Passino
    Department of Cardiovascular Medicine, CNR Institute of Clinical Physiology, Pisa, Italy
    Am J Hypertens 21:9. 2008
  9. doi request reprint Clinical relevance of non-cardiac determinants of natriuretic peptide levels
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 46:1515-23. 2008
    ..Because several of these diseases may be present in patients with left ventricular dysfunction, the possible influence on diagnostic and prognostic accuracy of natriuretic peptides in heart failure will be discussed...
  10. ncbi request reprint Abnormal ventricular repolarization in hypertensive patients: role of sympatho-vagal imbalance and left ventricular hypertrophy
    Claudio Passino
    Institute of Clinical Physiology, National Research Council, Via Moruzzi 1, 56124 Pisa, Italy
    Int J Cardiol 97:57-62. 2004
    ..To investigate the influence of autonomic imbalance and LVH on QT interval in hypertensive patients, we compared two different models of LVH: hypertension and endurance physical training...
  11. doi request reprint B-type natriuretic peptide secretion following scuba diving
    Claudio Passino
    Department of Cardiovascular Medicine, Fondazione G Monasterio, Pisa, Italy
    Biomark Med 5:205-9. 2011
    ..To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor...
  12. ncbi request reprint Ventricular repolarization is prolonged in nondipper hypertensive patients: role of left ventricular hypertrophy and autonomic dysfunction
    Claudio Passino
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Hypertens 21:445-51. 2003
    ..The aim of this study was to investigate the influence of circadian behavior of blood pressure, left ventricular hypertrophy, and autonomic function on QTc interval duration in untreated hypertensive patients...
  13. doi request reprint Prognostic value of plasma renin activity in heart failure
    Giuseppe Vergaro
    Division of Cardiovascular Medicine, Fondazione Toscana G Monasterio, Pisa, Italy
    Am J Cardiol 108:246-51. 2011
    ..PRA might help to select those patients needing an enhanced therapeutic effort, possibly targeting incomplete renin-angiotensin-aldosterone system blockade...
  14. doi request reprint Low triiodothyronine and exercise capacity in heart failure
    Marianna Fontana
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 154:153-7. 2012
    ....
  15. ncbi request reprint Comparison of brain natriuretic peptide (BNP) and amino-terminal ProBNP for early diagnosis of heart failure
    Michele Emdin
    CNR Institute of Clinical Physiology, Cardiovascular Medicine Department and Cardiovascular Endocrinology Laboratory, Pisa, Italy
    Clin Chem 53:1289-97. 2007
    ..We compared the diagnostic accuracy of brain natriuretic peptide (BNP) and amino-terminal proBNP (NT-proBNP) for diagnosis of preclinical and mild heart failure (HF)...
  16. doi request reprint Natriuretic peptide testing in primary care patients
    Michele Emdin
    Cardiovascular Medicine Department, G Monasterio Foundation, CNR Regione Toscana, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 46:1533-42. 2008
    ..Its implementation in this setting in screening programs and diagnostic algorithms might contribute to decrease the apparent disparity between the general practitioner and the specialist approach to disease management...
  17. doi request reprint Prognostic value of combined measurement of brain natriuretic peptide and triiodothyronine in heart failure
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    J Card Fail 15:35-40. 2009
    ..Both low free triiodothyronine (fT3) and high brain natriuretic peptide (BNP) have been separately described as prognostic predictors for mortality in heart failure (HF). We investigated whether their prognostic value is independent...
  18. ncbi request reprint Analytical performance and diagnostic accuracy of immunometric assays for the measurement of plasma B-type natriuretic peptide (BNP) and N-terminal proBNP
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 51:445-7. 2005
  19. ncbi request reprint Clinical significance of chemosensitivity in chronic heart failure: influence on neurohormonal derangement, Cheyne-Stokes respiration and arrhythmias
    Alberto Giannoni
    Department of Cardiovascular Medicine, Institute of Clinical Physiology, 56124 Pisa, Italy
    Clin Sci (Lond) 114:489-97. 2008
    ....
  20. doi request reprint Risk factors and prognostic value of daytime Cheyne-Stokes respiration in chronic heart failure patients
    Roberta Poletti
    Cardiovascular Medicine Department and Cardiovascular Endocrinology Laboratory, Foundation G Monasterio, CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 137:47-53. 2009
    ..We aimed to study the prevalence, clinical correlates, risk factors and prognostic relevance of daytime CS, as well as its relation with neurohormonal derangement...
  21. doi request reprint Atrial fibrillation and amino-terminal pro-brain natriuretic peptide as independent predictors of prognosis in systolic heart failure
    Frank Lloyd Dini
    Unità Operativa Malattie Cardiovascolari 2, Ospedale Santa Chiara, Pisa, Italy
    Int J Cardiol 140:344-50. 2010
    ....
  22. ncbi request reprint Cardiac natriuretic hormones, neuro-hormones, thyroid hormones and cytokines in normal subjects and patients with heart failure
    Michele Emdin
    Laboratory of Cardiovascular Endocrinology and Cell Biology, C N R Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 42:627-36. 2004
    ....
  23. doi request reprint Silent myocardial damage in cocaine addicts
    Giovanni Donato Aquaro
    UO Risonanza Magnetica and UO Malattie cardiovascolari, Fondazione G Monasterio Regione Toscana CNR, Pisa, Italy
    Heart 97:2056-62. 2011
    ..The prevalence of myocardial damage in asymptomatic addicts has never been evaluated by cardiovascular magnetic resonance (CMR), which allows non-invasive detection of myocardial oedema and fibrosis...
  24. doi request reprint Combined increased chemosensitivity to hypoxia and hypercapnia as a prognosticator in heart failure
    Alberto Giannoni
    Department of Cardiovascular Medicine, G Monasterio Foundation CNR Regione Toscana and CNR Institute of Clinical Physiology, Pisa, Italy
    J Am Coll Cardiol 53:1975-80. 2009
    ..The aim of the present study was to investigate the prognostic significance of chemosensitivity to hypercapnia in chronic heart failure (HF)...
  25. doi request reprint Cardiovascular risk factors and gamma-glutamyltransferase fractions in healthy individuals
    Maria Franzini
    Scuola Superiore S Anna, Pisa, Italy
    Clin Chem Lab Med 48:713-7. 2010
    ..Our goal was to identify the determinants of the GGT fractions (b-, m-, s-, and f-GGT) and their association with established cardiovascular risk factors in healthy subjects...
  26. ncbi request reprint Comparison of a fully automated immunoassay with a point-of-care testing method for B-type natriuretic peptide
    Concetta Prontera
    Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    Clin Chem 51:1274-6. 2005
  27. doi request reprint Myocardial fibrosis as a key determinant of left ventricular remodeling in idiopathic dilated cardiomyopathy: a contrast-enhanced cardiovascular magnetic study
    Pier Giorgio Masci
    Fondazione CNR Regione Toscana G Monasterio, Pisa, Italy
    Circ Cardiovasc Imaging 6:790-9. 2013
    ..In idiopathic dilated cardiomyopathy, there are scarce data on the influence of late gadolinium enhancement (LGE) assessed by cardiovascular magnetic resonance on left ventricular (LV) remodeling...
  28. ncbi request reprint Radioimmunoassay for plasma C-type natriuretic peptide determination: a methodological evaluation
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 43:641-5. 2005
    ..0001 and p = 0.001, respectively). The sensitivity, accuracy and variability levels of the method proposed for CNP assay was suitable for reliable detection of changes in CNP plasma levels in the clinical setting...
  29. doi request reprint Correlates and reference limits of plasma gamma-glutamyltransferase fractions from the Framingham Heart Study
    Maria Franzini
    Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chim Acta 417:19-25. 2013
    ..We assessed GGT fractions correlates and their reference values in the Offspring Cohort of the Framingham Heart Study...
  30. doi request reprint Effect of acute administration of vitamin C on muscle sympathetic activity, cardiac sympathovagal balance, and baroreflex sensitivity in hypertensive patients
    Rosa M Bruno
    Department of Internal Medicine, University Hospital of Pisa, Italy
    Am J Clin Nutr 96:302-8. 2012
    ..Essential hypertension is characterized by both increased oxidative stress and sympathetic traffic. Experimental studies have shown that reactive oxygen species can modulate autonomic activity...
  31. ncbi request reprint C-type natriuretic peptide plasma levels increase in patients with chronic heart failure as a function of clinical severity
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Eur J Heart Fail 7:1145-8. 2005
    ..corrected] C-type natriuretic peptide (CNP), secreted by the endothelium and the heart, is structurally related to atrial and brain natriuretic peptides, but its clinical significance in chronic heart failure (CHF) is controversial...
  32. ncbi request reprint Analytical performance and diagnostic accuracy of a fully-automated electrochemiluminescent assay for the N-terminal fragment of the pro-peptide of brain natriuretic peptide in patients with cardiomyopathy: comparison with immunoradiometric assay methods
    Concetta Prontera
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Clin Chem Lab Med 42:37-44. 2004
    ....
  33. ncbi request reprint Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure
    Cristina Vassalle
    Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Clin Chem 53:1886-90. 2007
    ..Despite the importance of NPs in heart failure (HF), the role of these polymorphisms in HF has not been evaluated...
  34. ncbi request reprint [Cheyne-Stokes respiration and heart failure: pathophysiological and clinical implications]
    Marianna Fontana
    UOC Medicina Cardiovascolare, Fondazione G Monasterio CNR Regione Toscana, Pisa
    Recenti Prog Med 100:458-64. 2009
    ....
  35. doi request reprint Influence of preload and afterload on stroke volume response to low-dose dobutamine stress in patients with non-ischemic heart failure: a cardiac MR study
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Pisa, Italy
    Int J Cardiol 166:475-81. 2013
    ..However, the role of the afterload and preload in SV changes is underestimated. The aim of the study was to investigate the effects of LDD on preload reserve and afterload in patients with non-ischemic heart failure...
  36. doi request reprint Myocardial delayed enhancement in paucisymptomatic nonischemic dilated cardiomyopathy
    Pier Giorgio Masci
    Fondazione G Monasterio CNR, Regione Toscana, Pisa, Italy
    Int J Cardiol 157:43-7. 2012
    ..We investigated the prognostic role of myocardial fibrosis by delayed enhancement (DE) cardiovascular magnetic resonance (CMR) in nonischemic dilated cardiomyopathy (NICM) patients with no or mild symptoms of heart failure (HF)...
  37. doi request reprint Comparison of NT-proCNP and CNP plasma levels in heart failure, diabetes and cirrhosis patients
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Regul Pept 166:15-20. 2011
    ..Due to its higher analytical feasibility, this determination could become widespread in clinical biochemistry laboratories and serve as a complementary marker of disease conditions...
  38. ncbi request reprint Influence of gender on circulating cardiac natriuretic hormones in patients with heart failure
    Michele Emdin
    Department of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Clin Chem Lab Med 41:686-92. 2003
    ....
  39. ncbi request reprint Cardiac production of C-type natriuretic peptide in heart failure
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 7:397-9. 2006
    ..In light of the difficulty in recruiting patients with these characteristics, this kind of study can be performed with a small number of subjects...
  40. ncbi request reprint Reduced hypoxic ventilatory response with preserved blood oxygenation in yoga trainees and Himalayan Buddhist monks at altitude: evidence of a different adaptive strategy?
    Luciano Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS Ospedale S Matteo, Pavia, Italy
    Eur J Appl Physiol 99:511-8. 2007
    ..Respiratory adaptations induced by the practice of yoga may represent an efficient strategy to cope with altitude-induced hypoxia...
  41. ncbi request reprint Markers of arrhythmogenic risk in hypertensive subjects
    Andrea Barison
    Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Curr Pharm Des 17:3062-73. 2011
    ....
  42. ncbi request reprint The significance of serum gamma-glutamyltransferase in cardiovascular diseases
    Alfonso Pompella
    Department of Experimental Pathology, University of Pisa Medical School, Pisa, Italy
    Clin Chem Lab Med 42:1085-91. 2004
    ..Further insights into potential therapeutic interest will probably be derived from studies investigating the origin of GGT activity in plaque tissue...
  43. doi request reprint Old and new biomarkers of heart failure
    Michele Emdin
    Cardiovascular Medicine Department, G Monasterio Foundation, CNR Regione Toscana, 56124 Pisa, Italy
    Eur J Heart Fail 11:331-5. 2009
    ....
  44. ncbi request reprint Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 290:H17-29. 2006
    ....
  45. ncbi request reprint Effects of physical training on cardiovascular control after heart transplantation
    Luciano Bernardi
    Department of Internal Medicine, IRCCS Policlinico S Matteo, University of Pavia, Italy
    Int J Cardiol 118:356-62. 2007
    ..We tested the effects of physical training on baroreceptors-mediated control of heart rate and blood pressure in recently heart-transplanted subjects...
  46. doi request reprint When the heart is burning: amino-terminal pro-brain natriuretic peptide as an early marker of cardiac involvement in active autoimmune rheumatic disease
    Alberto Giannoni
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Regione Toscana, Pisa, Italy Scuola Superiore S Anna, Pisa, Italy
    Int J Cardiol 148:161-7. 2011
    ..We evaluated the influence of inflammation on cardiac endocrine function in autoimmune rheumatic disease (RD) patients with preserved left ventricular systolic function...
  47. doi request reprint Additive prognostic value of gamma-glutamyltransferase in coronary artery disease
    Michele Emdin
    Cardiovascular Medicine Department, Foundation G Monasterio, CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 136:80-5. 2009
    ..However, to-date its value has not been compared with C-reactive protein (CRP) and other indexes in a multimarker prognostic strategy in patients with coronary artery disease...
  48. doi request reprint Systematic differences between BNP immunoassays: comparison of methods using standard protocols and quality control materials
    Maria Franzini
    Scuola Superiore Sant Anna, Pisa, Italy Department of Laboratory Medicine, Fondazione Toscana G Monasterio, Pisa, Italy Electronic address
    Clin Chim Acta 424:287-91. 2013
    ..In this study we compared the BNP data and clinical results obtained with different immunoassays, including a new method (ST-AIA-PACK, TOSOH Corporation)...
  49. doi request reprint Prognostic value of plasma renin activity in heart failure patients with chronic kidney disease
    Roberta Poletti
    Division of Cardiovascular Medicine, Fondazione G Monasterio, CNR Regione Toscana, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    Int J Cardiol 167:711-5. 2013
    ..It correlates with clinical and neurohormonal status, and affects prognosis. We aimed to identify the prognostic impact of plasma renin activity (PRA) in patients affected by CHF with chronic kidney disease (CKD)...
  50. doi request reprint Accuracy of b-GGT fraction for the diagnosis of non-alcoholic fatty liver disease
    Maria Franzini
    Scuola Superiore Sant Anna, Pz Martiri della Libertà 33, Pisa, Italy
    Liver Int 32:629-34. 2012
    ..Serum gamma-glutamyltransferase (GGT) activity is a sensitive but non-specific marker of non-alcoholic fatty liver disease (NAFLD). Recently, four GGT fractions (big-, medium-, small-, free-GGT) were described in humans...
  51. doi request reprint Effect of acetazolamide on chemosensitivity, Cheyne-Stokes respiration, and response to effort in patients with heart failure
    Marianna Fontana
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Am J Cardiol 107:1675-80. 2011
    ..However, it is associated with reduced maximal workload achieved during effort and increased chemosensitivity to hypercapnia, inducing a reduction in the ventilatory efficiency...
  52. ncbi request reprint Clinical relevance of biological variation: the lesson of brain natriuretic peptide (BNP) and NT-proBNP assay
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 44:366-78. 2006
    ..While awaiting more accurate studies, we suggest that variations of plasma BNP three-fold greater than the analytical imprecision should be considered as potentially relevant from a physiological and clinical point of view...
  53. ncbi request reprint Recommendations for the clinical use of cardiac natriuretic peptides
    Michele Emdin
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Ital Heart J 6:430-46. 2005
  54. ncbi request reprint Analytical performance and clinical results of a fully automated MEIA system for brain natriuretic peptide assay: comparison with a point of care testing method
    Simona Storti
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 42:1178-85. 2004
    ..Then, different reference values, as well as cut-off values, should be taken into account for the clinical use of these two immunoassays...
  55. ncbi request reprint C-type natriuretic peptide and heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology, National Research Council Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    Pharmacol Res 54:326-33. 2006
    ..In fact, CNP may represent an important new local autocrine and endocrine mediator in CHF although further evaluations are required to define its full pathophysiological role in this disease...
  56. ncbi request reprint [An atypical case of cardiac amyloidosis]
    Alberto Giannoni
    UOC Medicina Cardiovascolare e RM Lab, Fondazione G Monasterio CNR Regione Toscana, Pisa
    Recenti Prog Med 100:247-52. 2009
    ..However, after cardiac magnetic resonance, the typical amyloidotic pattern is found and the final diagnosis of multiple myeloma is made at osteomedullary biopsy...
  57. ncbi request reprint Circulating forms of the b-type natriuretic peptide prohormone: pathophysiologic and clinical considerations
    Aldo Clerico
    Fondazione G Monasterio, CNR Regione Toscana, Pisa, Italy
    Adv Clin Chem 58:31-44. 2012
    ....
  58. doi request reprint Measurement of the pro-hormone of brain type natriuretic peptide (proBNP): methodological considerations and pathophysiological relevance
    Aldo Clerico
    Scuola Superiore Sant Anna, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Clin Chem Lab Med 49:1949-54. 2011
    ....
  59. ncbi request reprint Images in cardiovascular medicine. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity
    Aldo Paolicchi
    Department of Experimental Pathology, University of Pisa, Pisa, Italy
    Circulation 109:1440. 2004
  60. doi request reprint Different substrates of non-sustained ventricular tachycardia in post-infarction patients with and without left ventricular dilatation
    Gianluca Di Bella
    CNR, Institute of Clinical Physiology, G Monasterio Foundation, Pisa, Italy
    J Card Fail 16:61-8. 2010
    ..We investigated the relationship between nonsustained ventricular tachycardia (NSVT) and left ventricular (LV) dilatation, function, remodeling, and scar tissue extent in patients with previous myocardial infarction (MI)...
  61. doi request reprint Clinical relevance of time course of BNP levels in neonates with congenital heart diseases
    Massimiliano Cantinotti
    Fondazione CNR Regione Toscana G Monasterio and Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chim Acta 412:2300-4. 2011
    ....
  62. doi request reprint New and emerging biomarkers of heart failure
    Aldo Clerico
    G Monasterio Foundation, Institute of Clinical Physiology National Research Council and Scuola Superiore di Studi Universitari e Perfezionamento Sant Anna, Pisa 56126, Italy
    Crit Rev Clin Lab Sci 46:107-28. 2009
    ..Finally, we present a scheme to search for more efficient diagnostic and prognostic biomarkers for HF...
  63. doi request reprint Thirty years of the heart as an endocrine organ: physiological role and clinical utility of cardiac natriuretic hormones
    Aldo Clerico
    Laboratory of Cardiovascular Endocrinology and Cell Biology, Fondazione CNR Regione Toscana G Monasterio, Scuola Superiore Sant Anna, Via Trieste 41, 56126 Pisa, Italy
    Am J Physiol Heart Circ Physiol 301:H12-20. 2011
    ..Finally, we will review the pathophysiological role and the clinical relevance of both peripheral maturation of the precursor of B-type natriuretic peptides and hormone signal transduction...
  64. ncbi request reprint [The prognostic role of gamma-glutamyltransferase for cardiovascular events]
    Michele Emdin
    Unità Operativa Medicina Cardiovascolare, Istituto di Fisiologia Clinica, CNR, Pisa
    Recenti Prog Med 97:241-5. 2006
    ....
  65. ncbi request reprint [Recommendations for the clinical use of cardiac natriuretic peptides]
    Michele Emdin
    Istituto di Fisiologia Clinica del CNR, Pisa
    Ital Heart J Suppl 6:308-25. 2005
  66. doi request reprint Predictive value of elevated neutrophil-lymphocyte ratio on cardiac mortality in patients with stable coronary artery disease
    Angela Papa
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Clin Chim Acta 395:27-31. 2008
    ..Our aim was to analyze the predictive ability for cardiac events of differential WBC, which is still not well characterized, against established risk factors in angiographically proven CAD patients...
  67. ncbi request reprint Serum gamma-glutamyl transpeptidase: a prognostic marker in cardiovascular diseases
    Michele Emdin
    CNR Institute of Clinical Physiology, Via G Moruzzi 1, Pisa, Italy
    Biofactors 17:199-205. 2003
  68. doi request reprint Single-shot cardiorenal scintigraphy with 99mTc-tetrofosmin: a dynamic characterization at rest and during adenosine infusion
    Enza Fommei
    Gabriele Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    J Nucl Med 50:1288-95. 2009
    ....
  69. ncbi request reprint Frequency-dependent baroreflex control of blood pressure and heart rate during physical exercise
    Giammario Spadacini
    Dipartimento di Medicina Interna IRCCS S Matteo and University of Pavia, Italy
    Int J Cardiol 107:171-9. 2006
    ..We hypothesised that this uncertainty arose from the differing responses of the vagus (fast) and sympathetic (slow) arms of the autonomic effectors, and to differing sympatho-vagal balance at different exercise intensities...
  70. ncbi request reprint Serum gamma-glutamyltransferase as a risk factor of ischemic stroke might be independent of alcohol consumption
    Michele Emdin
    Stroke 33:1163-4. 2002
  71. ncbi request reprint Respiratory and cerebrovascular responses to hypoxia and hypercapnia in familial dysautonomia
    Luciano Bernardi
    New York University Medical Center, New York University School of Medicine, New York, USA
    Am J Respir Crit Care Med 167:141-9. 2003
    ..Higher resting BP delays occurrence of syncope during hypoxia. Therapeutic measures preventing hypoxia/hypocapnia may correct cardiovascular accidents in patients with FD...
  72. ncbi request reprint Natriuretic peptides (NPs): Automated electrochemiluminescent immunoassay for N-terminal pro-BNP compared with IRMAs for ANP and BNP in heart failure patients and healthy individuals
    Concetta Prontera
    Clin Chem 49:1552-4. 2003
  73. ncbi request reprint Ventilation, autonomic function, sleep and erythropoietin. Chronic mountain sickness of Andean natives
    Luciano Bernardi
    Clinica Medica 2, IRCCS S Matteo, University of Pavia, Italy
    Adv Exp Med Biol 543:161-75. 2003
    ..Improving oxygenation can represent a possible therapeutic option for this syndrome...
  74. ncbi request reprint Beta-lipoprotein- and LDL-associated serum gamma-glutamyltransferase in patients with coronary atherosclerosis
    Aldo Paolicchi
    Department of Experimental Pathology, Dip di Patologia Sperimentale and B M I E, University of Pisa Medical School, Scuola Medica, Via Roma 55, 56126 Pisa, Italy
    Atherosclerosis 186:80-5. 2006
    ..05) and healthy subjects with elevated serum GGT (p<0.01). In addition, a relative decrease of total serum GGT was observed in CAD subjects of older age as compared to younger ones (p<0.005)...
  75. doi request reprint Fractions of plasma gamma-glutamyltransferase in healthy individuals: reference values
    Maria Franzini
    Clin Chim Acta 395:188-9. 2008
  76. ncbi request reprint Gamma-glutamyltransferase as a cardiovascular risk factor
    Michele Emdin
    Eur Heart J 27:2145-6. 2006