Giovanni Pacini

Summary

Affiliation: Institute of Biomedical Engineering
Country: Italy

Publications

  1. doi In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype
    Donal J O'Gorman
    Metabolic Research Unit, Department of Endocrinology, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    Diabetes Res Clin Pract 80:365-70. 2008
  2. doi Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Neurosciences IN CNR, Corso Stati Uniti 4, 35127 Padova, Italy Electronic address
    Peptides 71:66-71. 2015
  3. pmc Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery
    G Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padova, Italy
    Int J Endocrinol 2012:247392. 2012
  4. pmc Methods and models for metabolic assessment in mice
    G Pacini
    Metabolic Unit, ISIB CNR, Padua, Italy
    J Diabetes Res 2013:986906. 2013
  5. ncbi The hyperbolic equilibrium between insulin sensitivity and secretion
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Nutr Metab Cardiovasc Dis 16:S22-7. 2006
  6. doi Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Am J Physiol Regul Integr Comp Physiol 296:R1316-24. 2009
  7. doi Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Metabolism 59:988-92. 2010
  8. ncbi Methods for clinical assessment of insulin sensitivity and beta-cell function
    Giovanni Pacini
    Metabolic Modeling Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Best Pract Res Clin Endocrinol Metab 17:305-22. 2003
  9. pmc Progression to type 2 diabetes in women with former gestational diabetes: time trajectories of metabolic parameters
    Andrea Tura
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    PLoS ONE 7:e50419. 2012
  10. doi Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models
    Andrea Tura
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Metabolism 61:434-43. 2012

Collaborators

Detail Information

Publications68

  1. doi In vivo and in vitro studies of GAD-antibody positive subjects with Type 2 diabetes: A distinct sub-phenotype
    Donal J O'Gorman
    Metabolic Research Unit, Department of Endocrinology, St James s Hospital, Trinity College Dublin, Dublin 8, Ireland
    Diabetes Res Clin Pract 80:365-70. 2008
    ..TCC formation may be partly responsible for the insulin secretory dysfunction associated with this specific sub-type of Type 2 diabetes...
  2. doi Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Neurosciences IN CNR, Corso Stati Uniti 4, 35127 Padova, Italy Electronic address
    Peptides 71:66-71. 2015
    ..This shows that the risk of a marked insulinotropic action when the two compounds are given together most likely does not result in increased risk of hypoglycemia. ..
  3. pmc Incretin Effect in Women with Former Gestational Diabetes within a Short Period after Delivery
    G Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, 35127 Padova, Italy
    Int J Endocrinol 2012:247392. 2012
    ..Therefore, the diminished IE of fGDM seems to reflect an early abnormality of the general beta-cell dysfunction in the progression toward type 2 diabetes...
  4. pmc Methods and models for metabolic assessment in mice
    G Pacini
    Metabolic Unit, ISIB CNR, Padua, Italy
    J Diabetes Res 2013:986906. 2013
    ..Finally, a list of previous applications of these methods and analytical techniques is provided to better comprehend their use and the evidences that these studies yielded...
  5. ncbi The hyperbolic equilibrium between insulin sensitivity and secretion
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Nutr Metab Cardiovasc Dis 16:S22-7. 2006
    ....
  6. doi Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Am J Physiol Regul Integr Comp Physiol 296:R1316-24. 2009
    ..This easily usable formula for calculating CS(I) overcomes many experimental obstacles and may be a simple alternative to more complex procedures when large numbers of mice or repeated experiments in the same animals are required...
  7. doi Dissociated effects of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide-1 on beta-cell secretion and insulin clearance in mice
    Giovanni Pacini
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Metabolism 59:988-92. 2010
    ..However, the action of GIP is less effective than that of GLP-1. Insulin clearance with GIP is not significantly reduced. We conclude that GIP is less potent than GLP-1 in inducing glucose-stimulated hyperinsulinemia in the mouse...
  8. ncbi Methods for clinical assessment of insulin sensitivity and beta-cell function
    Giovanni Pacini
    Metabolic Modeling Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Best Pract Res Clin Endocrinol Metab 17:305-22. 2003
    ..Particular attention is paid to the oral glucose tolerance test, which has recently received considerable interest. The role of mathematical models in IS and BCF assessment is also emphasized...
  9. pmc Progression to type 2 diabetes in women with former gestational diabetes: time trajectories of metabolic parameters
    Andrea Tura
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    PLoS ONE 7:e50419. 2012
    ..In conclusion, in fGDM, marked deterioration of insulin sensitivity is associated with diabetes onset. Prevention strategies aimed at opposing to the insulin sensitivity derangement may be particularly beneficial...
  10. doi Estimation of prehepatic insulin secretion: comparison between standardized C-peptide and insulin kinetic models
    Andrea Tura
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Metabolism 61:434-43. 2012
    ..The insulin-based ISR method compares favorably with the C-peptide approach. The method will be particularly useful in data sets lacking C-peptide to assess β-cell function through models requiring prehepatic secretion...
  11. pmc Adequately adapted insulin secretion and decreased hepatic insulin extraction cause elevated insulin concentrations in insulin resistant non-diabetic adrenal incidentaloma patients
    Christian Heinz Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria Metabolic Unit, Institute of Biomedical Engineering, National Research Council ISIB CNR, Padua, Italy Mariahilf Community Pharmacy, Arnoldstein, Austria Medical Direction, Specialized Hospital Complex Agathenhof, Micheldorf, Austria
    PLoS ONE 8:e77326. 2013
    ..Insulin-resistance is commonly found in adrenal incidentaloma (AI) patients. However, little is known about beta-cell secretion in AI, because comparisons are difficult, since beta-cell-function varies with altered insulin-sensitivity...
  12. ncbi Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT
    Andrea Tura
    Metabolic Unit, ISIB CNR, Corso Stati Uniti, Padova, Italy
    Diabetes Res Clin Pract 72:298-301. 2006
    ..However, the weaker correlation of the C-peptide index with the more accurate index from the IVGTT suggests that it should be used with caution. The index at 60 min can be used as surrogate of IGI, but not the indices at 90 and 120 min...
  13. pmc Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity
    Christian Anderwald
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Diabetes Care 34:437-41. 2011
    ..Thus, we aimed to evaluate short-term effects of human insulin infusion on insulin secretion during normoglycemia in healthy humans and T2DM subjects of both sex...
  14. doi The augmenting effect on insulin secretion by oral versus intravenous glucose is exaggerated by high-fat diet in mice
    Bo Ahren
    Department of Clinical Sciences, Lund University, BMC B11, SE 221 84 Lund, Sweden Metabolic Unit, Institute of Biomedical Engineering ISIB CNR, Padova, Italy
    J Endocrinol 197:181-7. 2008
    ....
  15. doi Shape of glucose, insulin, C-peptide curves during a 3-h oral glucose tolerance test: any relationship with the degree of glucose tolerance?
    Andrea Tura
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Am J Physiol Regul Integr Comp Physiol 300:R941-8. 2011
    ..WHOSH(CP) (WHole-Ogtt-SHape-index) may be a powerful index of β-cell function much simpler than model-based indices...
  16. pmc Whole-body insulin sensitivity rather than body-mass-index determines fasting and post-glucose-load growth hormone concentrations
    Christian Heinz Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria Metabolic Unit, Institute of Biomedical Engineering, National Research Council ISIB CNR, Padua, Italy Mariahilf Community Pharmacy, Arnoldstein, Austria Medical Direction, Specialized Hospital Complex Agathenhof, Micheldorf, Austria
    PLoS ONE 9:e115184. 2014
    ..However, this finding has never been studied with regard to whole-body insulin-sensitivity as a possible regulator...
  17. pmc Sodium concentration measurement during hemodialysis through ion-exchange resin and conductivity measure approach: in vitro experiments
    Andrea Tura
    Institute of Biomedical Engineering, National Research Council, Padova, Italy
    PLoS ONE 8:e69227. 2013
    ....
  18. pmc Alterations in gastrointestinal, endocrine, and metabolic processes after bariatric Roux-en-Y gastric bypass surgery
    Christian Heinz Anderwald
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Diabetes Care 35:2580-7. 2012
    ..Roux-en-Y gastric bypass (RYGB) surgery induces excessive and continuous weight loss in (morbid) obesity, although it causes several abnormal anatomical and physiological conditions...
  19. ncbi Assessment of insulin secretion in relation to insulin resistance
    Andrea Mari
    Metabolic Modeling Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Curr Opin Clin Nutr Metab Care 8:529-33. 2005
    ..This review will discuss these concepts and the aspects that should be considered for an appropriate solution to the problem...
  20. doi Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: a randomised controlled two-centre intervention study
    Rosalba Giacco
    Institute of Food Science, National Research Council, Via Roma 64, 83100 Avellino, Italy Electronic address
    Clin Nutr 32:941-9. 2013
    ....
  21. doi No evidence of ectopic lipid accumulation in the pathophysiology of the acromegalic cardiomyopathy
    Yvonne Winhofer
    Department of Internal Medicine III, Division of Endocrinology and Metabolism Y W, P W, M Krs, A G, W R, A K W, M Kre, A L, Department of Biomedical Imaging and Image Guided Therapy, Centre of Excellence High field MR M Krš, I J K, S T, and Department of Neurosurgery S W, E K, Medical University of Vienna, A 1090 Vienna, Austria and Institute of Biomedical Engineering A T, G P, National Research Council, Metabolic Unit, I 35127 Padova, Italy
    J Clin Endocrinol Metab 99:4299-306. 2014
    ..Because insulin resistance and increased lipolysis have been linked to ectopic lipid deposition, altered lipid accumulation in the liver and the myocardium might contribute to metabolic and cardiac complications in these patients...
  22. pmc A low frequency electromagnetic sensor for indirect measurement of glucose concentration: in vitro experiments in different conductive solutions
    Andrea Tura
    ISIB CNR, Corso Stati Uniti 4, 35127 Padua, Italy
    Sensors (Basel) 10:5346-58. 2010
    ..22 mV/(mg/dL). Our proposed system may thus be useful in a new approach for non-invasive and non-contact glucose monitoring...
  23. ncbi Basal and dynamic proinsulin-insulin relationship to assess beta-cell function during OGTT in metabolic disorders
    Andrea Tura
    Metabolic Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Am J Physiol Endocrinol Metab 285:E155-62. 2003
    ..43 +/- 0.08, 0.61 +/- 0.10, and 0.56 +/- 0.03 in NGT, IGT, and T2DM subjects, respectively, P < 0.0001). Impaired beta-cell function in T2DM could then be indicated by proinsulin-to-insulin indexes at both basal and dynamic phases...
  24. doi Elevated insulin sensitivity and β-cell function during pregnancy in mothers of growth-restricted newborns
    Maria Grazia Dalfrà
    Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Am J Physiol Endocrinol Metab 301:E25-30. 2011
    ....
  25. ncbi A Markov chain probability model of glucose tolerance in post gestational diabetes follow up study
    Angela Grassi
    Institute of Biomedical Engineering, Italian National Research Council, Padova, Italy
    Stud Health Technol Inform 160:1155-9. 2010
    ..Women with normal glucose tolerance after partum will have a high probability (0.80) to be in the same state three years after...
  26. ncbi Importance of glycemic control on the course of glomerular filtration rate in type 2 diabetes with hypertension and microalbuminuria under tight blood pressure control
    Karl Thomaseth
    National Research Council, Institute of Biomedical Engineering, CNR, Corso Stati Uniti 4, 35127 Padova, Italy
    Nutr Metab Cardiovasc Dis 18:632-8. 2008
    ..5-8% threshold...
  27. doi Incretin and islet hormone responses to meals of increasing size in healthy subjects
    Wathik Alsalim
    Department of Clinical Sciences W A, B O, B A, Lund University, 221 84 Lund, Sweden and Metabolic Unit G P, R B, A M, Institute of Biomedical Engineering, Consiglio Nazionale delle Ricerche, 35127 Padova, Italy
    J Clin Endocrinol Metab 100:561-8. 2015
    ..However, how these processes dynamically adapt to demands created by caloric challenges achieved during daily life is not known...
  28. doi Incretin effect after oral amino acid ingestion in humans
    Ola Lindgren
    Department of Clinical Sciences O L, B A, Division of Medicine, Lund University, 221 84 Lund, Sweden Metabolic Unit G P, A T, Institute of Biomedical Engineering, National Research Council, 35127 Padova, Italy and Novo Nordisk Foundation Center for Basic Metabolic Research J J H, C F D, DK 2300 Copenhagen, Denmark and Department of Biomedical Sciences J J H, C F D, University of Copenhagen, DK 2400 Copenhagen, Denmark
    J Clin Endocrinol Metab 100:1172-6. 2015
    ..We previously demonstrated an augmented insulin secretion when fat is given orally rather than iv, suggesting an incretin effect also after fat. However, whether an incretin effect is also present after amino acid ingestion is not known...
  29. pmc Pathophysiological characteristics and effects of obesity in women with early and late manifestation of gestational diabetes diagnosed by the International Association of Diabetes and Pregnancy Study Groups criteria
    Latife Bozkurt
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, Unit of Gender Medicine L B, L P, K L, A L, S B P, A K W, Department of Obstetrics and Gynecology, Division of Feto Maternal Medicine C S G, D B T, Medical University of Vienna, A 1090 Vienna, Austria and Metabolic Unit G P, Institute of Biomedical Engineering, National Research Council, I 35127 Padova, Italy
    J Clin Endocrinol Metab 100:1113-20. 2015
    ..However, there are sparse data related to the newly recommended International Association of Diabetes and Pregnancy Study Groups criteria and their use in early pregnancy...
  30. doi Modeling glucose and free fatty acid kinetics during insulin-modified intravenous glucose tolerance test in healthy humans: role of counterregulatory response
    Karl Thomaseth
    Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Am J Physiol Regul Integr Comp Physiol 307:R321-31. 2014
    ....
  31. ncbi Non-invasive glucose monitoring: assessment of technologies and devices according to quantitative criteria
    Andrea Tura
    Metabolic Unit, ISIB CNR, Padua, Italy
    Diabetes Res Clin Pract 77:16-40. 2007
    ..Conclusions of the review were that, despite some interesting and promising technologies and devices, a satisfactory solution to the non-invasive glucose monitoring problem still requires further efforts...
  32. doi Effects of antidiabetic agents on pancreatic beta-cell function in gestational diabetes: is there enough evidence?
    Andrea Tura
    a CNR Institute of Neuroscience, Padova, Italy
    Expert Opin Drug Metab Toxicol 12:129-33. 2016
    ..Therefore, further studies should be carried out to clearly assess the effects on beta-cell function of the treatments in GDM women. ..
  33. doi Incretin levels in polycystic ovary syndrome
    Jana Vrbikova
    Institute of Endocrinology, Narodni 8, Prague 111694, Czech Republic
    Eur J Endocrinol 159:121-7. 2008
    ..This paper considers the secretion of GIP and GLP-1 after oral glucose load in a group of lean, glucose-tolerant PCOS women in comparison with age- and body mass index (BMI)-matched healthy women...
  34. ncbi The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus
    Edmund Cauza
    Department of Internal Medicine V, Department of Diabetes and Rheumatology, Wilhelminenspital, Vienna, Austria
    Arch Phys Med Rehabil 86:1527-33. 2005
    ..To compare the effects of a 4-month strength training (ST) versus aerobic endurance training (ET) program on metabolic control, muscle strength, and cardiovascular endurance in subjects with type 2 diabetes mellitus (T2D)...
  35. ncbi Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    Martina Kvist Reimer
    Department of Medicine, Lund University, Lund 22184, Sweden
    Endocrinology 144:916-21. 2003
    ..The effect is dependent on the dose and elicited on distal signaling steps in islet cells. The results suggest that the islet beta-cells are targets for ghrelin...
  36. ncbi The Clamp-Like Index: a novel and highly sensitive insulin sensitivity index to calculate hyperinsulinemic clamp glucose infusion rates from oral glucose tolerance tests in nondiabetic subjects
    Christian Anderwald
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Austria
    Diabetes Care 30:2374-80. 2007
    ..However, the gold standard for measuring insulin resistance, the hyperinsulinemic clamp test, is too labor intensive to be performed in large clinical studies/settings...
  37. ncbi Improved usability of the minimal model of insulin sensitivity based on an automated approach and genetic algorithms for parameter estimation
    Umberto Morbiducci
    Department of Mechanics, Universita Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy
    Clin Sci (Lond) 112:257-63. 2007
    ....
  38. ncbi Plasma ghrelin in obesity before and after weight loss after laparoscopical adjustable gastric banding
    Ursula Hanusch-Enserer
    Department of Internal Medicine, Wilhelminspital, A 1160 Vienna, Austria
    J Clin Endocrinol Metab 89:3352-8. 2004
    ..In conclusion, prolonged weight loss results in a rise of fasting ghrelin concentrations that correlates with fasting insulin concentrations but not improvement of insulin sensitivity...
  39. ncbi The effect of Ipomoea batatas (Caiapo) on glucose metabolism and serum cholesterol in patients with type 2 diabetes: a randomized study
    Bernhard H Ludvik
    Diabetes Care 25:239-40. 2002
  40. ncbi Acute alcohol consumption improves insulin action without affecting insulin secretion in type 2 diabetic subjects
    Angelo Avogaro
    Dipartimento Medicina Sperimentale Policlinico, University of Padua Medical School, Via Giustiniani 2, 35128 Padua, Italy
    Diabetes Care 27:1369-74. 2004
    ..The aim of the present study was to assess the role of acute moderate alcohol intake on insulin sensitivity and insulin secretion in comparable subjects with and without type 2 diabetes...
  41. ncbi Loss-of-function mutation of the galanin gene is associated with perturbed islet function in mice
    Bo Ahren
    Department of Medicine, Lund University, B11 Biomedical Centre, SE 221 84 Lund, Sweden
    Endocrinology 145:3190-6. 2004
    ..032). We conclude that 1) galanin may contribute to sympathetic influences inhibiting insulin secretion in mice, and 2) galanin KO mice have a reduced glucose-induced insulin secretion...
  42. ncbi Importance of quantifying insulin secretion in relation to insulin sensitivity to accurately assess beta cell function in clinical studies
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Eur J Endocrinol 150:97-104. 2004
    ..Acknowledging this inverse relationship between insulin secretion and insulin sensitivity therefore requires estimation of both variables for correct assessment in any individual...
  43. ncbi Mode of action of ipomoea batatas (Caiapo) in type 2 diabetic patients
    Bernhard Ludvik
    3rd Department of Medicine, Division of Endocrinology and Metabolism, University of Vienna, Austria
    Metabolism 52:875-80. 2003
    ..No side effects related to the treatment were observed. Thus these results indicate that Caiapo could potentially play a role in the treatment of type 2 diabetes...
  44. ncbi Increased intramyocellular lipid concentration identifies impaired glucose metabolism in women with previous gestational diabetes
    Alexandra Kautzky-Willer
    Department of Internal Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Austria
    Diabetes 52:244-51. 2003
    ..IMCL could serve as an additional parameter of increased diabetes risk because it identifies insulin-resistant pGDM and those who were diagnosed earlier and/or required insulin during pregnancy...
  45. ncbi Reduction of hepatic glycogen synthesis and breakdown in patients with agenesis of the dorsal pancreas
    Harald Stingl
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 87:4678-85. 2002
    ..3 vs. 2.8 +/- 1.0 ml/kg.min) were increased in all patients. In conclusion, patients with complete agenesis of the dorsal pancreas exhibit marked defects in hepatic glycogen metabolism, which are present even in the nondiabetic offspring...
  46. ncbi Islet function phenotype in gastrin-releasing peptide receptor gene-deficient mice
    Kristin Persson
    Department of Medicine, Lund University, Sweden
    Endocrinology 143:3717-26. 2002
    ....
  47. ncbi Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice
    Bo Ahren
    Department of Medicine, Lund University, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 283:E738-44. 2002
    ..Thus glucose intolerance induced by high-fat diet is, in early phases, solely explained by reduced glucose effectiveness, whereas insufficient early insulin secretion is of importance after long-term feeding...
  48. ncbi Beta-cell-targeted expression of a dominant-negative mutant of hepatocyte nuclear factor-1alpha in mice: diabetes model with beta-cell dysfunction partially rescued by nonglucose secretagogues
    Maria Sörhede Winzell
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Diabetes 53:S92-6. 2004
    ..In contrast, the insulin responses to nonglucose stimuli are not suppressed when the islet insulin content is taken into account...
  49. ncbi Early-onset insulin-resistant diabetes in obese Caucasians has features of typical type 2 diabetes, but 3 decades earlier
    Siobhan McQuaid
    Metabolic Research Unit, Department of Endocrinology, St James s Hospital, Dublin 8, Ireland
    Diabetes Care 28:1216-8. 2005
  50. ncbi Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1 year
    Bo Ahren
    Department of Medicine, Lund University, B11 BMC, SE 221 84 Lund, Sweden
    Diabetes Care 28:1936-40. 2005
    ..To examine the effects of dipeptidyl peptidase-IV (DPP-4) inhibition on meal-related beta-cell function and insulin sensitivity over 52 weeks in type 2 diabetes...
  51. ncbi Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation: A sign of impaired beta-cell function?
    Marietta Stadler
    Ludwig Boltzmann Institute of Metabolic Diseases and Nutrition, Vienna
    Diabetes Care 29:1031-8. 2006
    ..After successful pancreas-kidney transplantation (PKT), type 1 diabetic patients may revert to a nondiabetic metabolism without exogenous insulin therapy and re-secrete all beta-cell hormones...
  52. ncbi Impaired vascular nitric oxide bioactivity in women with previous gestational diabetes
    Johannes Pleiner
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 119:483-9. 2007
    ..The aim of this study was therefore to identify factors other than GDM that impair vascular function...
  53. ncbi Influence of metabolic control on splanchnic glucose uptake, insulin sensitivity, and the time required for glucose absorption in patients with type 1 diabetes
    Petra Georg
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, University of Vienna, Vienna, Austria
    Diabetes Care 25:2042-7. 2002
    ..We estimated SGU as well as peripheral glucose uptake and the time required for glucose absorption by a validated method, the oral glucose (OG) clamp, in type 1 diabetic patients with different levels of long-term glycemic control...
  54. ncbi Visfatin response to glucose is reduced in women with gestational diabetes mellitus
    Dominik G Haider
    Department of Clinical Pharmacology, Medical University of Vienna, Allgemeines Krankenhaus Wien, A 1090 Vienna, Austria
    Diabetes Care 30:1889-91. 2007
  55. ncbi Insulin resistance as a determinant of platelet activation in obese women
    Stefania Basili
    Department of Medical Therapy, University of Rome La Sapienza, Rome, Italy
    J Am Coll Cardiol 48:2531-8. 2006
    ..We tested the hypothesis that insulin resistance, per se, contributes to increased platelet activation in obesity, independently of underlying inflammation...
  56. ncbi Glucose tolerance during moderate alcohol intake: insights on insulin action from glucose/lactate dynamics
    Angelo Avogaro
    Department of Clinical and Experimental Medicine, University of Padova Medical School, 35128 Padova, Italy
    J Clin Endocrinol Metab 87:1233-8. 2002
    ..Because ETOH at moderate doses has a marked antilipolytic action, it might improve insulin action by improving substrate competition. The present findings suggest that moderate alcohol consumption in the diet should not be discouraged...
  57. ncbi Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association
    Gianfranco Pagano
    Department of Internal Medicine, University of Turin, Turin, Italy
    Hepatology 35:367-72. 2002
    ..The derangement of insulin regulation, often associated with the metabolic syndrome, may play a causal role in the pathogenesis of NASH...
  58. ncbi The role of endocrine counterregulation for estimating insulin sensitivity from intravenous glucose tolerance tests
    Attila Brehm
    Division of Endocrinology and Metabolism, Department of Internal Medicine 3, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Clin Endocrinol Metab 91:2272-8. 2006
    ..During insulin-modified frequently sampled iv glucose tolerance tests (IM-FSIGT), which allow assessment of insulin action, plasma glucose can markedly decrease...
  59. ncbi Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women
    Mario Romano
    Department of Medicine and Aging, University of Chieti G D Annunzio, School of Medicine, 66013 Chieti, Italy
    J Clin Endocrinol Metab 88:5321-6. 2003
    ..The elevated TGF-beta 1 levels detected in the obese population may provide a biochemical link between insulin resistance and an increased risk for cardiovascular disease...
  60. ncbi Efficacy of Ipomoea batatas (Caiapo) on diabetes control in type 2 diabetic subjects treated with diet
    Bernhard Ludvik
    Department of Medicine III, Division of Endocrinology and Metabolism, University of Vienna, Vienna, Austria
    Diabetes Care 27:436-40. 2004
    ..To investigate the tolerability, efficacy, and mode of action of Caiapo, an extract of white sweet potatoes, on metabolic control in type 2 diabetic patients...
  61. ncbi Contributions from the first SICOD (Swedish-Italian Cooperation on Diabetes Research) meeting, Stockholm, Sweden, October 2004
    Bo Ahren
    Nutr Metab Cardiovasc Dis 16:S1-2. 2006
  62. ncbi Improvement of insulin resistance and early atherosclerosis in patients after gastric banding
    Ursula Hanusch-Enserer
    Department of Internal Medicine V, Division of Endocrinology and Metabolism, Wilhelminenspital, Vienna, Austria
    Obes Res 12:284-91. 2004
    ..To evaluate the effect of massive weight loss on insulin sensitivity, soluble adhesion molecules, and markers of the insulin resistance syndrome (IRS)...
  63. ncbi Preeclampsia in lean normotensive normotolerant pregnant women can be predicted by simple insulin sensitivity indexes
    Elena Parretti
    Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Italy
    Hypertension 47:449-53. 2006
    ..Given their high sensitivity and specificity, these indexes could be useful in predicting the development of preeclampsia in early pregnancy, before the disease become clinically evident...
  64. ncbi Hypoadiponectinemia predicts the severity of hepatic fibrosis and pancreatic Beta-cell dysfunction in nondiabetic nonobese patients with nonalcoholic steatohepatitis
    Giovanni Musso
    Department of Internal Medicine, University of Turin, Italy
    Am J Gastroenterol 100:2438-46. 2005
    ....
  65. ncbi Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice
    Maria Sörhede Winzell
    Dept of Clinical Sciences, Medicine, Lund University, BMC, B11, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 290:E347-54. 2006
    ..Furthermore, the high-fat diet partly prevents the deleterious effects of CLA/PUFA, but this dietary supplementation was not able to counteract high-fat-diet-induced insulin resistance...
  66. ncbi Relationship between serum lipoprotein ratios and insulin resistance in obesity
    Attila Brehm
    Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
    Clin Chem 50:2316-22. 2004
    ..Because these individuals are also frequently insulin resistant, this study analyzed the relationships between lipid ratios and insulin sensitivity...
  67. ncbi A strategy to enhance the usability of the minimal model as used with the intravenous glucose tolerance test in diabetes research and clinical management
    Richard Hayes
    Dublin Institute of Technology, Dublin, Ireland
    Stud Health Technol Inform 90:519-24. 2002
    ..This paper proposes a more readily available and usable version of the program and discusses the issues which surround the use of the program by clinical researchers without computer mathematical modelling experience...
  68. ncbi Plasma adiponectin, insulin sensitivity, and subclinical inflammation in women with prior gestational diabetes mellitus
    Christine Winzer
    Department of Medicine III, Vienna University Hospital, Vienna, Austria
    Diabetes Care 27:1721-7. 2004
    ....