A Natali

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. doi request reprint Effects of short and prolonged mild intracellular nitric oxide manipulations on various aspects of insulin secretion in INS-1E β-cells
    A Natali
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
    Exp Clin Endocrinol Diabetes 120:210-6. 2012
  2. doi request reprint Endothelial dysfunction in type 2 diabetes
    A Natali
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 55:1559-63. 2012
  3. ncbi request reprint Erythrocyte sedimentation rate, coronary atherosclerosis, and cardiac mortality
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Italy
    Eur Heart J 24:639-48. 2003
  4. ncbi request reprint Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels
    Andrea Natali
    Department of Internal Medicine, Via Roma 67, 56100 Pisa, Italy
    Eur Heart J 26:464-71. 2005
  5. ncbi request reprint Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes
    Andrea Natali
    Department of Internal Medicine, CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetes Care 27:1349-57. 2004
  6. doi request reprint Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function
    A Natali
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa, 56100, Italy
    Diabetologia 51:862-71. 2008
  7. doi request reprint Metabolic characteristics of prehypertension: role of classification criteria and gender
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 27:2394-402. 2009
  8. doi request reprint Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 95:4703-11. 2010
  9. ncbi request reprint Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes
    Andrea Natali
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Diabetes 55:1133-40. 2006
  10. ncbi request reprint Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients
    A Gastaldelli
    Metabolism Unit of the C.N.R. Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 50:1807-12. 2001

Collaborators

Detail Information

Publications49

  1. doi request reprint Effects of short and prolonged mild intracellular nitric oxide manipulations on various aspects of insulin secretion in INS-1E β-cells
    A Natali
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
    Exp Clin Endocrinol Diabetes 120:210-6. 2012
    ..We aimed at evaluating the impact of short and prolonged mild manipulations of intracellular nitric oxide (NO) bioavailability on the main features of insulin secretion and whether NO promotes mitochondrial biogenesis in isolated β-cells...
  2. doi request reprint Endothelial dysfunction in type 2 diabetes
    A Natali
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 55:1559-63. 2012
    ....
  3. ncbi request reprint Erythrocyte sedimentation rate, coronary atherosclerosis, and cardiac mortality
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Italy
    Eur Heart J 24:639-48. 2003
    ..To test whether the erythrocyte sedimentation rate (ESR) is related to the extension of coronary atherosclerosis (ATS) and predicts cardiac mortality...
  4. ncbi request reprint Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels
    Andrea Natali
    Department of Internal Medicine, Via Roma 67, 56100 Pisa, Italy
    Eur Heart J 26:464-71. 2005
    ..In vitro, haemoglobin neutralizes nitric oxide very effectively. Whether red blood cells participate in the regulation of endothelial function in vivo has not been established...
  5. ncbi request reprint Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes
    Andrea Natali
    Department of Internal Medicine, CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetes Care 27:1349-57. 2004
    ..The aim of this study was to test whether vascular reactivity is modified by improving metabolic control and peripheral insulin resistance in type 2 diabetes...
  6. doi request reprint Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function
    A Natali
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa, 56100, Italy
    Diabetologia 51:862-71. 2008
    ..Hyperglycaemia and hyperinsulinaemia have opposite effects on endothelium-dependent vasodilatation in microcirculation, but the net effect elicited by glucose ingestion and the separate influence of glucose tolerance are unknown...
  7. doi request reprint Metabolic characteristics of prehypertension: role of classification criteria and gender
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 27:2394-402. 2009
    ....
  8. doi request reprint Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 95:4703-11. 2010
    ..What defects in glucose metabolism are present in offspring of type 2 diabetic patients (FHD(+) with a positive family history of diabetes) and to what extent they depend on line of inheritance are uncertain...
  9. ncbi request reprint Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes
    Andrea Natali
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Diabetes 55:1133-40. 2006
    ..In type 2 diabetes, insulin resistance is associated with vascular dysfunction/damage, impaired fibrinolysis, and low-grade inflammation independently of obesity and poor glycemic control...
  10. ncbi request reprint Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients
    A Gastaldelli
    Metabolism Unit of the C.N.R. Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 50:1807-12. 2001
    ..In type 2 diabetes, the excess GNG of the fasting state is carried over to the insulinized state, thereby contributing to glucose overproduction under both conditions...
  11. doi request reprint The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy women
    Elza Muscelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Am J Hypertens 22:364-70. 2009
    ....
  12. ncbi request reprint Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approach
    A Natali
    Metabolism Unit of the Consiglio Nazionale delle Ricerche Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, 56126 Pisa, Italy
    Am J Physiol Endocrinol Metab 278:E794-801. 2000
    ....
  13. pmc Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study
    Eleni Rebelos
    Department of Internal Medicine, University of Pisa, Italy
    Diabetes 60:1938-45. 2011
    ..Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes...
  14. ncbi request reprint Insulin: new roles for an ancient hormone
    E Ferrannini
    Metabolism Unit of the C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Eur J Clin Invest 29:842-52. 1999
    ..Description and understanding of these new roles, their interactions, the interplay between insulin resistance and hyperinsulinaemia, and their implications for cardiovascular disease have only begun...
  15. doi request reprint Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy population
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa 56122, Italy
    Eur Heart J 31:1511-9. 2010
    ..This study investigated whether sedentary behaviour and different activity levels have an independent association with carotid intima-media thickness (IMT) and with the 3-year IMT progression in different carotid segments...
  16. doi request reprint Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 54:1507-16. 2011
    ..The natural history and physiological determinants of glucose intolerance in subjects living in Europe have not been investigated. The aim of this study was to increase our understanding of this area...
  17. doi request reprint Plasma glucose levels as predictors of diabetes: the Mexico City diabetes study
    E Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetologia 52:818-24. 2009
    ....
  18. ncbi request reprint Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss
    M Emdin
    Metabolism Unit and Coronary Division, CNR Institute of Clinical Physiology, and Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 103:513-9. 2001
    ..Reversal of these changes by weight loss suggests a causal role for insulin...
  19. ncbi request reprint Association of fasting glucagon and proinsulin concentrations with insulin resistance
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetologia 50:2342-7. 2007
    ..Hyperproinsulinaemia and relative hyperglucagonaemia are features of type 2 diabetes. We hypothesised that raised fasting glucagon and proinsulin concentrations may be associated with insulin resistance (IR) in non-diabetic individuals...
  20. ncbi request reprint Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance
    E Ferrannini
    Metabolism Unit, C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetologia 46:1211-9. 2003
    ..Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed...
  21. ncbi request reprint Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertension
    A Natali
    CNR Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa, Italy
    Hypertension 31:632-6. 1998
    ..6). We conclude that in overweight male patients with essential hypertension, increasing forearm perfusion with sodium nitroprusside does not attenuate the insulin resistance of forearm tissues...
  22. doi request reprint Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population
    Amalia Gastaldelli
    Fondazione Toscana G Monasterio and Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche CNR Pisa, Pisa, Italy
    Hepatology 49:1537-44. 2009
    ..Conclusion: In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI...
  23. ncbi request reprint Coronary artery disease and arterial hypertension: clinical, angiographic and follow-up data
    A Natali
    Metabolism Unit and the Coronary Division of the C N R Institute of Clinical Physiology, Department of Internal Medicine of the University of Pisa, Pisa, Italy
    J Intern Med 247:219-30. 2000
    ..To evaluate how the presence of arterial hypertension affects coronary atherosclerosis and prognosis in patients with, or at high risk of, ischaemic heart disease...
  24. ncbi request reprint The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
    S A Hills
    EGIR RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetologia 47:566-70. 2004
    ....
  25. ncbi request reprint Insulin resistance, insulin response, and obesity as indicators of metabolic risk
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:2885-92. 2007
    ..Moreover, the differential impact of IR viz. insulin response has not been evaluated...
  26. ncbi request reprint Effect of insulin on renal sodium and uric acid handling in essential hypertension
    E Muscelli
    Metabolism Unit, C.N.R. Institute of Clinical Physiology, Pisa, Italy
    Am J Hypertens 9:746-52. 1996
    ..Despite insulin resistance of glucose metabolism, acute physiological hyperinsulinemia causes normal antinatriuresis, antikaliuresis, and antiuricosuria in these patients...
  27. doi request reprint Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion
    A Natali
    Dipartimento di Medicina Clinica e Sperimentale, Universita di Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 56:1183-91. 2013
    ..We assessed the overall effect of systemic inhibition of endogenous NO synthesis on glucose homeostasis in humans...
  28. ncbi request reprint Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
    A Natali
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126, Pisa, Italy
    Diabetologia 49:434-41. 2006
    ..This review analyses the evidence relevant to these mechanisms in vivo...
  29. ncbi request reprint Effective blood pressure treatment improves LDL-cholesterol susceptibility to oxidation in patients with essential hypertension
    A Quinones-Galvan
    CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    J Intern Med 250:322-6. 2001
    ..We tested whether blood pressure (BP) normalization can reverse this abnormality...
  30. pmc Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR)
    E Ferrannini
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Clin Invest 100:1166-73. 1997
    ..In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity...
  31. ncbi request reprint Metabolic effects of combined antihypertensive treatment in patients with essential hypertension
    Alfredo Quiñones-Galvan
    National Research Council CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Cardiovasc Pharmacol 40:916-21. 2002
    ....
  32. ncbi request reprint beta-cell function in obesity: effects of weight loss
    Ele Ferrannini
    Department of Internal Medicine, Via Savi, 8, 56126 Pisa, Italy
    Diabetes 53:S26-33. 2004
    ..Lipid-triggered messages from the gastrointestinal tract to the insulin target tissues and endocrine pancreas are the subject of intense investigation...
  33. doi request reprint Insulin resistance, adipose depots and gut: interactions and pathological implications
    Amalia Gastaldelli
    Institute of Clinical Physiology, Stable Isotope Laboratory, CNR National Research Council, Pisa, Italy
    Dig Liver Dis 42:310-9. 2010
    ..e., muscle, liver and adipose tissue. The roles of the gut and the liver, in particular of bile acids and gut microflora, are also discussed as possible determinants of energy balance and glucose metabolism...
  34. ncbi request reprint Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance
    Elza Muscelli
    Dept of Internal Medicine, University of Pisa, 56122 Pisa, Italy
    Am J Physiol Endocrinol Metab 291:E1144-50. 2006
    ..In IGT, beta-cell function is inherently impaired, whereas the incretin effect is only partially affected...
  35. ncbi request reprint Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein
    Giuseppina Basta
    Consiglio Nazionale delle Richerche Institute of Clinical Physiology, Via Moruzzi, 1, 56124 Pisa, Italy
    J Clin Endocrinol Metab 91:4628-34. 2006
    ..RAGE has a circulating secretory receptor form, soluble RAGE (sRAGE), which, by neutralizing the action of advanced glycation end products, might exert a protective role against the development of cardiovascular disease...
  36. ncbi request reprint LDL resistance to oxidation: effects of lipid phenotype, autologous HDL and alanine
    Simona Baldi
    Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Clin Chim Acta 379:95-100. 2007
    ....
  37. ncbi request reprint Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
    Danilo Neglia
    Institute of Clinical Physiology, National Council for Research, Pisa 56124, Italy
    Am J Physiol Heart Circ Physiol 293:H3270-8. 2007
    ..These metabolic abnormalities might contribute to progressive cardiac deterioration and represent a target for therapeutic strategies aimed at modulating cardiac substrate utilization...
  38. ncbi request reprint The effect of lipoproteins on endothelial nitric oxide synthase is modulated by lipoperoxides
    V Lubrano
    C N R, Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Eur J Clin Invest 33:117-25. 2003
    ..By coupling in vivo and in vitro experiments we evaluated the role of oxidized lipid substrates in the modulation of eNOS activity by LDLs...
  39. ncbi request reprint Effect of acute hyperglycemia on insulin secretion in humans
    Elena Toschi
    Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Via Savi 8, 56126 Pisa, Italy
    Diabetes 51:S130-3. 2002
    ..We conclude that first-phase insulin secretion is inhibited by short-term modest hyperglycemia, whereas the second-phase insulin secretion increases linearly with hyperglycemia...
  40. ncbi request reprint Coronary atherosclerosis and alcohol consumption: angiographic and mortality data
    Romana Femia
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Arterioscler Thromb Vasc Biol 26:1607-12. 2006
    ..Moderate alcohol consumption is associated with reduced cardiovascular disease (CVD) risk. Whether this protection is based on a lesser degree of coronary atherosclerosis has not been established...
  41. ncbi request reprint Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine
    Nadia Caraccio
    Department of Internal Medicine, and Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 90:4057-62. 2005
    ..Neuromuscular symptoms and impaired muscle energy metabolism have been described in subclinical hypothyroidism (sHT)...
  42. ncbi request reprint Role of thromboxane A2 receptor on the effects of oxidized LDL on microvascular endothelium nitric oxide, endothelin-1, and IL-6 production
    Valter Lubrano
    C N R Institute of Clinical Physiology, Pisa, Italy
    Microcirculation 15:543-53. 2008
    ....
  43. ncbi request reprint Metabolic syndrome: at the crossroads of cardiorenal risk
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Nephrol 22:29-38. 2009
    ....
  44. doi request reprint Body composition and common carotid artery remodeling in a healthy population
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 93:3325-32. 2008
    ..Body composition (BC) influences systemic hemodynamics and may participate in the remodeling of common carotid artery (CCA), independently of risk factors...
  45. ncbi request reprint Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database
    Giorgio Sesti
    Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
    Diabetes Metab Res Rev 24:130-6. 2008
    ..We assessed the accuracy of the American Diabetes Association (ADA)2003 definition of impaired fasting glucose (IFG) in identifying subjects with low insulin sensitivity, and determined cardiovascular risk factors in ADA2003 IFG subjects...
  46. ncbi request reprint Menopause, insulin resistance, and risk factors for cardiovascular disease
    Melania Manco
    Institute of Internal Medicine, Catholic University, Rome, Italy
    Menopause 13:809-17. 2006
    ....
  47. ncbi request reprint Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests
    Andrea Mari
    Consiglio Nazionale delle Ricerche Institute of Biomedical Engineering, Padua, Italy
    Am J Physiol Endocrinol Metab 288:E541-6. 2005
    ....
  48. ncbi request reprint Hypertension, insulin resistance, and the metabolic syndrome
    Andrea Natali
    Department of Internal Medicine and CNRS Institute of Clinical Physiology, Univeristy of Pisa School of Medicine, Italy
    Endocrinol Metab Clin North Am 33:417-29. 2004
    ..While awaiting the results of clinical trials with cardiovascular endpoints, we should treat the metabolic syndrome with aggressive lifestyle intervention and consider drugs that improve the whole cardiovascular risk profile...
  49. ncbi request reprint Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension
    Hanspeter Brunner
    Division of Cardiology, University Hospital, Basel, Switzerland
    J Hypertens 23:233-46. 2005
    ..This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments...