Research Topics
Species | A NataliSummaryAffiliation: Institute of Clinical Physiology Country: Italy Publications
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Detail Information
Publications
Effects of short and prolonged mild intracellular nitric oxide manipulations on various aspects of insulin secretion in INS-1E β-cellsA Natali
Metabolism Unit, Department of Internal Medicine, University of Pisa, Italy
Exp Clin Endocrinol Diabetes 120:210-6. 2012..We aimed at evaluating the impact of short and prolonged mild manipulations of intracellular nitric oxide (NO) bioavailability on the main features of insulin secretion and whether NO promotes mitochondrial biogenesis in isolated β-cells...- Endothelial dysfunction in type 2 diabetesA Natali
Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Diabetologia 55:1559-63. 2012.... 
Erythrocyte sedimentation rate, coronary atherosclerosis, and cardiac mortalityAndrea Natali
Department of Internal Medicine, University of Pisa, Italy
Eur Heart J 24:639-48. 2003..To test whether the erythrocyte sedimentation rate (ESR) is related to the extension of coronary atherosclerosis (ATS) and predicts cardiac mortality...- Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetesAndrea Natali
Department of Internal Medicine, CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Diabetes Care 27:1349-57. 2004..The aim of this study was to test whether vascular reactivity is modified by improving metabolic control and peripheral insulin resistance in type 2 diabetes... - Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vesselsAndrea Natali
Department of Internal Medicine, Via Roma 67, 56100 Pisa, Italy
Eur Heart J 26:464-71. 2005..In vitro, haemoglobin neutralizes nitric oxide very effectively. Whether red blood cells participate in the regulation of endothelial function in vivo has not been established... - Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular functionA Natali
Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa, 56100, Italy
Diabetologia 51:862-71. 2008..Hyperglycaemia and hyperinsulinaemia have opposite effects on endothelium-dependent vasodilatation in microcirculation, but the net effect elicited by glucose ingestion and the separate influence of glucose tolerance are unknown... - Metabolic characteristics of prehypertension: role of classification criteria and genderAndrea Natali
Department of Internal Medicine, University of Pisa, Pisa, Italy
J Hypertens 27:2394-402. 2009.... - Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetesAndrea Natali
Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
Diabetes 55:1133-40. 2006..In type 2 diabetes, insulin resistance is associated with vascular dysfunction/damage, impaired fibrinolysis, and low-grade inflammation independently of obesity and poor glycemic control... - Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritanceAndrea Natali
Department of Internal Medicine, University of Pisa, Pisa, Italy
J Clin Endocrinol Metab 95:4703-11. 2010..What defects in glucose metabolism are present in offspring of type 2 diabetic patients (FHD(+) with a positive family history of diabetes) and to what extent they depend on line of inheritance are uncertain... - Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patientsA Gastaldelli
Metabolism Unit of the C.N.R. Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
Diabetes 50:1807-12. 2001..In type 2 diabetes, the excess GNG of the fasting state is carried over to the insulinized state, thereby contributing to glucose overproduction under both conditions... - The effect of menopause on carotid artery remodeling, insulin sensitivity, and plasma adiponectin in healthy womenElza Muscelli
Department of Internal Medicine, University of Pisa, Pisa, Italy
Am J Hypertens 22:364-70. 2009.... - Dose-response characteristics of insulin action on glucose metabolism: a non-steady-state approachA Natali
Metabolism Unit of the Consiglio Nazionale delle Ricerche Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, 56126 Pisa, Italy
Am J Physiol Endocrinol Metab 278:E794-801. 2000.... - Insulin: new roles for an ancient hormoneE Ferrannini
Metabolism Unit of the C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
Eur J Clin Invest 29:842-52. 1999..Description and understanding of these new roles, their interactions, the interplay between insulin resistance and hyperinsulinaemia, and their implications for cardiovascular disease have only begun... 
Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC studyEleni Rebelos
Department of Internal Medicine, University of Pisa, Italy
Diabetes 60:1938-45. 2011..Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes...- Effect of sedentary behaviour and vigorous physical activity on segment-specific carotid wall thickness and its progression in a healthy populationMichaela Kozakova
Department of Internal Medicine, University of Pisa, Via Roma, 67, Pisa 56122, Italy
Eur Heart J 31:1511-9. 2010..This study investigated whether sedentary behaviour and different activity levels have an independent association with carotid intima-media thickness (IMT) and with the 3-year IMT progression in different carotid segments... - Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC StudyE Ferrannini
Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
Diabetologia 54:1507-16. 2011..The natural history and physiological determinants of glucose intolerance in subjects living in Europe have not been investigated. The aim of this study was to increase our understanding of this area... - Plasma glucose levels as predictors of diabetes: the Mexico City diabetes studyE Ferrannini
Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
Diabetologia 52:818-24. 2009.... - Association of fasting glucagon and proinsulin concentrations with insulin resistanceE Ferrannini
Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
Diabetologia 50:2342-7. 2007..Hyperproinsulinaemia and relative hyperglucagonaemia are features of type 2 diabetes. We hypothesised that raised fasting glucagon and proinsulin concentrations may be associated with insulin resistance (IR) in non-diabetic individuals... - Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose toleranceE Ferrannini
Metabolism Unit, C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
Diabetologia 46:1211-9. 2003..Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed... - Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight lossM Emdin
Metabolism Unit and Coronary Division, CNR Institute of Clinical Physiology, and Department of Internal Medicine, University of Pisa, Pisa, Italy
Circulation 103:513-9. 2001..Reversal of these changes by weight loss suggests a causal role for insulin... - Vasodilation with sodium nitroprusside does not improve insulin action in essential hypertensionA Natali
CNR Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa, Italy
Hypertension 31:632-6. 1998..6). We conclude that in overweight male patients with essential hypertension, increasing forearm perfusion with sodium nitroprusside does not attenuate the insulin resistance of forearm tissues... - The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectivesS A Hills
EGIR-RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
Diabetologia 47:566-70. 2004..CONCLUSIONS: This study will evaluate the importance of insulin resistance in the development of CVD and diabetes, and has implications for the development of prevention and treatment strategies... - Insulin resistance, insulin response, and obesity as indicators of metabolic riskEle Ferrannini
Department of Internal Medicine, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
J Clin Endocrinol Metab 92:2885-92. 2007..Moreover, the differential impact of IR viz. insulin response has not been evaluated... - Coronary artery disease and arterial hypertension: clinical, angiographic and follow-up dataA Natali
Metabolism Unit and the Coronary Division of the C N R Institute of Clinical Physiology, Department of Internal Medicine of the University of Pisa, Pisa, Italy
J Intern Med 247:219-30. 2000..To evaluate how the presence of arterial hypertension affects coronary atherosclerosis and prognosis in patients with, or at high risk of, ischaemic heart disease... - Effect of insulin on renal sodium and uric acid handling in essential hypertensionE Muscelli
Metabolism Unit, C.N.R. Institute of Clinical Physiology, Pisa, Italy
Am J Hypertens 9:746-52. 1996..Despite insulin resistance of glucose metabolism, acute physiological hyperinsulinemia causes normal antinatriuresis, antikaliuresis, and antiuricosuria in these patients... - Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European populationAmalia Gastaldelli
Fondazione Toscana G Monasterio and Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche CNR Pisa, Pisa, Italy
Hepatology 49:1537-44. 2009..Conclusion: In middle-age nondiabetic subjects, increased IMT, CHD risk, and reduced insulin sensitivity are associated with high values of FLI... - Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic reviewA Natali
Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126, Pisa, Italy
Diabetologia 49:434-41. 2006.... - Effective blood pressure treatment improves LDL-cholesterol susceptibility to oxidation in patients with essential hypertensionA Quinones-Galvan
CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
J Intern Med 250:322-6. 2001..We tested whether blood pressure (BP) normalization can reverse this abnormality... - Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR)E Ferrannini
CNR Institute of Clinical Physiology, Pisa, Italy
J Clin Invest 100:1166-73. 1997..In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity... - Metabolic effects of combined antihypertensive treatment in patients with essential hypertensionAlfredo Quiñones-Galvan
National Research Council CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
J Cardiovasc Pharmacol 40:916-21. 2002.... - Insulin resistance, adipose depots and gut: interactions and pathological implicationsAmalia Gastaldelli
Institute of Clinical Physiology, Stable Isotope Laboratory, CNR National Research Council, Pisa, Italy
Dig Liver Dis 42:310-9. 2010..e., muscle, liver and adipose tissue. The roles of the gut and the liver, in particular of bile acids and gut microflora, are also discussed as possible determinants of energy balance and glucose metabolism... - Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathyDanilo Neglia
Institute of Clinical Physiology, National Council for Research, Pisa 56124, Italy
Am J Physiol Heart Circ Physiol 293:H3270-8. 2007..These metabolic abnormalities might contribute to progressive cardiac deterioration and represent a target for therapeutic strategies aimed at modulating cardiac substrate utilization... - beta-cell function in obesity: effects of weight lossEle Ferrannini
Department of Internal Medicine, Via Savi, 8, 56126 Pisa, Italy
Diabetes 53:S26-33. 2004..Lipid-triggered messages from the gastrointestinal tract to the insulin target tissues and endocrine pancreas are the subject of intense investigation... - LDL resistance to oxidation: effects of lipid phenotype, autologous HDL and alanineSimona Baldi
Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
Clin Chim Acta 379:95-100. 2007.... - Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 proteinGiuseppina Basta
Consiglio Nazionale delle Richerche Institute of Clinical Physiology, Via Moruzzi, 1, 56124 Pisa, Italy
J Clin Endocrinol Metab 91:4628-34. 2006..RAGE has a circulating secretory receptor form, soluble RAGE (sRAGE), which, by neutralizing the action of advanced glycation end products, might exert a protective role against the development of cardiovascular disease... - Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose toleranceElza Muscelli
Dept. of Internal Medicine, University of Pisa, 56122 Pisa, Italy
Am J Physiol Endocrinol Metab 291:E1144-50. 2006..In IGT, beta-cell function is inherently impaired, whereas the incretin effect is only partially affected... - The effect of lipoproteins on endothelial nitric oxide synthase is modulated by lipoperoxidesV Lubrano
C.N.R, Institute of Clinical Physiology, University of Pisa, Pisa, Italy
Eur J Clin Invest 33:117-25. 2003..Atorvastatin amplify this eNOS response in HUVEC, but not in HMEC, and this effect is not associated with a parallel increased NO2/NO3 generation... - Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxineNadia Caraccio
Department of Internal Medicine, and Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
J Clin Endocrinol Metab 90:4057-62. 2005..CONCLUSIONS: The response to exercise is altered both in terms of tolerance and pattern of substrate utilization in sHT patients. Restoring stable euthyroidism does not correct this defect over a 1-yr period... - Coronary atherosclerosis and alcohol consumption: angiographic and mortality dataRomana Femia
Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
Arterioscler Thromb Vasc Biol 26:1607-12. 2006..84; 95% CI, 0.71 to 1.00). CONCLUSIONS: In a selected high-risk population, moderate alcohol consumption was independently associated with less coronary atherosclerosis and lower risk for cardiac mortality... - Effect of acute hyperglycemia on insulin secretion in humansElena Toschi
Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Via Savi 8, 56126 Pisa, Italy
Diabetes 51:S130-3. 2002..We conclude that first-phase insulin secretion is inhibited by short-term modest hyperglycemia, whereas the second-phase insulin secretion increases linearly with hyperglycemia... - Metabolic syndrome: at the crossroads of cardiorenal riskAndrea Natali
Department of Internal Medicine, University of Pisa, Pisa, Italy
J Nephrol 22:29-38. 2009.... - Role of thromboxane A2 receptor on the effects of oxidized LDL on microvascular endothelium nitric oxide, endothelin-1, and IL-6 productionValter Lubrano
C N R Institute of Clinical Physiology, Pisa, Italy
Microcirculation 15:543-53. 2008.... - Body composition and common carotid artery remodeling in a healthy populationMichaela Kozakova
Department of Internal Medicine, University of Pisa, Via Roma 67, 56126 Pisa, Italy
J Clin Endocrinol Metab 93:3325-32. 2008..Body composition (BC) influences systemic hemodynamics and may participate in the remodeling of common carotid artery (CCA), independently of risk factors... - Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR databaseGiorgio Sesti
Department of Experimental and Clinical Medicine, University of Catanzaro, Italy
Diabetes Metab Res Rev 24:130-6. 2008..We assessed the accuracy of the American Diabetes Association (ADA)2003 definition of impaired fasting glucose (IFG) in identifying subjects with low insulin sensitivity, and determined cardiovascular risk factors in ADA2003 IFG subjects... - Menopause, insulin resistance, and risk factors for cardiovascular diseaseMelania Manco
Institute of Internal Medicine, Catholic University, Rome, Italy
Menopause 13:809-17. 2006.... - Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal testsAndrea Mari
Consiglio Nazionale delle Ricerche Institute of Biomedical Engineering, Padua, Italy
Am J Physiol Endocrinol Metab 288:E541-6. 2005.... - Hypertension, insulin resistance, and the metabolic syndromeAndrea Natali
Department of Internal Medicine and CNRS Institute of Clinical Physiology, Univeristy of Pisa School of Medicine, Italy
Endocrinol Metab Clin North Am 33:417-29. 2004..While awaiting the results of clinical trials with cardiovascular endpoints, we should treat the metabolic syndrome with aggressive lifestyle intervention and consider drugs that improve the whole cardiovascular risk profile... - Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of HypertensionHanspeter Brunner
Division of Cardiology, University Hospital, Basel, Switzerland
J Hypertens 23:233-46. 2005..This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments...