Affiliation: Institute of Biomembranes and Bioenergetics
Moro L, Arbini A, Marra E, Greco M. Mitochondrial DNA depletion reduces PARP-1 levels and promotes progression of the neoplastic phenotype in prostate carcinoma. Cell Oncol. 2008;30:307-22 pubmed
..Overall, these results provide novel evidence demonstrating that mtDNA depletion in early prostate carcinoma may contribute to the acquisition of a more invasive phenotype that is less sensitive to paclitaxel-induced apoptosis. ..
Moro L, Guaragnella N, Giannattasio S. Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells. J Vis Exp. 2015;:e52849 pubmed publisher
..Adaptation of this protocol for efficient silencing and analysis of other 'large' proteins like BRCA2 should be readily achievable. ..
Guerra F, Arbini A, Moro L. Mitochondria and cancer chemoresistance. Biochim Biophys Acta Bioenerg. 2017;1858:686-699 pubmed publisher
..This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux. ..
Moro L, Arbini A, Yao J, di Sant agnese P, Marra E, Greco M. Loss of BRCA2 promotes prostate cancer cell invasion through up-regulation of matrix metalloproteinase-9. Cancer Sci. 2008;99:553-63 pubmed publisher
Moro L, Arbini A, Hsieh J, Ford J, Simpson E, Hajibeigi A, et al
. Aromatase deficiency inhibits the permeability transition in mouse liver mitochondria. Endocrinology. 2010;151:1643-52 pubmed publisher