Gabriella Minchiotti

Summary

Affiliation: Institute of Genetics and Biophysics
Country: Italy

Publications

  1. pmc Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction
    Daniela D'Andrea
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    J Cell Biol 180:597-605. 2008
  2. ncbi request reprint Nodal-dependant Cripto signaling in ES cells: from stem cells to tumor biology
    Gabriella Minchiotti
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino 111, 80131 Naples, Italy
    Oncogene 24:5668-75. 2005
  3. doi request reprint A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease
    Enza Lonardo
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics, Naples, Italy
    Stem Cells 28:1326-37. 2010
  4. ncbi request reprint G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway
    Cristina D'Aniello
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino 111, 80131 Naples, Italy
    Circ Res 105:231-8. 2009
  5. ncbi request reprint Role of the EGF-CFC gene cripto in cell differentiation and embryo development
    Gabriella Minchiotti
    International Institute of Genetics and Biophysics, CNR, Via Marconi 12, 80125 Naples, Italy
    Gene 287:33-7. 2002
  6. ncbi request reprint The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis
    Cristina D'Aniello
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Cardiovasc Res 100:95-104. 2013
  7. ncbi request reprint Cripto signaling in differentiating embryonic stem cells
    Gabriella Minchiotti
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy
    Methods Mol Biol 329:151-69. 2006
  8. pmc Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin
    Ombretta Guardiola
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 109:E3231-40. 2012
  9. ncbi request reprint Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease
    Clare L Parish
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Stem Cells 23:471-6. 2005
  10. doi request reprint An automated high throughput screening-compatible assay to identify regulators of stem cell neural differentiation
    Laura Casalino
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, National Research Council, Naples, Italy
    Mol Biotechnol 50:171-80. 2012

Collaborators

  • Ernest Arenas
  • Peter Carmeliet
  • Laura Casalino
  • Silvia Brunelli
  • Shahragim Tajbakhsh
  • Olov Andersson
  • Stefania Filosa
  • Giulio Cossu
  • Daniel B Constam
  • Frederic M Rosa
  • Eileen Adamson
  • Gilda Cobellis
  • Enza Lonardo
  • Cristina D'Aniello
  • Giovanna L Liguori
  • Daniela Marasco
  • Salvatore Iaconis
  • Ombretta Guardiola
  • Annalisa Fico
  • Menotti Ruvo
  • Clare L Parish
  • Daniela D'Andrea
  • Gennaro Andolfi
  • Silvia Parisi
  • Salvatore Ponticelli
  • J Ann Le Good
  • Marie Hélène Blanchet
  • Sandro De Falco
  • Maria G Persico
  • Angela Saporito
  • Carlo Pedone
  • Luisa Calvanese
  • Tazu O Aoki
  • Alessandro Fiorenzano
  • Peggy Lafuste
  • Philippos Mourikis
  • Michael M Shen
  • Ann Bouché
  • Thierry Touvier
  • Katrien De Bock
  • Diogo Ribeiro
  • Monica Autiero
  • Anna Maria Liguoro
  • Judith Klumperman
  • Daniel Mesnard
  • Stéphane Baflast
  • Stefano Guido
  • Genesia Manganelli
  • Marino Simeone
  • Viola Oorschot
  • Angela Chambery
  • Lucia Falcigno
  • Livio Paolillo
  • Gabriella D'Auria
  • Carmine T Lago
  • M Graziella Persico
  • Laure Saint-Etienne
  • Thomas Dickmeis
  • Nicolas B David
  • Uwe Strahle
  • Philippe Mourrain
  • Graziella M Persico

Detail Information

Publications18

  1. pmc Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction
    Daniela D'Andrea
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    J Cell Biol 180:597-605. 2008
    ....
  2. ncbi request reprint Nodal-dependant Cripto signaling in ES cells: from stem cells to tumor biology
    Gabriella Minchiotti
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino 111, 80131 Naples, Italy
    Oncogene 24:5668-75. 2005
    ..This review will discuss recent findings on the molecular basis of Cripto signaling in ES cell differentiation, providing an intriguing link between stem cell and tumor biology...
  3. doi request reprint A small synthetic cripto blocking Peptide improves neural induction, dopaminergic differentiation, and functional integration of mouse embryonic stem cells in a rat model of Parkinson's disease
    Enza Lonardo
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics, Naples, Italy
    Stem Cells 28:1326-37. 2010
    ..We therefore suggest that specific blockers such as Cripto BP may be used to improve the differentiation of ESC-derived DA neurons in vitro and their engraftment in vivo, bringing us closer towards an application of ESCs in CRT...
  4. ncbi request reprint G protein-coupled receptor APJ and its ligand apelin act downstream of Cripto to specify embryonic stem cells toward the cardiac lineage through extracellular signal-regulated kinase/p70S6 kinase signaling pathway
    Cristina D'Aniello
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino 111, 80131 Naples, Italy
    Circ Res 105:231-8. 2009
    ..The EGF-CFC (epidermal growth factor-Cripto/FRL-1/Cryptic) Cripto protein is essential for cardiac myogenesis in embryonic stem cells (ESCs)...
  5. ncbi request reprint Role of the EGF-CFC gene cripto in cell differentiation and embryo development
    Gabriella Minchiotti
    International Institute of Genetics and Biophysics, CNR, Via Marconi 12, 80125 Naples, Italy
    Gene 287:33-7. 2002
    ..Here we review the biological role of cripto in development and differentiation, pointing out recent findings on the biochemical interactions of Cripto, Nodal and Activin-like receptors...
  6. ncbi request reprint The G-protein-coupled receptor APJ is expressed in the second heart field and regulates Cerberus-Baf60c axis in embryonic stem cell cardiomyogenesis
    Cristina D'Aniello
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Cardiovasc Res 100:95-104. 2013
    ..Pluripotent embryonic stem cells (ESCs) recapitulate many aspects of development, and have provided an excellent opportunity to dissect the molecular mechanisms underlying cardiomyogenesis, which is still incompletely defined...
  7. ncbi request reprint Cripto signaling in differentiating embryonic stem cells
    Gabriella Minchiotti
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy
    Methods Mol Biol 329:151-69. 2006
    ..Although referred to as modulation of Cripto signaling, these methods build the basis for the use of other classes of secreted molecules to control ES cell differentiation...
  8. pmc Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin
    Ombretta Guardiola
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 109:E3231-40. 2012
    ..Our data provide unique insights into the molecular and cellular basis of Cripto activity in skeletal muscle regeneration and raise previously undescribed implications for stem cell biology and regenerative medicine...
  9. ncbi request reprint Cripto as a target for improving embryonic stem cell-based therapy in Parkinson's disease
    Clare L Parish
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    Stem Cells 23:471-6. 2005
    ..The use of knockout ES cells that can generate dopamine cells while eliminating tumor risk holds enormous potential for cell replacement therapy in Parkinson's disease...
  10. doi request reprint An automated high throughput screening-compatible assay to identify regulators of stem cell neural differentiation
    Laura Casalino
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, National Research Council, Naples, Italy
    Mol Biotechnol 50:171-80. 2012
    ..Moreover, we performed a pilot screening providing proof of concept that this assay allows the identification of regulators of ESC neural differentiation in full automation...
  11. doi request reprint High-throughput screening-compatible single-step protocol to differentiate embryonic stem cells in neurons
    Annalisa Fico
    Stem Cell Fate Lab, Istituto di Genetica e Biofisica Adriano Buzzati Traverso CNR, Via Pietro Castellino 111, 80131 Napoli, Italy
    Stem Cells Dev 17:573-84. 2008
    ....
  12. doi request reprint Control of embryonic stem cell metastability by L-proline catabolism
    Laura Casalino
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Naples, Italy
    J Mol Cell Biol 3:108-22. 2011
    ..All together, our data provide evidence that ESC metastability can be regulated at a metabolic level...
  13. ncbi request reprint Chemical synthesis of mouse cripto CFC variants
    Daniela Marasco
    Istituto di Biostrutture e Bioimmagini del CNR, Sezione Biostrutture, Napoli, Italy
    Proteins 64:779-88. 2006
    ..A comparative study of receptor binding shows that the CFC domain can bind Alk4 and confirms the importance of W107 and H104 for receptor recognition...
  14. ncbi request reprint Cripto: a tumor growth factor and more
    Eileen D Adamson
    La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Cell Physiol 190:267-78. 2002
    ..Meanwhile some speculations on possible receptor complexes for Cripto signaling in mammary cells are offered here as a spur to further discoveries...
  15. pmc Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells
    Silvia Parisi
    Institute of Genetics and Biophysics, Adriano Buzzati Traverso, Consiglio Naziolale delle Ricerche, Naples, Italy
    J Cell Biol 163:303-14. 2003
    ..Finally, we show that Nodal antagonists inhibit Cripto-regulated cardiomyocyte induction and differentiation in ES cells. All together our findings provide evidence for a novel role of the Nodal/Cripto/Alk4 pathway in this process...
  16. pmc Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
    Marie Hélène Blanchet
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Epalinges, Switzerland
    EMBO J 27:2580-91. 2008
    ..We conclude that Nodal processing and endocytosis are coupled in signal-receiving cells...
  17. ncbi request reprint Solution structure of mouse Cripto CFC domain and its inactive variant Trp107Ala
    Luisa Calvanese
    Dipartimento di Chimica, Universita Federico II, Complesso Universitario MSA, via Cintia 45, 80126 Napoli, Italy
    J Med Chem 49:7054-62. 2006
    ..A second hydrophilic patch surrounding His104 and Trp107 is present only in the wild type variant, suggesting a possible involvement in modulating Alk4 recognition...
  18. ncbi request reprint Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation
    Tazu O Aoki
    U 368 INSERM, Ecole Normale Superieure, 46, rue d Ulm, F 75230 Paris cedex 05, France
    Development 129:275-86. 2002
    ..In addition, casanova efficiently restores later endodermal differentiation in these mutants, but this process requires, in addition, a partial activation of Nodal signalling...