C Matrone

Summary

Affiliation: Institute of Neurobiology and Molecular Medicine
Country: Italy

Publications

  1. pmc Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation
    C Matrone
    Institute of Neurobiology and Molecular Medicine, National Research Council, via del Fosso del Fiorano 64, 00143 Rome, Italy
    Proc Natl Acad Sci U S A 106:11358-63. 2009
  2. pmc APP is phosphorylated by TrkA and regulates NGF/TrkA signaling
    Carmela Matrone
    Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, 00143 Rome, Italy
    J Neurosci 31:11756-61. 2011
  3. doi request reprint Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF
    P Calissano
    Institute of Neurobiology and Molecular Medicine, via del Fosso di Fiorano 64 65, Rome 00143, Italy
    Cell Death Differ 17:1126-33. 2010
  4. doi request reprint Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage
    R Marolda
    Institute of Cell Biology and Neurobiology, CNR, Via del Fosso di Fiorano, 65, 00143 Rome, Italy
    Neuropharmacology 62:1954-63. 2012
  5. doi request reprint Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease
    P Calissano
    Institute of Neurobiology and Molecular Medicine, C N R Fondazione Santa Lucia, Italy
    Dev Neurobiol 70:372-83. 2010

Collaborators

  • P Calissano
  • R Marolda
  • S Cavallaro
  • C Severini
  • R Possenti
  • M T Ciotti

Detail Information

Publications5

  1. pmc Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation
    C Matrone
    Institute of Neurobiology and Molecular Medicine, National Research Council, via del Fosso del Fiorano 64, 00143 Rome, Italy
    Proc Natl Acad Sci U S A 106:11358-63. 2009
    ....
  2. pmc APP is phosphorylated by TrkA and regulates NGF/TrkA signaling
    Carmela Matrone
    Institute of Cellular Biology and Neurobiology, National Council of Research of Rome, 00143 Rome, Italy
    J Neurosci 31:11756-61. 2011
    ..This evidence suggests that these two membrane protein's functions are strictly interconnected and that the NGF/TrkA signaling pathway is involved in AD pathogenesis and can be used as a therapeutic target...
  3. doi request reprint Does the term 'trophic' actually mean anti-amyloidogenic? The case of NGF
    P Calissano
    Institute of Neurobiology and Molecular Medicine, via del Fosso di Fiorano 64 65, Rome 00143, Italy
    Cell Death Differ 17:1126-33. 2010
    ..This inhibitory action appears to be mediated by a complex series of molecular events and by interactions among NGF receptors (TrkA and p75), APP processing and tau metabolic fate and function...
  4. doi request reprint Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage
    R Marolda
    Institute of Cell Biology and Neurobiology, CNR, Via del Fosso di Fiorano, 65, 00143 Rome, Italy
    Neuropharmacology 62:1954-63. 2012
    ..In addition to its neuroprotective properties, this study shows that SP is able to stimulate non-amyloidogenic APP processing, thereby reducing the possibility of generation of toxic Aβ peptides in brain...
  5. doi request reprint Nerve growth factor as a paradigm of neurotrophins related to Alzheimer's disease
    P Calissano
    Institute of Neurobiology and Molecular Medicine, C N R Fondazione Santa Lucia, Italy
    Dev Neurobiol 70:372-83. 2010
    ..In this scenario, the so-called trophic action exerted by NGF (and possibly also by other neurotrophins) in these targets neurons is actually the result of an anti-amyloidogenic activity...