A Mari

Summary

Affiliation: Institute of Systems Science and Biomedical Engineering
Country: Italy

Publications

  1. ncbi A model-based method for assessing insulin sensitivity from the oral glucose tolerance test
    A Mari
    Institute of Systems Science and Biomedical Engineering, National Research Council, Padova, Italy
    Diabetes Care 24:539-48. 2001
  2. ncbi Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation
    Andrea Mari
    C N R National Research Council Institute of Systems Science and Biomedical Engineering, Padua, Italy
    Diabetes 51:S221-6. 2002
  3. ncbi Mathematical modeling in glucose metabolism and insulin secretion
    Andrea Mari
    Institute of Systems Science and Biomedical Engineering, National Research Councl, Padova, Italy
    Curr Opin Clin Nutr Metab Care 5:495-501. 2002
  4. ncbi Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects
    Andrea Mari
    Consiglio Nazionale delle Ricerche Institute of Systems Science and Biomedical Engineering, 35127 Padua, Italy
    Am J Physiol Endocrinol Metab 283:E1159-66. 2002
  5. ncbi A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models
    Andrea Mari
    Institute of Systems Science and Biomedical Engineering, National Research Council, LADSEB CNR, Corso Stati Uniti 4, 35127 Padova, Italy
    Comput Methods Programs Biomed 71:269-81. 2003
  6. ncbi Value of the intravenous and oral glucose tolerance tests for detecting subtle impairments in insulin sensitivity and beta-cell function in former gestational diabetes
    A Tura
    Institute of Biomedical Engineering, CNR, Padua, Italy
    Clin Endocrinol (Oxf) 69:237-43. 2008
  7. ncbi Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes
    A Mari
    C N R Institute of Biomedical Engineering, Padua, Italy
    Diabet Med 25:671-7. 2008
  8. ncbi Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance
    A Mari
    ISIB CNR, Corso Stati Uniti 4, 35127 Padua, Italy
    Diabetologia 53:749-56. 2010
  9. ncbi Impaired beta-cell function in lean normotolerant former gestational diabetic women
    A Tura
    Metabolic Unit, Institute of Biomedical Engineering, CNR, Padua, Italy
    Eur J Clin Invest 36:22-8. 2006
  10. doi Beta-cell function assessment from modelling of oral tests: an effective approach
    A Mari
    Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Diabetes Obes Metab 10:77-87. 2008

Collaborators

Detail Information

Publications40

  1. ncbi A model-based method for assessing insulin sensitivity from the oral glucose tolerance test
    A Mari
    Institute of Systems Science and Biomedical Engineering, National Research Council, Padova, Italy
    Diabetes Care 24:539-48. 2001
    ..We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulin sensitivity [OGIS]) index, which predicts glucose clearance in a glucose clamp. We validated OGIS against clamp data...
  2. ncbi Assessing insulin secretion by modeling in multiple-meal tests: role of potentiation
    Andrea Mari
    C N R National Research Council Institute of Systems Science and Biomedical Engineering, Padua, Italy
    Diabetes 51:S221-6. 2002
    ..Use of the model in patients with type 2 diabetes retrieves known defects in insulin secretion but also uncovers new facets of beta-cell dysfunction...
  3. ncbi Mathematical modeling in glucose metabolism and insulin secretion
    Andrea Mari
    Institute of Systems Science and Biomedical Engineering, National Research Councl, Padova, Italy
    Curr Opin Clin Nutr Metab Care 5:495-501. 2002
    ..The available models are illustrated, and their common aspects and differences discussed...
  4. ncbi Meal and oral glucose tests for assessment of beta -cell function: modeling analysis in normal subjects
    Andrea Mari
    Consiglio Nazionale delle Ricerche Institute of Systems Science and Biomedical Engineering, 35127 Padua, Italy
    Am J Physiol Endocrinol Metab 283:E1159-66. 2002
    ..With cautious interpretation, a 2-h MT or a standard OGTT can be used as surrogates of 24-h tests in assessing spontaneous beta-cell function...
  5. ncbi A circulatory model for calculating non-steady-state glucose fluxes. Validation and comparison with compartmental models
    Andrea Mari
    Institute of Systems Science and Biomedical Engineering, National Research Council, LADSEB CNR, Corso Stati Uniti 4, 35127 Padova, Italy
    Comput Methods Programs Biomed 71:269-81. 2003
    ..Recovery of the infused glucose dose was 93+/-2, 94+/-2, 92+/-2 and 85+/-2%, respectively. These results show that the circulatory model is an appropriate model for assessing glucose turnover during an oral glucose load...
  6. ncbi Value of the intravenous and oral glucose tolerance tests for detecting subtle impairments in insulin sensitivity and beta-cell function in former gestational diabetes
    A Tura
    Institute of Biomedical Engineering, CNR, Padua, Italy
    Clin Endocrinol (Oxf) 69:237-43. 2008
    ..Our aim was to study insulin sensitivity and beta-cell function with two independent glucose tolerance tests in fGDM women divided according to their glucose tolerance...
  7. ncbi Relationships between insulin secretion after intravenous and oral glucose administration in subjects with glucose tolerance ranging from normal to overt diabetes
    A Mari
    C N R Institute of Biomedical Engineering, Padua, Italy
    Diabet Med 25:671-7. 2008
    ..To elucidate this phenomenon, we examined the relationships between fasting plasma glucose (FPG) and the secretory responses to an IVGTT and an oral glucose test (OGTT)...
  8. ncbi Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance
    A Mari
    ISIB CNR, Corso Stati Uniti 4, 35127 Padua, Italy
    Diabetologia 53:749-56. 2010
    ..e. impaired glucose tolerance or impaired fasting glucose...
  9. ncbi Impaired beta-cell function in lean normotolerant former gestational diabetic women
    A Tura
    Metabolic Unit, Institute of Biomedical Engineering, CNR, Padua, Italy
    Eur J Clin Invest 36:22-8. 2006
    ..Former gestational diabetes (fGDM) constitutes a risk condition for the development of Type 2 diabetes. Former gestational diabetes is often characterized by obesity and hyperglycaemia, which may be concomitant and independent risk factors...
  10. doi Beta-cell function assessment from modelling of oral tests: an effective approach
    A Mari
    Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Diabetes Obes Metab 10:77-87. 2008
    ....
  11. ncbi Restoration of normal glucose tolerance in severely obese patients after bilio-pancreatic diversion: role of insulin sensitivity and beta cell function
    A Mari
    CNR Institute of Biomedical Engineering, Corso Stati Uniti 4, 35127, Padua, Italy
    Diabetologia 49:2136-43. 2006
    ..The aim of this study was to analyse the mechanisms underlying the improvement in glucose tolerance seen in morbidly obese patients undergoing bilio-pancreatic diversion (BPD)...
  12. ncbi Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes
    A Mari
    National Research Center, Institute of Biomedical Engineering, Corso Stati Uniti 4, 35127 Padova, Italy
    J Clin Endocrinol Metab 90:4888-94. 2005
    ....
  13. ncbi Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test
    A Mari
    Metabolic Modelling Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Diabetologia 48:748-51. 2005
    ..We compared five surrogate insulin sensitivity (IS) methods against the euglycaemic-hyperinsulinaemic clamp. These methods were the homeostasis model assessment (HOMA) and four methods based on the OGTT (OGIS, MCRest, ISIcomp, SIORAL)...
  14. ncbi Mathematical modeling shows exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin or metformin and a sulfonylurea
    A Mari
    National Research Council Institute of Biomedical Engineering, Padova, Italy
    Horm Metab Res 38:838-44. 2006
    ..This model suggests exenatide improved beta-cell function in patients with type 2 diabetes treated with metformin+/-a sulfonylurea...
  15. ncbi The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    Bogdan Balas
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Drive, MC 7886, San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 92:1249-55. 2007
    ..However, little is known about the mechanism(s) by which vildagliptin promotes reduction in plasma glucose concentration...
  16. ncbi Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions
    Andrea Mari
    Institute of Biomedical Engineering CNR, Corso Stati Uniti 4, 35127 Padova, Italy
    Diabetes Care 30:2032-3. 2007
  17. ncbi Insulin resistance, insulin response, and obesity as indicators of metabolic risk
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:2885-92. 2007
    ..Moreover, the differential impact of IR viz. insulin response has not been evaluated...
  18. ncbi Pancreatic fat content and beta-cell function in men with and without type 2 diabetes
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Center, VU University Medical Center, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Diabetes Care 30:2916-21. 2007
    ..Experimental data indicate that fatty infiltration of pancreatic islets may also contribute to beta-cell dysfunction, but whether this occurs in humans in vivo is unknown...
  19. ncbi Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function
    Laura Pascoe
    Diabetes Research Group, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 56:3101-4. 2007
    ..Our objective was to explore the relationships between the diabetes-associated alleles and measures of beta-cell function and whole-body insulin sensitivity...
  20. ncbi Characterization of the influence of vildagliptin on model-assessed -cell function in patients with type 2 diabetes and mild hyperglycemia
    Andrea Mari
    Institute of Biomedical Engineering, National Research Council, I 35127 Padova, Italy
    J Clin Endocrinol Metab 93:103-9. 2008
    ..This study was conducted to characterize the effects of vildagliptin on beta-cell function in patients with type 2 diabetes and mild hyperglycemia...
  21. ncbi Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    Elza Muscelli
    Department of Internal Medicine, Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, University of Pisa, Italy
    Diabetes 57:1340-8. 2008
    ..To quantitate the separate impact of obesity and hyperglycemia on the incretin effect (i.e., the gain in beta-cell function after oral glucose versus intravenous glucose)...
  22. pmc Effect of ovarian suppression with gonadotropin-releasing hormone agonist on glucose disposal and insulin secretion
    Michael J Toth
    Department of Medicine and Obstetrics and Gynecology, University of Vermont, Burlington, VT 05405, USA
    Am J Physiol Endocrinol Metab 294:E1035-45. 2008
    ..Our data do, however, support a role for ovarian hormones in the regulation of plasma adiponectin levels...
  23. ncbi Effect of acute hyperglycemia on insulin secretion in humans
    Elena Toschi
    Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Via Savi 8, 56126 Pisa, Italy
    Diabetes 51:S130-3. 2002
    ..We conclude that first-phase insulin secretion is inhibited by short-term modest hyperglycemia, whereas the second-phase insulin secretion increases linearly with hyperglycemia...
  24. ncbi Visceral fat in hypertension: influence on insulin resistance and beta-cell function
    Anna Maria Sironi
    National Research Council, Institute of Clinical Physiology, Area of research, Via Moruzzi, 1 S Cataldo, 56100 Pisa, Italy
    Hypertension 44:127-33. 2004
    ..Such visceral adiposity is quantitatively related to both height of blood pressure and severity of insulin resistance, but has no impact on the dynamics of beta-cell function...
  25. ncbi Thiazolidinediones improve beta-cell function in type 2 diabetic patients
    Amalia Gastaldelli
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 292:E871-83. 2007
    ..In T2DM patients, TZD treatment leads to improved beta-cell function, which correlates strongly with improved glycemic control...
  26. ncbi Lipid-induced beta-cell dysfunction in vivo in models of progressive beta-cell failure
    Tracy T Goh
    Department of Physiology, University of Toronto, Toronto, ON, M5S 1A8, Canada
    Am J Physiol Endocrinol Metab 292:E549-60. 2007
    ..3) This compensation is lost in diabetic rats with more marked hyperglycemia and loss of glucose sensing...
  27. ncbi beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis
    Ele Ferrannini
    Diabetes Division, Department of Internal Medicine, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Clin Endocrinol Metab 90:493-500. 2005
    ....
  28. ncbi Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests
    Andrea Mari
    Consiglio Nazionale delle Ricerche Institute of Biomedical Engineering, Padua, Italy
    Am J Physiol Endocrinol Metab 288:E541-6. 2005
    ....
  29. ncbi Beta-cell function in mild type 2 diabetic patients: effects of 6-month glucose lowering with nateglinide
    Andrea Mari
    Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti 4, 35127 Padua, Italy
    Diabetes Care 28:1132-8. 2005
    ....
  30. ncbi beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss
    Stefania Camastra
    Department of Internal Medicine, Metabolism Unit, National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetes 54:2382-9. 2005
    ..With continued weight loss over a 2-year period, moderately obese subjects become supersensitive to insulin and, correspondingly, insulin hyposecretors...
  31. ncbi Effects of portal free fatty acid elevation on insulin clearance and hepatic glucose flux
    Hidenori Yoshii
    Dept of Physiology, Univ of Toronto, Medical Sciences Bldg, Rm 3336, Toronto, ON M5S1A8 Canada
    Am J Physiol Endocrinol Metab 290:E1089-97. 2006
    ..This may, in the long term, contribute to the metabolic and cardiovascular risk of visceral obesity...
  32. ncbi Preeclampsia in lean normotensive normotolerant pregnant women can be predicted by simple insulin sensitivity indexes
    Elena Parretti
    Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Italy
    Hypertension 47:449-53. 2006
    ..Given their high sensitivity and specificity, these indexes could be useful in predicting the development of preeclampsia in early pregnancy, before the disease become clinically evident...
  33. ncbi Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans
    Bo Ahren
    Department of Medicine, Lund University, Lund, Sweden
    Diabetes Care 26:2860-4. 2003
    ..Previously, beta-cell effects of GLP-1 have been characterized in humans during graded intravenous infusions of glucose, whereas its effects after more physiological stimuli, like meal intake, are not known...
  34. ncbi Mechanisms of recovery from type 2 diabetes after malabsorptive bariatric surgery
    Caterina Guidone
    Dipartimento di Medicina Interna, Catholic University, Largo A Gemelli, 8, 00168 Rome, Italy
    Diabetes 55:2025-31. 2006
    ..This operation may affect the enteroinsular axis function by diverting nutrients away from the proximal gastrointestinal tract and by delivering incompletely digested nutrients to the ileum...
  35. ncbi Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance
    Elza Muscelli
    Dept of Internal Medicine, University of Pisa, 56122 Pisa, Italy
    Am J Physiol Endocrinol Metab 291:E1144-50. 2006
    ..In IGT, beta-cell function is inherently impaired, whereas the incretin effect is only partially affected...
  36. ncbi Assessment of insulin secretion in relation to insulin resistance
    Andrea Mari
    Metabolic Modeling Unit, Institute of Biomedical Engineering, National Research Council, Padova, Italy
    Curr Opin Clin Nutr Metab Care 8:529-33. 2005
    ..This review will discuss these concepts and the aspects that should be considered for an appropriate solution to the problem...
  37. ncbi Methods for clinical assessment of insulin sensitivity and beta-cell function
    Giovanni Pacini
    Metabolic Modeling Unit, Institute of Biomedical Engineering, National Research Council, Padua, Italy
    Best Pract Res Clin Endocrinol Metab 17:305-22. 2003
    ..Particular attention is paid to the oral glucose tolerance test, which has recently received considerable interest. The role of mathematical models in IS and BCF assessment is also emphasized...
  38. ncbi beta-cell function in obesity: effects of weight loss
    Ele Ferrannini
    Department of Internal Medicine, Via Savi, 8, 56126 Pisa, Italy
    Diabetes 53:S26-33. 2004
    ..Lipid-triggered messages from the gastrointestinal tract to the insulin target tissues and endocrine pancreas are the subject of intense investigation...
  39. ncbi Beta-cell function in severely obese type 2 diabetic patients: long-term effects of bariatric surgery
    Stefania Camastra
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 30:1002-4. 2007
  40. ncbi Lack of association of liver fat with model parameters of beta-cell function in men with impaired glucose tolerance and type 2 diabetes
    Maarten E Tushuizen
    Department of Endocrinology Diabetes Centre, Institute of Biomedical Engineering, National Research Council, I 35127, Padova, Italy
    Eur J Endocrinol 159:251-7. 2008
    ..Hepatic steatosis and obesity are components of the metabolic syndrome and risk factors for developing type 2 diabetes (T2DM). We studied how liver fat and body fat distribution relate to various aspects of beta-cell function...